Spasticity

Symptom Information:

Symptom ID: HPO:0001257
Synonyms:
Muscle spasticity [HPO:0001257]
Muscular spasticity [HPO:0001257]
Muscle spasticity [Orphanet:43340]
Spasticity (finding) [Orphanet:43340]
Spastic (qualifier value) [Orphanet:43340]
Spasticity (qualifier value) [Orphanet:43340]
Spastic [Orphanet:43340]
Muscle Spasticity [Orphanet:43340]
Spasticity [OMIM:Spasticity]
Hypertonia/spasticity/rigidity/stiffness [Orphanet:43340]
Muscle spasticity [MedDRA:10028335]
Finger spasticity [MedDRA:10028335]
Leg spasticity [MedDRA:10028335]
Muscle spasticity aggravated [MedDRA:10028335]
Spasticity [MedDRA:10028335]
Spasticity muscle [MedDRA:10028335]
Arm spasticity [MedDRA:10028335]
Cortical thumbing [MedDRA:10028335]
Leg scissoring [MedDRA:10028335]
Cortical thumbs [OMIM:Cortical thumbs]
Leg spasticity [OMIM:Leg spasticity]
Spasticity (1 family) [OMIM:Spasticity (1 family)]
Spasticity (1 of 4 patients) [OMIM:Spasticity (1 of 4 patients)]
Spasticity (1 patient) [OMIM:Spasticity (1 patient)]
Spasticity (in some patients) [OMIM:Spasticity (in some patients)]
Spasticity (in some) [OMIM:Spasticity (in some)]
Spasticity (later onset) [OMIM:Spasticity (later onset)]
Spasticity (later) [OMIM:Spasticity (later)]
Spasticity (less common) [OMIM:Spasticity (less common)]
Spasticity (rare) [OMIM:Spasticity (rare)]
Spasticity (reported in 1 patient) [OMIM:Spasticity (reported in 1 patient)]
Spasticity (type II) [OMIM:Spasticity (type II)]
Quality:
Cross references:
Orphanet:43340 "Hypertonia/spasticity/rigidity/stiffness" [Orphanet:43340]
OMIM: "Spasticity" [OMIM:Spasticity]
OMIM: "Cortical thumbs" [OMIM:Cortical thumbs]
OMIM: "Leg spasticity" [OMIM:Leg spasticity]
OMIM: "Spasticity (1 family)" [OMIM:Spasticity (1 family)]
OMIM: "Spasticity (1 of 4 patients)" [OMIM:Spasticity (1 of 4 patients)]
OMIM: "Spasticity (1 patient)" [OMIM:Spasticity (1 patient)]
OMIM: "Spasticity (in some patients)" [OMIM:Spasticity (in some patients)]
OMIM: "Spasticity (in some)" [OMIM:Spasticity (in some)]
OMIM: "Spasticity (later onset)" [OMIM:Spasticity (later onset)]
OMIM: "Spasticity (later)" [OMIM:Spasticity (later)]
OMIM: "Spasticity (less common)" [OMIM:Spasticity (less common)]
OMIM: "Spasticity (rare)" [OMIM:Spasticity (rare)]
OMIM: "Spasticity (reported in 1 patient)" [OMIM:Spasticity (reported in 1 patient)]
OMIM: "Spasticity (type II)" [OMIM:Spasticity (type II)]
UMLS:C0026838 "Spasticity" [HPO:0001257]
UMLS:C0443306 "Spastic" [Orphanet:43340]
UMLS:C0026838 "Muscle Spasticity" [Orphanet:43340]
Is a (Direct Parents):
MedDRA Neuromuscular disorders NEC
Orphanet [DEL]Motor deficit/trouble
HPO         Hypertonia
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Abnormality of central motor function(HPO:0011442)
                Abnormal pyramidal signs(HPO:0007256)
                   Hypertonia(HPO:0001276)
                      Spasticity(HPO:0001257)
MedDRA:
Nervous system disorders(MedDRA:10029205)
    Neuromuscular disorders(MedDRA:10029317)
       Neuromuscular disorders NEC(MedDRA:10029318)
          Spasticity(HPO:0001257)
Database Frequency: 251 / 7739
Resource:

All diseases associated with this symptom:

14q11.2 microdeletion syndrome (Orphanet:261120)
2,4-@DIENOYL-CoA REDUCTASE DEFICIENCY (OMIM:616034)
2p15p16.1 microdeletion syndrome (Orphanet:261349)
3-@METHYLGLUTACONIC ACIDURIA WITH CATARACTS, NEUROLOGIC INVOLVEMENT,AND NEUTROPENIA (OMIM:616271)
3-methylglutaconic aciduria type 3 (Orphanet:67047)
