Hyperkeratosis
Symptom Information:
Symptom ID: | HPO:0000962 | |||||||||||||||||||||||||||||||||
Synonyms: |
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Quality: | ||||||||||||||||||||||||||||||||||
Cross references: |
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Is a (Direct Parents): |
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Is a (Whole tree): |
HPO:
All(HPO:0000001) Phenotypic abnormality(HPO:0000118) Abnormality of the integument(HPO:0001574) Abnormality of the skin(HPO:0000951) Generalized abnormality of skin(HPO:0011354) Abnormality of skin morphology(HPO:0011121) Thickened skin(HPO:0001072) Epidermal thickening(HPO:0011368) Hyperkeratosis(HPO:0000962) MedDRA: Skin and subcutaneous tissue disorders(MedDRA:10040785) Cornification and dystrophic skin disorders(MedDRA:10011063) Hyperkeratoses(MedDRA:10020648) Hyperkeratosis(HPO:0000962) |
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Database Frequency: | 216 / 7739 | |||||||||||||||||||||||||||||||||
Resource: |
All diseases associated with this symptom:
ALACRIMA, ACHALASIA, AND MENTAL RETARDATION SYNDROME | (OMIM:615510) |
ANGIOMA SERPIGINOSUM, AUTOSOMAL DOMINANT | (OMIM:106050) |
ANGIOMA SERPIGINOSUM, X-LINKED | (OMIM:300652) |
Acanthosis nigricans | (Orphanet:924) |
Acquired ichthyosis | (Orphanet:454) |
Acro-osteolysis-keloid-like lesions-premature aging syndrome | (Orphanet:363665) |
Acro-oto-ocular syndrome | (Orphanet:2980) |
Acrokeratoelastoidosis of Costa | (Orphanet:38) |
Acrokeratosis verruciformis of Hopf | (Orphanet:79151) |
Acromelanosis | (Orphanet:39) |
Alopecia - contractures - dwarfism - intellectual deficit | (Orphanet:1005) |
Alpha-N-acetylgalactosaminidase deficiency type 1 | (Orphanet:79279) |
Alpha-N-acetylgalactosaminidase deficiency type 2 | (Orphanet:79280) |
Alström syndrome | (Orphanet:64) |
Amelo-onycho-hypohidrotic syndrome | (Orphanet:1028) |
Angioma serpiginosum | (Orphanet:95429) |
Ankyloblepharon - ectodermal defects - cleft lip/palate | (Orphanet:1071) |
Ankylosing vertebral hyperostosis with tylosis | (Orphanet:2206) |
Arthrogryposis - hyperkeratosis, lethal form | (Orphanet:1485) |
Autosomal dominant Charcot-Marie-Tooth disease type 2B | (Orphanet:99936) |
Autosomal dominant palmoplantar keratoderma and congenital alopecia | (Orphanet:1010) |
Autosomal recessive epidermolysis bullosa simplex | (Orphanet:89838) |
Autosomal recessive palmoplantar keratoderma and congenital alopecia | (Orphanet:1366) |
BRESEK syndrome | (Orphanet:85284) |
CARDIOFACIOCUTANEOUS SYNDROME 1 | (OMIM:115150) |
CEDNIK syndrome | (Orphanet:66631) |
CHILD syndrome | (Orphanet:139) |
Cardiofaciocutaneous syndrome | (Orphanet:1340) |
Cardiomyopathy, dilated, with woolly hair, keratoderma, and toothagenesis | (OMIM:615821) |
Chronic mucocutaneous candidiasis | (Orphanet:1334) |
Classical mycosis fungoides | (Orphanet:2584) |
Cobb syndrome | (Orphanet:53721) |
Congenital ichthyosis - intellectual deficit - spastic quadriplegia | (Orphanet:352333) |
Congenital non-bullous ichthyosiform erythroderma | (Orphanet:79394) |
Congenital reticular ichthyosiform erythroderma | (Orphanet:281190) |
Costello syndrome | (Orphanet:3071) |
Cowden syndrome | (Orphanet:201) |
Craniosynostosis - anal anomalies - porokeratosis | (Orphanet:85199) |
Cutaneous lupus erythematosus | (Orphanet:535) |
Cutis gyrata - acanthosis nigricans - craniosynostosis | (Orphanet:1555) |
Darier disease | (Orphanet:218) |
Dermatoleukodystrophy | (Orphanet:1659) |
Diffuse palmoplantar keratoderma-acrocyanosis syndrome | (Orphanet:86918) |
Disseminated superficial actinic porokeratosis | (Orphanet:79152) |
Dyskeratosis congenita | (Orphanet:1775) |
ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME | (OMIM:616029) |
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME3 | (OMIM:604292) |
EEC syndrome | (Orphanet:1896) |
EPIDERMOLYSIS BULLOSA, NONSPECIFIC, AUTOSOMAL RECESSIVE | (OMIM:615028) |
Ectodermal dysplasia - blindness | (Orphanet:1806) |
Ectodermal dysplasia - sensorineural deafness | (Orphanet:1883) |
Ectodermal dysplasia syndrome | (Orphanet:79373) |
Ectodermal dysplasia, Berlin type | (Orphanet:1816) |
Ehlers-Danlos syndrome, periodontitis type | (Orphanet:75392) |
Epidermolysis bullosa simplex | (Orphanet:304) |
Epidermolysis bullosa simplex due to plakophilin deficiency | (Orphanet:158668) |
Epidermolysis bullosa simplex with mottled pigmentation | (Orphanet:79397) |
Epidermolysis bullosa simplex, Dowling-Meara type | (Orphanet:79396) |
Epidermolysis bullosa simplex, Ogna type | (Orphanet:79401) |
Epidermolytic ichthyosis | (Orphanet:312) |
Epidermolytic palmoplantar keratoderma | (Orphanet:2199) |
Erythrokeratoderma \"en cocardes\" | (Orphanet:315) |
Erythrokeratodermia - ataxia | (Orphanet:1955) |
Erythrokeratodermia variabilis | (Orphanet:317) |
Exfoliative ichthyosis | (Orphanet:289586) |
Fabry disease | (Orphanet:324) |
Familial benign chronic pemphigus | (Orphanet:2841) |
Familial keratoacanthoma | (Orphanet:493) |
Familial progressive hyperpigmentation | (Orphanet:79146) |
Fetal Gaucher disease | (Orphanet:85212) |
Flynn-Aird syndrome | (Orphanet:2047) |
Focal palmoplantar and gingival keratoderma | (Orphanet:2200) |
Fucosidosis | (Orphanet:349) |
Generalized epidermolysis bullosa simplex, non-Dowling-Meara type | (Orphanet:79399) |
Gorlin syndrome | (Orphanet:377) |
Graham Little-Piccardi-Lassueur syndrome | (Orphanet:505) |
HYPERTRICHOSIS, HYPERKERATOSIS, MENTAL RETARDATION, AND DISTINCTIVEFACIAL FEATURES | (OMIM:609943) |
Haim-Munk syndrome | (Orphanet:2342) |
Harlequin ichthyosis | (Orphanet:457) |
Hereditary acrokeratotic poikiloderma, Weary type | (Orphanet:2907) |
Hereditary mucoepithelial dysplasia | (Orphanet:1839) |
Hereditary painful callosities | (Orphanet:79141) |
Hereditary palmoplantar keratoderma | (Orphanet:79357) |
Hereditary palmoplantar keratoderma, Gamborg-Nielsen type | (Orphanet:86923) |
Hermansky-Pudlak syndrome | (Orphanet:79430) |
Hidrotic ectodermal dysplasia | (Orphanet:189) |
Hidrotic ectodermal dysplasia, Halal type | (Orphanet:1809) |
Hurler-Scheie syndrome | (Orphanet:93476) |
Hyperkeratosis lenticularis perstans | (Orphanet:409) |
Hyperkeratosis-hyperpigmentation syndrome | (Orphanet:1336) |
Hypohidrotic ectodermal dysplasia | (Orphanet:238468) |
Hypopigmentation-punctate palmoplantar keratoderma syndrome | (Orphanet:324561) |
Hypotrichosis simplex | (Orphanet:55654) |
Hypotrichosis with juvenile macular degeneration | (Orphanet:1573) |
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2 | (OMIM:242100) |
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 3 | (OMIM:606545) |
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 5 | (OMIM:604777) |
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 6 | (OMIM:612281) |
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 8 | (OMIM:613943) |
Ichthyosis follicularis - alopecia - photophobia | (Orphanet:2273) |
Ichthyosis hystrix of Curth-Macklin | (Orphanet:79503) |
Incontinentia pigmenti | (Orphanet:464) |
Insulin-resistance syndrome type A | (Orphanet:2297) |
Intellectual deficit, X-linked - seizures - psoriasis | (Orphanet:3052) |
Isolated punctate palmoplantar keratoderma | (Orphanet:2338) |
Juvenile idiopathic arthritis | (Orphanet:92) |
KERATITIS-ICHTHYOSIS-DEAFNESS SYNDROME, AUTOSOMAL DOMINANT | (OMIM:148210) |
KID syndrome | (Orphanet:477) |
Keratoderma hereditarium mutilans | (Orphanet:494) |
Keratoderma hereditarium mutilans with ichthyosis | (Orphanet:79395) |
Keratolytic winter erythema | (Orphanet:50943) |
Keratosis follicularis - dwarfism - cerebral atrophy | (Orphanet:2339) |
Keratosis follicularis spinulosa decalvans | (Orphanet:2340) |
Keratosis linearis-ichthyosis congenita-sclerosing keratoderma syndrome | (Orphanet:281201) |
Keratosis palmaris et plantaris - clinodactyly | (Orphanet:86919) |
Keratosis palmoplantaris striata | (Orphanet:50942) |
Keratosis pilaris atrophicans | (Orphanet:498) |
Kindler syndrome | (Orphanet:2908) |
Knuckle pads-leuconychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome | (Orphanet:2698) |
LEOPARD SYNDROME 3 | (OMIM:613707) |
Lamellar ichthyosis | (Orphanet:313) |
Leprechaunism | (Orphanet:508) |
Lethal restrictive dermopathy | (Orphanet:1662) |
Leukoencephalopathy-palmoplantar keratoderma syndrome | (Orphanet:2386) |
Lichen planopilaris | (Orphanet:525) |
Linear verrucous nevus syndrome | (Orphanet:2611) |
Lipodystrophy due to peptidic growth factors deficiency | (Orphanet:1979) |
Lipoid proteinosis | (Orphanet:530) |
Localized epidermolysis bullosa simplex | (Orphanet:79400) |
MICROCEPHALIC OSTEODYSPLASTIC PRIMORDIAL DWARFISM, TYPE I | (OMIM:210710) |
MPDU1-CDG | (Orphanet:79323) |
Mal de Meleda | (Orphanet:87503) |
Microcephalic osteodysplastic primordial dwarfism types 1 and 3 | (Orphanet:2636) |
Microcornea - glaucoma - absent frontal sinuses | (Orphanet:2536) |
Monilethrix | (Orphanet:573) |
Moynahan syndrome | (Orphanet:2574) |
Mucolipidosis type 4 | (Orphanet:578) |
Mutilating palmoplantar keratoderma with periorificial keratotic plaques | (Orphanet:659) |
NEUROPATHY, HEREDITARY SENSORY, TYPE IF | (OMIM:615632) |
NOONAN SYNDROME 6 | (OMIM:613224) |
NOONAN SYNDROME 8 | (OMIM:615355) |
Naegeli-Franceschetti-Jadassohn syndrome | (Orphanet:69087) |
Naxos disease | (Orphanet:34217) |
Non-epidermolytic palmoplantar keratoderma | (Orphanet:2337) |
Oculocutaneous albinism type 1A | (Orphanet:79431) |
Oculodentodigital dysplasia | (Orphanet:2710) |
Odonto-onycho dysplasia - alopecia | (Orphanet:2722) |
Odonto-onycho-dermal dysplasia | (Orphanet:2721) |
PALMOPLANTAR KERATODERMA, PUNCTATE TYPE IB | (OMIM:614936) |
PAPILLOMATOSIS, CONFLUENT AND RETICULATED | (OMIM:167900) |
PSORIASIS 2 | (OMIM:602723) |
PTEN hamartoma tumor syndrome | (Orphanet:306498) |
Pachydermoperiostosis | (Orphanet:2796) |
Pachyonychia congenita | (Orphanet:2309) |
