Young adult-onset Parkinsonism
General Information (adopted from Orphanet):
| Synonyms, Signs: |
Familial Parkinson disease Young-onset Parkinson disease Hereditary Parkinson disease Early-onset Parkinson disease |
| Number of Symptoms | 14 |
| OrphanetNr: | 2828 |
| OMIM Id: |
168601
300557 600116 602404 605543 605909 606324 606852 607060 607688 610297 613643 614203 614251 |
| ICD-10: |
G20 |
| UMLs: |
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| MeSH: |
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| MedDRA: |
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| Snomed: |
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Prevalence, inheritance and age of onset:
| Prevalence: | 15 of 100 000 [Orphanet] |
| Inheritance: |
Autosomal dominant Autosomal recessive [Orphanet] |
| Age of onset: |
Adult [Orphanet] |
Disease classification (adopted from Orphanet):
| Parent Diseases: |
Primary orthostatic hypotension
-Rare neurologic disease Rare parkinsonian syndrome due to genetic neurodegenerative disease -Rare genetic disease Rare parkinsonian syndrome due to neurodegenerative disease -Rare neurologic disease |
Symptom Information:
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(HPO:0000012) | Urinary urgency | 35 / 7739 | ||||
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(HPO:0002172) | Postural instability | 22 / 7739 | ||||
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(HPO:0001268) | Mental deterioration | 88 / 7739 | ||||
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(HPO:0001300) | Parkinsonism | 75 / 7739 | ||||
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(HPO:0001336) | Myoclonus | 115 / 7739 | ||||
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(HPO:0002063) | Rigidity | 92 / 7739 | ||||
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(HPO:0002360) | Sleep disturbance | 113 / 7739 | ||||
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(HPO:0002375) | Hypokinesia | 25 / 7739 | ||||
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(HPO:0001260) | Dysarthria | 329 / 7739 | ||||
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(HPO:0002362) | Shuffling gait | 13 / 7739 | ||||
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(HPO:0001332) | Dystonia | 197 / 7739 | ||||
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(HPO:0002015) | Dysphagia | 301 / 7739 | ||||
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(HPO:0002067) | Bradykinesia | 62 / 7739 | ||||
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(HPO:0002322) | Resting tremor | 14 / 7739 |
Associated genes:
ClinVar (via SNiPA)
| Gene symbol | Variation | Clinical significance | Reference |
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