Intellectual deficit, X-linked, Pai type

General Information (adopted from Orphanet):

Synonyms, Signs:
Number of Symptoms 18
OrphanetNr: 85322
OMIM Id:
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: 1 family [Orphanet]
Inheritance: X-linked recessive
[Orphanet]
Age of onset: Childhood
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Multiple congenital anomalies/dysmorphic syndrome-intellectual deficit
 -Rare developmental defect during embryogenesis
 -Rare genetic disease
X-linked syndromic intellectual deficit
 -Rare genetic disease
 -Rare neurologic disease

Symptom Information: Sort by abundance 

1
(HPO:0000045) Abnormality of the scrotum Occasional [Orphanet] 14 / 7739
2
(HPO:0000035) Abnormality of the testis Occasional [Orphanet] 296 / 7739
3
(HPO:0000286) Epicanthus Occasional [Orphanet] 371 / 7739
4
(HPO:0000160) Narrow mouth Occasional [Orphanet] 188 / 7739
5
(HPO:0000426) Prominent nasal bridge Occasional [Orphanet] 121 / 7739
6
(HPO:0000411) Protruding ear Occasional [Orphanet] 140 / 7739
7
(HPO:0001288) Gait disturbance Occasional [Orphanet] 318 / 7739
8
(HPO:0001276) Hypertonia Occasional [Orphanet] 317 / 7739
9
(HPO:0011442) Abnormality of central motor function Occasional [Orphanet] 76 / 7739
10
(HPO:0002167) Neurological speech impairment Frequent [Orphanet] 308 / 7739
11
(HPO:0001250) Seizures Very frequent [Orphanet] 1245 / 7739
12
(HPO:0001182) Tapered finger Occasional [Orphanet] 93 / 7739
13
(HPO:0002750) Delayed skeletal maturation Occasional [Orphanet] 250 / 7739
14
(HPO:0004299) Hernia of the abdominal wall Occasional [Orphanet] 176 / 7739
15
(HPO:0001511) Intrauterine growth retardation Frequent [Orphanet] 358 / 7739
16
(HPO:0010978) Abnormality of immune system physiology Very frequent [Orphanet] 148 / 7739
17
(HPO:0012758) Neurodevelopmental delay Very frequent [Orphanet] 949 / 7739
18
(HPO:0001522) Death in infancy Frequent [Orphanet] 275 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: