Cognitive impairment
Symptom Information:
Symptom ID: | HPO:0100543 | ||||||||||||||||||||||||
Synonyms: |
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Quality: | |||||||||||||||||||||||||
Cross references: |
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Is a (Direct Parents): |
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Is a (Whole tree): |
HPO:
All(HPO:0000001) Phenotypic abnormality(HPO:0000118) Abnormality of the nervous system(HPO:0000707) Abnormality of nervous system physiology(HPO:0012638) Abnormality of higher mental function(HPO:0011446) Cognitive impairment(HPO:0100543) MedDRA: Nervous system disorders(MedDRA:10029205) Mental impairment disorders(MedDRA:10057167) Cognitive impairment(HPO:0100543) |
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Database Frequency: | 230 / 7739 | ||||||||||||||||||||||||
Resource: |
All diseases associated with this symptom:
14q12 microdeletion syndrome | (Orphanet:261144) |
17q11.2 microduplication syndrome | (Orphanet:139474) |
3-methylglutaconic aciduria type 1 | (Orphanet:67046) |
3-methylglutaconic aciduria type 3 | (Orphanet:67047) |
48,XXYY syndrome | (Orphanet:10) |
ATAXIA-OCULOMOTOR APRAXIA 4 | (OMIM:616267) |
Acyl-CoA dehydrogenase 9 deficiency | (Orphanet:99901) |
Adiposis dolorosa | (Orphanet:36397) |
Adult neuronal ceroid lipofuscinosis | (Orphanet:79262) |
Adult polyglucosan body disease | (Orphanet:206583) |
Adult-onset autosomal dominant leukodystrophy | (Orphanet:99027) |
Albright hereditary osteodystrophy | (Orphanet:665) |
Alexander disease | (Orphanet:58) |
Alpha-N-acetylgalactosaminidase deficiency | (Orphanet:3137) |
Alpha-N-acetylgalactosaminidase deficiency type 1 | (Orphanet:79279) |
Alpha-N-acetylgalactosaminidase deficiency type 2 | (Orphanet:79280) |
Alpha-mannosidosis | (Orphanet:61) |
Alström syndrome | (Orphanet:64) |
Amelo-cerebro-hypohidrotic syndrome | (Orphanet:1946) |
Aphalangy - syndactyly - microcephaly | (Orphanet:1113) |
Argininemia | (Orphanet:90) |
Argininosuccinic aciduria | (Orphanet:23) |
Ataxia - oculomotor apraxia type 1 | (Orphanet:1168) |
Ataxia with vitamin E deficiency | (Orphanet:96) |
Atypical Rett syndrome | (Orphanet:3095) |
Atypical hemolytic uremic syndrome | (Orphanet:2134) |
Atypical hemolytic uremic syndrome with H factor anomaly | (Orphanet:93579) |
Atypical hemolytic uremic syndrome with anti-factor H antibodies | (Orphanet:93581) |
Autosomal dominant dopa-responsive dystonia | (Orphanet:98808) |
Autosomal dominant spastic paraplegia type 3 | (Orphanet:100984) |
Autosomal dominant spastic paraplegia type 4 | (Orphanet:100985) |
Autosomal dominant spastic paraplegia type 6 | (Orphanet:100988) |
Autosomal recessive spastic ataxia with leukoencephalopathy | (Orphanet:314603) |
Autosomal recessive spastic paraplegia type 11 | (Orphanet:2822) |
Autosomal recessive spastic paraplegia type 23 | (Orphanet:101003) |
Autosomal recessive spastic paraplegia type 45 | (Orphanet:320396) |
Autosomal recessive spastic paraplegia type 46 | (Orphanet:320391) |
Autosomal recessive spastic paraplegia type 48 | (Orphanet:306511) |
Autosomal recessive spastic paraplegia type 55 | (Orphanet:320375) |
Autosomal recessive spastic paraplegia type 56 | (Orphanet:320411) |
Autosomal recessive spastic paraplegia type 7 | (Orphanet:99013) |
BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 5 | (OMIM:615483) |
Bangstad syndrome | (Orphanet:1227) |
Bardet-Biedl syndrome 1 | (OMIM:209900 ) |
Bardet-Biedl syndrome 10 | (OMIM:615987) |
Bardet-Biedl syndrome 11 | (OMIM:615988) |
Bardet-Biedl syndrome 12 | (OMIM:615989) |
Bardet-Biedl syndrome 13 | (OMIM:615990) |
Bardet-Biedl syndrome 14 | (OMIM:615991) |
Bardet-Biedl syndrome 16 | (OMIM:615993) |
Bardet-Biedl syndrome 17 | (OMIM:615994) |
Bardet-Biedl syndrome 18 | (OMIM:615995) |
Bardet-Biedl syndrome 2 | (OMIM:615981) |
Bardet-Biedl syndrome 3 | (OMIM:600151) |
Bardet-Biedl syndrome 4 | (OMIM:615982) |
Bardet-Biedl syndrome 5 | (OMIM:615983) |
Bardet-Biedl syndrome 6 | (OMIM:605231) |
Bardet-Biedl syndrome 7 | (OMIM:615984) |
Bardet-Biedl syndrome 8 | (OMIM:615985) |
Behçet disease | (Orphanet:117) |
Berardinelli-Seip congenital lipodystrophy | (Orphanet:528) |
Bilateral perisylvian polymicrogyria | (Orphanet:98889) |
Bilateral polymicrogyria | (Orphanet:268940) |
CACH syndrome | (Orphanet:135) |
CADASIL | (Orphanet:136) |
CATARACT, CONGENITAL, WITH MENTAL IMPAIRMENT AND DENTATE GYRUS ATROPHY | (OMIM:607674) |
COGNITIVE IMPAIRMENT WITH OR WITHOUT CEREBELLAR ATAXIA | (OMIM:614306) |
CORNELIA DE LANGE SYNDROME 2 | (OMIM:300590) |
CYCLIC VOMITING SYNDROME | (OMIM:500007) |
CYSTINOSIS, NEPHROPATHIC | (OMIM:219800) |
Canavan disease | (Orphanet:141) |
Cardiodysrhythmic potassium-sensitive periodic paralysis | (Orphanet:37553) |
Carnosinemia | (Orphanet:1361) |
Central nervous system calcification - deafness - tubular acidosis - anemia | (Orphanet:3240) |
Cerebellar ataxia - hypogonadism | (Orphanet:1173) |
Cerebrotendinous xanthomatosis | (Orphanet:909) |
Choreoacanthocytosis | (Orphanet:2388) |
Chédiak-Higashi syndrome | (Orphanet:167) |
Citrullinemia type II | (Orphanet:247585) |
Classical phenylketonuria | (Orphanet:79254) |
Combined oxidative phosphorylation defect type 15 | (Orphanet:319524) |
Congenital cataracts - facial dysmorphism - neuropathy | (Orphanet:48431) |
Congenital muscular dystrophy due to LMNA mutation | (Orphanet:157973) |
Congenital muscular dystrophy with integrin alpha-7 deficiency | (Orphanet:34520) |
Congenital myopathy with internal nuclei and atypical cores | (Orphanet:319160) |
Congenital or early infantile CACH syndrome | (Orphanet:157713) |
Costello syndrome | (Orphanet:3071) |
Cree leukoencephalopathy | (Orphanet:99854) |
Cystinosis | (Orphanet:213) |
Cytomegalic congenital adrenal hypoplasia | (Orphanet:95702) |
DK1-CDG | (Orphanet:91131) |
Dent disease type 2 | (Orphanet:93623) |
Developmental malformations - deafness - dystonia | (Orphanet:79107) |
Dihydropteridine reductase deficiency | (Orphanet:226) |
Down syndrome | (Orphanet:870) |
Duchenne and Becker muscular dystrophy | (Orphanet:262) |
Dysosteosclerosis | (Orphanet:1782) |
Dystonia 16 | (Orphanet:210571) |
EPILEPSY, FAMILIAL ADULT MYOCLONIC, 2 | (OMIM:607876) |
EPILEPSY, NOCTURNAL FRONTAL LOBE, 5 | (OMIM:615005) |
Encephalopathy due to sulfite oxidase deficiency | (Orphanet:833) |
Fabry disease | (Orphanet:324) |
Familial atrial myxoma | (Orphanet:615) |
Febrile infection-related epilepsy syndrome | (Orphanet:163703) |
Flynn-Aird syndrome | (Orphanet:2047) |
Fragile X-associated tremor/ataxia syndrome | (Orphanet:93256) |
GTP cyclohydrolase I deficiency | (Orphanet:2102) |
Gaucher disease | (Orphanet:355) |
Gaucher disease type 3 | (Orphanet:77261) |
