Cognitive impairment

Symptom Information:

Symptom ID: HPO:0100543
Synonyms:
Abnormality of cognition [HPO:0100543]
Cognitive abnormality [HPO:0100543]
Cognitive defects [HPO:0100543]
Cognitive deficits [HPO:0100543]
Intellectual impairment [HPO:0100543]
Mental impairment [HPO:0100543]
Cognitive defects [OMIM:Cognitive defects]
Cognitive deficits [OMIM:Cognitive deficits]
Cognitive impairment [OMIM:Cognitive impairment]
Intellectual impairment [OMIM:Intellectual impairment]
Mental impairment [OMIM:Mental impairment]
Cognitive defects (rare) [OMIM:Cognitive defects (rare)]
Cognitive defects (variable from mild to severe) [OMIM:Cognitive defects (variable from mild to severe)]
Cognitive deficits (less common) [OMIM:Cognitive deficits (less common)]
Cognitive impairment (1 patient) [OMIM:Cognitive impairment (1 patient)]
Cognitive impairment (3 patients) [OMIM:Cognitive impairment (3 patients)]
Cognitive impairment (CVS+) [OMIM:Cognitive impairment (CVS+)]
Cognitive impairment (in 1 of 3 patients) [OMIM:Cognitive impairment (in 1 of 3 patients)]
Cognitive impairment (in some patients) [OMIM:Cognitive impairment (in some patients)]
Cognitive impairment (in some) [OMIM:Cognitive impairment (in some)]
Cognitive impairment (rare) [OMIM:Cognitive impairment (rare)]
Intellectual impairment (rare) [OMIM:Intellectual impairment (rare)]
Mental impairment (excl dementia and memory loss) [MedDRA:10027375]
Decreased mental processing speed [OMIM,du]
Quality:
Cross references:
OMIM: "Cognitive defects" [OMIM:Cognitive defects]
OMIM: "Cognitive deficits" [OMIM:Cognitive deficits]
OMIM: "Cognitive impairment" [OMIM:Cognitive impairment]
OMIM: "Intellectual impairment" [OMIM:Intellectual impairment]
OMIM: "Mental impairment" [OMIM:Mental impairment]
OMIM: "Cognitive defects (rare)" [OMIM:Cognitive defects (rare)]
OMIM: "Cognitive defects (variable from mild to severe)" [OMIM:Cognitive defects (variable from mild to severe)]
OMIM: "Cognitive deficits (less common)" [OMIM:Cognitive deficits (less common)]
OMIM: "Cognitive impairment (1 patient)" [OMIM:Cognitive impairment (1 patient)]
OMIM: "Cognitive impairment (3 patients)" [OMIM:Cognitive impairment (3 patients)]
OMIM: "Cognitive impairment (CVS+)" [OMIM:Cognitive impairment (CVS+)]
OMIM: "Cognitive impairment (in 1 of 3 patients)" [OMIM:Cognitive impairment (in 1 of 3 patients)]
OMIM: "Cognitive impairment (in some patients)" [OMIM:Cognitive impairment (in some patients)]
OMIM: "Cognitive impairment (in some)" [OMIM:Cognitive impairment (in some)]
OMIM: "Cognitive impairment (rare)" [OMIM:Cognitive impairment (rare)]
OMIM: "Intellectual impairment (rare)" [OMIM:Intellectual impairment (rare)]
Is a (Direct Parents):
MedDRA Mental impairment disorders
HPO         Abnormality of higher mental function
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Abnormality of higher mental function(HPO:0011446)
                Cognitive impairment(HPO:0100543)
MedDRA:
Nervous system disorders(MedDRA:10029205)
    Mental impairment disorders(MedDRA:10057167)
       Cognitive impairment(HPO:0100543)
Database Frequency: 230 / 7739
Resource:

All diseases associated with this symptom:

14q12 microdeletion syndrome (Orphanet:261144)
17q11.2 microduplication syndrome (Orphanet:139474)
3-methylglutaconic aciduria type 1 (Orphanet:67046)
3-methylglutaconic aciduria type 3 (Orphanet:67047)
48,XXYY syndrome (Orphanet:10)
ATAXIA-OCULOMOTOR APRAXIA 4 (OMIM:616267)
Acyl-CoA dehydrogenase 9 deficiency (Orphanet:99901)
Adiposis dolorosa (Orphanet:36397)
Adult neuronal ceroid lipofuscinosis (Orphanet:79262)
Adult polyglucosan body disease (Orphanet:206583)
Adult-onset autosomal dominant leukodystrophy (Orphanet:99027)
Albright hereditary osteodystrophy (Orphanet:665)
Alexander disease (Orphanet:58)
Alpha-N-acetylgalactosaminidase deficiency (Orphanet:3137)
Alpha-N-acetylgalactosaminidase deficiency type 1 (Orphanet:79279)
Alpha-N-acetylgalactosaminidase deficiency type 2 (Orphanet:79280)
Alpha-mannosidosis (Orphanet:61)
Alström syndrome (Orphanet:64)
Amelo-cerebro-hypohidrotic syndrome (Orphanet:1946)
Aphalangy - syndactyly - microcephaly (Orphanet:1113)
Argininemia (Orphanet:90)
Argininosuccinic aciduria (Orphanet:23)
Ataxia - oculomotor apraxia type 1 (Orphanet:1168)
Ataxia with vitamin E deficiency (Orphanet:96)
Atypical Rett syndrome (Orphanet:3095)
Atypical hemolytic uremic syndrome (Orphanet:2134)
Atypical hemolytic uremic syndrome with H factor anomaly (Orphanet:93579)
Atypical hemolytic uremic syndrome with anti-factor H antibodies (Orphanet:93581)
Autosomal dominant dopa-responsive dystonia (Orphanet:98808)
Autosomal dominant spastic paraplegia type 3 (Orphanet:100984)
Autosomal dominant spastic paraplegia type 4 (Orphanet:100985)
Autosomal dominant spastic paraplegia type 6 (Orphanet:100988)
Autosomal recessive spastic ataxia with leukoencephalopathy (Orphanet:314603)
Autosomal recessive spastic paraplegia type 11 (Orphanet:2822)
Autosomal recessive spastic paraplegia type 23 (Orphanet:101003)
Autosomal recessive spastic paraplegia type 45 (Orphanet:320396)
Autosomal recessive spastic paraplegia type 46 (Orphanet:320391)
Autosomal recessive spastic paraplegia type 48 (Orphanet:306511)
Autosomal recessive spastic paraplegia type 55 (Orphanet:320375)
Autosomal recessive spastic paraplegia type 56 (Orphanet:320411)
Autosomal recessive spastic paraplegia type 7 (Orphanet:99013)
BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 5 (OMIM:615483)
Bangstad syndrome (Orphanet:1227)
Bardet-Biedl syndrome 1 (OMIM:209900 )
Bardet-Biedl syndrome 10 (OMIM:615987)
Bardet-Biedl syndrome 11 (OMIM:615988)
Bardet-Biedl syndrome 12 (OMIM:615989)
Bardet-Biedl syndrome 13 (OMIM:615990)
Bardet-Biedl syndrome 14 (OMIM:615991)
Bardet-Biedl syndrome 16 (OMIM:615993)
Bardet-Biedl syndrome 17 (OMIM:615994)
Bardet-Biedl syndrome 18 (OMIM:615995)
Bardet-Biedl syndrome 2 (OMIM:615981)
