Hypertonia
Symptom Information:
Symptom ID: | HPO:0001276 | ||||||||||||||||||||||||||||||||
Synonyms: |
|
||||||||||||||||||||||||||||||||
Quality: | |||||||||||||||||||||||||||||||||
Cross references: |
|
||||||||||||||||||||||||||||||||
Is a (Direct Parents): |
|
||||||||||||||||||||||||||||||||
Is a (Whole tree): |
HPO:
All(HPO:0000001) Phenotypic abnormality(HPO:0000118) Abnormality of the nervous system(HPO:0000707) Abnormality of nervous system physiology(HPO:0012638) Abnormality of central motor function(HPO:0011442) Abnormal pyramidal signs(HPO:0007256) Hypertonia(HPO:0001276) MedDRA: Musculoskeletal and connective tissue disorders(MedDRA:10028395) Muscle disorders(MedDRA:10028302) Muscle tone abnormalities(MedDRA:10028343) Hypertonia(HPO:0001276) |
||||||||||||||||||||||||||||||||
Database Frequency: | 317 / 7739 | ||||||||||||||||||||||||||||||||
Resource: |
All diseases associated with this symptom:
14q11.2 microdeletion syndrome | (Orphanet:261120) |
16p13.11 microdeletion syndrome | (Orphanet:261236) |
1q21.1 microduplication syndrome | (Orphanet:250994) |
2p15p16.1 microdeletion syndrome | (Orphanet:261349) |
3-methylglutaconic aciduria type 4 | (Orphanet:67048) |
3-phosphoglycerate dehydrogenase deficiency | (Orphanet:79351) |
3-phosphoserine phosphatase deficiency | (Orphanet:79350) |
6-pyruvoyl-tetrahydropterin synthase deficiency | (Orphanet:13) |
6q25 microdeletion syndrome | (Orphanet:251056) |
ALG3-CDG | (Orphanet:79321) |
Aceruloplasminemia | (Orphanet:48818) |
Acetazolamide-responsive myotonia | (Orphanet:99736) |
Acro-cardio-facial syndrome | (Orphanet:2008) |
Adams-Oliver syndrome | (Orphanet:974) |
Adenylosuccinate lyase deficiency | (Orphanet:46) |
Adult polyglucosan body disease | (Orphanet:206583) |
Adult-onset autosomal dominant leukodystrophy | (Orphanet:99027) |
Aicardi syndrome | (Orphanet:50) |
Aicardi-Goutières syndrome | (Orphanet:51) |
Alexander disease | (Orphanet:58) |
Alpers syndrome | (Orphanet:726) |
Alpha-N-acetylgalactosaminidase deficiency | (Orphanet:3137) |
Alpha-N-acetylgalactosaminidase deficiency type 1 | (Orphanet:79279) |
Amelo-cerebro-hypohidrotic syndrome | (Orphanet:1946) |
Amish lethal microcephaly | (Orphanet:99742) |
Arachnodactyly - intellectual deficit - dysmorphism | (Orphanet:1130) |
Argininemia | (Orphanet:90) |
Arthrogryposis - hyperkeratosis, lethal form | (Orphanet:1485) |
Ataxia with vitamin E deficiency | (Orphanet:96) |
Ataxia-telangiectasia | (Orphanet:100) |
Atherosclerosis - deafness - diabetes - epilepsy - nephropathy | (Orphanet:1192) |
Attenuated Chédiak-Higashi syndrome | (Orphanet:352723) |
Atypical Rett syndrome | (Orphanet:3095) |
Autosomal dominant Charcot-Marie-Tooth disease type 2A2 | (Orphanet:99947) |
Autosomal dominant cerebellar ataxia | (Orphanet:99) |
Autosomal dominant spastic paraplegia type 9 | (Orphanet:100990) |
Autosomal recessive chorioretinopathy-microcephaly | (Orphanet:2518) |
Autosomal recessive spastic paraplegia type 11 | (Orphanet:2822) |
Autosomal recessive spastic paraplegia type 46 | (Orphanet:320391) |
Autosomal recessive spastic paraplegia type 53 | (Orphanet:319199) |
Bardet-Biedl syndrome 1 | (OMIM:209900 ) |
Bardet-Biedl syndrome 16 | (OMIM:615993) |
Behr syndrome | (Orphanet:1239) |
Benign familial infantile seizures | (Orphanet:306) |
Benign familial neonatal seizures | (Orphanet:1949) |
Bilateral frontoparietal polymicrogyria | (Orphanet:101070) |
Biotinidase deficiency | (Orphanet:79241) |
Bird headed-dwarfism, Montreal type | (Orphanet:2617) |
Bonnemann-Meinecke-Reich syndrome | (Orphanet:1261) |
CADASIL | (Orphanet:136) |
CARDIOFACIOCUTANEOUS SYNDROME 1 | (OMIM:115150) |
CEREBRAL PALSY, SPASTIC QUADRIPLEGIC, 1 | (OMIM:603513) |
CEREBROOCULOFACIOSKELETAL SYNDROME 4 | (OMIM:610758) |
COFS syndrome | (Orphanet:1466) |
CORNELIA DE LANGE SYNDROME 1 | (OMIM:122470) |
CRANIOSYNOSTOSIS-MENTAL RETARDATION SYNDROME OF LIN AND GETTIG | (OMIM:218649) |
Canavan disease | (Orphanet:141) |
Cardiofaciocutaneous syndrome | (Orphanet:1340) |
Cataract - ataxia - deafness | (Orphanet:1368) |
Cataract-congenital heart disease-neural tube defect syndrome | (Orphanet:314993) |
Central nervous system calcification - deafness - tubular acidosis - anemia | (Orphanet:3240) |
Cerebro-reno-digital syndrome | (Orphanet:1396) |
Cerebrotendinous xanthomatosis | (Orphanet:909) |
Chédiak-Higashi syndrome | (Orphanet:167) |
Classic maple syrup urine disease | (Orphanet:268145) |
Classical phenylketonuria | (Orphanet:79254) |
Cocaine embryofetopathy | (Orphanet:1911) |
Cockayne syndrome | (Orphanet:191) |
Coffin-Lowry syndrome | (Orphanet:192) |
Combined oxidative phosphorylation defect type 4 | (Orphanet:254925) |
Congenital ichthyosis - intellectual deficit - spastic quadriplegia | (Orphanet:352333) |
Congenital intrauterine infection-like syndrome | (Orphanet:1229) |
Congenital myopathy with excess of thin filaments | (Orphanet:98904) |
Congenital rubella syndrome | (Orphanet:290) |
Congenital unilateral hypoplasia of depressor anguli oris | (Orphanet:1166) |
Corneal-cerebellar syndrome | (Orphanet:3177) |
Cornelia de Lange syndrome | (Orphanet:199) |
Cortical blindness - intellectual deficit - polydactyly | (Orphanet:1389) |
Craniosynostosis - hydrocephalus - Chiari I malformation - radioulnar synostosis | (Orphanet:171839) |
DYSTONIA 1, TORSION, AUTOSOMAL DOMINANT | (OMIM:128100) |
Deaf blind hypopigmentation syndrome, Yemenite type | (Orphanet:3214) |
Dehydratase deficiency | (Orphanet:1578) |
Desmosterolosis | (Orphanet:35107) |
Dihydropteridine reductase deficiency | (Orphanet:226) |
Dihydropyrimidine dehydrogenase deficiency | (Orphanet:1675) |
Distal hereditary motor neuropathy type 1 | (Orphanet:139518) |
Distal monosomy 13q | (Orphanet:1590) |
Distal monosomy 3p | (Orphanet:1620) |
Distal monosomy 7q36 | (Orphanet:1636) |
Distal trisomy 15q | (Orphanet:1707) |
Dopa-responsive dystonia | (Orphanet:255) |
Dyschromatosis symmetrica hereditaria | (Orphanet:41) |
Early-onset generalized limb-onset dystonia | (Orphanet:256) |
Early-onset parkinsonism - intellectual deficit | (Orphanet:2379) |
Edinburgh malformation syndrome | (Orphanet:1895) |
Encephalocraniocutaneous lipomatosis | (Orphanet:2396) |
Encephalopathy due to GLUT1 deficiency | (Orphanet:71277) |