3-methylglutaconic aciduria type 4 (Orphanet:67048)
AICARDI-GOUTIERES SYNDROME 1 (OMIM:225750)
AICARDI-GOUTIERES SYNDROME 3 (OMIM:610329)
AICARDI-GOUTIERES SYNDROME 4 (OMIM:610333)
ALPHA-METHYLACYL-CoA RACEMASE DEFICIENCY (OMIM:614307)
AMYOTROPHIC LATERAL SCLEROSIS 1 (OMIM:105400)
AMYOTROPHIC LATERAL SCLEROSIS 10 WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA (OMIM:612069)
AMYOTROPHIC LATERAL SCLEROSIS 16, JUVENILE (OMIM:614373)
AMYOTROPHIC LATERAL SCLEROSIS 18 (OMIM:614808)
AMYOTROPHIC LATERAL SCLEROSIS 5 (OMIM:602099)
AMYOTROPHIC LATERAL SCLEROSIS 9 (OMIM:611895)
ARTHROGRYPOSIS, DISTAL, TYPE 2A (OMIM:193700)
ASPARAGINE SYNTHETASE (OMIM:108370)
ATAXIA, SPASTIC, CHILDHOOD-ONSET, AUTOSOMAL RECESSIVE, WITH OPTICATROPHY AND MENTAL RETARDATION (OMIM:270500)
ATTRV122I amyloidosis (Orphanet:85451)
Aceruloplasminemia (Orphanet:48818)
Adenylosuccinate lyase deficiency (Orphanet:46)
Adrenomyeloneuropathy (Orphanet:139399)
Adult-onset autosomal dominant leukodystrophy (Orphanet:99027)
Adult-onset dystonia-parkinsonism (Orphanet:199351)
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (Orphanet:313808)
Aicardi-Goutières syndrome (Orphanet:51)
Alexander disease (Orphanet:58)
Alpha-N-acetylgalactosaminidase deficiency (Orphanet:3137)
Alpha-N-acetylgalactosaminidase deficiency type 1 (Orphanet:79279)
Alpha-N-acetylgalactosaminidase deficiency type 3 (Orphanet:79281)
Alpha-mannosidosis (Orphanet:61)
Alpha-thalassemia - X-linked intellectual deficit syndrome (Orphanet:847)
Amelo-cerebro-hypohidrotic syndrome (Orphanet:1946)
Amyotrophic lateral sclerosis (Orphanet:803)
Argininemia (Orphanet:90)
Arnold-Chiari malformation type II (Orphanet:1136)
Aspartylglucosaminuria (Orphanet:93)
Ataxia - hypogonadism - choroidal dystrophy (Orphanet:1180)
Atherosclerosis - deafness - diabetes - epilepsy - nephropathy (Orphanet:1192)
Autosomal dominant Charcot-Marie-Tooth disease type 2A2 (Orphanet:99947)
Autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures (Orphanet:363454)
Autosomal dominant spastic paraplegia type 10 (Orphanet:100991)
Autosomal dominant spastic paraplegia type 8 (Orphanet:100989)
Autosomal recessive cerebellar ataxia - epilepsy - intellectual deficit (Orphanet:284282)
Autosomal recessive cerebelloparenchymal disorder type 3 (Orphanet:1170)
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (Orphanet:98)
Autosomal recessive spastic ataxia with leukoencephalopathy (Orphanet:314603)
Autosomal recessive spastic paraplegia type 24 (Orphanet:101004)
Autosomal recessive spastic paraplegia type 43 (Orphanet:320370)
Autosomal recessive spastic paraplegia type 55 (Orphanet:320375)
Behr syndrome (Orphanet:1239)
Bilateral generalized polymicrogyria (Orphanet:208447)
Bonnemann-Meinecke-Reich syndrome (Orphanet:1261)
CACH syndrome (Orphanet:135)
CADASIL (Orphanet:136)
CAMOS syndrome (Orphanet:83472)
CARASIL (Orphanet:199354)
CATARACT, MICROCEPHALY, FAILURE TO THRIVE, KYPHOSCOLIOSIS SYNDROME (OMIM:212540)
CLN1 disease (Orphanet:228329)
CLN10 disease (Orphanet:228337)
Cerebellar ataxia-deafness-narcolepsy syndrome (Orphanet:314404)
Cerebrotendinous xanthomatosis (Orphanet:909)
Childhood encephalopathy due to thiamine pyrophosphokinase deficiency (Orphanet:293955)
Classical phenylketonuria (Orphanet:79254)
Coats plus syndrome (Orphanet:313838)
Combined oxidative phosphorylation defect type 4 (Orphanet:254925)
Congenital intrauterine infection-like syndrome (Orphanet:1229)
Congenital neuronal ceroid lipofuscinosis (Orphanet:168486)