Bardet-Biedl syndrome 3 (OMIM:600151)
Bardet-Biedl syndrome 4 (OMIM:615982)
Bardet-Biedl syndrome 5 (OMIM:615983)
Bardet-Biedl syndrome 6 (OMIM:605231)
Bardet-Biedl syndrome 7 (OMIM:615984)
Bardet-Biedl syndrome 8 (OMIM:615985)
Behçet disease (Orphanet:117)
Berardinelli-Seip congenital lipodystrophy (Orphanet:528)
Bilateral perisylvian polymicrogyria (Orphanet:98889)
Bilateral polymicrogyria (Orphanet:268940)
CACH syndrome (Orphanet:135)
CADASIL (Orphanet:136)
CATARACT, CONGENITAL, WITH MENTAL IMPAIRMENT AND DENTATE GYRUS ATROPHY (OMIM:607674)
COGNITIVE IMPAIRMENT WITH OR WITHOUT CEREBELLAR ATAXIA (OMIM:614306)
CORNELIA DE LANGE SYNDROME 2 (OMIM:300590)
CYCLIC VOMITING SYNDROME (OMIM:500007)
CYSTINOSIS, NEPHROPATHIC (OMIM:219800)
Canavan disease (Orphanet:141)
Cardiodysrhythmic potassium-sensitive periodic paralysis (Orphanet:37553)
Carnosinemia (Orphanet:1361)
Central nervous system calcification - deafness - tubular acidosis - anemia (Orphanet:3240)
Cerebellar ataxia - hypogonadism (Orphanet:1173)
Cerebrotendinous xanthomatosis (Orphanet:909)
Choreoacanthocytosis (Orphanet:2388)
Chédiak-Higashi syndrome (Orphanet:167)
Citrullinemia type II (Orphanet:247585)
Classical phenylketonuria (Orphanet:79254)
Combined oxidative phosphorylation defect type 15 (Orphanet:319524)
Congenital cataracts - facial dysmorphism - neuropathy (Orphanet:48431)
Congenital muscular dystrophy due to LMNA mutation (Orphanet:157973)
Congenital muscular dystrophy with integrin alpha-7 deficiency (Orphanet:34520)
Congenital myopathy with internal nuclei and atypical cores (Orphanet:319160)
Congenital or early infantile CACH syndrome (Orphanet:157713)
Costello syndrome (Orphanet:3071)
Cree leukoencephalopathy (Orphanet:99854)
Cystinosis (Orphanet:213)
Cytomegalic congenital adrenal hypoplasia (Orphanet:95702)
DK1-CDG (Orphanet:91131)
Dent disease type 2 (Orphanet:93623)
Developmental malformations - deafness - dystonia (Orphanet:79107)
Dihydropteridine reductase deficiency (Orphanet:226)
Down syndrome (Orphanet:870)
Duchenne and Becker muscular dystrophy (Orphanet:262)
Dysosteosclerosis (Orphanet:1782)
Dystonia 16 (Orphanet:210571)
EPILEPSY, FAMILIAL ADULT MYOCLONIC, 2 (OMIM:607876)
EPILEPSY, NOCTURNAL FRONTAL LOBE, 5 (OMIM:615005)
Encephalopathy due to sulfite oxidase deficiency (Orphanet:833)
Fabry disease (Orphanet:324)
Familial atrial myxoma (Orphanet:615)
Febrile infection-related epilepsy syndrome (Orphanet:163703)
Flynn-Aird syndrome (Orphanet:2047)
Fragile X-associated tremor/ataxia syndrome (Orphanet:93256)
GTP cyclohydrolase I deficiency (Orphanet:2102)
Gaucher disease (Orphanet:355)
Gaucher disease type 3 (Orphanet:77261)
Glutaryl-CoA dehydrogenase deficiency (Orphanet:25)
Glycogen storage disease due to LAMP-2 deficiency (Orphanet:34587)
Glycogen storage disease due to acid maltase deficiency (Orphanet:365)
Glycogen storage disease due to acid maltase deficiency, infantile onset (Orphanet:308552)
Gómez-López-Hernández syndrome (Orphanet:1532)
Hemolytic anemia due to adenylate kinase deficiency (Orphanet:86817)
Hereditary cerebral hemorrhage with amyloidosis, Arctic type (Orphanet:324723)
Hereditary cerebral hemorrhage with amyloidosis, Dutch type (Orphanet:100006)
Hereditary cerebral hemorrhage with amyloidosis, Iowa type (Orphanet:324708)
Hereditary cerebral hemorrhage with amyloidosis, Italian type (Orphanet:324713)
Hereditary cerebral hemorrhage with amyloidosis, Piedmont type (Orphanet:324703)
Homocystinuria without methylmalonic aciduria (Orphanet:622)
Hurler syndrome (Orphanet:93473)
Hurler-Scheie syndrome (Orphanet:93476)
Hyperammonemia due to N-acetylglutamate synthetase deficiency (Orphanet:927)
Hyperornithinemia-hyperammonemia-homocitrullinuria (Orphanet:415)
IMMUNODEFICIENCY 23 (OMIM:615816)
Ichthyosis - hepatosplenomegaly - cerebellar degeneration (Orphanet:2274)
Ichthyosis follicularis - alopecia - photophobia (Orphanet:2273)
Infantile axonal neuropathy (Orphanet:2679)
Infantile neuroaxonal dystrophy (Orphanet:35069)
Intellectual deficit - cataracts - calcified pinnae - myopathy (Orphanet:3042)
Intellectual deficit, X-linked - psychosis - macroorchidism (Orphanet:3077)
Isolated focal cortical dysplasia type II (Orphanet:268994)
Isolated succinate-CoQ reductase deficiency (Orphanet:3208)
Joubert syndrome 2 (OMIM:608091)
Joubert syndrome with renal defect (Orphanet:220497)
Juvenile or adult CACH syndrome (Orphanet:157719)
Kleefstra syndrome (Orphanet:261494)
Krabbe disease (Orphanet:487)
LEOPARD SYNDROME 3 (OMIM:613707)
LISSENCEPHALY 6 WITH MICROCEPHALY (OMIM:616212)
Late infantile CACH syndrome (Orphanet:157716)
Late infantile neuronal ceroid lipofuscinosis (Orphanet:168491)
Leigh syndrome (Orphanet:506)
Leprechaunism (Orphanet:508)
Lesch-Nyhan syndrome (Orphanet:510)
Leukoencephalopathy with brain stem and spinal cord involvement - lactate elevation (Orphanet:137898)
Leukoencephalopathy-palmoplantar keratoderma syndrome (Orphanet:2386)
Lymphangioleiomyomatosis (Orphanet:538)
MELAS (Orphanet:550)
MERRF (Orphanet:551)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 2 (OMIM:615157)
MITOCHONDRIAL DNA DEPLETION SYNDROME 12 (CARDIOMYOPATHIC TYPE) (OMIM:615418)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (LIMB-GIRDLE), TYPE C, 12 (OMIM:616094)
Maple syrup urine disease (Orphanet:511)
Maternal hyperphenylalaninemia (Orphanet:2209)
McLeod neuroacanthocytosis syndrome (Orphanet:59306)
Metachromatic leukodystrophy (Orphanet:512)
Methylmalonic acidemia with homocystinuria, type cblF (Orphanet:79284)
Mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to MTO1 deficiency (Orphanet:314637)
Mitochondrial myopathy and sideroblastic anemia (Orphanet:2598)
Mucopolysaccharidosis type 1 (Orphanet:579)
Mucopolysaccharidosis type 3 (Orphanet:581)
Multiple sulfatase deficiency (Orphanet:585)
Multiple system atrophy (Orphanet:102)
Myopathy, lactic acidosis, and sideroblastic anemia 1; MLASA1 (OMIM:600462)
