Delayed speech and language development

Symptom Information:

Symptom ID: HPO:0000750
Synonyms:
Deficiency of speech development [HPO:0000750]
Delayed language development [HPO:0000750]
Delayed speech acquisition [HPO:0000750]
Delayed speech development [HPO:0000750]
Impaired speech and language development [HPO:0000750]
Impaired speech development [HPO:0000750]
Language delay [HPO:0000750]
Language delayed [HPO:0000750]
Language development deficit [HPO:0000750]
Late-onset speech development [HPO:0000750]
Poor language development [HPO:0000750]
POOR SPEECH ACQUISITION [HPO:0000750]
POOR SPEECH DEVELOPMENT [HPO:0000750]
Speech and language delay [HPO:0000750]
Speech and language difficulties [HPO:0000750]
Speech delay [HPO:0000750]
Speech difficulties [HPO:0000750]
Delayed language development [OMIM:Delayed language development]
Delayed speech acquisition [OMIM:Delayed speech acquisition]
Delayed speech and language development [OMIM:Delayed speech and language development]
Delayed speech development [OMIM:Delayed speech development]
Impaired speech development [OMIM:Impaired speech development]
Language delay [OMIM:Language delay]
Language delayed [OMIM:Language delayed]
Language development deficit [OMIM:Language development deficit]
Late-onset speech development [OMIM:Late-onset speech development]
Poor language development [OMIM:Poor language development]
Poor speech acquisition [OMIM:Poor speech acquisition]
Poor speech development [OMIM:Poor speech development]
Speech and language delay [OMIM:Speech and language delay]
Speech and language difficulties [OMIM:Speech and language difficulties]
Speech delay [OMIM:Speech delay]
Speech difficulties [OMIM:Speech difficulties]
Delayed speech [OMIM:Delayed speech]
Delayed speech and language [OMIM:Delayed speech and language]
Language delay (55%) [OMIM:Language delay (55%)]
Speech delay (1 patient) [OMIM:Speech delay (1 patient)]
Speech delay (10%) [OMIM:Speech delay (10%)]
Speech delay (in some patients) [OMIM:Speech delay (in some patients)]
Speech development delayed (in some patients) [OMIM:Speech development delayed (in some patients)]
Speech difficulties (48%) [OMIM:Speech difficulties (48%)]
Quality:
Cross references:
OMIM: "Delayed language development" [OMIM:Delayed language development]
OMIM: "Delayed speech acquisition" [OMIM:Delayed speech acquisition]
OMIM: "Delayed speech and language development" [OMIM:Delayed speech and language development]
OMIM: "Delayed speech development" [OMIM:Delayed speech development]
OMIM: "Impaired speech development" [OMIM:Impaired speech development]
OMIM: "Language delay" [OMIM:Language delay]
OMIM: "Language delayed" [OMIM:Language delayed]
OMIM: "Language development deficit" [OMIM:Language development deficit]
OMIM: "Late-onset speech development" [OMIM:Late-onset speech development]
OMIM: "Poor language development" [OMIM:Poor language development]
OMIM: "Poor speech acquisition" [OMIM:Poor speech acquisition]
OMIM: "Poor speech development" [OMIM:Poor speech development]
OMIM: "Speech and language delay" [OMIM:Speech and language delay]
OMIM: "Speech and language difficulties" [OMIM:Speech and language difficulties]
OMIM: "Speech delay" [OMIM:Speech delay]
OMIM: "Speech difficulties" [OMIM:Speech difficulties]
OMIM: "Delayed speech" [OMIM:Delayed speech]
OMIM: "Delayed speech and language" [OMIM:Delayed speech and language]
OMIM: "Language delay (55%)" [OMIM:Language delay (55%)]
OMIM: "Speech delay (1 patient)" [OMIM:Speech delay (1 patient)]
OMIM: "Speech delay (10%)" [OMIM:Speech delay (10%)]
OMIM: "Speech delay (in some patients)" [OMIM:Speech delay (in some patients)]