Congenital or early infantile CACH syndrome (Orphanet:157713)
Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation (Orphanet:300570)
Cree leukoencephalopathy (Orphanet:99854)
Cystic leukoencephalopathy without megalencephaly (Orphanet:85136)
DE SANCTIS-CACCHIONE SYNDROME (OMIM:278800)
DIAMINOPENTANURIA (OMIM:222350)
Desmosterolosis (Orphanet:35107)
Distal monosomy 3p (Orphanet:1620)
Dopa-responsive dystonia due to sepiapterin reductase deficiency (Orphanet:70594)
ENCEPHALOPATHY, PROGRESSIVE, WITH OR WITHOUT LIPODYSTROPHY (OMIM:615924)
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 12 (OMIM:613722)
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 14 (OMIM:614959)
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 28 (OMIM:616211)
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 29 (OMIM:616339)
Early infantile epileptic encephalopathy (Orphanet:1934)
Early myoclonic encephalopathy (Orphanet:1935)
Early-onset spastic ataxia-neuropathy syndrome (Orphanet:313772)
Encephalopathy due to GLUT1 deficiency (Orphanet:71277)
Epileptic encephalopathy with global cerebral demyelination (Orphanet:353217)
Episodic ataxia type 4 (Orphanet:79136)
Familial amyloid polyneuropathy (Orphanet:85447)
Familial dementia, British type (Orphanet:97345)
Familial dementia, Danish type (Orphanet:97346)
Fetal Gaucher disease (Orphanet:85212)
Gaucher disease type 2 (Orphanet:77260)
Gerstmann-Straussler-Scheinker syndrome (Orphanet:356)
Griscelli disease type 2 (Orphanet:79477)
HYPOGLYCEMIA, LEUCINE-INDUCED (OMIM:240800)
HYPOPREBETALIPOPROTEINEMIA, ACANTHOCYTOSIS, RETINITIS PIGMENTOSA,AND PALLIDAL DEGENERATION (OMIM:607236)
Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1 (Orphanet:137681)
Hereditary motor and sensory neuropathy type 5 (Orphanet:64751)
Huntington disease (Orphanet:399)
Huntington disease-like 3 (Orphanet:157946)
Hydrocephalus with stenosis of aqueduct of Sylvius (Orphanet:2182)
Hyperornithinemia-hyperammonemia-homocitrullinuria (Orphanet:415)
Hypomyelination with atrophy of basal ganglia and cerebellum (Orphanet:139441)
Hypomyelination with brain stem and spinal cord involvement and leg spasticity (Orphanet:363412)
Incontinentia pigmenti (Orphanet:464)
Infantile epileptic-dyskinetic encephalopathy (Orphanet:364063)
Infantile-onset autosomal recessive nonprogressive cerebellar ataxia (Orphanet:284332)
Intellectual deficiency - hypotonia - spasticity - sleep disorder (Orphanet:356996)
Intellectual deficit, X-linked - Dandy-Walker malformation - basal ganglia disease - Seizures (Orphanet:1568)
Intellectual deficit, X-linked - psychosis - macroorchidism (Orphanet:3077)
Intellectual deficit, X-linked, Cantagrel type (Orphanet:85277)
Intellectual deficit, X-linked, Schimke type (Orphanet:85285)
Intellectual disability-developmental delay-contractures syndrome (Orphanet:3454)
Isolated CoQ-cytochrome C reductase deficiency (Orphanet:1460)
Isolated NADH-CoQ reductase deficiency (Orphanet:2609)
Isolated succinate-CoQ reductase deficiency (Orphanet:3208)
Jacobsen syndrome (Orphanet:2308)
Joubert syndrome with hepatic defect (Orphanet:1454)
Juvenile or adult CACH syndrome (Orphanet:157719)
Kufor-Rakeb syndrome (Orphanet:306674)
LEBER OPTIC ATROPHY AND DYSTONIA (OMIM:500001)
LESCH-NYHAN PHENOTYPE WITH NORMAL HGPRT (OMIM:308950)
LEUKODYSTROPHY, HYPOMYELINATING, 8, WITH OR WITHOUT OLIGODONTIA AND/ORHYPOGONADOTROPIC HYPOGONADISM (OMIM:614381)
LEUKOENCEPHALOPATHY, BRAIN CALCIFICATIONS, AND CYSTS (OMIM:614561)
