Hyperkeratosis

Symptom Information:

Symptom ID: HPO:0000962
Synonyms:
Hyperkeratosis (disorder) [Orphanet:23090]
Hyperkeratosis (morphologic abnormality) [Orphanet:23090]
Hyperkeratosis [Orphanet:23090]
Hyperkeratosis [OMIM:Hyperkeratosis]
Hyperkeratosis/ainhum/hyperkeratotic skin fissures [Orphanet:23090]
Hyperkeratosis [MedDRA:10020649]
Acquired keratoderma [MedDRA:10020649]
Callosities [MedDRA:10020649]
Callosity [MedDRA:10020649]
Callus [MedDRA:10020649]
Corns [MedDRA:10020649]
Corns and callosities [MedDRA:10020649]
Cutaneous horn [MedDRA:10020649]
Erythrokeratoderma [MedDRA:10020649]
Foot callus [MedDRA:10020649]
Hard corn [MedDRA:10020649]
Keratoderma [MedDRA:10020649]
Keratoderma, acquired [MedDRA:10020649]
Keratosis [MedDRA:10020649]
Skin keratosis [MedDRA:10020649]
Soft corn [MedDRA:10020649]
Tyloma [MedDRA:10020649]
Tylosis [MedDRA:10020649]
Skin callus [MedDRA:10020649]
Foot callus [OMIM:Foot callus]
Hyperkeratosis (especially extensor surfaces) [OMIM:Hyperkeratosis (especially extensor surfaces)]
Hyperkeratosis (in some patients) [OMIM:Hyperkeratosis (in some patients)]
Hyperkeratosis (palms, soles, elbows, knees) [OMIM:Hyperkeratosis (palms, soles, elbows, knees)]
Keratoderma (palms and soles) [OMIM:Keratoderma (palms and soles)]
Tylosis [OMIM:Tylosis]
Ainhum [MedDRA:10001524]
Ainhum (disorder) [Orphanet:23090]
Ainhum [Orphanet:23090]
Quality:
Cross references:
HPO:0005595 "Generalized hyperkeratosis" [Orphanet:23090]
Orphanet:23090 "Hyperkeratosis/ainhum/hyperkeratotic skin fissures" [Orphanet:23090]
OMIM: "Hyperkeratosis" [OMIM:Hyperkeratosis]
OMIM: "Foot callus" [OMIM:Foot callus]
OMIM: "Hyperkeratosis (especially extensor surfaces)" [OMIM:Hyperkeratosis (especially extensor surfaces)]
OMIM: "Hyperkeratosis (in some patients)" [OMIM:Hyperkeratosis (in some patients)]
OMIM: "Hyperkeratosis (palms, soles, elbows, knees)" [OMIM:Hyperkeratosis (palms, soles, elbows, knees)]
OMIM: "Keratoderma (palms and soles)" [OMIM:Keratoderma (palms and soles)]
OMIM: "Tylosis" [OMIM:Tylosis]
UMLS:C0870082 "Hyperkeratosis" [HPO:0000962]
UMLS:C0870082 "Hyperkeratosis" [Orphanet:23090]
UMLS:C0001860 "Ainhum" [Orphanet:23090]
Is a (Direct Parents):
HPO         Epidermal thickening
HPO         Hyperkeratotic papule
Orphanet Abnormality of the skin
MedDRA Hyperkeratoses
HPO         Hyperparakeratosis
HPO         Hyperkeratosis pilaris
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the integument(HPO:0001574)
          Abnormality of the skin(HPO:0000951)
             Generalized abnormality of skin(HPO:0011354)
                Abnormality of skin morphology(HPO:0011121)
                   Thickened skin(HPO:0001072)
                      Epidermal thickening(HPO:0011368)
                         Hyperkeratosis(HPO:0000962)
MedDRA:
Skin and subcutaneous tissue disorders(MedDRA:10040785)
    Cornification and dystrophic skin disorders(MedDRA:10011063)
       Hyperkeratoses(MedDRA:10020648)
          Hyperkeratosis(HPO:0000962)
Database Frequency: 216 / 7739
Resource:

All diseases associated with this symptom:

ALACRIMA, ACHALASIA, AND MENTAL RETARDATION SYNDROME (OMIM:615510)
ANGIOMA SERPIGINOSUM, AUTOSOMAL DOMINANT (OMIM:106050)
ANGIOMA SERPIGINOSUM, X-LINKED (OMIM:300652)
Acanthosis nigricans (Orphanet:924)
Acquired ichthyosis (Orphanet:454)
Acro-osteolysis-keloid-like lesions-premature aging syndrome (Orphanet:363665)
Acro-oto-ocular syndrome (Orphanet:2980)
Acrokeratoelastoidosis of Costa (Orphanet:38)
Acrokeratosis verruciformis of Hopf (Orphanet:79151)
Acromelanosis (Orphanet:39)
