Whipple disease

General Information (adopted from Orphanet):

Synonyms, Signs: Intestinal lipodystrophy
Secondary non-tropical sprue
Intestinal lipophagic granulomatosis
Number of Symptoms 43
OrphanetNr: 3452
OMIM Id:
ICD-10: K90.8+
M14.8*
UMLs: C0023788
C2930851
MeSH: C531849
D008061
MedDRA: 10047931
Snomed: 41545003

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Not applicable
[Orphanet]
Age of onset: All ages
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Rare bacterial infectious disease
 -Rare infectious disease
Rare disease with myoclonus as a major feature
 -Rare neurologic disease
Rare intestinal disease
 -Rare gastroenterologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0100639) Erectile abnormalities Occasional [Orphanet] 15 / 7739
2
 (HPO:0000520) Proptosis Occasional [Orphanet] 192 / 7739
3
 (HPO:0100533) Inflammatory abnormality of the eye Frequent [Orphanet] 70 / 7739
4
 (HPO:0006824) Cranial nerve paralysis Occasional [Orphanet] 81 / 7739
5
 (HPO:0002383) Encephalitis Occasional [Orphanet] 41 / 7739
6
 (HPO:0007256) Abnormal pyramidal signs Occasional [Orphanet] 116 / 7739
7
 (HPO:0002516) Increased intracranial pressure Occasional [Orphanet] 47 / 7739
8
 (HPO:0001250) Seizures Occasional [Orphanet] 1245 / 7739
9
 (HPO:0009830) Peripheral neuropathy Occasional [Orphanet] 206 / 7739
10
 (HPO:0100543) Cognitive impairment Very frequent [Orphanet] 230 / 7739
11
 (HPO:0002066) Gait ataxia Occasional [Orphanet] 327 / 7739
12
 (HPO:0002360) Sleep disturbance Frequent [Orphanet] 113 / 7739
13
 (HPO:0100851) Abnormal emotion/affect behavior Very frequent [Orphanet] 85 / 7739
14
 (HPO:0004305) Involuntary movements Very frequent [Orphanet] 50 / 7739
15
 (HPO:0100829) Galactorrhea Occasional [Orphanet] 7 / 7739
16
 (HPO:0000821) Hypothyroidism Occasional [Orphanet] 141 / 7739
17
 (HPO:0100749) Chest pain Occasional [Orphanet] 92 / 7739
18
 (HPO:0005059) Arthralgia/arthritis Very frequent [Orphanet] 141 / 7739
19
 (HPO:0100769) Synovitis Very frequent [Orphanet] 86 / 7739
20
 (HPO:0002239) Gastrointestinal hemorrhage Occasional [Orphanet] 97 / 7739
21
 (HPO:0002039) Anorexia Very frequent [Orphanet] 62 / 7739
22
 (HPO:0002240) Hepatomegaly Frequent [Orphanet] 467 / 7739
23
 (HPO:0001744) Splenomegaly Frequent [Orphanet] 337 / 7739
24
 (HPO:0002027) Abdominal pain Very frequent [Orphanet] 184 / 7739
25
 (HPO:0002024) Malabsorption Very frequent [Orphanet] 142 / 7739
26
 (HPO:0004326) Cachexia Very frequent [Orphanet] 71 / 7739
27
 (HPO:0000953) Hyperpigmentation of the skin Occasional [Orphanet] 75 / 7739
28
 (HPO:0002615) Hypotension Frequent [Orphanet] 52 / 7739
29
 (HPO:0001637) Abnormality of the myocardium Occasional [Orphanet] 76 / 7739
30
 (HPO:0001697) Abnormality of the pericardium Occasional [Orphanet] 52 / 7739
31
 (HPO:0001903) Anemia Occasional [Orphanet] 289 / 7739
32
 (HPO:0000855) Insulin resistance Occasional [Orphanet] 32 / 7739
33
 (HPO:0010741) Edema of the lower limbs Occasional [Orphanet] 34 / 7739
34
 (HPO:0001945) Fever Very frequent [Orphanet] 218 / 7739
35
 (HPO:0002902) Hyponatremia Occasional [Orphanet] 37 / 7739
36
 (HPO:0002093) Respiratory insufficiency Occasional [Orphanet] 410 / 7739
37
 (HPO:0002103) Abnormality of the pleura Frequent [Orphanet] 58 / 7739
38
 (HPO:0100721) Mediastinal lymphadenopathy Very frequent [Orphanet] 19 / 7739
39
 (HPO:0100614) Myositis Occasional [Orphanet] 21 / 7739
40
 (HPO:0003326) Myalgia Frequent [Orphanet] 143 / 7739
41
 (HPO:0001324) Muscle weakness Occasional [Orphanet] 859 / 7739
42
 (HPO:0000238) Hydrocephalus Occasional [Orphanet] 278 / 7739
43
 ([DEL]MedDRA:10011224) Cough Occasional [Orphanet] 70 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: