Spasticity
Symptom Information:
Symptom ID: | HPO:0001257 | ||||||||||||||||||||||||||||||||
Synonyms: |
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Quality: | |||||||||||||||||||||||||||||||||
Cross references: |
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Is a (Direct Parents): |
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Is a (Whole tree): |
HPO:
All(HPO:0000001) Phenotypic abnormality(HPO:0000118) Abnormality of the nervous system(HPO:0000707) Abnormality of nervous system physiology(HPO:0012638) Abnormality of central motor function(HPO:0011442) Abnormal pyramidal signs(HPO:0007256) Hypertonia(HPO:0001276) Spasticity(HPO:0001257) MedDRA: Nervous system disorders(MedDRA:10029205) Neuromuscular disorders(MedDRA:10029317) Neuromuscular disorders NEC(MedDRA:10029318) Spasticity(HPO:0001257) |
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Database Frequency: | 251 / 7739 | ||||||||||||||||||||||||||||||||
Resource: |
All diseases associated with this symptom:
14q11.2 microdeletion syndrome | (Orphanet:261120) |
2,4-@DIENOYL-CoA REDUCTASE DEFICIENCY | (OMIM:616034) |
2p15p16.1 microdeletion syndrome | (Orphanet:261349) |
3-@METHYLGLUTACONIC ACIDURIA WITH CATARACTS, NEUROLOGIC INVOLVEMENT,AND NEUTROPENIA | (OMIM:616271) |
3-methylglutaconic aciduria type 3 | (Orphanet:67047) |
3-methylglutaconic aciduria type 4 | (Orphanet:67048) |
AICARDI-GOUTIERES SYNDROME 1 | (OMIM:225750) |
AICARDI-GOUTIERES SYNDROME 3 | (OMIM:610329) |
AICARDI-GOUTIERES SYNDROME 4 | (OMIM:610333) |
ALPHA-METHYLACYL-CoA RACEMASE DEFICIENCY | (OMIM:614307) |
AMYOTROPHIC LATERAL SCLEROSIS 1 | (OMIM:105400) |
AMYOTROPHIC LATERAL SCLEROSIS 10 WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA | (OMIM:612069) |
AMYOTROPHIC LATERAL SCLEROSIS 16, JUVENILE | (OMIM:614373) |
AMYOTROPHIC LATERAL SCLEROSIS 18 | (OMIM:614808) |
AMYOTROPHIC LATERAL SCLEROSIS 5 | (OMIM:602099) |
AMYOTROPHIC LATERAL SCLEROSIS 9 | (OMIM:611895) |
ARTHROGRYPOSIS, DISTAL, TYPE 2A | (OMIM:193700) |
ASPARAGINE SYNTHETASE | (OMIM:108370) |
ATAXIA, SPASTIC, CHILDHOOD-ONSET, AUTOSOMAL RECESSIVE, WITH OPTICATROPHY AND MENTAL RETARDATION | (OMIM:270500) |
ATTRV122I amyloidosis | (Orphanet:85451) |
Aceruloplasminemia | (Orphanet:48818) |
Adenylosuccinate lyase deficiency | (Orphanet:46) |
Adrenomyeloneuropathy | (Orphanet:139399) |
Adult-onset autosomal dominant leukodystrophy | (Orphanet:99027) |
Adult-onset dystonia-parkinsonism | (Orphanet:199351) |
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia | (Orphanet:313808) |
Aicardi-Goutières syndrome | (Orphanet:51) |
Alexander disease | (Orphanet:58) |
Alpha-N-acetylgalactosaminidase deficiency | (Orphanet:3137) |
Alpha-N-acetylgalactosaminidase deficiency type 1 | (Orphanet:79279) |
Alpha-N-acetylgalactosaminidase deficiency type 3 | (Orphanet:79281) |
Alpha-mannosidosis | (Orphanet:61) |
Alpha-thalassemia - X-linked intellectual deficit syndrome | (Orphanet:847) |
Amelo-cerebro-hypohidrotic syndrome | (Orphanet:1946) |
Amyotrophic lateral sclerosis | (Orphanet:803) |
Argininemia | (Orphanet:90) |
Arnold-Chiari malformation type II | (Orphanet:1136) |
Aspartylglucosaminuria | (Orphanet:93) |
Ataxia - hypogonadism - choroidal dystrophy | (Orphanet:1180) |
