Wilson-Turner syndrome
General Information (adopted from Orphanet):
Synonyms, Signs: |
MENTAL RETARDATION, X-LINKED, WITH GYNECOMASTIA AND OBESITY MENTAL RETARDATION, X-LINKED, SYNDROMIC 6 WTS MRXS6 X-linked intellectual deficit - gynecomastia - obesity |
Number of Symptoms | 111 |
OrphanetNr: | 3459 |
OMIM Id: |
309585
|
ICD-10: |
|
UMLs: |
|
MeSH: |
|
MedDRA: |
|
Snomed: |
|
Prevalence, inheritance and age of onset:
Prevalence: | > 14 cases [Orphanet] |
Inheritance: |
X-linked recessive X-linked dominant [Orphanet] |
Age of onset: |
Childhood [Orphanet] |
Disease classification (adopted from Orphanet):
Parent Diseases: |
Syndromic obesity
-Rare developmental defect during embryogenesis -Rare endocrine disease -Rare genetic disease X-linked syndromic intellectual deficit -Rare genetic disease -Rare neurologic disease |
Symptom Information:
|
(HPO:0000028) | Cryptorchidism | Occasional [Orphanet] | 347 / 7739 | |||
|
(HPO:0008689) | Bilateral cryptorchidism | Occasional [Orphanet] occasional [HPO] | 38 / 7739 | |||
|
(HPO:0000054) | Micropenis | Occasional [Orphanet] | 257 / 7739 | |||
|
(HPO:0012646) | Retractile testis | Occasional [Orphanet] | 8 / 7739 | |||
|
(HPO:0008734) | Decreased testicular size | Frequent [Orphanet] | 105 / 7739 | |||
|
(HPO:0000135) | Hypogonadism | 89 / 7739 | ||||
|
(HPO:0008736) | Hypoplasia of penis | Occasional [Orphanet] | 7 / 7739 | |||
|
(HPO:0000692) | Misalignment of teeth | 18 / 7739 | ||||
|
(HPO:0000414) | Bulbous nose | 63 / 7739 | ||||
|
(HPO:0000490) | Deeply set eye | 131 / 7739 | ||||
|
(HPO:0002648) | Abnormality of calvarial morphology | Occasional [Orphanet] | 2 / 7739 | |||
|
(HPO:0000252) | Microcephaly | 832 / 7739 | ||||
|
(HPO:0000574) | Thick eyebrow | Occasional [Orphanet] | 96 / 7739 | |||
|
(HPO:0000278) | Retrognathia | 100 / 7739 | ||||
|
(HPO:0000677) | Oligodontia | Occasional [Orphanet] | 41 / 7739 | |||
|
(HPO:0000232) | Everted lower lip vermilion | Occasional [Orphanet] | 90 / 7739 | |||
|
(HPO:0000280) | Coarse facial features | Occasional [Orphanet] | 189 / 7739 | |||
|
(HPO:0000664) | Synophrys | Occasional [Orphanet] | 112 / 7739 | |||
|
(HPO:0000668) | Hypodontia | Occasional [Orphanet] | 81 / 7739 | |||
|
(HPO:0002209) | Sparse scalp hair | Occasional [Orphanet] | 59 / 7739 | |||
|
(HPO:0009804) | Reduced number of teeth | Occasional [Orphanet] | 137 / 7739 | |||
|
(HPO:0000160) | Narrow mouth | Occasional [Orphanet] | 188 / 7739 | |||
|
(HPO:0000455) | Broad nasal tip | 67 / 7739 | ||||
|
(HPO:0000336) | Prominent supraorbital ridges | 45 / 7739 | ||||
|
(HPO:0005469) | Flat occiput | Occasional [Orphanet] | 30 / 7739 | |||
|
(HPO:0000248) | Brachycephaly | Occasional [Orphanet] | 222 / 7739 | |||
|
(HPO:0000303) | Mandibular prognathia | Occasional [Orphanet] | 179 / 7739 | |||
|
(HPO:0000307) | Pointed chin | Occasional [Orphanet] | 45 / 7739 | |||
|
(HPO:0000674) | Anodontia | Occasional [Orphanet] | 18 / 7739 | |||
|
(HPO:0008551) | Microtia | Occasional [Orphanet] | 98 / 7739 | |||
|
(HPO:0002321) | Vertigo | Occasional [Orphanet] | 58 / 7739 | |||
|
(HPO:0011252) | Cryptotia | Occasional [Orphanet] | 2 / 7739 | |||
|
(HPO:0000384) | Preauricular skin tag | Occasional [Orphanet] | 62 / 7739 | |||
|
(HPO:0000385) | Small earlobe | Occasional [Orphanet] | 9 / 7739 | |||
|
(HPO:0100830) | Round ear | Occasional [Orphanet] | 7 / 7739 | |||
|
(HPO:0009892) | Anotia | Occasional [Orphanet] | 8 / 7739 | |||
|
(HPO:0000400) | Macrotia | Occasional [Orphanet] | 108 / 7739 | |||
|
(HPO:0009906) | Aplasia/Hypoplasia of the earlobes | Occasional [Orphanet] | 41 / 7739 | |||
|
(HPO:0009907) | Attached earlobe | Occasional [Orphanet] | 2 / 7739 | |||
|
(HPO:0009748) | Large earlobe | Occasional [Orphanet] | 27 / 7739 | |||
|
(HPO:0000413) | Atresia of the external auditory canal | Occasional [Orphanet] | 32 / 7739 | |||
|
(HPO:0000387) | Absent earlobe | Occasional [Orphanet] | 5 / 7739 | |||
|
(HPO:0002381) | Aphasia | Frequent [Orphanet] | 27 / 7739 | |||
|
(HPO:0001270) | Motor delay | Occasional [Orphanet] | 322 / 7739 | |||
|
(HPO:0100543) | Cognitive impairment | Occasional [Orphanet] | 230 / 7739 | |||
|
(HPO:0000712) | Emotional lability | 44 / 7739 | ||||
|
(HPO:0002357) | Dysphasia | Frequent [Orphanet] | 33 / 7739 | |||
|
(HPO:0001249) | Intellectual disability | Occasional [Orphanet] | 1089 / 7739 | |||
|
(HPO:0000750) | Delayed speech and language development | 197 / 7739 | ||||
|
(HPO:0002133) | Status epilepticus | Occasional [Orphanet] | 59 / 7739 | |||
|
(HPO:0002066) | Gait ataxia | Occasional [Orphanet] occasional [HPO] | 327 / 7739 | |||
|
(HPO:0010529) | Echolalia | Frequent [Orphanet] | 20 / 7739 | |||
|
(HPO:0001250) | Seizures | Occasional [Orphanet] | 1245 / 7739 | |||
|
(HPO:0011097) | Epileptic spasms | Occasional [Orphanet] | 45 / 7739 | |||
|
(HPO:0001328) | Specific learning disability | Occasional [Orphanet] | 114 / 7739 | |||
|
(HPO:0001263) | Global developmental delay | Occasional [Orphanet] | 853 / 7739 | |||
|
(HPO:0002300) | Mutism | Frequent [Orphanet] | 28 / 7739 | |||
|
(HPO:0002121) | Absence seizures | Occasional [Orphanet] | 62 / 7739 | |||
|
(HPO:0011147) | Typical absence seizures | Occasional [Orphanet] | 33 / 7739 | |||
|
(HPO:0001251) | Ataxia | Occasional [Orphanet] occasional [HPO] | 413 / 7739 | |||
|
(HPO:0002200) | Pseudobulbar signs | 15 / 7739 | ||||
|
(HPO:0002167) | Neurological speech impairment | Frequent [Orphanet] | 308 / 7739 | |||
|
(HPO:0001288) | Gait disturbance | Occasional [Orphanet] | 318 / 7739 | |||
|
(HPO:0002311) | Incoordination | Occasional [Orphanet] | 84 / 7739 | |||
|
(HPO:0002141) | Gait imbalance | Occasional [Orphanet] | 55 / 7739 | |||
|
(HPO:0008376) | Nasal, dysarthic speech | Occasional [Orphanet] | 8 / 7739 | |||
|
(HPO:0000771) | Gynecomastia | Frequent [Orphanet] | 53 / 7739 | |||
|
(HPO:0010313) | Breast hypertrophy | Frequent [Orphanet] | 6 / 7739 | |||
|
(HPO:0000823) | Delayed puberty | 65 / 7739 | ||||
|
(HPO:0001182) | Tapered finger | Occasional [Orphanet] | 93 / 7739 | |||
|
(HPO:0001369) | Arthritis | Occasional [Orphanet] | 44 / 7739 | |||
|
(HPO:0002758) | Osteoarthritis | Occasional [Orphanet] occasional [HPO] | 78 / 7739 | |||
|
(HPO:0004279) | Short palm | Occasional [Orphanet] | 323 / 7739 | |||
|
(HPO:0005059) | Arthralgia/arthritis | Occasional [Orphanet] occasional [HPO] | 141 / 7739 | |||
|
(HPO:0002808) | Kyphosis | 289 / 7739 | ||||
|
(HPO:0001238) | Slender finger | Occasional [Orphanet] | 23 / 7739 | |||
|
(HPO:0100769) | Synovitis | Occasional [Orphanet] | 86 / 7739 | |||
