Joint hypermobility

Symptom Information:

Symptom ID: HPO:0001382
Synonyms:
Extensible joints [HPO:0001382]
Hyperextensible joints [HPO:0001382]
Increased mobility of joints [HPO:0001382]
Joint hyperextensibility [HPO:0001382]
Joint laxity (finding) [Orphanet:46360]
Range of joint movement increased (finding) [Orphanet:46360]
Hypermobility, Joint [Orphanet:46360]
Extensible joints [OMIM:Extensible joints]
Hyperextensible joints [OMIM:Hyperextensible joints]
Joint hyperextensibility [OMIM:Joint hyperextensibility]
Joint hypermobility [OMIM:Joint hypermobility]
Hyperextensible joints/articular hyperlaxity [Orphanet:46360]
Joint laxity [Orphanet:46360]
Joint laxity [MedDRA:10070874]
Joint hypermobility (in some patients) [OMIM:Joint hypermobility (in some patients)]
Joint hypermobility (large and small joints) [OMIM:Joint hypermobility (large and small joints)]
Joint hypermobility (rare) [OMIM:Joint hypermobility (rare)]
Joint laxity (elbow) [OMIM:Joint laxity (elbow)]
Joint laxity (elbow, wrist, fingers) [OMIM:Joint laxity (elbow, wrist, fingers)]
Joint laxity (except elbow) [OMIM:Joint laxity (except elbow)]
Joint laxity (fingers and wrist) [OMIM:Joint laxity (fingers and wrist)]
Joint laxity (hands and feet) [OMIM:Joint laxity (hands and feet)]
Joint laxity (hip, knee, shoulder, wrist, fingers) [OMIM:Joint laxity (hip, knee, shoulder, wrist, fingers)]
Quality:
Cross references:
HPO:0001388 "Joint laxity" [Orphanet:46360]
HPO:0005692 "Joint hyperflexibility" [Orphanet:46360]
Orphanet:46360 "Hyperextensible joints/articular hyperlaxity" [Orphanet:46360]
OMIM: "Extensible joints" [OMIM:Extensible joints]
OMIM: "Hyperextensible joints" [OMIM:Hyperextensible joints]
OMIM: "Joint hyperextensibility" [OMIM:Joint hyperextensibility]
OMIM: "Joint hypermobility" [OMIM:Joint hypermobility]
OMIM: "Joint hypermobility (in some patients)" [OMIM:Joint hypermobility (in some patients)]
OMIM: "Joint hypermobility (large and small joints)" [OMIM:Joint hypermobility (large and small joints)]
OMIM: "Joint hypermobility (rare)" [OMIM:Joint hypermobility (rare)]
OMIM: "Joint laxity (elbow)" [OMIM:Joint laxity (elbow)]
OMIM: "Joint laxity (elbow, wrist, fingers)" [OMIM:Joint laxity (elbow, wrist, fingers)]
OMIM: "Joint laxity (except elbow)" [OMIM:Joint laxity (except elbow)]
OMIM: "Joint laxity (fingers and wrist)" [OMIM:Joint laxity (fingers and wrist)]
OMIM: "Joint laxity (hands and feet)" [OMIM:Joint laxity (hands and feet)]
OMIM: "Joint laxity (hip, knee, shoulder, wrist, fingers)" [OMIM:Joint laxity (hip, knee, shoulder, wrist, fingers)]
UMLS:C0086437 "Hypermobility, Joint" [Orphanet:46360]
Is a (Direct Parents):
HPO         Abnormality of joint mobility
MedDRA Joint related disorders NEC
Orphanet Abnormal cartilage morphology
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the skeletal system(HPO:0000924)
          Abnormality of skeletal morphology(HPO:0011842)
             Abnormal joint morphology(HPO:0001367)
                Abnormality of joint mobility(HPO:0011729)
                   Joint hypermobility(HPO:0001382)
MedDRA:
Musculoskeletal and connective tissue disorders(MedDRA:10028395)
    Joint disorders(MedDRA:10023213)
       Joint related disorders NEC(MedDRA:10027685)
          Joint hypermobility(HPO:0001382)
Database Frequency: 231 / 7739
Resource:

All diseases associated with this symptom:

10q22.3q23.3 microdeletion syndrome (Orphanet:276413)
15q11q13 microduplication syndrome (Orphanet:238446)
15q24 microdeletion syndrome (Orphanet:94065)
16p13.11 microduplication syndrome (Orphanet:261243)
17q11.2 microduplication syndrome (Orphanet:139474)
1q21.1 microdeletion syndrome (Orphanet:250989)
2q32q33 microdeletion syndrome (Orphanet:251019)
2q37 microdeletion syndrome (Orphanet:1001)
3M syndrome (Orphanet:2616)
3MC SYNDROME 2 (OMIM:265050)
3q29 microdeletion syndrome (Orphanet:65286)
48,XXXY syndrome (Orphanet:96263)
48,XXYY syndrome (Orphanet:10)
49,XXXXY syndrome (Orphanet:96264)
ALDH18A1-related De Barsy syndrome (Orphanet:35664)
Aarskog-Scott syndrome (Orphanet:915)
Achondroplasia (Orphanet:15)
Acrogeria (Orphanet:2500)
Acromegaloid facial appearance syndrome (Orphanet:965)
Acromesomelic dysplasia, Maroteaux type (Orphanet:40)
Acroosteolysis, dominant type (Orphanet:955)
Angel-shaped phalango-epiphyseal dysplasia (Orphanet:63442)
Arachnodactyly - abnormal ossification - intellectual deficit (Orphanet:1129)
Arachnodactyly - intellectual deficit - dysmorphism (Orphanet:1130)
Arterial tortuosity syndrome (Orphanet:3342)
Ataxia-deafness-retardation syndrome (Orphanet:1188)
Autosomal dominant Larsen syndrome (Orphanet:503)
Autosomal dominant cutis laxa (Orphanet:90348)
Autosomal dominant hyper-IgE syndrome (Orphanet:2314)
Autosomal recessive Stickler syndrome (Orphanet:250984)
Autosomal recessive cutis laxa type 1 (Orphanet:90349)
Autosomal recessive cutis laxa type 2 (Orphanet:90350)
Autosomal recessive cutis laxa type 2, classic type (Orphanet:357074)
Autosomal recessive cutis laxa type 2A (Orphanet:357058)
Autosomal recessive cutis laxa type 2B (Orphanet:357064)
Autosomal recessive facio-digito-genital syndrome (Orphanet:1974)
BRUCK SYNDROME 1 (OMIM:259450)
Bannayan-Riley-Ruvalcaba syndrome (Orphanet:109)
Bazex-Dupré-Christol syndrome (Orphanet:113)
Blepharonasofacial malformation syndrome (Orphanet:1252)
Blepharophimosis-intellectual deficit syndrome, MKB type (Orphanet:293707)
Blepharophimosis-intellectual deficit syndrome, Ohdo type (Orphanet:2728)
Blepharophimosis-intellectual deficit syndrome, SBBYS type (Orphanet:3047)
Bone dysplasia, lethal Holmgren type (Orphanet:1842)
Borjeson-Forssman-Lehmann syndrome (Orphanet:127)
Brachydactyly type E (Orphanet:93387)
Brachyolmia, Maroteaux type (Orphanet:93302)
Brittle cornea syndrome (Orphanet:90354)
CARDIOFACIOCUTANEOUS SYNDROME 1 (OMIM:115150)
CHARGE syndrome (Orphanet:138)
CK syndrome (Orphanet:251383)
CODAS syndrome (Orphanet:1458)
CUTIS LAXA, AUTOSOMAL RECESSIVE, TYPE IB (OMIM:614437)
Cabezas syndrome (Orphanet:85293)
Cardiodysrhythmic potassium-sensitive periodic paralysis (Orphanet:37553)
Cardiofaciocutaneous syndrome (Orphanet:1340)
Cartilage-hair hypoplasia (Orphanet:175)
Cataract - deafness - hypogonadism (Orphanet:1383)
Catel-Manzke syndrome (Orphanet:1388)
Cerebro-facio-thoracic dysplasia (Orphanet:1394)
Christianson syndrome (Orphanet:85278)
Cleft palate - short stature - vertebral anomalies (Orphanet:2015)
Coffin-Lowry syndrome (Orphanet:192)
Coffin-Siris syndrome (Orphanet:1465)
Cohen syndrome (Orphanet:193)
Cole-Carpenter syndrome (Orphanet:2050)
Congenital muscular dystrophy - infantile cataract - hypogonadism (Orphanet:1875)
Congenital muscular dystrophy due to LMNA mutation (Orphanet:157973)
Congenital osteogenesis imperfecta - microcephaly - cataracts (Orphanet:2772)
Cooper-Jabs syndrome (Orphanet:1488)
Costello syndrome (Orphanet:3071)
Cranioectodermal dysplasia (Orphanet:1515)
Cranioectodermal dysplasia 4 (OMIM:614378)
Craniofaciofrontodigital syndrome (Orphanet:363705)
Craniofrontonasal dysplasia (Orphanet:1520)
Craniolenticulosutural dysplasia (Orphanet:50814)
De Barsy syndrome (Orphanet:2962)
Desbuquois syndrome (Orphanet:1425)
Diastrophic dwarfism (Orphanet:628)
Dislocation of the hip - dysmorphism (Orphanet:2412)
Distal 22q11.2 microdeletion syndrome (Orphanet:261330)
Distal monosomy 19p13.3 (Orphanet:96129)
Down syndrome (Orphanet:870)
Dubowitz syndrome (Orphanet:235)
Dysmorphism - pectus carinatum - joint laxity (Orphanet:2104)
EHLERS-DANLOS SYNDROME, BEASLEY-COHEN TYPE (OMIM:608763)
Ear-patella-short stature syndrome (Orphanet:2554)
Ehlers-Danlos syndrome due to tenascin-X deficiency (Orphanet:230839)
Ehlers-Danlos syndrome type 1 (Orphanet:90309)
Ehlers-Danlos syndrome type 11 (Orphanet:2295)
Ehlers-Danlos syndrome type 2 (Orphanet:90318)
Ehlers-Danlos syndrome type 7A (Orphanet:99875)
Ehlers-Danlos syndrome type 7B (Orphanet:99876)
Ehlers-Danlos syndrome with periventricular heterotopia (Orphanet:82004)
Ehlers-Danlos syndrome, arthrochalasic type (Orphanet:1899)
Ehlers-Danlos syndrome, classic type (Orphanet:287)
Ehlers-Danlos syndrome, dermatosparaxis type (Orphanet:1901)
Ehlers-Danlos syndrome, fibronectinemic type (Orphanet:75501)
Ehlers-Danlos syndrome, hypermobility type (Orphanet:285)
Ehlers-Danlos syndrome, kyphoscoliotic type (Orphanet:1900)
Ehlers-Danlos syndrome, periodontitis type (Orphanet:75392)
Ehlers-Danlos syndrome, progeroid type (Orphanet:75496)
Ehlers-Danlos syndrome, spondylocheirodysplastic type (Orphanet:157965)
Ehlers-Danlos syndrome, vascular type (Orphanet:286)
Encephalopathy due to beta-mercaptolactate-cysteine disulfiduria (Orphanet:1035)
Facial dysmorphism - shawl scrotum - joint laxity (Orphanet:1778)
Floating-Harbor syndrome (Orphanet:2044)
Fragile X syndrome (Orphanet:908)
Fried syndrome (Orphanet:85335)
Fryns-Smeets-Thiry syndrome (Orphanet:2058)
GAPO syndrome (Orphanet:2067)
Geroderma osteodysplastica (Orphanet:2078)
Goldblatt syndrome (Orphanet:166272)
Grant syndrome (Orphanet:2097)
Hallermann-Streiff syndrome (Orphanet:2108)
Harrod syndrome (Orphanet:2115)
Hereditary acrokeratotic poikiloderma, Weary type (Orphanet:2907)
Holoprosencephaly (Orphanet:2162)
Hydrocephaly - tall stature - joint laxity (Orphanet:2181)
Hypertrichosis cubiti - short stature (Orphanet:2220)
Hypertryptophanemia (Orphanet:2224)
Hypochondroplasia (Orphanet:429)
Imperforate oropharynx - costo vetebral anomalies (Orphanet:2759)
Intellectual deficit - balding - patella luxation - acromicria (Orphanet:3041)
Intellectual deficit, X-linked - seizures - psoriasis (Orphanet:3052)
Intellectual deficit, X-linked, Miles-Carpenter type (Orphanet:85283)
KABUKI SYNDROME 1 (OMIM:147920)
Kabuki syndrome (Orphanet:2322)
Kaler-Garrity-Stern syndrome (Orphanet:2324)
Knobloch syndrome (Orphanet:1571)
Koolen-De Vries syndrome (Orphanet:96169)
LOEYS-DIETZ SYNDROME, TYPE 2A (OMIM:608967)
Langer-Giedion syndrome (Orphanet:502)
Larsen-like osseous dysplasia - short stature (Orphanet:2370)
Lateral meningocele syndrome (Orphanet:2789)
Lenz-Majewski hyperostotic dwarfism (Orphanet:2658)
Lethal recessive chondrodysplasia (Orphanet:1423)
Loeys-Dietz syndrome type 1 (Orphanet:60030)
Low birth weight - dwarfism - dysgammaglobulinemia (Orphanet:2621)
MACS syndrome (Orphanet:217335)
MARFANOID HYPERMOBILITY SYNDROME (OMIM:154750)
MEIER-GORLIN SYNDROME 2 (OMIM:613800)
MENTAL RETARDATION, X-LINKED 21 (OMIM:300143)
MICROPHTHALMIA WITH CYST, BILATERAL FACIAL CLEFTS, AND LIMB ANOMALIES (OMIM:607597)
Marfan syndrome (Orphanet:558)
Marfan syndrome type 1 (Orphanet:284963)
Marshall-Smith syndrome (Orphanet:561)
Megalencephaly-capillary malformation-polymicrogyria syndrome (Orphanet:60040)
Megalocornea-intellectual deficit syndrome (Orphanet:2479)
Menkes disease (Orphanet:565)
Micro syndrome (Orphanet:2510)
Microcephalic osteodysplastic primordial dwarfism type 2 (Orphanet:2637)
Microcephaly - brachydactyly - kyphoscoliosis (Orphanet:3433)
Microcephaly - glomerulonephritis - marfanoid habitus (Orphanet:2172)
Monosomy 5p (Orphanet:281)
Monosomy 9q22.3 (Orphanet:77301)
Mucopolysaccharidosis type 4 (Orphanet:582)
Multiminicore myopathy (Orphanet:598)
Multiple endocrine neoplasia type 2 (Orphanet:653)
NEMALINE MYOPATHY 7 (OMIM:610687)
Nail-patella syndrome (Orphanet:2614)
Neuhauser-Eichner-Opitz syndrome (Orphanet:2672)
Night blindness - skeletal anomalies - dysmorphism (Orphanet:1390)
Non-distal trisomy 10q (Orphanet:1695)
Noonan syndrome (Orphanet:648)
Noonan syndrome-like disorder with juvenile myelomonocytic leukemia (Orphanet:363972)
Noonan syndrome-like disorder with loose anagen hair (Orphanet:2701)
OSTEOGENESIS IMPERFECTA, TYPE XIII (OMIM:614856)
Occipital horn syndrome (Orphanet:198)
Oculo-palato-cerebral syndrome (Orphanet:2714)
Oculo-reno-cerebellar syndrome (Orphanet:2715)
Oculocerebrorenal syndrome (Orphanet:534)
Osteodysplasty, Melnick-Needles type (Orphanet:2484)
Osteogenesis imperfecta (Orphanet:666)
Osteogenesis imperfecta type 1 (Orphanet:216796)
Osteogenesis imperfecta type 5 (Orphanet:216828)
Osteoporosis - macrocephaly - blindness - joint hyperlaxity (Orphanet:2787)
Osteoporosis - pseudoglioma (Orphanet:2788)
PIERRE ROBIN SEQUENCE WITH PECTUS EXCAVATUM AND RIB AND SCAPULAR ANOMALIES (OMIM:602196)
Paraplegia - intellectual deficit - hyperkeratosis (Orphanet:2824)
Peters-plus syndrome (Orphanet:709)
Pili torti - developmental delay - neurological abnormalities (Orphanet:2891)
Polyvalvular heart disease syndrome (Orphanet:228410)
Pseudoachondroplasia (Orphanet:750)
Pseudoxanthoma elasticum (Orphanet:758)
Pterygium colli - intellectual deficit - digital anomalies (Orphanet:2988)
RAPADILINO syndrome (Orphanet:3021)
RETINOPATHY, PIGMENTARY, AND MENTAL RETARDATION (OMIM:268050)
RIENHOFF SYNDROME (OMIM:615582)
Renal coloboma syndrome (Orphanet:1475)
Renal cysts and diabetes syndrome (Orphanet:93111)
Renal tubular dysgenesis (Orphanet:3033)
Rothmund-Thomson syndrome (Orphanet:2909)
Rubinstein-Taybi syndrome (Orphanet:783)
Rubinstein-Taybi syndrome due to CREBBP mutations (Orphanet:353277)
SCARF syndrome (Orphanet:3134)
SHORT syndrome (Orphanet:3163)
SPONASTRIME dysplasia (Orphanet:93357)
Sakati-Nyhan syndrome (Orphanet:3128)
Seckel syndrome (Orphanet:808)
Short stature - valvular heart disease - characteristic facies (Orphanet:2868)
Shprintzen-Goldberg syndrome (Orphanet:2462)
Spinocerebellar ataxia - dysmorphism (Orphanet:1185)
Spondylo-ocular syndrome (Orphanet:85194)
Spondyloepimetaphyseal dysplasia with joint laxity (Orphanet:93359)
Spondyloepimetaphyseal dysplasia with multiple dislocations (Orphanet:93360)
Spondyloepimetaphyseal dysplasia, Shohat type (Orphanet:93352)
Stickler syndrome (Orphanet:828)
Stickler syndrome type 1 (Orphanet:90653)
Stickler syndrome type 2 (Orphanet:90654)
TEMPLE SYNDROME (OMIM:616222)
THREE M SYNDROME 1 (OMIM:273750)
Tel Hashomer camptodactyly syndrome (Orphanet:3292)
Temtamy syndrome (Orphanet:1777)
Tetrasomy 12p (Orphanet:884)
Tetrasomy X (Orphanet:9)
Thanatophoric dysplasia (Orphanet:2655)
Thoracomelic dysplasia (Orphanet:1803)
Trisomy 20p (Orphanet:261318)
Trisomy X (Orphanet:3375)
VESICOURETERAL REFLUX 8 (OMIM:615963)
WARBURG MICRO SYNDROME 1 (OMIM:600118)
Weaver syndrome (Orphanet:3447)
White forelock with malformations (Orphanet:2475)
Williams syndrome (Orphanet:904)
Wilson disease (Orphanet:905)
Wrinkly skin syndrome (Orphanet:2834)
X-linked Ehlers-Danlos syndrome (Orphanet:75497)
X-linked creatine transporter deficiency (Orphanet:52503)
X-linked intellectual deficit with marfanoid habitus (Orphanet:776)
Zimmermann-Laband syndrome (Orphanet:3473)