Mental deterioration

Symptom Information:

Symptom ID: HPO:0001268
Synonyms:
Cognitive decline [HPO:0001268]
Cognitive decline, progressive [HPO:0001268]
Intellectual deterioration [HPO:0001268]
Progressive cognitive decline [HPO:0001268]
Intellectual decline [Orphanet:43520]
Mental deterioration [Orphanet:43520]
Cognitive decline [OMIM:Cognitive decline]
Cognitive decline, progressive [OMIM:Cognitive decline, progressive]
Intellectual deterioration [OMIM:Intellectual deterioration]
Mental deterioration [OMIM:Mental deterioration]
Progressive cognitive decline [OMIM:Progressive cognitive decline]
Psychic/psychomotor regression/dementia/intellectual decline [Orphanet:43520]
Mental impairment [MedDRA:10027374]
Cerebration impaired [MedDRA:10027374]
Deterioration mental (NOS) [MedDRA:10027374]
Difficulty thinking [MedDRA:10027374]
Intellect impaired [MedDRA:10027374]
Intelligence decreased [MedDRA:10027374]
Intelligence reduced [MedDRA:10027374]
Mental activity decreased [MedDRA:10027374]
Mental deterioration [MedDRA:10027374]
Mental dullness [MedDRA:10027374]
Mental function decreased [MedDRA:10027374]
Mental impairment NOS [MedDRA:10027374]
Mentation impaired [MedDRA:10027374]
Minimal brain dysfunction [MedDRA:10027374]
Thinking reduced [MedDRA:10027374]
Cognitive decline (1 family) [OMIM:Cognitive decline (1 family)]
Cognitive decline (1 patient) [OMIM:Cognitive decline (1 patient)]
Cognitive decline (in some patients) [OMIM:Cognitive decline (in some patients)]
Cognitive decline (rare) [OMIM:Cognitive decline (rare)]
Mental impairment (excl dementia and memory loss) [MedDRA:10027375]
Quality:
Cross references:
HPO:0002376 "Developmental regression" [Orphanet:43520]
HPO:0002361 "Psychomotor deterioration" [Orphanet:43520]
Orphanet:43520 "Psychic/psychomotor regression/dementia/intellectual decline" [Orphanet:43520]
OMIM: "Cognitive decline" [OMIM:Cognitive decline]
OMIM: "Cognitive decline, progressive" [OMIM:Cognitive decline, progressive]
OMIM: "Intellectual deterioration" [OMIM:Intellectual deterioration]
OMIM: "Mental deterioration" [OMIM:Mental deterioration]
OMIM: "Progressive cognitive decline" [OMIM:Progressive cognitive decline]
OMIM: "Cognitive decline (1 family)" [OMIM:Cognitive decline (1 family)]
OMIM: "Cognitive decline (1 patient)" [OMIM:Cognitive decline (1 patient)]
OMIM: "Cognitive decline (in some patients)" [OMIM:Cognitive decline (in some patients)]
OMIM: "Cognitive decline (rare)" [OMIM:Cognitive decline (rare)]
UMLS:C0234985 "Mental deterioration" [Orphanet:43520]
Is a (Direct Parents):
Orphanet Functional anomalies of the nervous system
HPO         Cognitive impairment
Orphanet Dementia
MedDRA Mental impairment disorders
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Abnormality of higher mental function(HPO:0011446)
                Cognitive impairment(HPO:0100543)
                   Mental deterioration(HPO:0001268)
MedDRA:
Nervous system disorders(MedDRA:10029205)
    Mental impairment disorders(MedDRA:10057167)
       Mental deterioration(HPO:0001268)
Database Frequency: 88 / 7739
Resource:

All diseases associated with this symptom:

ACTH-independent macronodular adrenal hyperplasia (Orphanet:189427)
ALTERNATING HEMIPLEGIA OF CHILDHOOD 1 (OMIM:104290)
ALTERNATING HEMIPLEGIA OF CHILDHOOD 2 (OMIM:614820)
Aceruloplasminemia (Orphanet:48818)
Adrenomyeloneuropathy (Orphanet:139399)
Adult polyglucosan body disease (Orphanet:206583)
Adult-onset dystonia-parkinsonism (Orphanet:199351)
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (Orphanet:313808)
Alternating hemiplegia of childhood (Orphanet:2131)
Ataxia - oculomotor apraxia type 1 (Orphanet:1168)
Atherosclerosis - deafness - diabetes - epilepsy - nephropathy (Orphanet:1192)
Autosomal dominant Charcot-Marie-Tooth disease type 2A2 (Orphanet:99947)
Autosomal dominant spastic paraplegia type 4 (Orphanet:100985)
Autosomal recessive spastic paraplegia type 11 (Orphanet:2822)
Autosomal recessive spastic paraplegia type 15 (Orphanet:100996)
Autosomal recessive spastic paraplegia type 35 (Orphanet:171629)
Autosomal recessive spastic paraplegia type 46 (Orphanet:320391)
BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 1 (OMIM:213600)
Behavioral variant of frontotemporal dementia (Orphanet:275864)
Bilateral striopallidodentate calcinosis (Orphanet:1980)
CADASIL (Orphanet:136)
CLN11 disease (Orphanet:314629)
CLN13 disease (Orphanet:352709)
CLN6 disease (Orphanet:228363)
CLN7 disease (Orphanet:228366)
Cerebroretinal vasculopathy (Orphanet:3421)
Coats plus syndrome (Orphanet:313838)
DE SANCTIS-CACCHIONE SYNDROME (OMIM:278800)
Dravet syndrome (Orphanet:33069)
Dyschromatosis symmetrica hereditaria (Orphanet:41)
ENCEPHALOPATHY, PROGRESSIVE, WITH OR WITHOUT LIPODYSTROPHY (OMIM:615924)
EPILEPSY, PROGRESSIVE MYOCLONIC 7 (OMIM:616187)
EPILEPSY, PROGRESSIVE MYOCLONIC, 5 (OMIM:613832)
Familial encephalopathy with neuroserpin inclusion bodies (Orphanet:85110)
Fatal mitochondrial disease due to combined oxidative phosphorylation deficiency 3 (Orphanet:168566)
Fragile X-associated tremor/ataxia syndrome (Orphanet:93256)
Gaucher disease (Orphanet:355)
Gaucher disease type 3 (Orphanet:77261)
HERNS syndrome (Orphanet:63261)
Hereditary vascular retinopathy (Orphanet:71291)
Huntington disease (Orphanet:399)
Huntington disease-like 1 (Orphanet:157941)
Huntington disease-like 3 (Orphanet:157946)
Hurler syndrome (Orphanet:93473)
KRABBE DISEASE (OMIM:245200)
KURU, SUSCEPTIBILITY TO (OMIM:245300)
Knobloch syndrome (Orphanet:1571)
Kufor-Rakeb syndrome (Orphanet:306674)
LEUKOENCEPHALOPATHY, BRAIN CALCIFICATIONS, AND CYSTS (OMIM:614561)
Lafora disease (Orphanet:501)
Leukoencephalopathy with brain stem and spinal cord involvement - lactate elevation (Orphanet:137898)
MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 2A (OMIM:613925)
MEGDEL syndrome (Orphanet:352328)
MELAS (Orphanet:550)
MERRF (Orphanet:551)
METACHROMATIC LEUKODYSTROPHY (OMIM:250100)
METACHROMATIC LEUKODYSTROPHY DUE TO SAPOSIN B DEFICIENCY (OMIM:249900)
McLeod neuroacanthocytosis syndrome (Orphanet:59306)
Menkes disease (Orphanet:565)
Mohr-Tranebjaerg syndrome (Orphanet:52368)
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2B (OMIM:610217)
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 6 (OMIM:615643)
NIEMANN-PICK DISEASE, TYPE C1 (OMIM:257220)
NIEMANN-PICK DISEASE, TYPE C2 (OMIM:607625)
Necrotizing encephalomyelopathy, subacute, of Leigh, adult (OMIM:161700)
Neurocutaneous melanocytosis (Orphanet:2481)
Neurodegeneration with brain iron accumulation due to C19orf12 mutation (Orphanet:289560)
Niemann-Pick disease type C (Orphanet:646)
OPTICOCOCHLEODENTATE DEGENERATION (OMIM:258700)
PARKINSON DISEASE 20, EARLY-ONSET (OMIM:615530)
PARKINSON DISEASE 8, AUTOSOMAL DOMINANT (OMIM:607060)
PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1 (OMIM:610489)
PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 2 (OMIM:610475)
Pantothenate kinase-associated neurodegeneration (Orphanet:157850)
Parkinsonim due to ATP13A2 deficiency (Orphanet:314632)
Primary pigmented nodular adrenocortical disease (Orphanet:189439)
Progressive epilepsy-intellectual deficit, Finnish type (Orphanet:1947)
Retinal vasculopathy and cerebral leukodystrophy (Orphanet:247691)
Sneddon syndrome (Orphanet:820)
Spinocerebellar ataxia type 14 (Orphanet:98763)
Spinocerebellar ataxia type 7 (Orphanet:94147)
Unverricht-Lundborg disease (Orphanet:308)
Wolfram syndrome (Orphanet:3463)
X-linked cerebral adrenoleukodystrophy (Orphanet:139396)
Xeroderma pigmentosum complementation group A (Orphanet:276249)
Xeroderma pigmentosum complementation group D (Orphanet:276258)
Xeroderma pigmentosum/Cockayne syndrome complex (Orphanet:220295)
Young adult-onset Parkinsonism (Orphanet:2828)