LEUKOENCEPHALOPATHY, PROGRESSIVE, WITH OVARIAN FAILURE (OMIM:615889)
LISSENCEPHALY 6 WITH MICROCEPHALY (OMIM:616212)
Late infantile CACH syndrome (Orphanet:157716)
Leber plus disease (Orphanet:99718)
Leigh syndrome (Orphanet:506)
Leprechaunism (Orphanet:508)
Lesch-Nyhan syndrome (Orphanet:510)
Leukoencephalopathy - ataxia - hypodontia - hypomyelination (Orphanet:137639)
Leukoencephalopathy with brain stem and spinal cord involvement - lactate elevation (Orphanet:137898)
MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 1 (OMIM:604004)
MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 2A (OMIM:613925)
MEGALENCEPHALY WITH DYSMYELINATION (OMIM:249240)
MEGDEL syndrome (Orphanet:352328)
MENTAL RETARDATION, AUTOSOMAL DOMINANT 9 (OMIM:614255)
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 40 (OMIM:615599)
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 43 (OMIM:615817)
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 5 (OMIM:611091)
MERRF (Orphanet:551)
METACHROMATIC LEUKODYSTROPHY DUE TO SAPOSIN B DEFICIENCY (OMIM:249900)
MICROCEPHALY, POSTNATAL PROGRESSIVE, WITH SEIZURES AND BRAIN ATROPHY (OMIM:613668)
MITOCHONDRIAL SHORT-CHAIN ENOYL-CoA HYDRATASE 1 DEFICIENCY (OMIM:616277)
MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO (OMIM:126200)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYEANOMALIES), TYPE A, 3 (OMIM:253280)
Malignant migrating partial seizures of infancy (Orphanet:293181)
Marinesco-Sjögren syndrome (Orphanet:559)
Megalencephalic leukoencephalopathy with subcortical cysts (Orphanet:2478)
Menkes disease (Orphanet:565)
Microcephalic primordial dwarfism due to ZNF335 deficiency (Orphanet:329228)
Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria (Orphanet:1933)
Mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to MTO1 deficiency (Orphanet:314637)
Mitochondrial myopathy - lactic acidosis - deafness (Orphanet:2597)
Mohr-Tranebjaerg syndrome (Orphanet:52368)
Multiple acyl-CoA dehydrogenase deficiency (Orphanet:26791)
Multiple sulfatase deficiency (Orphanet:585)
N syndrome (Orphanet:2608)
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2B (OMIM:610217)
NEUROPATHY, CONGENITAL, WITH ARTHROGRYPOSIS MULTIPLEX (OMIM:162370)
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IIB (OMIM:613115)
NIEMANN-PICK DISEASE, TYPE C1 (OMIM:257220)
NIEMANN-PICK DISEASE, TYPE C2 (OMIM:607625)
Nasu-Hakola disease (Orphanet:2770)
Neurodegeneration with brain iron accumulation due to C19orf12 mutation (Orphanet:289560)
Neuroectodermal melanolysosomal disease (Orphanet:33445)
Neuroferritinopathy (Orphanet:157846)
Niemann-Pick disease type A (Orphanet:77292)
Nijmegen breakage syndrome-like disorder (Orphanet:240760)
OCULODENTODIGITAL DYSPLASIA (OMIM:164200)
OPTICOCOCHLEODENTATE DEGENERATION (OMIM:258700)
Oculo-palato-cerebral syndrome (Orphanet:2714)
Oculocerebral hypopigmentation syndrome, Cross type (Orphanet:2719)
Oculodentodigital dysplasia (Orphanet:2710)
Odontoleukodystrophy (Orphanet:77295)
Ovarioleukodystrophy (Orphanet:99853)
PELIZAEUS-MERZBACHER DISEASE (OMIM:312080)
PEROXISOMAL FATTY ACYL-CoA REDUCTASE 1 DISORDER (OMIM:616154)
PONTOCEREBELLAR HYPOPLASIA, TYPE 10 (OMIM:615803)
PONTOCEREBELLAR HYPOPLASIA, TYPE 1B (OMIM:614678)
PONTOCEREBELLAR HYPOPLASIA, TYPE 2A (OMIM:277470)
PORENCEPHALY 1 (OMIM:175780)
PORENCEPHALY 2 (OMIM:614483)
Pachygyria - epilepsy - intellectual deficit - dysmorphism (Orphanet:94084)
Pantothenate kinase-associated neurodegeneration (Orphanet:157850)