|
(HPO:0001773) | Short foot | 86 / 7739 | ||||
|
(HPO:0002650) | Scoliosis | Occasional [Orphanet] | 705 / 7739 | |||
|
(HPO:0200055) | Small hand | Occasional [Orphanet] | 71 / 7739 | |||
|
(HPO:0100601) | Eclampsia | Occasional [Orphanet] | 6 / 7739 | |||
|
(HPO:0100602) | Preeclampsia | Occasional [Orphanet] | 9 / 7739 | |||
|
(HPO:0100603) | Toxemia of pregnancy | Occasional [Orphanet] | 7 / 7739 | |||
|
(HPO:0008071) | Maternal hypertension | Occasional [Orphanet] | 6 / 7739 | |||
|
(HPO:0001537) | Umbilical hernia | Occasional [Orphanet] | 206 / 7739 | |||
|
(HPO:0001513) | Obesity | Very frequent [Orphanet] | 172 / 7739 | |||
|
(HPO:0001956) | Truncal obesity | 39 / 7739 | ||||
|
(HPO:0004322) | Short stature | 1232 / 7739 | ||||
|
(HPO:0004528) | Generalized hypotrichosis | Occasional [Orphanet] | 18 / 7739 | |||
|
(HPO:0001007) | Hirsutism | Occasional [Orphanet] | 91 / 7739 | |||
|
(HPO:0004554) | Generalized hypertrichosis | Occasional [Orphanet] | 30 / 7739 | |||
|
(HPO:0000998) | Hypertrichosis | Occasional [Orphanet] | 52 / 7739 | |||
|
(HPO:0001006) | Hypotrichosis | Occasional [Orphanet] | 219 / 7739 | |||
|
(HPO:0002230) | Generalized hirsutism | Occasional [Orphanet] | 32 / 7739 | |||
|
(HPO:0001065) | Striae distensae | Occasional [Orphanet] | 26 / 7739 | |||
|
(HPO:0001004) | Lymphedema | Occasional [Orphanet] | 62 / 7739 | |||
|
(HPO:0001608) | Abnormality of the voice | Occasional [Orphanet] | 126 / 7739 | |||
|
(HPO:0001611) | Nasal speech | Occasional [Orphanet] | 48 / 7739 | |||
|
(HPO:0100271) | Hyponasal speech | Occasional [Orphanet] | 7 / 7739 | |||
|
(HPO:0001324) | Muscle weakness | 859 / 7739 | ||||
|
(HPO:0008947) | Infantile muscular hypotonia | 482 / 7739 | ||||
|
(HPO:0001252) | Muscular hypotonia | 990 / 7739 | ||||
|
(HPO:0010547) | Muscle flaccidity | 466 / 7739 | ||||
|
(HPO:0003199) | Decreased muscle mass | 27 / 7739 | ||||
|
(OMIM) | Short ears | 2 / 7739 | ||||
|
(OMIM) | Long columella | 3 / 7739 | ||||
|
(OMIM) | Thin upper vermilion | 3 / 7739 | ||||
|
(Orphanet:20300) | Irregular length/shape of fingers | Occasional [Orphanet] | 1 / 7739 | |||
|
(Orphanet:9200) | Protruding lips | Occasional [Orphanet] | 4 / 7739 | |||
|
(OMIM) | High malar bones | 1 / 7739 | ||||
|
(Orphanet:13140) | Long/large ear | Occasional [Orphanet] | 4 / 7739 |
Associated genes:
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
---|
Additional Information:
Description: (OMIM) | WTS is an X-linked neurologic disorder characterized by severe intellectual disability, dysmorphic facial features, hypogonadism, short stature, and truncal obesity. Affected females have a milder phenotype than affected males (summary by Harakalova et al., 2012). |
Clinical Description OMIM |
Wilson et al. (1991) described a kindred in which males in 5 successive generations in an X-linked recessive pedigree pattern had a mental retardation syndrome. The 14 living males in the 3 most recent generations permitted definition of ... |
Molecular genetics OMIM |
By next-generation sequencing of the chromosome X exome in 5 members of a Dutch family with syndromic X-linked mental retardation, Harakalova et al. (2012) identified a mutation in the HDAC8 gene (300269.0001). Female carriers showed complex X inactivation, ... |