Dyschromatosis symmetrica hereditaria
General Information (adopted from Orphanet):
Synonyms, Signs: |
SYMMETRIC DYSCHROMATOSIS OF THE EXTREMITIES RETICULATE ACROPIGMENTATION OF DOHI DYSCHROMATOSIS SYMMETRICA HEREDITARIA 1 DSH DSH1 RAD Acropigmentation of Dohi |
Number of Symptoms | 33 |
OrphanetNr: | 41 |
OMIM Id: |
127400
|
ICD-10: |
L81.8 |
UMLs: |
C0406775 |
MeSH: |
C535729 |
MedDRA: |
|
Snomed: |
239085000 |
Prevalence, inheritance and age of onset:
Prevalence: | No data available. |
Inheritance: |
|
Age of onset: |
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Disease classification (adopted from Orphanet):
Parent Diseases: |
Genetic hyperpigmentation of the skin
-Rare genetic disease Hyperpigmentation of the skin -Rare skin disease |
Comment:
Dyschromatosis symmetric hereditary is caused by mutations in the gene ADAR encoding the RNA-specific enzyme adenosine deaminase. It is predominantly transmitted in an autosomal dominant manner with high penetrance, but families with autosomal recessive transmission do exist (PMID:22722384). It is a rare pigmentary genodermatosis which is characterized by a combination of hyperpigmented and hypopigmented macules. The clinical symptoms are similar to dyschromatosis universalis hereditaria (PMID:25382520). Up to now, there is no definitive treatment for this disease. |
Symptom Information:
|
(HPO:0000343) | Long philtrum | 19584476 | IBIS | 262 / 7739 | ||
|
(HPO:0000643) | Blepharospasm | Frequent [Orphanet] | X | 20 / 7739 | ||
|
(HPO:0001999) | Abnormal facial shape | 19584476 | IBIS | 169 / 7739 | ||
|
(HPO:0000473) | Torticollis | Frequent [Orphanet] | 16817193 | IBIS | 42 / 7739 | |
|
(HPO:0000508) | Ptosis | 19584476 | IBIS | 459 / 7739 | ||
|
(HPO:0006801) | Hyperactive deep tendon reflexes | 25382520 | IBIS | 21 / 7739 | ||
|
(HPO:0000737) | Irritability | 16817193 | IBIS | 93 / 7739 | ||
|
(HPO:0001304) | Torsion dystonia | 7911621 | IBIS | 13 / 7739 | ||
|
(HPO:0000716) | Depression | 25382520 | IBIS | 99 / 7739 | ||
|
(HPO:0000719) | Inappropriate behavior | 25382520 | IBIS | 5 / 7739 | ||
|
(HPO:0001288) | Gait disturbance | 25382520 | IBIS | 318 / 7739 | ||
|
(HPO:0002533) | Abnormal posturing | 19584476 | IBIS | 6 / 7739 | ||
|
(HPO:0002356) | Writer's cramp | Frequent [Orphanet] | X | 16 / 7739 | ||
|
(HPO:0000729) | Autistic behavior | 25382520 | IBIS | 27 / 7739 | ||
|
(HPO:0001268) | Mental deterioration | 16817193 | IBIS | 88 / 7739 | ||
|
(HPO:0001332) | Dystonia | Frequent [Orphanet] | 25382520 | IBIS | 197 / 7739 | |
|
(HPO:0000750) | Delayed speech and language development | 25382520 | IBIS | 197 / 7739 | ||
|
(HPO:0001276) | Hypertonia | 25382520 | IBIS | 317 / 7739 | ||
|
(HPO:0001250) | Seizures | 25382520 | IBIS | 1245 / 7739 | ||
|
(HPO:0002376) | Developmental regression | 25382520 | IBIS | 74 / 7739 | ||
|
(HPO:0002514) | Cerebral calcification | 16817193 | IBIS | 89 / 7739 | ||
|
(HPO:0002135) | Basal ganglia calcification | 25382520 | IBIS | 37 / 7739 | ||
|
(HPO:0002571) | Achalasia | 22594859 | IBIS | 19 / 7739 | ||
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(HPO:0001034) | Hypermelanotic macule | Very frequent [Orphanet] | 25382520 | IBIS | 22 / 7739 | |
|
(HPO:0005585) | Spotty hyperpigmentation | 25382520 | IBIS | 8 / 7739 | ||
|
(HPO:0007400) | Irregular hyperpigmentation | Very frequent [Orphanet] | 25382520 | IBIS | 72 / 7739 | |
|
(HPO:0007441) | Hyperpigmented/hypopigmented macules | Very frequent [IBIS] | 25382520 | IBIS | 6 / 7739 | |
|
(HPO:0007588) | Reticular hyperpigmentation | Very frequent [Orphanet] | 25382520 | IBIS | 9 / 7739 | |
|
(HPO:0007427) | Reticulated skin pigmentation | Very frequent [Orphanet] | 25382520 | IBIS | 7 / 7739 | |
|
(HPO:0001053) | Hypopigmented skin patches | Very frequent [Orphanet] | 25382520 | IBIS | 80 / 7739 | |
|
(HPO:0007587) | Numerous pigmented freckles | 25382520 | IBIS | 22 / 7739 | ||
|
(HPO:0005590) | Spotty hypopigmentation | Very frequent [Orphanet] hallmark [HPO] | 25382520 | IBIS | 10 / 7739 | |
|
(MedDRA:10025421) | Macule | Very frequent [Orphanet] | X | 55 / 7739 |
Associated genes:
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
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Additional Information:
Description: (OMIM) |
Dyschromatosis symmetrica hereditaria (DSH), also called symmetric dyschromatosis of the extremities and symmetric or reticulate acropigmentation of Dohi (Komaya, 1924), is characterized by hyperpigmented and hypopigmented macules on the face and dorsal aspects of the extremities that appear ... |
Clinical Description OMIM |
Patrizi et al. (1994) described a 9-year-old Caucasian girl with a mixture of hyperpigmented and hypopigmented macules on the backs of the feet. Two brothers had the same lesions, and all had small freckle-like pigmented macules on their ... |
Molecular genetics OMIM |
In affected members of 4 Japanese families segregating DSH, Miyamura et al. (2003) identified heterozygous mutations in the ADAR gene (146920.0001-146920.0004). In affected members of 6 Chinese multigeneration families and 2 sporadic patients with DSH, Zhang ... |
Population genetics OMIM | Miyamura et al. (2003) stated that the prevalence of DSH in the Japanese population is estimated to be 1.5 per 100,000. |