Palmoplantar keratoderma - XX sex reversal - predisposition to squamous cell carcinoma | (Orphanet:85112) |
Palmoplantar keratoderma, Nagashima type | (Orphanet:140966) |
Palmoplantar keratoderma-deafness syndrome | (Orphanet:2202) |
Palmoplantar keratoderma-esophageal carcinoma syndrome | (Orphanet:2198) |
Palmoplantar keratoderma-sclerodactyly syndrome | (Orphanet:384) |
Palmoplantar keratoderma-spastic paralysis syndrome | (Orphanet:2201) |
Papillon-Lefèvre syndrome | (Orphanet:678) |
Parana hard-skin syndrome | (Orphanet:2812) |
Paraplegia - intellectual deficit - hyperkeratosis | (Orphanet:2824) |
Pilodental dysplasia - refractive errors | (Orphanet:2892) |
Pityriasis rubra pilaris | (Orphanet:2897) |
Porokeratosis | (Orphanet:79358) |
Porokeratosis of Mibelli | (Orphanet:735) |
Porokeratosis plantaris palmaris et disseminata | (Orphanet:737) |
Pretibial dystrophic epidermolysis bullosa | (Orphanet:79410) |
Primary cutaneous lymphoma | (Orphanet:542) |
Progressive symmetric erythrokeratodermia | (Orphanet:316) |
Prolidase deficiency | (Orphanet:742) |
Proteus syndrome | (Orphanet:744) |
Punctate palmoplantar keratoderma type 1 | (Orphanet:79501) |
Ramon syndrome | (Orphanet:3019) |
Reactive arthritis | (Orphanet:29207) |
Recessive X-linked ichthyosis | (Orphanet:461) |
Rombo syndrome | (Orphanet:3110) |
Rothmund-Thomson syndrome | (Orphanet:2909) |
Rothmund-Thomson syndrome type 1 | (Orphanet:221008) |
Rothmund-Thomson syndrome type 2 | (Orphanet:221016) |
SINGLETON-MERTEN SYNDROME 2 | (OMIM:616298) |
SJOGREN-LARSSON-LIKE ICHTHYOSIS WITHOUT CNS OR EYE INVOLVEMENT | (OMIM:270220) |
SRD5A3-CDG | (Orphanet:324737) |
Schöpf-Schulz-Passarge syndrome | (Orphanet:50944) |
Scleroderma | (Orphanet:801) |
Seborrhea-like dermatitis with psoriasiform elements | (Orphanet:168606) |
Sialidosis type 1 | (Orphanet:812) |
Sjögren-Larsson syndrome | (Orphanet:816) |
Sparse hair - short stature - skin anomalies | (Orphanet:79132) |
Sterile multifocal osteomyelitis with periostitis and pustulosis | (Orphanet:210115) |
Stern-Lubinsky-Durrie syndrome | (Orphanet:3194) |
Stuccokeratosis | (Orphanet:830) |
Superficial epidermolytic ichthyosis | (Orphanet:455) |
Superficial pemphigus | (Orphanet:46485) |
Sweet syndrome | (Orphanet:3243) |
Syndromic X-linked ichthyosis | (Orphanet:281090) |
Systemic sclerosis | (Orphanet:90291) |
Sézary syndrome | (Orphanet:3162) |
Thumb deformity - alopecia - pigmentation anomaly | (Orphanet:2251) |
Transgrediens et progrediens palmoplantar keratoderma | (Orphanet:495) |
Tricho-oculo-dermo-vertebral syndrome | (Orphanet:3354) |
Tricho-odonto-onychial dysplasia | (Orphanet:3355) |
Trichodermodysplasia - dental alterations | (Orphanet:3353) |
Triple A syndrome | (Orphanet:869) |
Tyrosinemia type 2 | (Orphanet:28378) |
Ulerythema ophryogenesis | (Orphanet:3406) |
Van den Bosch syndrome | (Orphanet:3417) |
Werner syndrome | (Orphanet:902) |
Wolman disease | (Orphanet:75233) |
Woolly hair - hypotrichosis - everted lower lip - outstanding ears | (Orphanet:1409) |
Woolly hair-palmoplantar keratoderma-dilated cardiomyopathy syndrome | (Orphanet:65282) |
X-linked dominant chondrodysplasia, Chassaing-Lacombe type | (Orphanet:163966) |
Xeroderma pigmentosum | (Orphanet:910) |
Zlotogora-Ogur syndrome | (Orphanet:3253) |
Zunich-Kaye syndrome | (Orphanet:3474) |