Mirhosseini et al. (1972) described 2 brothers with pigmentary retinal degeneration, cataract, microcephaly, severe mental retardation, hyperextensible joints, scoliosis, and arachnodactyly. One had hypogonadism. The parents were apparently not related. Mendez et al. (1985) reported the cases of ... Mirhosseini et al. (1972) described 2 brothers with pigmentary retinal degeneration, cataract, microcephaly, severe mental retardation, hyperextensible joints, scoliosis, and arachnodactyly. One had hypogonadism. The parents were apparently not related. Mendez et al. (1985) reported the cases of 2 sisters with first-cousin parents. Horn et al. (2000) reported 2 brothers and a cousin from a multiply consanguineous kindred of Lebanese descent with a syndrome of microcephaly, progressive postnatal growth deficiency, mental retardation, hypotonia, chorioretinal dystrophy, and myopia. The severity of the condition varied among the affected family members.