MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO

General Information (adopted from Orphanet):

Synonyms, Signs: MS1, INCLUDED
DISSEMINATED SCLEROSIS MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO, 1, INCLUDED
MS
Number of Symptoms 21
OrphanetNr:
OMIM Id: 126200
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Multifactorial
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000020) Urinary incontinence 75 / 7739
2
(HPO:0000019) Urinary hesitancy 3 / 7739
3
(HPO:0000651) Diplopia 37 / 7739
4
(HPO:0003401) Paresthesia 42 / 7739
5
(HPO:0000716) Depression 99 / 7739
6
(HPO:0000712) Emotional lability 44 / 7739
7
(HPO:0003474) Sensory impairment 54 / 7739
8
(HPO:0002311) Incoordination 84 / 7739
9
(HPO:0001257) Spasticity 251 / 7739
10
(HPO:0001324) Muscle weakness 859 / 7739
11
(OMIM) Scattered CNS demyelination 1 / 7739
12
(OMIM) Cognitive dysfunction 2 / 7739
13
(OMIM) High intensity area in white matter on head MRI 1 / 7739
14
(OMIM) Myelin basic protein in CSF 1 / 7739
15
(OMIM) Vision loss, monocular 1 / 7739
16
(OMIM) Oligoclonal bands in CSF 1 / 7739
17
(HPO:0007305) CNS demyelination 21 / 7739
18
(HPO:0001426) Multifactorial inheritance 37 / 7739
19
(OMIM) Increased CSF immunoglobulin levels 1 / 7739
20
(OMIM) Incomplete bladder emptying 2 / 7739
21
(MedDRA:10021639) Incontinence 11 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Molecular genetics OMIM Among 163 patients with sporadic MS, DeLuca et al. (2007) observed an association between relatively benign outcome and HLA-DRB1*01. The allele was present in 19% of 112 patients with milder disease compared to 3.9% of 51 patients with ...
Population genetics OMIM Pugliatti et al. (2002) demonstrated a hotspot of MS in the southwestern part of Sassari province in Sardinia, bordering with the commune of Macomer, where MS was once hypothesized as having occurred as an epidemic. These areas of ...