Hyperpigmentation of the skin

Symptom Information:

Symptom ID: HPO:0000953
Synonyms:
Cutaneous hyperpigmentation [HPO:0000953]
Increased skin pigmentation [HPO:0000953]
Skin hyperpigmentation [HPO:0000953]
Melanoderma [Orphanet:23530]
Melanoderma (disorder) [Orphanet:23530]
Increased skin pigmentation [OMIM:Increased skin pigmentation]
Skin hyperpigmentation [OMIM:Skin hyperpigmentation]
Diffuse/generalised skin hyperpigmentation/melanoderma [Orphanet:23530]
Melanodermia [Orphanet:23530]
Melanoderma [MedDRA:10027146]
Black spot [MedDRA:10027146]
Leucomelanoderma [MedDRA:10027146]
Melanodermia [MedDRA:10027146]
Leukomelanoderma [MedDRA:10027146]
Cutaneous hyperpigmentation (in some patients) [OMIM:Cutaneous hyperpigmentation (in some patients)]
Skin hyperpigmentation [MedDRA:10040865]
Quality:
Cross references:
HPO:0007440 "Generalized hyperpigmentation" [Orphanet:23530]
Orphanet:23530 "Diffuse/generalised skin hyperpigmentation/melanoderma" [Orphanet:23530]
OMIM: "Increased skin pigmentation" [OMIM:Increased skin pigmentation]
OMIM: "Skin hyperpigmentation" [OMIM:Skin hyperpigmentation]
OMIM: "Cutaneous hyperpigmentation (in some patients)" [OMIM:Cutaneous hyperpigmentation (in some patients)]
UMLS:C0221436 "Melanoderma" [Orphanet:23530]
Is a (Direct Parents):
Orphanet Abnormality of skin pigmentation
HPO         Abnormality of skin pigmentation
MedDRA Hyperpigmentation disorders
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the integument(HPO:0001574)
          Abnormality of the skin(HPO:0000951)
             Generalized abnormality of skin(HPO:0011354)
                Abnormality of skin morphology(HPO:0011121)
                   Abnormality of skin pigmentation(HPO:0001000)
                      Hyperpigmentation of the skin(HPO:0000953)
MedDRA:
Skin and subcutaneous tissue disorders(MedDRA:10040785)
    Pigmentation disorders(MedDRA:10035023)
       Hyperpigmentation disorders(MedDRA:10020713)
          Hyperpigmentation of the skin(HPO:0000953)
Database Frequency: 75 / 7739
Resource:

All diseases associated with this symptom:

46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency (Orphanet:168558)
ACTH-dependent Cushing syndrome (Orphanet:99892)
ADRENAL HYPOPLASIA, CONGENITAL (OMIM:300200)
ADRENOCORTICAL UNRESPONSIVENESS TO ACTH WITH POSTRECEPTOR DEFECT (OMIM:202355)
ANE syndrome (Orphanet:157954)
APC-related attenuated familial adenomatous polyposis (Orphanet:247806)
Acanthosis nigricans (Orphanet:924)
Acromegaly (Orphanet:963)
Addison disease (Orphanet:85138)
Adrenomyodystrophy (Orphanet:977)
Alström syndrome (Orphanet:64)
Ankyloblepharon - ectodermal defects - cleft lip/palate (Orphanet:1071)
Attenuated familial adenomatous polyposis (Orphanet:220460)
Bazex-Dupré-Christol syndrome (Orphanet:113)
Becker nevus syndrome (Orphanet:64755)
Bullous dystrophy, macular type (Orphanet:1867)
Cardiofaciocutaneous syndrome (Orphanet:1340)
Castleman disease (Orphanet:160)
Chédiak-Higashi syndrome (Orphanet:167)
Cockayne syndrome (Orphanet:191)
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency (Orphanet:90795)
Congenital erythropoietic porphyria (Orphanet:79277)
Costello syndrome (Orphanet:3071)
Cronkhite-Canada syndrome (Orphanet:2930)
Cushing disease (Orphanet:96253)
Cushing syndrome due to ectopic ACTH secretion (Orphanet:99889)
DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE, 1 (OMIM:224230)
EXTRASYSTOLES, MULTIFORM VENTRICULAR, WITH SHORT STATURE, HYPERPIGMENTATIONAND MICROCEPHALY (OMIM:133750)
Familial adenomatous polyposis (Orphanet:733)
Familial glucocorticoid deficiency (Orphanet:361)
Felty syndrome (Orphanet:47612)
Foveal hypoplasia - presenile cataract (Orphanet:2253)
GLUCOCORTICOID DEFICIENCY 2 (OMIM:607398)
GLUCOCORTICOID DEFICIENCY 3 (OMIM:609197)
Gardner syndrome (Orphanet:79665)
Gastrointestinal stromal tumor (Orphanet:44890)
Gaucher disease type 1 (Orphanet:77259)
HYPERPIGMENTATION OF FULDAUER AND KUIJPERS (OMIM:145200)
Heart defect - round face - congenital developmental delay (Orphanet:1355)
Hemochromatosis type 2 (Orphanet:79230)
Hemochromatosis type 3 (Orphanet:225123)
Hemochromatosis type 4 (Orphanet:139491)
Hemochromatosis, type 1 (OMIM:235200)
Hemochromatosis, type 2A (OMIM:602390)
Hemochromatosis, type 2B (OMIM:613313)
Hereditary coproporphyria (Orphanet:79273)
Hidrotic ectodermal dysplasia (Orphanet:189)
Hoyeraal-Hreidarsson syndrome (Orphanet:3322)
Insulin-resistance syndrome type A (Orphanet:2297)
McCune-Albright syndrome (Orphanet:562)
NASAL HYPERPIGMENTATION, FAMILIAL TRANSVERSE (OMIM:161530)
NOONAN SYNDROME 7 (OMIM:613706)
Nakajo-Nishimura syndrome (Orphanet:2615)
Neurocutaneous melanocytosis (Orphanet:2481)
Neuroectodermal melanolysosomal disease (Orphanet:33445)
Neurofibromatosis type 1 (Orphanet:636)
Noonan syndrome-like disorder with juvenile myelomonocytic leukemia (Orphanet:363972)
Noonan syndrome-like disorder with loose anagen hair (Orphanet:2701)
Pantothenate kinase-associated neurodegeneration (Orphanet:157850)
Parana hard-skin syndrome (Orphanet:2812)
Phakomatosis pigmentovascularis (Orphanet:2875)
Porphyria cutanea tarda (Orphanet:101330)
Porphyria variegata (Orphanet:79473)
Proteus syndrome (Orphanet:744)
Pseudoleprechaunism syndrome, Patterson type (Orphanet:2976)
Rabson-Mendenhall syndrome (Orphanet:769)
Sjögren-Larsson syndrome (Orphanet:816)
Sparse hair - short stature - skin anomalies (Orphanet:79132)
Toriello-Lacassie-Droste syndrome (Orphanet:3339)
Triple A syndrome (Orphanet:869)
Turcot syndrome with polyposis (Orphanet:99818)
Whipple disease (Orphanet:3452)
X-linked cerebral adrenoleukodystrophy (Orphanet:139396)
Xeroderma pigmentosum (Orphanet:910)
Zellweger-like syndrome without peroxisomal anomalies (Orphanet:50812)