Felty syndrome
General Information (adopted from Orphanet):
| Synonyms, Signs: |
Splenomegaly-neutropenia-rheumatoid arthritis syndrome |
| Number of Symptoms | 37 |
| OrphanetNr: | 47612 |
| OMIM Id: |
134750
|
| ICD-10: |
M05.0 |
| UMLs: |
C0015773 |
| MeSH: |
D005258 |
| MedDRA: |
10016386 |
| Snomed: |
57160007 |
Prevalence, inheritance and age of onset:
| Prevalence: | No data available. |
| Inheritance: |
Unknown [Orphanet] |
| Age of onset: |
Adult [Orphanet] |
Disease classification (adopted from Orphanet):
| Parent Diseases: |
Acquired neutropenia
-Rare immune disease Rare rheumatologic disease -Rare systemic or rheumatologic disease |
Symptom Information:
|
|
(HPO:0000010) | Recurrent urinary tract infections | Occasional [Orphanet] | 56 / 7739 | |||
|
|
(HPO:0000246) | Sinusitis | Frequent [Orphanet] | 73 / 7739 | |||
|
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(HPO:0100776) | Recurrent pharyngitis | Frequent [Orphanet] | 18 / 7739 | |||
|
|
(HPO:0100533) | Inflammatory abnormality of the eye | Occasional [Orphanet] | 70 / 7739 | |||
|
|
(HPO:0000389) | Chronic otitis media | Frequent [Orphanet] | 64 / 7739 | |||
|
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(HPO:0009830) | Peripheral neuropathy | Occasional [Orphanet] | 206 / 7739 | |||
|
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(HPO:0001370) | Rheumatoid arthritis | 12 / 7739 | ||||
|
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(HPO:0001387) | Joint stiffness | Very frequent [Orphanet] | 322 / 7739 | |||
|
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(HPO:0005059) | Arthralgia/arthritis | Very frequent [Orphanet] | 141 / 7739 | |||
|
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(HPO:0002797) | Osteolysis | Very frequent [Orphanet] | 68 / 7739 | |||
|
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(HPO:0100769) | Synovitis | Very frequent [Orphanet] | 86 / 7739 | |||
|
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(HPO:0001367) | Abnormal joint morphology | Very frequent [Orphanet] | 53 / 7739 | |||
|
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(HPO:0001744) | Splenomegaly | Frequent [Orphanet] | 337 / 7739 | |||
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(HPO:0002240) | Hepatomegaly | Occasional [Orphanet] | 467 / 7739 | |||
|
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(HPO:0004325) | Decreased body weight | Frequent [Orphanet] | 492 / 7739 | |||
|
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(HPO:0007400) | Irregular hyperpigmentation | Occasional [Orphanet] | 72 / 7739 | |||
|
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(HPO:0000953) | Hyperpigmentation of the skin | Occasional [Orphanet] | 75 / 7739 | |||
|
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(HPO:0001031) | Subcutaneous lipoma | Very frequent [Orphanet] | 112 / 7739 | |||
|
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(HPO:0200042) | Skin ulcer | Occasional [Orphanet] | 138 / 7739 | |||
|
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(HPO:0001697) | Abnormality of the pericardium | Occasional [Orphanet] | 52 / 7739 | |||
|
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(HPO:0001875) | Neutropenia | 83 / 7739 | ||||
|
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(HPO:0001873) | Thrombocytopenia | Occasional [Orphanet] | 224 / 7739 | |||
|
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(HPO:0001876) | Pancytopenia | Occasional [Orphanet] | 89 / 7739 | |||
|
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(HPO:0001874) | Abnormality of neutrophils | Very frequent [Orphanet] | 47 / 7739 | |||
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(HPO:0002665) | Lymphoma | Occasional [Orphanet] | 60 / 7739 | |||
|
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(HPO:0001903) | Anemia | Frequent [Orphanet] | 289 / 7739 | |||
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(HPO:0004332) | Abnormality of lymphocytes | Frequent [Orphanet] | 12 / 7739 | |||
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(HPO:0002206) | Pulmonary fibrosis | Occasional [Orphanet] | 51 / 7739 | |||
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(HPO:0002103) | Abnormality of the pleura | Occasional [Orphanet] | 58 / 7739 | |||
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(HPO:0002205) | Recurrent respiratory infections | Very frequent [Orphanet] | 254 / 7739 | |||
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(HPO:0002716) | Lymphadenopathy | Frequent [Orphanet] | 129 / 7739 | |||
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(HPO:0010978) | Abnormality of immune system physiology | Very frequent [Orphanet] | 148 / 7739 | |||
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(HPO:0002960) | Autoimmunity | Very frequent [Orphanet] | 78 / 7739 | |||
|
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(HPO:0100806) | Sepsis | Occasional [Orphanet] | 48 / 7739 | |||
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(HPO:0003549) | Abnormality of connective tissue | Occasional [Orphanet] | 22 / 7739 | |||
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(HPO:0001522) | Death in infancy | Occasional [Orphanet] | 275 / 7739 | |||
|
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(HPO:0000006) | Autosomal dominant inheritance | 2518 / 7739 |
Associated genes:
ClinVar (via SNiPA)
| Gene symbol | Variation | Clinical significance | Reference |
|---|