Alopecia - contractures - dwarfism - intellectual deficit (Orphanet:1005)
Alpha-N-acetylgalactosaminidase deficiency type 1 (Orphanet:79279)
Alpha-N-acetylgalactosaminidase deficiency type 2 (Orphanet:79280)
Alström syndrome (Orphanet:64)
Amelo-onycho-hypohidrotic syndrome (Orphanet:1028)
Angioma serpiginosum (Orphanet:95429)
Ankyloblepharon - ectodermal defects - cleft lip/palate (Orphanet:1071)
Ankylosing vertebral hyperostosis with tylosis (Orphanet:2206)
Arthrogryposis - hyperkeratosis, lethal form (Orphanet:1485)
Autosomal dominant Charcot-Marie-Tooth disease type 2B (Orphanet:99936)
Autosomal dominant palmoplantar keratoderma and congenital alopecia (Orphanet:1010)
Autosomal recessive epidermolysis bullosa simplex (Orphanet:89838)
Autosomal recessive palmoplantar keratoderma and congenital alopecia (Orphanet:1366)
BRESEK syndrome (Orphanet:85284)
CARDIOFACIOCUTANEOUS SYNDROME 1 (OMIM:115150)
CEDNIK syndrome (Orphanet:66631)
CHILD syndrome (Orphanet:139)
Cardiofaciocutaneous syndrome (Orphanet:1340)
Cardiomyopathy, dilated, with woolly hair, keratoderma, and toothagenesis (OMIM:615821)
Chronic mucocutaneous candidiasis (Orphanet:1334)
Classical mycosis fungoides (Orphanet:2584)
Cobb syndrome (Orphanet:53721)
Congenital ichthyosis - intellectual deficit - spastic quadriplegia (Orphanet:352333)
Congenital non-bullous ichthyosiform erythroderma (Orphanet:79394)
Congenital reticular ichthyosiform erythroderma (Orphanet:281190)
Costello syndrome (Orphanet:3071)
Cowden syndrome (Orphanet:201)
Craniosynostosis - anal anomalies - porokeratosis (Orphanet:85199)
Cutaneous lupus erythematosus (Orphanet:535)
Cutis gyrata - acanthosis nigricans - craniosynostosis (Orphanet:1555)
Darier disease (Orphanet:218)
Dermatoleukodystrophy (Orphanet:1659)
Diffuse palmoplantar keratoderma-acrocyanosis syndrome (Orphanet:86918)
Disseminated superficial actinic porokeratosis (Orphanet:79152)
Dyskeratosis congenita (Orphanet:1775)
ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME (OMIM:616029)
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME3 (OMIM:604292)
EEC syndrome (Orphanet:1896)
EPIDERMOLYSIS BULLOSA, NONSPECIFIC, AUTOSOMAL RECESSIVE (OMIM:615028)
Ectodermal dysplasia - blindness (Orphanet:1806)
Ectodermal dysplasia - sensorineural deafness (Orphanet:1883)
Ectodermal dysplasia syndrome (Orphanet:79373)
Ectodermal dysplasia, Berlin type (Orphanet:1816)
Ehlers-Danlos syndrome, periodontitis type (Orphanet:75392)
Epidermolysis bullosa simplex (Orphanet:304)
Epidermolysis bullosa simplex due to plakophilin deficiency (Orphanet:158668)
Epidermolysis bullosa simplex with mottled pigmentation (Orphanet:79397)
Epidermolysis bullosa simplex, Dowling-Meara type (Orphanet:79396)
Epidermolysis bullosa simplex, Ogna type (Orphanet:79401)
Epidermolytic ichthyosis (Orphanet:312)
Epidermolytic palmoplantar keratoderma (Orphanet:2199)
Erythrokeratoderma \"en cocardes\" (Orphanet:315)
Erythrokeratodermia - ataxia (Orphanet:1955)
Erythrokeratodermia variabilis (Orphanet:317)
Exfoliative ichthyosis (Orphanet:289586)
Fabry disease (Orphanet:324)
Familial benign chronic pemphigus (Orphanet:2841)
Familial keratoacanthoma (Orphanet:493)
Familial progressive hyperpigmentation (Orphanet:79146)
Fetal Gaucher disease (Orphanet:85212)
Flynn-Aird syndrome (Orphanet:2047)
Focal palmoplantar and gingival keratoderma (Orphanet:2200)
Fucosidosis (Orphanet:349)
Generalized epidermolysis bullosa simplex, non-Dowling-Meara type (Orphanet:79399)
Gorlin syndrome (Orphanet:377)
Graham Little-Piccardi-Lassueur syndrome (Orphanet:505)