Encephalopathy due to hydroxykynureninuria | (Orphanet:79155) |
Encephalopathy due to sulfite oxidase deficiency | (Orphanet:833) |
Encephalopathy-hypertrophic cardiomyopathy-renal tubular disease syndrome | (Orphanet:319678) |
Facial dysmorphism - macrocephaly - myopia - Dandy-Walker malformation | (Orphanet:1970) |
Fallot complex - intellectual deficit - growth delay | (Orphanet:3304) |
Familial acute necrotizing encephalopathy | (Orphanet:88619) |
Familial dementia, British type | (Orphanet:97345) |
Familial hemophagocytic lymphohistiocytosis | (Orphanet:540) |
Familial lambdoid synostosis | (Orphanet:3267) |
Fetal Gaucher disease | (Orphanet:85212) |
Fetal brain disruption sequence | (Orphanet:1665) |
Fetal iodine syndrome | (Orphanet:1910) |
Fragile X-associated tremor/ataxia syndrome | (Orphanet:93256) |
Free sialic acid storage disease | (Orphanet:834) |
Fucosidosis | (Orphanet:349) |
GM1 gangliosidosis | (Orphanet:354) |
GM2-gangliosidosis, AB variant | (Orphanet:309246) |
Galloway-Mowat syndrome | (Orphanet:2065) |
Gaucher disease - ophthalmoplegia - cardiovascular calcification | (Orphanet:2072) |
Gaucher disease type 2 | (Orphanet:77260) |
Gaucher disease type 3 | (Orphanet:77261) |
Glutaryl-CoA dehydrogenase deficiency | (Orphanet:25) |
Griscelli disease | (Orphanet:381) |
Griscelli disease type 1 | (Orphanet:79476) |
Griscelli disease type 2 | (Orphanet:79477) |
Grix-Blankenship-Peterson syndrome | (Orphanet:2099) |
Guanidinoacetate methyltransferase deficiency | (Orphanet:382) |
Gómez-López-Hernández syndrome | (Orphanet:1532) |
HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1 | (OMIM:267700) |
HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 2 | (OMIM:603553) |
HYPEREKPLEXIA 2 | (OMIM:614619) |
HYPEREKPLEXIA 3 | (OMIM:614618) |
HYPEREKPLEXIA, HEREDITARY 1 | (OMIM:149400) |
Hartnup syndrome | (Orphanet:2116) |
Hepatic fibrosis - renal cysts - intellectual deficit | (Orphanet:2031) |
Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1 | (Orphanet:137681) |
Hereditary continuous muscle fiber activity | (Orphanet:972) |
Hereditary hyperekplexia | (Orphanet:3197) |
Hereditary motor and sensory neuropathy type 5 | (Orphanet:64751) |
Hereditary sensory and autonomic neuropathy with spastic paraplegia | (Orphanet:139578) |
Hereditary spastic paraplegia | (Orphanet:685) |
Holocarboxylase synthetase deficiency | (Orphanet:79242) |
Holoprosencephaly | (Orphanet:2162) |
Hoyeraal-Hreidarsson syndrome | (Orphanet:3322) |
Huntington disease | (Orphanet:399) |
Hydrocephalus with stenosis of aqueduct of Sylvius | (Orphanet:2182) |
Hyperekplexia - epilepsy | (Orphanet:163985) |
Hyperkalemic periodic paralysis | (Orphanet:682) |
Incontinentia pigmenti | (Orphanet:464) |
Infantile Refsum disease | (Orphanet:772) |
Infantile axonal neuropathy | (Orphanet:2679) |
Infantile dystonia-parkinsonism | (Orphanet:238455) |
Infantile epileptic-dyskinetic encephalopathy | (Orphanet:364063) |
Infantile symmetrical thalamic degeneration | (Orphanet:3311) |
Infantile thalamic degeneration | (Orphanet:1577) |
Infantile-onset ascending hereditary spastic paralysis | (Orphanet:293168) |