Parkinsonim due to ATP13A2 deficiency (Orphanet:314632)
Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity (Orphanet:53583)
Polyneuropathy - hearing loss - ataxia - retinitis pigmentosa - cataract (Orphanet:171848)
Pontocerebellar hypoplasia type 3 (Orphanet:97249)
Pontocerebellar hypoplasia type 4 (Orphanet:166063)
Pontocerebellar hypoplasia type 6 (Orphanet:166073)
Pontocerebellar hypoplasia type 8 (Orphanet:324569)
Pontocerebellar hypoplasia, type 9 (OMIM:615809)
Porencephaly (Orphanet:2940)
Porencephaly-microcephaly-bilateral congenital cataract syndrome (Orphanet:306547)
Pyruvate dehydrogenase E3 deficiency (Orphanet:2394)
RETT SYNDROME, CONGENITAL VARIANT (OMIM:613454)
RFT1-CDG (Orphanet:244310)
Recessive hereditary methemoglobinemia type 1 (Orphanet:139373)
Recessive hereditary methemoglobinemia type 2 (Orphanet:139380)
Renal tubulopathy - encephalopathy - liver failure (Orphanet:254902)
Renpenning syndrome (Orphanet:3242)
Rett syndrome (Orphanet:778)
Rhizomelic chondrodysplasia punctata (Orphanet:177)
Rhizomelic chondrodysplasia punctata type 1 (Orphanet:309789)
Ribose 5-phosphate isomerase deficiency (OMIM:608611)
SPASTIC ATAXIA 2, AUTOSOMAL RECESSIVE (OMIM:611302)
SPASTIC PARAPLEGIA 47, AUTOSOMAL RECESSIVE (OMIM:614066)
SPASTIC PARAPLEGIA 52, AUTOSOMAL RECESSIVE (OMIM:614067)
SPINOCEREBELLAR ATAXIA WITH RIGIDITY AND PERIPHERAL NEUROPATHY (OMIM:183050)
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 16 (OMIM:615768)
STRIATONIGRAL DEGENERATION, INFANTILE (OMIM:271930)
Salla disease (Orphanet:309334)
Schinzel-Giedion syndrome (Orphanet:798)
Severe X-linked intellectual deficit, Gustavson type (Orphanet:3078)
Sjögren-Larsson syndrome (Orphanet:816)
Spastic paraplegia - epilepsy - intellectual deficit (Orphanet:2816)
Spasticity - intellectual deficit - X-linked epilepsy (Orphanet:3175)
Spectrin-associated autosomal recessive cerebellar ataxia (Orphanet:352403)
Spinocerebellar ataxia type 1 (Orphanet:98755)
Spinocerebellar ataxia type 2 (Orphanet:98756)
Spinocerebellar ataxia type 28 (Orphanet:101109)
Spinocerebellar ataxia type 3 (Orphanet:98757)
Spinocerebellar ataxia type 7 (Orphanet:94147)
Spinocerebellar ataxia type 8 (Orphanet:98760)
Spondyloenchondrodysplasia (Orphanet:1855)
Sporadic Leigh syndrome (Orphanet:255199)
Steinert myotonic dystrophy (Orphanet:273)
Triose phosphate-isomerase deficiency (Orphanet:868)
W syndrome (Orphanet:2804)
WEBB-DATTANI SYNDROME (OMIM:615926)
Waardenburg syndrome type 3 (Orphanet:896)
Weaver syndrome (Orphanet:3447)
X-linked cerebral adrenoleukodystrophy (Orphanet:139396)
X-linked complicated corpus callosum dysgenesis (Orphanet:1497)
X-linked creatine transporter deficiency (Orphanet:52503)
X-linked intellectual deficit - cerebellar hypoplasia (Orphanet:137831)
X-linked intellectual deficit, Najm type (Orphanet:163937)
X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome (Orphanet:324410)
X-linked intellectual disability-choreoathetosis-abnormal behavior syndrome (Orphanet:85295)
X-linked lissencephaly with abnormal genitalia (Orphanet:452)
X-linked parkinsonism-spasticity syndrome (Orphanet:363654)
X-linked spinocerebellar ataxia type 3 (Orphanet:85297)
Xeroderma pigmentosum complementation group A (Orphanet:276249)
Xeroderma pigmentosum complementation group D (Orphanet:276258)
Xeroderma pigmentosum complementation group G (Orphanet:276267)
Xeroderma pigmentosum/Cockayne syndrome complex (Orphanet:220295)
[DEL] LEIGH SYNDROME, X-LINKED (OMIM:308930)