In a 5-generation family with multiple musculoskeletal anomalies, Stalker and Zori (1997) described an apparently new malformation syndrome with autosomal dominant inheritance. The features included the Pierre Robin-type cleft palate (261800), pectus excavatum, rib anomalies, and hypoplasia of ... In a 5-generation family with multiple musculoskeletal anomalies, Stalker and Zori (1997) described an apparently new malformation syndrome with autosomal dominant inheritance. The features included the Pierre Robin-type cleft palate (261800), pectus excavatum, rib anomalies, and hypoplasia of the distal segments of the scapulae. The propositus at birth was mildly hypotonic with a Robin-type cleft involving the soft and hard palate with micrognathia, and with moderately severe pectus excavatum. Radiographs showed 11 pairs of ribs and hypoplasia of the inferior subscapular area, more pronounced on the left than on the right. The mother at birth had a U-shaped cleft of the soft palate and micrognathia, a grade II/VI systolic murmur that resolved neonatally, moderate pectus excavatum, low-set hairline, and hyperextensibility of joints. The maternal grandmother of the propositus had micrognathia with intact palate, webbed neck with low-set hairline, hypoplastic scapulae, severe pectus excavatum, and no joint hyperextensibility. Radiographs showed 11 pairs of ribs, hypoplasia of the subscapular areas, and a dysplastic right third rib. Among the other members of the family, there was one instance of male-to-male transmission. Stalker and Zori (1997) considered the syndrome in this family to be distinct from other reported syndromes, including the disorder reported by Chitayat et al. (1991) in 2 half brothers (see 311895).