HYPERTRICHOSIS, HYPERKERATOSIS, MENTAL RETARDATION, AND DISTINCTIVEFACIAL FEATURES (OMIM:609943)
Haim-Munk syndrome (Orphanet:2342)
Harlequin ichthyosis (Orphanet:457)
Hereditary acrokeratotic poikiloderma, Weary type (Orphanet:2907)
Hereditary mucoepithelial dysplasia (Orphanet:1839)
Hereditary painful callosities (Orphanet:79141)
Hereditary palmoplantar keratoderma (Orphanet:79357)
Hereditary palmoplantar keratoderma, Gamborg-Nielsen type (Orphanet:86923)
Hermansky-Pudlak syndrome (Orphanet:79430)
Hidrotic ectodermal dysplasia (Orphanet:189)
Hidrotic ectodermal dysplasia, Halal type (Orphanet:1809)
Hurler-Scheie syndrome (Orphanet:93476)
Hyperkeratosis lenticularis perstans (Orphanet:409)
Hyperkeratosis-hyperpigmentation syndrome (Orphanet:1336)
Hypohidrotic ectodermal dysplasia (Orphanet:238468)
Hypopigmentation-punctate palmoplantar keratoderma syndrome (Orphanet:324561)
Hypotrichosis simplex (Orphanet:55654)
Hypotrichosis with juvenile macular degeneration (Orphanet:1573)
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2 (OMIM:242100)
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 3 (OMIM:606545)
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 5 (OMIM:604777)
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 6 (OMIM:612281)
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 8 (OMIM:613943)
Ichthyosis follicularis - alopecia - photophobia (Orphanet:2273)
Ichthyosis hystrix of Curth-Macklin (Orphanet:79503)
Incontinentia pigmenti (Orphanet:464)
Insulin-resistance syndrome type A (Orphanet:2297)
Intellectual deficit, X-linked - seizures - psoriasis (Orphanet:3052)
Isolated punctate palmoplantar keratoderma (Orphanet:2338)
Juvenile idiopathic arthritis (Orphanet:92)
KERATITIS-ICHTHYOSIS-DEAFNESS SYNDROME, AUTOSOMAL DOMINANT (OMIM:148210)
KID syndrome (Orphanet:477)
Keratoderma hereditarium mutilans (Orphanet:494)
Keratoderma hereditarium mutilans with ichthyosis (Orphanet:79395)
Keratolytic winter erythema (Orphanet:50943)
Keratosis follicularis - dwarfism - cerebral atrophy (Orphanet:2339)
Keratosis follicularis spinulosa decalvans (Orphanet:2340)
Keratosis linearis-ichthyosis congenita-sclerosing keratoderma syndrome (Orphanet:281201)
Keratosis palmaris et plantaris - clinodactyly (Orphanet:86919)
Keratosis palmoplantaris striata (Orphanet:50942)
Keratosis pilaris atrophicans (Orphanet:498)
Kindler syndrome (Orphanet:2908)
Knuckle pads-leuconychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome (Orphanet:2698)
LEOPARD SYNDROME 3 (OMIM:613707)
Lamellar ichthyosis (Orphanet:313)
Leprechaunism (Orphanet:508)
Lethal restrictive dermopathy (Orphanet:1662)
Leukoencephalopathy-palmoplantar keratoderma syndrome (Orphanet:2386)
Lichen planopilaris (Orphanet:525)
Linear verrucous nevus syndrome (Orphanet:2611)
Lipodystrophy due to peptidic growth factors deficiency (Orphanet:1979)
Lipoid proteinosis (Orphanet:530)
Localized epidermolysis bullosa simplex (Orphanet:79400)
MICROCEPHALIC OSTEODYSPLASTIC PRIMORDIAL DWARFISM, TYPE I (OMIM:210710)
MPDU1-CDG (Orphanet:79323)
Mal de Meleda (Orphanet:87503)
Microcephalic osteodysplastic primordial dwarfism types 1 and 3 (Orphanet:2636)
Microcornea - glaucoma - absent frontal sinuses (Orphanet:2536)
Monilethrix (Orphanet:573)
Moynahan syndrome (Orphanet:2574)
Mucolipidosis type 4 (Orphanet:578)
Mutilating palmoplantar keratoderma with periorificial keratotic plaques (Orphanet:659)
NEUROPATHY, HEREDITARY SENSORY, TYPE IF (OMIM:615632)
NOONAN SYNDROME 6 (OMIM:613224)
NOONAN SYNDROME 8 (OMIM:615355)
Naegeli-Franceschetti-Jadassohn syndrome (Orphanet:69087)
Naxos disease (Orphanet:34217)
Non-epidermolytic palmoplantar keratoderma (Orphanet:2337)
Oculocutaneous albinism type 1A (Orphanet:79431)
Oculodentodigital dysplasia (Orphanet:2710)
Odonto-onycho dysplasia - alopecia (Orphanet:2722)
Odonto-onycho-dermal dysplasia (Orphanet:2721)
PALMOPLANTAR KERATODERMA, PUNCTATE TYPE IB (OMIM:614936)
PAPILLOMATOSIS, CONFLUENT AND RETICULATED (OMIM:167900)
PSORIASIS 2 (OMIM:602723)
PTEN hamartoma tumor syndrome (Orphanet:306498)
Pachydermoperiostosis (Orphanet:2796)
Pachyonychia congenita (Orphanet:2309)
Palmoplantar keratoderma - XX sex reversal - predisposition to squamous cell carcinoma (Orphanet:85112)
Palmoplantar keratoderma, Nagashima type (Orphanet:140966)
Palmoplantar keratoderma-deafness syndrome (Orphanet:2202)
Palmoplantar keratoderma-esophageal carcinoma syndrome (Orphanet:2198)
Palmoplantar keratoderma-sclerodactyly syndrome (Orphanet:384)
Palmoplantar keratoderma-spastic paralysis syndrome (Orphanet:2201)
Papillon-Lefèvre syndrome (Orphanet:678)
Parana hard-skin syndrome (Orphanet:2812)
Paraplegia - intellectual deficit - hyperkeratosis (Orphanet:2824)
Pilodental dysplasia - refractive errors (Orphanet:2892)
Pityriasis rubra pilaris (Orphanet:2897)
Porokeratosis (Orphanet:79358)
Porokeratosis of Mibelli (Orphanet:735)
Porokeratosis plantaris palmaris et disseminata (Orphanet:737)
Pretibial dystrophic epidermolysis bullosa (Orphanet:79410)
Primary cutaneous lymphoma (Orphanet:542)
Progressive symmetric erythrokeratodermia (Orphanet:316)
Prolidase deficiency (Orphanet:742)
Proteus syndrome (Orphanet:744)
Punctate palmoplantar keratoderma type 1 (Orphanet:79501)
Ramon syndrome (Orphanet:3019)
Reactive arthritis (Orphanet:29207)
Recessive X-linked ichthyosis (Orphanet:461)
Rombo syndrome (Orphanet:3110)
Rothmund-Thomson syndrome (Orphanet:2909)
Rothmund-Thomson syndrome type 1 (Orphanet:221008)
Rothmund-Thomson syndrome type 2 (Orphanet:221016)
SINGLETON-MERTEN SYNDROME 2 (OMIM:616298)
SJOGREN-LARSSON-LIKE ICHTHYOSIS WITHOUT CNS OR EYE INVOLVEMENT (OMIM:270220)
SRD5A3-CDG (Orphanet:324737)
Schöpf-Schulz-Passarge syndrome (Orphanet:50944)
Scleroderma (Orphanet:801)
Seborrhea-like dermatitis with psoriasiform elements (Orphanet:168606)
Sialidosis type 1 (Orphanet:812)
Sjögren-Larsson syndrome (Orphanet:816)
Sparse hair - short stature - skin anomalies (Orphanet:79132)
Sterile multifocal osteomyelitis with periostitis and pustulosis (Orphanet:210115)
Stern-Lubinsky-Durrie syndrome (Orphanet:3194)
Stuccokeratosis (Orphanet:830)
Superficial epidermolytic ichthyosis (Orphanet:455)
Superficial pemphigus (Orphanet:46485)
Sweet syndrome (Orphanet:3243)
Syndromic X-linked ichthyosis (Orphanet:281090)
Systemic sclerosis (Orphanet:90291)
Sézary syndrome (Orphanet:3162)
Thumb deformity - alopecia - pigmentation anomaly (Orphanet:2251)
Transgrediens et progrediens palmoplantar keratoderma (Orphanet:495)
Tricho-oculo-dermo-vertebral syndrome (Orphanet:3354)
Tricho-odonto-onychial dysplasia (Orphanet:3355)
Trichodermodysplasia - dental alterations (Orphanet:3353)
Triple A syndrome (Orphanet:869)
Tyrosinemia type 2 (Orphanet:28378)
Ulerythema ophryogenesis (Orphanet:3406)
Van den Bosch syndrome (Orphanet:3417)
Werner syndrome (Orphanet:902)
Wolman disease (Orphanet:75233)
Woolly hair - hypotrichosis - everted lower lip - outstanding ears (Orphanet:1409)
Woolly hair-palmoplantar keratoderma-dilated cardiomyopathy syndrome (Orphanet:65282)
X-linked dominant chondrodysplasia, Chassaing-Lacombe type (Orphanet:163966)
Xeroderma pigmentosum (Orphanet:910)
Zlotogora-Ogur syndrome (Orphanet:3253)
Zunich-Kaye syndrome (Orphanet:3474)