Acanthosis nigricans consists of thickening and hyperpigmentation of the skin of the entire body but especially in flexural areas. In an affected mother and daughter reported by Tasjian and Jarratt (1984), skin lesions were first noted in infancy. ... Acanthosis nigricans consists of thickening and hyperpigmentation of the skin of the entire body but especially in flexural areas. In an affected mother and daughter reported by Tasjian and Jarratt (1984), skin lesions were first noted in infancy. Chuang et al. (1995) reported familial acanthosis nigricans affecting a 35-year-old woman, her 7-year-old son, and 5-year-old daughter. Absence of the eyebrows and eyelashes was also present in the affected members of this family. The mother had no axillary hair and her pubic hair was sparse. The boy also suffered from congenital heart disease and a congenital cataract in the left eye. Chuang et al. (1995) suggested that the combination of acanthosis nigricans and ectodermal defects in this family may represent a distinct nosologic entity. They referred to the hair problem as madarosis (loss of the eyebrows or of the eyelashes).