Intellectual disability, progressive

Symptom Information:

Symptom ID: HPO:0006887
Synonyms:
Mental retardation, progressive [HPO:0006887]
Progressive mental retardation [HPO:0006887]
Progressive mental retardation [OMIM:Progressive mental retardation]
Mental retardation, progressive (50% of patients) [OMIM:Mental retardation, progressive (50% of patients)]
Quality:
Cross references:
OMIM: "Progressive mental retardation" [OMIM:Progressive mental retardation]
OMIM: "Mental retardation, progressive (50% of patients)" [OMIM:Mental retardation, progressive (50% of patients)]
Is a (Direct Parents):
HPO         Intellectual disability
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Abnormality of higher mental function(HPO:0011446)
                Cognitive impairment(HPO:0100543)
                   Intellectual disability(HPO:0001249)
                      Intellectual disability, progressive(HPO:0006887)
MedDRA:
Database Frequency: 68 / 7739
Resource:

All diseases associated with this symptom:

6-pyruvoyl-tetrahydropterin synthase deficiency (Orphanet:13)
ARTHROGRYPOSIS, DISTAL, WITH HYPOPITUITARISM, MENTAL RETARDATION,AND FACIAL ANOMALIES (OMIM:208080)
Aicardi-Goutières syndrome (Orphanet:51)
Allan-Herndon-Dudley syndrome (Orphanet:59)
Alopecia - contractures - dwarfism - intellectual deficit (Orphanet:1005)
Alopecia-intellectual deficit syndrome (Orphanet:2850)
Angelman syndrome (Orphanet:72)
CAMOS syndrome (Orphanet:83472)
CATARACT, MICROCEPHALY, FAILURE TO THRIVE, KYPHOSCOLIOSIS SYNDROME (OMIM:212540)
CEDNIK syndrome (Orphanet:66631)
CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME2 (OMIM:610185)
CHOROID PLEXUS CALCIFICATION AND MENTAL RETARDATION (OMIM:215480)
CRANIOSYNOSTOSIS-MENTAL RETARDATION SYNDROME OF LIN AND GETTIG (OMIM:218649)
Cataract - intellectual deficit - hypogonadism (Orphanet:1387)
Christianson syndrome (Orphanet:85278)
Congenital neuronal ceroid lipofuscinosis (Orphanet:168486)
Ectodermal dysplasia - intellectual deficit - central nervous system malformation (Orphanet:1812)
Facial dysmorphism - macrocephaly - myopia - Dandy-Walker malformation (Orphanet:1970)
Faciocardiorenal syndrome (Orphanet:1973)
GOMBO SYNDROME (OMIM:233270)
GROWTH FAILURE, MICROCEPHALY, MENTAL RETARDATION, CATARACTS, LARGEJOINT CONTRACTURES, OSTEOPOROSIS, CORTICAL DYSPLASIA, AND CEREBELLARATROPHY (OMIM:608278)
GTP cyclohydrolase I deficiency (Orphanet:2102)
Genitopatellar syndrome (Orphanet:85201)
HOLOPROSENCEPHALY, RECURRENT INFECTIONS, AND MONOCYTOSIS (OMIM:610680)
HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 5 (OMIM:225250)
Hyperekplexia - epilepsy (Orphanet:163985)
Intellectual deficit - myopathy - short stature - endocrine defect (Orphanet:3068)
Intellectual deficit, X-linked, Brooks type (Orphanet:3056)
Intellectual deficit, X-linked, Vitale type (Orphanet:85289)
Isolated thyroid-stimulating hormone deficiency (Orphanet:90674)
Joubert syndrome with oculorenal defect (Orphanet:2318)
KAHRIZI SYNDROME (OMIM:612713)
Kapur-Toriello syndrome (Orphanet:2328)
L-2-hydroxyglutaric aciduria (Orphanet:79314)
Leukocyte adhesion deficiency type II (Orphanet:99843)
MACROCEPHALY AND EPILEPTIC ENCEPHALOPATHY (OMIM:606369)
MENTAL RETARDATION WITH OPTIC ATROPHY, FACIAL DYSMORPHISM, MICROCEPHALY,AND SHORT STATURE (OMIM:609037)
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 3 (OMIM:608443)
MENTAL RETARDATION, KERATOCONUS, FEBRILE SEIZURES, AND SINOATRIALBLOCK (OMIM:609438)
MGAT2-CDG (Orphanet:79329)
MICROHYDRANENCEPHALY (OMIM:605013)
MICROPHTHALMIA, SYNDROMIC 7 (OMIM:309801)
Methylcobalamin deficiency type cblE (Orphanet:2169)
Micrencephaly - corpus callosum agenesis - abnormal genitalia (Orphanet:2508)
Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria (Orphanet:1933)
Mitochondrial DNA depletion syndrome, myopathic form (Orphanet:254875)
NEUROLOGIC DISEASE, INFANTILE MULTISYSTEM, WITH OSSEOUS FRAGILITY (OMIM:256720)
Norrie disease (Orphanet:649)
PALANT CLEFT PALATE SYNDROME (OMIM:260150)
Pachygyria - epilepsy - intellectual deficit - dysmorphism (Orphanet:94084)
Peroxisomal acyl-CoA oxidase deficiency (Orphanet:2971)
Peters-plus syndrome (Orphanet:709)
Pitt-Hopkins syndrome (Orphanet:2896)
Pseudoleprechaunism syndrome, Patterson type (Orphanet:2976)
RENAL AND MULLERIAN DUCT HYPOPLASIA (OMIM:266810)
RETINOPATHY, PIGMENTARY, AND MENTAL RETARDATION (OMIM:268050)
SPONASTRIME dysplasia (Orphanet:93357)
Severe intellectual deficit and progressive spastic paraplegia (Orphanet:280763)
Severe neonatal-onset encephalopathy with microcephaly (Orphanet:209370)
Simpson-Golabi-Behmel syndrome type 2 (Orphanet:79022)
Spondyloepimetaphyseal dysplasia, Bieganski type (Orphanet:168448)
Steinert myotonic dystrophy (Orphanet:273)
Syndromic X-linked intellectual deficit due to JARID1C mutation (Orphanet:85279)
TEMPLE-BARAITSER SYNDROME (OMIM:611816)
Urocanic aciduria (Orphanet:210128)
X-linked intellectual deficit - hypotonic face (Orphanet:73220)
Zellweger syndrome (Orphanet:912)
Zimmermann-Laband syndrome (Orphanet:3473)