Atherosclerosis - deafness - diabetes - epilepsy - nephropathy | (Orphanet:1192) |
Autosomal dominant Charcot-Marie-Tooth disease type 2A2 | (Orphanet:99947) |
Autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures | (Orphanet:363454) |
Autosomal dominant spastic paraplegia type 10 | (Orphanet:100991) |
Autosomal dominant spastic paraplegia type 8 | (Orphanet:100989) |
Autosomal recessive cerebellar ataxia - epilepsy - intellectual deficit | (Orphanet:284282) |
Autosomal recessive cerebelloparenchymal disorder type 3 | (Orphanet:1170) |
Autosomal recessive spastic ataxia of Charlevoix-Saguenay | (Orphanet:98) |
Autosomal recessive spastic ataxia with leukoencephalopathy | (Orphanet:314603) |
Autosomal recessive spastic paraplegia type 24 | (Orphanet:101004) |
Autosomal recessive spastic paraplegia type 43 | (Orphanet:320370) |
Autosomal recessive spastic paraplegia type 55 | (Orphanet:320375) |
Behr syndrome | (Orphanet:1239) |
Bilateral generalized polymicrogyria | (Orphanet:208447) |
Bonnemann-Meinecke-Reich syndrome | (Orphanet:1261) |
CACH syndrome | (Orphanet:135) |
CADASIL | (Orphanet:136) |
CAMOS syndrome | (Orphanet:83472) |
CARASIL | (Orphanet:199354) |
CATARACT, MICROCEPHALY, FAILURE TO THRIVE, KYPHOSCOLIOSIS SYNDROME | (OMIM:212540) |
CLN1 disease | (Orphanet:228329) |
CLN10 disease | (Orphanet:228337) |
Cerebellar ataxia-deafness-narcolepsy syndrome | (Orphanet:314404) |
Cerebrotendinous xanthomatosis | (Orphanet:909) |
Childhood encephalopathy due to thiamine pyrophosphokinase deficiency | (Orphanet:293955) |
Classical phenylketonuria | (Orphanet:79254) |
Coats plus syndrome | (Orphanet:313838) |
Combined oxidative phosphorylation defect type 4 | (Orphanet:254925) |
Congenital intrauterine infection-like syndrome | (Orphanet:1229) |
Congenital neuronal ceroid lipofuscinosis | (Orphanet:168486) |
Congenital or early infantile CACH syndrome | (Orphanet:157713) |
Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation | (Orphanet:300570) |
Cree leukoencephalopathy | (Orphanet:99854) |
Cystic leukoencephalopathy without megalencephaly | (Orphanet:85136) |
DE SANCTIS-CACCHIONE SYNDROME | (OMIM:278800) |
DIAMINOPENTANURIA | (OMIM:222350) |
Desmosterolosis | (Orphanet:35107) |
Distal monosomy 3p | (Orphanet:1620) |
Dopa-responsive dystonia due to sepiapterin reductase deficiency | (Orphanet:70594) |
ENCEPHALOPATHY, PROGRESSIVE, WITH OR WITHOUT LIPODYSTROPHY | (OMIM:615924) |
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 12 | (OMIM:613722) |
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 14 | (OMIM:614959) |
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 28 | (OMIM:616211) |
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 29 | (OMIM:616339) |
Early infantile epileptic encephalopathy | (Orphanet:1934) |
Early myoclonic encephalopathy | (Orphanet:1935) |
Early-onset spastic ataxia-neuropathy syndrome | (Orphanet:313772) |
Encephalopathy due to GLUT1 deficiency | (Orphanet:71277) |
Epileptic encephalopathy with global cerebral demyelination | (Orphanet:353217) |
Episodic ataxia type 4 | (Orphanet:79136) |
Familial amyloid polyneuropathy | (Orphanet:85447) |
Familial dementia, British type | (Orphanet:97345) |
Familial dementia, Danish type | (Orphanet:97346) |
Fetal Gaucher disease | (Orphanet:85212) |
Gaucher disease type 2 | (Orphanet:77260) |
Gerstmann-Straussler-Scheinker syndrome | (Orphanet:356) |
Griscelli disease type 2 | (Orphanet:79477) |
HYPOGLYCEMIA, LEUCINE-INDUCED | (OMIM:240800) |
HYPOPREBETALIPOPROTEINEMIA, ACANTHOCYTOSIS, RETINITIS PIGMENTOSA,AND PALLIDAL DEGENERATION | (OMIM:607236) |
Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1 | (Orphanet:137681) |
Hereditary motor and sensory neuropathy type 5 | (Orphanet:64751) |
Huntington disease | (Orphanet:399) |
Huntington disease-like 3 | (Orphanet:157946) |
Hydrocephalus with stenosis of aqueduct of Sylvius | (Orphanet:2182) |
Hyperornithinemia-hyperammonemia-homocitrullinuria | (Orphanet:415) |
Hypomyelination with atrophy of basal ganglia and cerebellum | (Orphanet:139441) |
Hypomyelination with brain stem and spinal cord involvement and leg spasticity | (Orphanet:363412) |
Incontinentia pigmenti | (Orphanet:464) |
Infantile epileptic-dyskinetic encephalopathy | (Orphanet:364063) |
Infantile-onset autosomal recessive nonprogressive cerebellar ataxia | (Orphanet:284332) |
Intellectual deficiency - hypotonia - spasticity - sleep disorder | (Orphanet:356996) |
Intellectual deficit, X-linked - Dandy-Walker malformation - basal ganglia disease - Seizures | (Orphanet:1568) |
Intellectual deficit, X-linked - psychosis - macroorchidism | (Orphanet:3077) |
Intellectual deficit, X-linked, Cantagrel type | (Orphanet:85277) |
Intellectual deficit, X-linked, Schimke type | (Orphanet:85285) |
Intellectual disability-developmental delay-contractures syndrome | (Orphanet:3454) |
Isolated CoQ-cytochrome C reductase deficiency | (Orphanet:1460) |
Isolated NADH-CoQ reductase deficiency | (Orphanet:2609) |
Isolated succinate-CoQ reductase deficiency | (Orphanet:3208) |
Jacobsen syndrome | (Orphanet:2308) |
Joubert syndrome with hepatic defect | (Orphanet:1454) |
Juvenile or adult CACH syndrome | (Orphanet:157719) |
Kufor-Rakeb syndrome | (Orphanet:306674) |
LEBER OPTIC ATROPHY AND DYSTONIA | (OMIM:500001) |
LESCH-NYHAN PHENOTYPE WITH NORMAL HGPRT | (OMIM:308950) |
LEUKODYSTROPHY, HYPOMYELINATING, 8, WITH OR WITHOUT OLIGODONTIA AND/ORHYPOGONADOTROPIC HYPOGONADISM | (OMIM:614381) |
LEUKOENCEPHALOPATHY, BRAIN CALCIFICATIONS, AND CYSTS | (OMIM:614561) |
LEUKOENCEPHALOPATHY, PROGRESSIVE, WITH OVARIAN FAILURE | (OMIM:615889) |
LISSENCEPHALY 6 WITH MICROCEPHALY | (OMIM:616212) |
Late infantile CACH syndrome | (Orphanet:157716) |
Leber plus disease | (Orphanet:99718) |
Leigh syndrome | (Orphanet:506) |
Leprechaunism | (Orphanet:508) |
Lesch-Nyhan syndrome | (Orphanet:510) |
Leukoencephalopathy - ataxia - hypodontia - hypomyelination | (Orphanet:137639) |
Leukoencephalopathy with brain stem and spinal cord involvement - lactate elevation | (Orphanet:137898) |
MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 1 | (OMIM:604004) |
MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 2A | (OMIM:613925) |
MEGALENCEPHALY WITH DYSMYELINATION | (OMIM:249240) |
MEGDEL syndrome | (Orphanet:352328) |
MENTAL RETARDATION, AUTOSOMAL DOMINANT 9 | (OMIM:614255) |
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 40 | (OMIM:615599) |
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 43 | (OMIM:615817) |
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 5 | (OMIM:611091) |
MERRF | (Orphanet:551) |
METACHROMATIC LEUKODYSTROPHY DUE TO SAPOSIN B DEFICIENCY | (OMIM:249900) |
MICROCEPHALY, POSTNATAL PROGRESSIVE, WITH SEIZURES AND BRAIN ATROPHY | (OMIM:613668) |
MITOCHONDRIAL SHORT-CHAIN ENOYL-CoA HYDRATASE 1 DEFICIENCY | (OMIM:616277) |
MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO | (OMIM:126200) |
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYEANOMALIES), TYPE A, 3 | (OMIM:253280) |
Malignant migrating partial seizures of infancy | (Orphanet:293181) |
Marinesco-Sjögren syndrome | (Orphanet:559) |
Megalencephalic leukoencephalopathy with subcortical cysts | (Orphanet:2478) |
Menkes disease | (Orphanet:565) |
Microcephalic primordial dwarfism due to ZNF335 deficiency | (Orphanet:329228) |
Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria | (Orphanet:1933) |
Mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to MTO1 deficiency | (Orphanet:314637) |
Mitochondrial myopathy - lactic acidosis - deafness | (Orphanet:2597) |
Mohr-Tranebjaerg syndrome | (Orphanet:52368) |
Multiple acyl-CoA dehydrogenase deficiency | (Orphanet:26791) |
Multiple sulfatase deficiency | (Orphanet:585) |
N syndrome | (Orphanet:2608) |
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2B | (OMIM:610217) |
NEUROPATHY, CONGENITAL, WITH ARTHROGRYPOSIS MULTIPLEX | (OMIM:162370) |
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IIB | (OMIM:613115) |
NIEMANN-PICK DISEASE, TYPE C1 | (OMIM:257220) |
NIEMANN-PICK DISEASE, TYPE C2 | (OMIM:607625) |
Nasu-Hakola disease | (Orphanet:2770) |
Neurodegeneration with brain iron accumulation due to C19orf12 mutation | (Orphanet:289560) |
Neuroectodermal melanolysosomal disease | (Orphanet:33445) |
Neuroferritinopathy | (Orphanet:157846) |
Niemann-Pick disease type A | (Orphanet:77292) |
Nijmegen breakage syndrome-like disorder | (Orphanet:240760) |
OCULODENTODIGITAL DYSPLASIA | (OMIM:164200) |
OPTICOCOCHLEODENTATE DEGENERATION | (OMIM:258700) |
Oculo-palato-cerebral syndrome | (Orphanet:2714) |
Oculocerebral hypopigmentation syndrome, Cross type | (Orphanet:2719) |
Oculodentodigital dysplasia | (Orphanet:2710) |
Odontoleukodystrophy | (Orphanet:77295) |
Ovarioleukodystrophy | (Orphanet:99853) |
PELIZAEUS-MERZBACHER DISEASE | (OMIM:312080) |
PEROXISOMAL FATTY ACYL-CoA REDUCTASE 1 DISORDER | (OMIM:616154) |
PONTOCEREBELLAR HYPOPLASIA, TYPE 10 | (OMIM:615803) |
PONTOCEREBELLAR HYPOPLASIA, TYPE 1B | (OMIM:614678) |
PONTOCEREBELLAR HYPOPLASIA, TYPE 2A | (OMIM:277470) |
PORENCEPHALY 1 | (OMIM:175780) |
PORENCEPHALY 2 | (OMIM:614483) |
Pachygyria - epilepsy - intellectual deficit - dysmorphism | (Orphanet:94084) |
Pantothenate kinase-associated neurodegeneration | (Orphanet:157850) |
Parkinsonim due to ATP13A2 deficiency | (Orphanet:314632) |
Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity | (Orphanet:53583) |
Polyneuropathy - hearing loss - ataxia - retinitis pigmentosa - cataract | (Orphanet:171848) |
Pontocerebellar hypoplasia type 3 | (Orphanet:97249) |
Pontocerebellar hypoplasia type 4 | (Orphanet:166063) |
Pontocerebellar hypoplasia type 6 | (Orphanet:166073) |
Pontocerebellar hypoplasia type 8 | (Orphanet:324569) |
Pontocerebellar hypoplasia, type 9 | (OMIM:615809) |
Porencephaly | (Orphanet:2940) |
Porencephaly-microcephaly-bilateral congenital cataract syndrome | (Orphanet:306547) |
Pyruvate dehydrogenase E3 deficiency | (Orphanet:2394) |
RETT SYNDROME, CONGENITAL VARIANT | (OMIM:613454) |
RFT1-CDG | (Orphanet:244310) |
Recessive hereditary methemoglobinemia type 1 | (Orphanet:139373) |
Recessive hereditary methemoglobinemia type 2 | (Orphanet:139380) |
Renal tubulopathy - encephalopathy - liver failure | (Orphanet:254902) |
Renpenning syndrome | (Orphanet:3242) |
Rett syndrome | (Orphanet:778) |
Rhizomelic chondrodysplasia punctata | (Orphanet:177) |
Rhizomelic chondrodysplasia punctata type 1 | (Orphanet:309789) |
Ribose 5-phosphate isomerase deficiency | (OMIM:608611) |
SPASTIC ATAXIA 2, AUTOSOMAL RECESSIVE | (OMIM:611302) |
SPASTIC PARAPLEGIA 47, AUTOSOMAL RECESSIVE | (OMIM:614066) |
SPASTIC PARAPLEGIA 52, AUTOSOMAL RECESSIVE | (OMIM:614067) |
SPINOCEREBELLAR ATAXIA WITH RIGIDITY AND PERIPHERAL NEUROPATHY | (OMIM:183050) |
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 16 | (OMIM:615768) |
STRIATONIGRAL DEGENERATION, INFANTILE | (OMIM:271930) |
Salla disease | (Orphanet:309334) |
Schinzel-Giedion syndrome | (Orphanet:798) |
Severe X-linked intellectual deficit, Gustavson type | (Orphanet:3078) |
Sjögren-Larsson syndrome | (Orphanet:816) |
Spastic paraplegia - epilepsy - intellectual deficit | (Orphanet:2816) |
Spasticity - intellectual deficit - X-linked epilepsy | (Orphanet:3175) |
Spectrin-associated autosomal recessive cerebellar ataxia | (Orphanet:352403) |
Spinocerebellar ataxia type 1 | (Orphanet:98755) |
Spinocerebellar ataxia type 2 | (Orphanet:98756) |
Spinocerebellar ataxia type 28 | (Orphanet:101109) |
Spinocerebellar ataxia type 3 | (Orphanet:98757) |
Spinocerebellar ataxia type 7 | (Orphanet:94147) |
Spinocerebellar ataxia type 8 | (Orphanet:98760) |
Spondyloenchondrodysplasia | (Orphanet:1855) |
Sporadic Leigh syndrome | (Orphanet:255199) |
Steinert myotonic dystrophy | (Orphanet:273) |
Triose phosphate-isomerase deficiency | (Orphanet:868) |
W syndrome | (Orphanet:2804) |
WEBB-DATTANI SYNDROME | (OMIM:615926) |
Waardenburg syndrome type 3 | (Orphanet:896) |
Weaver syndrome | (Orphanet:3447) |
X-linked cerebral adrenoleukodystrophy | (Orphanet:139396) |
X-linked complicated corpus callosum dysgenesis | (Orphanet:1497) |
X-linked creatine transporter deficiency | (Orphanet:52503) |
X-linked intellectual deficit - cerebellar hypoplasia | (Orphanet:137831) |
X-linked intellectual deficit, Najm type | (Orphanet:163937) |
X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome | (Orphanet:324410) |
X-linked intellectual disability-choreoathetosis-abnormal behavior syndrome | (Orphanet:85295) |
X-linked lissencephaly with abnormal genitalia | (Orphanet:452) |
X-linked parkinsonism-spasticity syndrome | (Orphanet:363654) |
X-linked spinocerebellar ataxia type 3 | (Orphanet:85297) |
Xeroderma pigmentosum complementation group A | (Orphanet:276249) |
Xeroderma pigmentosum complementation group D | (Orphanet:276258) |
Xeroderma pigmentosum complementation group G | (Orphanet:276267) |
Xeroderma pigmentosum/Cockayne syndrome complex | (Orphanet:220295) |
[DEL] LEIGH SYNDROME, X-LINKED | (OMIM:308930) |