Intellectual deficit - athetosis - microphthalmia | (Orphanet:1236) |
Intellectual deficit - hypoplastic corpus callosum - preauricular tag | (Orphanet:1495) |
Intellectual deficit - spasticity - ectrodactyly | (Orphanet:1891) |
Intellectual deficit, Buenos-Aires type | (Orphanet:3079) |
Intellectual deficit, X-linked - psychosis - macroorchidism | (Orphanet:3077) |
Intellectual deficit, X-linked, Brooks type | (Orphanet:3056) |
Intellectual deficit, X-linked, Pai type | (Orphanet:85322) |
Intermittent maple syrup urine disease | (Orphanet:268173) |
Isolated 3-methylcrotonyl-CoA carboxylase deficiency | (Orphanet:6) |
Isolated cerebellar hypoplasia/agenesis | (Orphanet:1398) |
Isolated spina bifida | (Orphanet:823) |
Isolated sulfite oxidase deficiency | (Orphanet:99731) |
Juvenile amyotrophic lateral sclerosis | (Orphanet:300605) |
Juvenile primary lateral sclerosis | (Orphanet:247604) |
KEPPEN-LUBINSKY SYNDROME | (OMIM:614098) |
KRABBE DISEASE, ATYPICAL, DUE TO SAPOSIN A DEFICIENCY | (OMIM:611722) |
Keratoderma hereditarium mutilans with ichthyosis | (Orphanet:79395) |
Krabbe disease | (Orphanet:487) |
L-2-hydroxyglutaric aciduria | (Orphanet:79314) |
L1 syndrome | (Orphanet:275543) |
Laryngeal abductor paralysis - intellectual deficit | (Orphanet:2375) |
Leigh syndrome | (Orphanet:506) |
Lesch-Nyhan syndrome | (Orphanet:510) |
Lethal polymalformative syndrome, Boissel type | (Orphanet:210144) |
Leukoencephalopathy-palmoplantar keratoderma syndrome | (Orphanet:2386) |
Lissencephaly type 1 due to doublecortin gene mutation | (Orphanet:2148) |
Locked-in syndrome | (Orphanet:2406) |
MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 3 | (OMIM:154276) |
MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 2A | (OMIM:613925) |
MEHMO syndrome | (Orphanet:85282) |
MELAS | (Orphanet:550) |
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 5 | (OMIM:611091) |
MICROCEPHALY 2, PRIMARY, AUTOSOMAL RECESSIVE, WITH OR WITHOUT CORTICALMALFORMATIONS | (OMIM:604317) |
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 4 | (OMIM:615159) |
MOLYBDENUM COFACTOR DEFICIENCY, COMPLEMENTATION GROUP C | (OMIM:615501) |
MPDU1-CDG | (Orphanet:79323) |
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH MENTAL RETARDATION),TYPE B, 14 | (OMIM:615351) |
MUSCULAR HYPERTONIA, LETHAL | (OMIM:254120) |
Macrocephaly - short stature - paraplegia | (Orphanet:2427) |
Macrocephaly - spastic paraplegia - dysmorphism | (Orphanet:2429) |
Marinesco-Sjögren syndrome | (Orphanet:559) |
Maternal hyperthermia induced birth defects | (Orphanet:2216) |
McLeod neuroacanthocytosis syndrome | (Orphanet:59306) |
Menkes disease | (Orphanet:565) |
Metachromatic leukodystrophy | (Orphanet:512) |
Micrencephaly - corpus callosum agenesis - abnormal genitalia | (Orphanet:2508) |
Micro syndrome | (Orphanet:2510) |
Microcephalic osteodysplastic primordial dwarfism types 1 and 3 | (Orphanet:2636) |
Microcephalic primordial dwarfism due to ZNF335 deficiency | (Orphanet:329228) |
Microcephaly - brachydactyly - kyphoscoliosis | (Orphanet:3433) |
Microcephaly - brain defect - spasticity - hypernatremia | (Orphanet:2523) |
Microcephaly - intellectual deficit - phalangeal and neurological anomalies | (Orphanet:137658) |
Microcephaly - lymphedema - chorioretinopathy | (Orphanet:2526) |
Microcephaly-microcornea syndrome, Seemanova type | (Orphanet:2528) |
Microlissencephaly | (Orphanet:1083) |
Microlissencephaly - micromelia | (Orphanet:50810) |
Monosomy 5p | (Orphanet:281) |
Monosomy 9p | (Orphanet:261112) |
Mucopolysaccharidosis type 3 | (Orphanet:581) |
Muscle-eye-brain disease | (Orphanet:588) |
Myotonia fluctuans | (Orphanet:99734) |
Myotonia permanens | (Orphanet:99735) |
N syndrome | (Orphanet:2608) |
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2B | (OMIM:610217) |
Nasu-Hakola disease | (Orphanet:2770) |
Nemaline myopathy | (Orphanet:607) |
Neonatal hemochromatosis | (Orphanet:446) |
Neuhauser-Eichner-Opitz syndrome | (Orphanet:2672) |
Neuroectodermal melanolysosomal disease | (Orphanet:33445) |
Neuroferritinopathy | (Orphanet:157846) |
Neurologic Waardenburg-Shah syndrome | (Orphanet:163746) |
Neuronal intranuclear inclusion disease | (Orphanet:2289) |
Night blindness - skeletal anomalies - dysmorphism | (Orphanet:1390) |
Non-polyposis Turcot syndrome | (Orphanet:99817) |
Norrie disease | (Orphanet:649) |
Oculo-palato-cerebral syndrome | (Orphanet:2714) |
Oculo-reno-cerebellar syndrome | (Orphanet:2715) |
Oculocerebral hypopigmentation syndrome, Cross type | (Orphanet:2719) |
Oculodentodigital dysplasia | (Orphanet:2710) |
Olivopontocerebellar atrophy - deafness | (Orphanet:2732) |
Orofaciodigital syndrome type 3 | (Orphanet:2752) |
Otofaciocervical syndrome | (Orphanet:2792) |
Oxoglutaricaciduria | (Orphanet:31) |
PLANTAR LIPOMATOSIS, UNUSUAL FACIES, AND DEVELOPMENTAL DELAY | (OMIM:602342) |
Palmoplantar keratoderma-spastic paralysis syndrome | (Orphanet:2201) |
Pantothenate kinase-associated neurodegeneration | (Orphanet:157850) |
Papilloma of choroid plexus | (Orphanet:2807) |
Paraplegia - brachydactyly - cone-shaped epiphysis | (Orphanet:2823) |
Paraplegia - intellectual deficit - hyperkeratosis | (Orphanet:2824) |
Pelizaeus-Merzbacher disease | (Orphanet:702) |
Peroxisomal acyl-CoA oxidase deficiency | (Orphanet:2971) |
Pfeiffer-Palm-Teller syndrome | (Orphanet:2871) |
Phosphoserine aminotransferase deficiency | (Orphanet:284417) |
Pontocerebellar hypoplasia type 1 | (Orphanet:2254) |
Porencephaly | (Orphanet:2940) |
Potassium-aggravated myotonia | (Orphanet:612) |
Premature ageing appearance-developmental delay-cardiac arrhythmia syndrome | (Orphanet:276432) |
Prominent glabella - microcephaly - hypogenitalism | (Orphanet:2083) |
Pseudoprogeria syndrome | (Orphanet:2985) |
Purine nucleoside phosphorylase deficiency | (Orphanet:760) |
Pyruvate dehydrogenase E3-binding protein deficiency | (Orphanet:255182) |
Pyruvate dehydrogenase deficiency | (Orphanet:765) |
RIGIDITY AND MULTIFOCAL SEIZURE SYNDROME, LETHAL NEONATAL | (OMIM:614498) |
Recessive hereditary methemoglobinemia type 1 | (Orphanet:139373) |
Recessive hereditary methemoglobinemia type 2 | (Orphanet:139380) |
Recombinant 8 syndrome | (Orphanet:96167) |