OMIM: "Speech development delayed (in some patients)" [OMIM:Speech development delayed (in some patients)]
OMIM: "Speech difficulties (48%)" [OMIM:Speech difficulties (48%)]
Is a (Direct Parents):
HPO         Cognitive impairment
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Abnormality of higher mental function(HPO:0011446)
                Cognitive impairment(HPO:0100543)
                   Delayed speech and language development(HPO:0000750)
MedDRA:
Database Frequency: 197 / 7739
Resource:

All diseases associated with this symptom:

15q11q13 microduplication syndrome (Orphanet:238446)
15q24 microdeletion syndrome (Orphanet:94065)
17p11.2 microduplication syndrome (Orphanet:1713)
17q11 microdeletion syndrome (Orphanet:97685)
17q11.2 microduplication syndrome (Orphanet:139474)
17q12 microdeletion syndrome (Orphanet:261265)
1p36 deletion syndrome (Orphanet:1606)
2-aminoadipic 2-oxoadipic aciduria (Orphanet:79154)
22q11.2 deletion syndrome (Orphanet:567)
22q11.2 microduplication syndrome (Orphanet:1727)
2q32q33 microdeletion syndrome (Orphanet:251019)
3-methylglutaconic aciduria type 1 (Orphanet:67046)
3-methylglutaconic aciduria type 3 (Orphanet:67047)
3q13 microdeletion syndrome (Orphanet:1621)
4-hydroxybutyric aciduria (Orphanet:22)
ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE (OMIM:614613)
AGAMMAGLOBULINEMIA, X-LINKED (OMIM:300755)
AUTISM (OMIM:209850)
AUTISM, SUSCEPTIBILITY TO, 3 (OMIM:608049)
AUTISM, SUSCEPTIBILITY TO, 8 (OMIM:607373)
AUTISM, SUSCEPTIBILITY TO, X-LINKED 1 (OMIM:300425)
AUTISM, SUSCEPTIBILITY TO, X-LINKED 2 (OMIM:300495)
AUTISM, SUSCEPTIBILITY TO, X-LINKED 3 (OMIM:300496)
Ablepharon macrostomia syndrome (Orphanet:920)
Adenylosuccinate lyase deficiency (Orphanet:46)
Alström syndrome (Orphanet:64)
Arginine:glycine amidinotransferase deficiency (Orphanet:35704)
Aspartylglucosaminuria (Orphanet:93)
Autosomal recessive cerebelloparenchymal disorder type 3 (Orphanet:1170)
Autosomal recessive dopa-responsive dystonia (Orphanet:101150)
Autosomal recessive limb-girdle muscular dystrophy type 2P (Orphanet:280333)
Autosomal recessive spastic ataxia - optic atrophy - dysarthria (Orphanet:254343)
Autosomal recessive spastic paraplegia type 45 (Orphanet:320396)
Autosomal recessive spastic paraplegia type 53 (Orphanet:319199)
BARATELA-SCOTT SYNDROME (OMIM:300881)
Bannayan-Riley-Ruvalcaba syndrome (Orphanet:109)
Bardet-Biedl syndrome (Orphanet:110)
Bardet-Biedl syndrome 1 (OMIM:209900 )
Bardet-Biedl syndrome 10 (OMIM:615987)
Bardet-Biedl syndrome 2 (OMIM:615981)
Bardet-Biedl syndrome 4 (OMIM:615982)
Bardet-Biedl syndrome 7 (OMIM:615984)
Bardet-Biedl syndrome 9 (OMIM:615986)
Beckwith-Wiedemann syndrome due to imprinting defect of 11p15 (Orphanet:231117)
Bilateral polymicrogyria (Orphanet:268940)
CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME1 (OMIM:224050)
CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME2 (OMIM:610185)
CHROMOSOME 15q11.2 DELETION SYNDROME (OMIM:615656)
CHROMOSOME 16p12.1 DELETION SYNDROME, 520-KBFRAGILE SITE, DISTAMYCIN A TYPE, RARE, FRA(16)(p12.1), INCLUDED (OMIM:136570)
CHROMOSOME 5q12 DELETION SYNDROME (OMIM:615668)
CHROMOSOME Xp11.22 DUPLICATION SYNDROME (OMIM:300705)
CK syndrome (Orphanet:251383)
CLN2 disease (Orphanet:228349)
CLN7 disease (Orphanet:228366)
CLN8 disease (Orphanet:228354)
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 18 (OMIM:615578)
CONGENITAL CONTRACTURES OF THE LIMBS AND FACE, HYPOTONIA, AND DEVELOPMENTALDELAY (OMIM:616266)
CORNELIA DE LANGE SYNDROME 1 (OMIM:122470)
CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 6 (OMIM:615771)
Childhood apraxia of speech (Orphanet:209908)
Combined oxidative phosphorylation defect type 15 (Orphanet:319524)
Congenital lactic acidosis, Saguenay-Lac-St. Jean type (Orphanet:70472)
Congenital muscular dystrophy due to phosphatidylcholine biosynthesis defect (Orphanet:280671)
Cornelia de Lange syndrome (Orphanet:199)
Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation (Orphanet:300570)
Costello syndrome (Orphanet:3071)
Cystic leukoencephalopathy without megalencephaly (Orphanet:85136)
DEAFNESS, AUTOSOMAL RECESSIVE 79 (OMIM:613307)
DIGEORGE SYNDROME (OMIM:188400)
DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT, 3 (OMIM:613990)
DYSTONIA WITH RINGBINDEN (OMIM:224550)
Delayed speech - facial asymmetry - strabismus - ear lobe creases (Orphanet:3038)
Dihydropyrimidine dehydrogenase deficiency (Orphanet:1675)
Dihydropyrimidinuria (Orphanet:38874)
Distal monosomy 10q (Orphanet:96148)
Distal monosomy 6p (Orphanet:96125)
Dubowitz syndrome (Orphanet:235)
Duchenne muscular dystrophy (Orphanet:98896)
Dyschromatosis symmetrica hereditaria (Orphanet:41)
Dysequilibrium syndrome (Orphanet:1766)
Dystonia 16 (Orphanet:210571)
EAST syndrome (Orphanet:199343)
ECTODERMAL DYSPLASIA SYNDROME WITH DISTINCTIVE FACIAL APPEARANCE ANDPREAXIAL POLYDACTYLY OF FEET (OMIM:129540)
ENCEPHALOPATHY, PROGRESSIVE, WITH OR WITHOUT LIPODYSTROPHY (OMIM:615924)
Emanuel syndrome (Orphanet:96170)
Encephalopathy due to GLUT1 deficiency (Orphanet:71277)
Epileptic encephalopathy with continuous spike-and-wave during sleep (Orphanet:725)
FG SYNDROME 2 (OMIM:300321)
FORSYTHE-WAKELING SYNDROME (OMIM:613606)
FRAXE intellectual deficit (Orphanet:100973)
Familial hyperthyroidism due to mutations in TSH receptor (Orphanet:424)
Fucosidosis (Orphanet:349)
Galactose epimerase deficiency (Orphanet:79238)
Generalized resistance to thyroid hormone (Orphanet:3221)
Geroderma osteodysplastica (Orphanet:2078)
Glycogen storage disease due to phosphoglycerate kinase 1 deficiency (Orphanet:713)
Growth delay due to insulin-like growth factor I resistance (Orphanet:73273)
Grubben-de Cock-Borghgraef syndrome (Orphanet:2101)
Guanidinoacetate methyltransferase deficiency (Orphanet:382)
HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 1 (OMIM:239300)
HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 2 (OMIM:614749)
Hurler syndrome (Orphanet:93473)
Hyperlysinemia, type I (OMIM:238700)
Hypermethioninemia encephalopathy due to adenosine kinase deficiency (Orphanet:289290)
Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome (Orphanet:363523)
Hypomyelination with atrophy of basal ganglia and cerebellum (Orphanet:139441)
Infantile-onset autosomal recessive nonprogressive cerebellar ataxia (Orphanet:284332)
Intellectual deficit, X-linked - psychosis - macroorchidism (Orphanet:3077)
Intellectual deficit, X-linked, Brooks type (Orphanet:3056)
Intellectual deficit, X-linked, Wilson type (Orphanet:85290)
Intellectual disability-developmental delay-contractures syndrome (Orphanet:3454)
Isobutyryl-CoA dehydrogenase deficiency (Orphanet:79159)
Isolated congenital hypoglossia/aglossia (Orphanet:141152)
Kleefstra syndrome (Orphanet:261494)
Koolen-De Vries syndrome (Orphanet:96169)
Kostmann syndrome (Orphanet:99749)
Landau-Kleffner syndrome (Orphanet:98818)
Langer-Giedion syndrome (Orphanet:502)
Late infantile neuronal ceroid lipofuscinosis (Orphanet:168491)
Leigh syndrome (Orphanet:506)
Lymphedema - atrial septal defects - facial changes (Orphanet:86915)
MACROCEPHALY/MEGALENCEPHALY SYNDROME, AUTOSOMAL RECESSIVE (OMIM:248000)
MAXILLOFACIAL DYSOSTOSIS (OMIM:155000)
MEGDEL syndrome (Orphanet:352328)
MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTICFEATURES (OMIM:613670)
MENTAL RETARDATION, ANTERIOR MAXILLARY PROTRUSION, AND STRABISMUS (OMIM:613671)
