Woodhouse-Sakati syndrome
General Information (adopted from Orphanet):
Synonyms, Signs: |
HYPOGONADISM, ALOPECIA, DIABETES MELLITUS, MENTAL RETARDATION, DEAFNESS, AND EXTRAPYRAMIDAL SYNDROME EXTRAPYRAMIDAL DISORDER, PROGRESSIVE, WITH PRIMARY HYPOGONADISM, MENTAL RETARDATION, AND ALOPECIA Diabetes - hypogonadism - deafness - intellectual deficit |
Number of Symptoms | 63 |
OrphanetNr: | 3464 |
OMIM Id: |
241080
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ICD-10: |
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UMLs: |
C0342286 |
MeSH: |
C536742 |
MedDRA: |
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Snomed: |
237616002 |
Prevalence, inheritance and age of onset:
Prevalence: | 0.1 of 100 000 [Orphanet] |
Inheritance: |
[Orphanet] |
Age of onset: |
Adolescent [Orphanet] |
Disease classification (adopted from Orphanet):
Parent Diseases: |
Neurodegeneration with brain iron accumulation
-Rare genetic disease -Rare neurologic disease Non-hypogonadotropic hypogonadism -Rare endocrine disease -Rare genetic disease Other rare diabetes mellitus -Rare endocrine disease Rare disorder with dystonia and other neurologic or systemic manifestation -Rare neurologic disease Rare genetic diabetes mellitus -Rare genetic disease Rare genetic intellectual deficit with developmental anomaly -Rare genetic disease Rare intellectual deficit with developmental anomaly -Rare neurologic disease Syndrome with hypogonadotropic hypogonadism -Rare endocrine disease -Rare genetic disease -Rare gynecologic or obstetric disease |
Symptom Information:
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(HPO:0001587) | Primary ovarian failure | 9 / 7739 | ||||
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(HPO:0000078) | Abnormality of the genital system | Very frequent [Orphanet] | 33 / 7739 | |||
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(HPO:0000135) | Hypogonadism | Very frequent [Orphanet] | 89 / 7739 | |||
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(HPO:0000044) | Hypogonadotrophic hypogonadism | 56 / 7739 | ||||
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(HPO:0000013) | Hypoplasia of the uterus | 21 / 7739 | ||||
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(HPO:0000054) | Micropenis | 257 / 7739 | ||||
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(HPO:0000815) | Hypergonadotropic hypogonadism | 48 / 7739 | ||||
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(HPO:0010464) | Streak ovary | 8 / 7739 | ||||
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(HPO:0008697) | Hypoplasia of the fallopian tube | 3 / 7739 | ||||
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(HPO:0008734) | Decreased testicular size | 105 / 7739 | ||||
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(HPO:0002209) | Sparse scalp hair | Frequent [Orphanet] | 59 / 7739 | |||
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(HPO:0000426) | Prominent nasal bridge | 121 / 7739 | ||||
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(HPO:0000674) | Anodontia | 18 / 7739 | ||||
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(HPO:0000325) | Triangular face | 91 / 7739 | ||||
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(HPO:0008625) | Severe sensorineural hearing impairment | 150 / 7739 | ||||
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(HPO:0008527) | Congenital sensorineural hearing impairment | 165 / 7739 | ||||
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(HPO:0000365) | Hearing impairment | Very frequent [Orphanet] | 539 / 7739 | |||
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(HPO:0000411) | Protruding ear | 140 / 7739 | ||||
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(HPO:0009904) | Prominent ear helix | 8 / 7739 | ||||
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(HPO:0000407) | Sensorineural hearing impairment | 524 / 7739 | ||||
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(HPO:0001270) | Motor delay | Very frequent [Orphanet] | 322 / 7739 | |||
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(HPO:0001332) | Dystonia | 197 / 7739 | ||||
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(HPO:0002071) | Abnormality of extrapyramidal motor function | 76 / 7739 | ||||
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(HPO:0001266) | Choreoathetosis | 57 / 7739 | ||||
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(HPO:0000709) | Psychosis | 61 / 7739 | ||||
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(HPO:0100543) | Cognitive impairment | Very frequent [Orphanet] | 230 / 7739 | |||
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(HPO:0001263) | Global developmental delay | Very frequent [Orphanet] | 853 / 7739 | |||
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(HPO:0001249) | Intellectual disability | Very frequent [Orphanet] | 1089 / 7739 | |||
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(HPO:0000738) | Hallucinations | 60 / 7739 | ||||
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(HPO:0001260) | Dysarthria | 329 / 7739 | ||||
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(HPO:0001328) | Specific learning disability | Very frequent [Orphanet] | 114 / 7739 | |||
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(HPO:0002925) | Thyroid-stimulating hormone excess | 12 / 7739 | ||||
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(HPO:0100651) | Type I diabetes mellitus | Very frequent [Orphanet] | 44 / 7739 | |||
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(HPO:0000819) | Diabetes mellitus | 131 / 7739 | ||||
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(HPO:0000823) | Delayed puberty | Very frequent [Orphanet] | 65 / 7739 | |||
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(HPO:0004528) | Generalized hypotrichosis | Frequent [Orphanet] | 18 / 7739 | |||
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(HPO:0008070) | Sparse hair | 94 / 7739 | ||||
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(HPO:0002215) | Sparse axillary hair | Very frequent [Orphanet] | 21 / 7739 | |||
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(HPO:0001006) | Hypotrichosis | Frequent [Orphanet] | 219 / 7739 | |||
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(HPO:0002289) | Alopecia universalis | 20 / 7739 | ||||
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(HPO:0002225) | Sparse pubic hair | Very frequent [Orphanet] | 76 / 7739 | |||
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(HPO:0001596) | Alopecia | 162 / 7739 | ||||
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(HPO:0002231) | Sparse body hair | Very frequent [Orphanet] | 9 / 7739 | |||
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(HPO:0002213) | Fine hair | 77 / 7739 | ||||
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(HPO:0001678) | Atrioventricular block | 59 / 7739 | ||||
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(HPO:0011675) | Arrhythmia | Very frequent [Orphanet] | 226 / 7739 | |||
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(HPO:0005135) | EKG: T-wave abnormalities | 19 / 7739 | ||||
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(HPO:0003077) | Hyperlipidemia | 37 / 7739 | ||||
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(OMIM) | Atrophic seminiferous tubules | 1 / 7739 | ||||
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(OMIM) | MRI shows white matter lesions | 2 / 7739 | ||||
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(OMIM) | ECG shows flattened T waves | 1 / 7739 | ||||
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(OMIM) | Alopecia, partial, primarily involving scalp and eyebrows | 1 / 7739 | ||||
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(OMIM) | Decreased serum insulin-like growth factor 1 (IGF1) | 3 / 7739 | ||||
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(OMIM) | Loss of eyebrow hair | 1 / 7739 | ||||
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(OMIM) | Progressive cognitive decline following normal development in childhood (in some patients) | 1 / 7739 | ||||
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(OMIM) | Decreased testosterone | 2 / 7739 | ||||
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(OMIM) | Failure of secondary sexual development | 1 / 7739 | ||||
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(OMIM) | Testicular biopsy shows hypospermatogenesis | 1 / 7739 | ||||
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(OMIM) | MRI shows decreased signal intensities in the basal ganglia | 1 / 7739 | ||||
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(OMIM) | Short, sparse, fine hair | 1 / 7739 | ||||
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(OMIM) | Decreased estradiol | 1 / 7739 | ||||
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(OMIM) | Hypogonadotropic hypergonadism | 1 / 7739 | ||||
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(MedDRA:10043816) | Thyroxine decreased | 3 / 7739 |
Associated genes:
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
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Additional Information:
Clinical Description OMIM |
Woodhouse and Sakati (1983) reported a total of 7 Saudi Arabian individuals from 2 consanguineous families with a combination of hypogonadism, partial alopecia, diabetes mellitus, mental retardation, and deafness. The first family had 2 affected males and 2 ... |
Molecular genetics OMIM |
In affected members of 2 Saudi families with Woodhouse-Sakati syndrome, including 1 of the original families described by Woodhouse and Sakati (1983), Alazami et al. (2008) identified homozygosity for a 1-bp deletion in the C2ORF37 gene (612515.0001); 6 ... |