Renpenning syndrome | (Orphanet:3242) |
Retinopathy - anemia- central nervous system anomalies | (Orphanet:3088) |
Rett syndrome | (Orphanet:778) |
Richards-Rundle syndrome | (Orphanet:1399) |
SEIZURES, BENIGN FAMILIAL NEONATAL, AUTOSOMAL RECESSIVE | (OMIM:269720) |
SPASTIC PARAPLEGIA 50, AUTOSOMAL RECESSIVE | (OMIM:612936) |
SPASTIC PARAPLEGIA 52, AUTOSOMAL RECESSIVE | (OMIM:614067) |
Scheie syndrome | (Orphanet:93474) |
Schinzel-Giedion syndrome | (Orphanet:798) |
Schizencephaly | (Orphanet:799) |
Schwartz-Jampel syndrome | (Orphanet:800) |
Severe Canavan disease | (Orphanet:314911) |
Severe X-linked intellectual deficit, Gustavson type | (Orphanet:3078) |
Short chain acyl-CoA dehydrogenase deficiency | (Orphanet:26792) |
Short stature - wormian bones - dextrocardia | (Orphanet:2863) |
Sjögren-Larsson syndrome | (Orphanet:816) |
Smith-Lemli-Opitz syndrome | (Orphanet:818) |
Spastic ataxia - corneal dystrophy | (Orphanet:2572) |
Spastic ataxia with congenital miosis | (Orphanet:1182) |
Spastic paraparesis - deafness | (Orphanet:2815) |
Spastic paraplegia - facial-cutaneous lesions | (Orphanet:2819) |
Spastic paraplegia - glaucoma - intellectual deficit | (Orphanet:2818) |
Spastic paraplegia - nephritis - deafness | (Orphanet:2820) |
Spastic paraplegia - neuropathy - poikiloderma | (Orphanet:2821) |
Spastic paraplegia type 2 | (Orphanet:99015) |
Spasticity - intellectual deficit - X-linked epilepsy | (Orphanet:3175) |
Steinert myotonic dystrophy | (Orphanet:273) |
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A | (Orphanet:308386) |
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type B | (Orphanet:308393) |
Symmetrical thalamic calcifications | (Orphanet:1314) |
Syndromic X-linked intellectual deficit due to JARID1C mutation | (Orphanet:85279) |
Tay-Sachs disease | (Orphanet:845) |
Tetrasomy 12p | (Orphanet:884) |
Tetrasomy 18p | (Orphanet:3307) |
Thiamine-responsive maple syrup urine disease | (Orphanet:268184) |
Trisomy 17p | (Orphanet:261290) |
Trisomy 18 | (Orphanet:3380) |
Typhoid | (Orphanet:99745) |
Tyrosinemia type 1 | (Orphanet:882) |
W syndrome | (Orphanet:2804) |
WAARDENBURG SYNDROME, TYPE 2E | (OMIM:611584) |
Waardenburg syndrome type 3 | (Orphanet:896) |
Weaver syndrome | (Orphanet:3447) |
Weaver-Williams syndrome | (Orphanet:3448) |
Williams syndrome | (Orphanet:904) |
Wolcott-Rallison syndrome | (Orphanet:1667) |
X-linked Charcot-Marie-Tooth disease type 3 | (Orphanet:101077) |
X-linked complicated corpus callosum dysgenesis | (Orphanet:1497) |
X-linked creatine transporter deficiency | (Orphanet:52503) |
X-linked immunoneurologic disorder | (Orphanet:2571) |
X-linked intellectual deficit, Golabi-Ito-Hall type | (Orphanet:93947) |
X-linked intellectual deficit, Najm type | (Orphanet:163937) |
X-linked lissencephaly with abnormal genitalia | (Orphanet:452) |
X-linked neurodegenerative syndrome, Hamel type | (Orphanet:85336) |
Xeroderma pigmentosum | (Orphanet:910) |
Xeroderma pigmentosum/Cockayne syndrome complex | (Orphanet:220295) |
Yunis-Varon syndrome | (Orphanet:3472) |
Zellweger-like syndrome without peroxisomal anomalies | (Orphanet:50812) |