MENTAL RETARDATION, AUTOSOMAL DOMINANT 23 (OMIM:615761)
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 39 (OMIM:615541)
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 5 (OMIM:611091)
MENTAL RETARDATION, OBESITY, MANDIBULAR PROGNATHISM, AND EYE AND SKINANOMALIES (OMIM:606772)
MENTAL RETARDATION, TRUNCAL OBESITY, RETINAL DYSTROPHY, AND MICROPENISSYNDROME (OMIM:610156)
MENTAL RETARDATION, X-LINKED 19 (OMIM:300844)
MENTAL RETARDATION, X-LINKED 30 (OMIM:300558)
MENTAL RETARDATION, X-LINKED 89 (OMIM:300848)
MENTAL RETARDATION, X-LINKED 9 (OMIM:309549)
MENTAL RETARDATION, X-LINKED 90 (OMIM:300850)
MENTAL RETARDATION, X-LINKED 93 (OMIM:300659)
MENTAL RETARDATION, X-LINKED 95 (OMIM:300716)
MICROCEPHALY 2, PRIMARY, AUTOSOMAL RECESSIVE, WITH OR WITHOUT CORTICALMALFORMATIONS (OMIM:604317)
MICROCEPHALY 5, PRIMARY, AUTOSOMAL RECESSIVE (OMIM:608716)
Mandibulofacial dysostosis-microcephaly syndrome (Orphanet:79113)
Moebius syndrome (Orphanet:570)
Monosomy 13q14 (Orphanet:1587)
Monosomy 22q13 (Orphanet:48652)
Monosomy 5p (Orphanet:281)
Monosomy 9p (Orphanet:261112)
Mucopolysaccharidosis type 2 (Orphanet:580)
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2B (OMIM:610217)
NOONAN SYNDROME 6 (OMIM:613224)
Nager syndrome (Orphanet:245)
Nephronophthisis 18 (OMIM:615862)
Neurodegeneration with brain iron accumulation due to C19orf12 mutation (Orphanet:289560)
Non-progressive cerebellar ataxia with intellectual deficit (Orphanet:314647)
Noonan syndrome-like disorder with juvenile myelomonocytic leukemia (Orphanet:363972)
Osteoglophonic dwarfism (Orphanet:2645)
Osteopathia striata - cranial sclerosis (Orphanet:2780)
PELIZAEUS-MERZBACHER DISEASE (OMIM:312080)
PERIVENTRICULAR NODULAR HETEROTOPIA 6 (OMIM:615544)
PEROXISOME BIOGENESIS DISORDER 1B (OMIM:601539)
PLANTAR LIPOMATOSIS, UNUSUAL FACIES, AND DEVELOPMENTAL DELAY (OMIM:602342)
PORETTI-BOLTSHAUSER SYNDROME (OMIM:615960)
PYCR1-related DeBarsy syndrome (Orphanet:293633)
Partington syndrome (Orphanet:94083)
Pitt-Hopkins-like syndrome 2 (OMIM:614325)
Prader-Willi syndrome (Orphanet:739)
Purine nucleoside phosphorylase deficiency (Orphanet:760)
Pyridoxine-dependent epilepsy (Orphanet:3006)
Pyruvate dehydrogenase E3-binding protein deficiency (Orphanet:255182)
Rolandic epilepsy - speech dyspraxia (Orphanet:163721)
Rubinstein-Taybi syndrome due to CREBBP mutations (Orphanet:353277)
Rubinstein-Taybi syndrome due to EP300 haploinsufficiency (Orphanet:353284)
SECKEL SYNDROME 6 (OMIM:614728)
SHORT syndrome (Orphanet:3163)
SPASTIC PARAPLEGIA 47, AUTOSOMAL RECESSIVE (OMIM:614066)
SPECIFIC LANGUAGE IMPAIRMENT 1 (OMIM:606711)
SPECIFIC LANGUAGE IMPAIRMENT 2 (OMIM:606712)
Saccharopinuria (Orphanet:3124)
Salla disease (Orphanet:309334)
Short chain 3-hydroxyacyl-CoA dehydrogenase deficiency (Orphanet:35123)
Short chain acyl-CoA dehydrogenase deficiency (Orphanet:26792)
Short-rib thoracic dysplasia 11 with or without polydactyly (OMIM:615633)
Smith-Magenis syndrome (Orphanet:819)
Spectrin-associated autosomal recessive cerebellar ataxia (Orphanet:352403)
Steinert myotonic dystrophy (Orphanet:273)
TEMPLE SYNDROME (OMIM:616222)
TENORIO SYNDROME (OMIM:616260)
THYROID HORMONE RESISTANCE, GENERALIZED, AUTOSOMAL DOMINANT (OMIM:188570)
TREACHER COLLINS SYNDROME 2 (OMIM:613717)
Transketolase deficiency (ORPHA:488618)
Weaver syndrome (Orphanet:3447)
Wiedemann-Steiner syndrome (Orphanet:319182)
Wilson-Turner syndrome (Orphanet:3459)
Wrinkly skin syndrome (Orphanet:2834)
X-linked creatine transporter deficiency (Orphanet:52503)
X-linked intellectual deficit - cerebellar hypoplasia (Orphanet:137831)
X-linked intellectual disability, Hedera type (Orphanet:93952)
[DEL] NEUROFIBROMATOSIS-NOONAN SYNDROME (OMIM:601321)