Glutaryl-CoA dehydrogenase deficiency | (Orphanet:25) |
Glycogen storage disease due to LAMP-2 deficiency | (Orphanet:34587) |
Glycogen storage disease due to acid maltase deficiency | (Orphanet:365) |
Glycogen storage disease due to acid maltase deficiency, infantile onset | (Orphanet:308552) |
Gómez-López-Hernández syndrome | (Orphanet:1532) |
Hemolytic anemia due to adenylate kinase deficiency | (Orphanet:86817) |
Hereditary cerebral hemorrhage with amyloidosis, Arctic type | (Orphanet:324723) |
Hereditary cerebral hemorrhage with amyloidosis, Dutch type | (Orphanet:100006) |
Hereditary cerebral hemorrhage with amyloidosis, Iowa type | (Orphanet:324708) |
Hereditary cerebral hemorrhage with amyloidosis, Italian type | (Orphanet:324713) |
Hereditary cerebral hemorrhage with amyloidosis, Piedmont type | (Orphanet:324703) |
Homocystinuria without methylmalonic aciduria | (Orphanet:622) |
Hurler syndrome | (Orphanet:93473) |
Hurler-Scheie syndrome | (Orphanet:93476) |
Hyperammonemia due to N-acetylglutamate synthetase deficiency | (Orphanet:927) |
Hyperornithinemia-hyperammonemia-homocitrullinuria | (Orphanet:415) |
IMMUNODEFICIENCY 23 | (OMIM:615816) |
Ichthyosis - hepatosplenomegaly - cerebellar degeneration | (Orphanet:2274) |
Ichthyosis follicularis - alopecia - photophobia | (Orphanet:2273) |
Infantile axonal neuropathy | (Orphanet:2679) |
Infantile neuroaxonal dystrophy | (Orphanet:35069) |
Intellectual deficit - cataracts - calcified pinnae - myopathy | (Orphanet:3042) |
Intellectual deficit, X-linked - psychosis - macroorchidism | (Orphanet:3077) |
Isolated focal cortical dysplasia type II | (Orphanet:268994) |
Isolated succinate-CoQ reductase deficiency | (Orphanet:3208) |
Joubert syndrome 2 | (OMIM:608091) |
Joubert syndrome with renal defect | (Orphanet:220497) |
Juvenile or adult CACH syndrome | (Orphanet:157719) |
Kleefstra syndrome | (Orphanet:261494) |
Krabbe disease | (Orphanet:487) |
LEOPARD SYNDROME 3 | (OMIM:613707) |
LISSENCEPHALY 6 WITH MICROCEPHALY | (OMIM:616212) |
Late infantile CACH syndrome | (Orphanet:157716) |
Late infantile neuronal ceroid lipofuscinosis | (Orphanet:168491) |
Leigh syndrome | (Orphanet:506) |
Leprechaunism | (Orphanet:508) |
Lesch-Nyhan syndrome | (Orphanet:510) |
Leukoencephalopathy with brain stem and spinal cord involvement - lactate elevation | (Orphanet:137898) |
Leukoencephalopathy-palmoplantar keratoderma syndrome | (Orphanet:2386) |
Lymphangioleiomyomatosis | (Orphanet:538) |
MELAS | (Orphanet:550) |
MERRF | (Orphanet:551) |
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 2 | (OMIM:615157) |
MITOCHONDRIAL DNA DEPLETION SYNDROME 12 (CARDIOMYOPATHIC TYPE) | (OMIM:615418) |
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (LIMB-GIRDLE), TYPE C, 12 | (OMIM:616094) |
Maple syrup urine disease | (Orphanet:511) |
Maternal hyperphenylalaninemia | (Orphanet:2209) |
McLeod neuroacanthocytosis syndrome | (Orphanet:59306) |
Metachromatic leukodystrophy | (Orphanet:512) |
Methylmalonic acidemia with homocystinuria, type cblF | (Orphanet:79284) |
Mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to MTO1 deficiency | (Orphanet:314637) |
Mitochondrial myopathy and sideroblastic anemia | (Orphanet:2598) |
Mucopolysaccharidosis type 1 | (Orphanet:579) |
Mucopolysaccharidosis type 3 | (Orphanet:581) |
Multiple sulfatase deficiency | (Orphanet:585) |
Multiple system atrophy | (Orphanet:102) |
Myopathy, lactic acidosis, and sideroblastic anemia 1; MLASA1 | (OMIM:600462) |
Nasu-Hakola disease | (Orphanet:2770) |
Neonatal adrenoleukodystrophy | (Orphanet:44) |
Neurodegeneration with brain iron accumulation due to C19orf12 mutation | (Orphanet:289560) |
Neuroectodermal syndrome, Johnson type | (Orphanet:2316) |
Neuroferritinopathy | (Orphanet:157846) |
Neuronal ceroid lipofuscinosis | (Orphanet:216) |
Neuronal intranuclear inclusion disease | (Orphanet:2289) |
Non-polyposis Turcot syndrome | (Orphanet:99817) |
Norrie disease | (Orphanet:649) |
Ornithine transcarbamylase deficiency | (Orphanet:664) |
Ovarioleukodystrophy | (Orphanet:99853) |
Pantothenate kinase-associated neurodegeneration | (Orphanet:157850) |
Paraplegia - brachydactyly - cone-shaped epiphysis | (Orphanet:2823) |
Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity | (Orphanet:53583) |
Paroxysmal exertion-induced dyskinesia | (Orphanet:98811) |
Partial acquired lipodystrophy | (Orphanet:79087) |
Pelizaeus-Merzbacher disease | (Orphanet:702) |
Pelizaeus-Merzbacher-like due to GJC2 mutation | (Orphanet:280282) |
Peroxisomal acyl-CoA oxidase deficiency | (Orphanet:2971) |
Perrault Syndrome | (Orphanet:2855) |
Perrault Syndrome 1 | (OMIM:233400) |
Perry syndrome | (Orphanet:178509) |
Posterior cortical atrophy | (Orphanet:54247) |
Pseudohypoparathyroidism type 1A | (Orphanet:79443) |
Pseudohypoparathyroidism type 1C | (Orphanet:79444) |
Pseudopseudohypoparathyroidism | (Orphanet:79445) |
Recessive mitochondrial ataxia syndrome | (Orphanet:94125) |
Refsum disease | (Orphanet:773) |
Renal cysts and diabetes syndrome | (Orphanet:93111) |
Rett syndrome | (Orphanet:778) |
SCLEROSTEOSIS 1 | (OMIM:269500) |
SECKEL SYNDROME 4 | (OMIM:613676) |
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 18 | (OMIM:616204) |
SPINOCEREBELLAR DEGENERATION WITH SLOW EYE MOVEMENTS | (OMIM:271322) |
Saldino-Mainzer syndrome | (Orphanet:140969) |
Scheie syndrome | (Orphanet:93474) |
Sclerosteosis | (Orphanet:3152) |
Senior-Loken syndrome 8 | (OMIM:616307) |
Severe combined immunodeficiency due to adenosine deaminase deficiency | (Orphanet:277) |
Sneddon syndrome | (Orphanet:820) |
Spinocerebellar ataxia type 1 | (Orphanet:98755) |
Spinocerebellar ataxia type 10 | (Orphanet:98761) |
Spinocerebellar ataxia type 19/22 | (Orphanet:98772) |
Spinocerebellar ataxia type 21 | (Orphanet:98773) |
Spinocerebellar ataxia type 29 | (Orphanet:208513) |
Spinocerebellar ataxia with epilepsy | (Orphanet:254881) |
Steinert myotonic dystrophy | (Orphanet:273) |
Syndromic diarrhea | (Orphanet:84064) |
TRICHOHEPATOENTERIC SYNDROME 1 | (OMIM:222470) |
Tay-Sachs disease | (Orphanet:845) |
Triple A syndrome | (Orphanet:869) |
Trisomy 5p | (Orphanet:1742) |
Typical hemolytic uremic syndrome | (Orphanet:90038) |
Tyrosinemia type 2 | (Orphanet:28378) |
Whipple disease | (Orphanet:3452) |
Williams syndrome | (Orphanet:904) |
Wilson-Turner syndrome | (Orphanet:3459) |
Wolcott-Rallison syndrome | (Orphanet:1667) |
Wolfram syndrome 1 | (OMIM:222300) |
Woodhouse-Sakati syndrome | (Orphanet:3464) |
X-linked Charcot-Marie-Tooth disease type 4 | (Orphanet:101078) |
Xeroderma pigmentosum | (Orphanet:910) |
Xeroderma pigmentosum/Cockayne syndrome complex | (Orphanet:220295) |
Xq27.3q28 duplication syndrome | (Orphanet:261483) |