Nasu-Hakola disease (Orphanet:2770)
Neonatal adrenoleukodystrophy (Orphanet:44)
Neurodegeneration with brain iron accumulation due to C19orf12 mutation (Orphanet:289560)
Neuroectodermal syndrome, Johnson type (Orphanet:2316)
Neuroferritinopathy (Orphanet:157846)
Neuronal ceroid lipofuscinosis (Orphanet:216)
Neuronal intranuclear inclusion disease (Orphanet:2289)
Non-polyposis Turcot syndrome (Orphanet:99817)
Norrie disease (Orphanet:649)
Ornithine transcarbamylase deficiency (Orphanet:664)
Ovarioleukodystrophy (Orphanet:99853)
Pantothenate kinase-associated neurodegeneration (Orphanet:157850)
Paraplegia - brachydactyly - cone-shaped epiphysis (Orphanet:2823)
Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity (Orphanet:53583)
Paroxysmal exertion-induced dyskinesia (Orphanet:98811)
Partial acquired lipodystrophy (Orphanet:79087)
Pelizaeus-Merzbacher disease (Orphanet:702)
Pelizaeus-Merzbacher-like due to GJC2 mutation (Orphanet:280282)
Peroxisomal acyl-CoA oxidase deficiency (Orphanet:2971)
Perrault Syndrome (Orphanet:2855)
Perrault Syndrome 1 (OMIM:233400)
Perry syndrome (Orphanet:178509)
Posterior cortical atrophy (Orphanet:54247)
Pseudohypoparathyroidism type 1A (Orphanet:79443)
Pseudohypoparathyroidism type 1C (Orphanet:79444)
Pseudopseudohypoparathyroidism (Orphanet:79445)
Recessive mitochondrial ataxia syndrome (Orphanet:94125)
Refsum disease (Orphanet:773)
Renal cysts and diabetes syndrome (Orphanet:93111)
Rett syndrome (Orphanet:778)
SCLEROSTEOSIS 1 (OMIM:269500)
SECKEL SYNDROME 4 (OMIM:613676)
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 18 (OMIM:616204)
SPINOCEREBELLAR DEGENERATION WITH SLOW EYE MOVEMENTS (OMIM:271322)
Saldino-Mainzer syndrome (Orphanet:140969)
Scheie syndrome (Orphanet:93474)
Sclerosteosis (Orphanet:3152)
Senior-Loken syndrome 8 (OMIM:616307)
Severe combined immunodeficiency due to adenosine deaminase deficiency (Orphanet:277)
Sneddon syndrome (Orphanet:820)
Spinocerebellar ataxia type 1 (Orphanet:98755)
Spinocerebellar ataxia type 10 (Orphanet:98761)
Spinocerebellar ataxia type 19/22 (Orphanet:98772)
Spinocerebellar ataxia type 21 (Orphanet:98773)
Spinocerebellar ataxia type 29 (Orphanet:208513)
Spinocerebellar ataxia with epilepsy (Orphanet:254881)
Steinert myotonic dystrophy (Orphanet:273)
Syndromic diarrhea (Orphanet:84064)
TRICHOHEPATOENTERIC SYNDROME 1 (OMIM:222470)
Tay-Sachs disease (Orphanet:845)
Triple A syndrome (Orphanet:869)
Trisomy 5p (Orphanet:1742)
Typical hemolytic uremic syndrome (Orphanet:90038)
Tyrosinemia type 2 (Orphanet:28378)
Whipple disease (Orphanet:3452)
Williams syndrome (Orphanet:904)
Wilson-Turner syndrome (Orphanet:3459)
Wolcott-Rallison syndrome (Orphanet:1667)
Wolfram syndrome 1 (OMIM:222300)
Woodhouse-Sakati syndrome (Orphanet:3464)
X-linked Charcot-Marie-Tooth disease type 4 (Orphanet:101078)
Xeroderma pigmentosum (Orphanet:910)
Xeroderma pigmentosum/Cockayne syndrome complex (Orphanet:220295)
Xq27.3q28 duplication syndrome (Orphanet:261483)