Odonto-onycho-dermal dysplasia
General Information (adopted from Orphanet):
Synonyms, Signs: |
OODD |
Number of Symptoms | 53 |
OrphanetNr: | 2721 |
OMIM Id: |
257980
|
ICD-10: |
Q82.4 |
UMLs: |
C1275074 |
MeSH: |
C537742 |
MedDRA: |
|
Snomed: |
403762003 |
Prevalence, inheritance and age of onset:
Prevalence: | < 15 cases [Orphanet] |
Inheritance: |
Autosomal recessive [Orphanet] |
Age of onset: |
Childhood [Orphanet] |
Disease classification (adopted from Orphanet):
Parent Diseases: |
Autosomal recessive disease with diffuse palmoplantar keratoderma as a major feature
-Rare genetic disease -Rare skin disease Ectodermal dysplasia syndrome -Rare developmental defect during embryogenesis -Rare genetic disease -Rare skin disease Genetic malformation syndrome with odontal and/or periodontal component -Rare genetic disease Malformation syndrome with odontal and/or periodontal component -Rare developmental defect during embryogenesis -Rare odontologic disease |
Symptom Information:
|
(HPO:0000613) | Photophobia | Frequent [Orphanet] 3/10 [HPO] | 19559398 | IBIS | 158 / 7739 | |
|
(HPO:0100533) | Inflammatory abnormality of the eye | Frequent [Orphanet] | 70 / 7739 | |||
|
(HPO:0000498) | Blepharitis | Frequent [Orphanet] | 27 / 7739 | |||
|
(HPO:0001357) | Plagiocephaly | Very frequent [Orphanet] | 106 / 7739 | |||
|
(HPO:0008070) | Sparse hair | 94 / 7739 | ||||
|
(HPO:0010719) | Abnormality of hair texture | Very frequent [Orphanet] | 24 / 7739 | |||
|
(HPO:0011359) | Dry hair | 16 / 7739 | ||||
|
(HPO:0100840) | Aplasia/Hypoplasia of the eyebrow | Frequent [Orphanet] | 117 / 7739 | |||
|
(HPO:0000535) | Sparse and thin eyebrow | 7/10 [HPO] | 19559398 | IBIS | 76 / 7739 | |
|
(HPO:0001006) | Hypotrichosis | Very frequent [Orphanet] | 219 / 7739 | |||
|
(HPO:0002231) | Sparse body hair | 5/8 [HPO] | 19559398 | IBIS | 9 / 7739 | |
|
(HPO:0002225) | Sparse pubic hair | Very frequent [Orphanet] | 76 / 7739 | |||
|
(HPO:0002209) | Sparse scalp hair | 6/10 [HPO] | 19559398 | IBIS | 59 / 7739 | |
|
(HPO:0008391) | Dystrophic fingernails | 6 / 7739 | ||||
|
(HPO:0001805) | Thick nail | Very frequent [Orphanet] | 96 / 7739 | |||
|
(HPO:0001798) | Anonychia | 28 / 7739 | ||||
|
(HPO:0002164) | Nail dysplasia | 82 / 7739 | ||||
|
(HPO:0001810) | Dystrophic toenail | 7/11 [HPO] | 19559398 | IBIS | 9 / 7739 | |
|
(HPO:0000975) | Hyperhidrosis | 2/10 [HPO] | 19559398 | IBIS | 64 / 7739 | |
|
(HPO:0007410) | Palmoplantar hyperhidrosis | 6 / 7739 | ||||
|
(HPO:0000966) | Hypohidrosis | 3/10 [HPO] | 19559398 | IBIS | 41 / 7739 | |
|
(HPO:0000689) | Dental malocclusion | Very frequent [Orphanet] | 114 / 7739 | |||
|
(HPO:0000163) | Abnormality of the oral cavity | Frequent [Orphanet] | 37 / 7739 | |||
|
(HPO:0006349) | Agenesis of permanent teeth | 10/10 [HPO] | 19559398 | IBIS | 13 / 7739 | |
|
(HPO:0009804) | Reduced number of teeth | Very frequent [Orphanet] | 137 / 7739 | |||
|
(HPO:0006482) | Abnormality of dental morphology | Very frequent [Orphanet] | 81 / 7739 | |||
|
(HPO:0006481) | Abnormality of primary teeth | 5/11 [HPO] | 19559398 | IBIS | 2 / 7739 | |
|
(HPO:0000668) | Hypodontia | 81 / 7739 | ||||
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(HPO:0010298) | Smooth tongue | 2 / 7739 | ||||
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(HPO:0000956) | Acanthosis nigricans | Frequent [Orphanet] | 54 / 7739 | |||
|
(HPO:0000992) | Cutaneous photosensitivity | Frequent [Orphanet] | 75 / 7739 | |||
|
(HPO:0000958) | Dry skin | 6/10 [HPO] | 19559398 | IBIS | 152 / 7739 | |
|
(HPO:0005595) | Generalized hyperkeratosis | 14 / 7739 | ||||
|
(HPO:0000962) | Hyperkeratosis | Very frequent [Orphanet] | 216 / 7739 | |||
|
(HPO:0007556) | Plantar hyperkeratosis | 3/10 [HPO] | 19559398 | IBIS | 8 / 7739 | |
|
(HPO:0010783) | Erythema | Very frequent [Orphanet] | 138 / 7739 | |||
|
(MedDRA:10033551) | Palmar erythema | 2 / 7739 | ||||
|
(HPO:0008069) | Neoplasm of the skin | Occasional [Orphanet] | 84 / 7739 | |||
|
(HPO:0000988) | Skin rash | Very frequent [Orphanet] | 98 / 7739 | |||
|
(HPO:0001025) | Urticaria | Very frequent [Orphanet] | 73 / 7739 | |||
|
(HPO:0100585) | Telangiectasia of the skin | Frequent [Orphanet] | 66 / 7739 | |||
|
(HPO:0000007) | Autosomal recessive inheritance | 2538 / 7739 | ||||
|
(MedDRA:10066295) | Keratosis pilaris | 11 / 7739 | ||||
|
(OMIM) | Acanthosis, mild, in epidermis | 1 / 7739 | ||||
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(OMIM) | Congenital absence of nails (anonychia) | 1 / 7739 | ||||
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(OMIM) | Hair is absent at birth | 1 / 7739 | ||||
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(OMIM) | Hypergranulosis in epidermis | 1 / 7739 | ||||
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(OMIM) | Hyperkeratosis in epidermis | 1 / 7739 | ||||
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(OMIM) | Longitudinal depressions on microscopic examination | 1 / 7739 | ||||
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(OMIM) | Orthokeratosis in epidermis | 1 / 7739 | ||||
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(OMIM) | Reduced filiform papillae | 1 / 7739 | ||||
|
(OMIM) | Reduced fungiform papillae | 1 / 7739 | ||||
|
(OMIM) | Severe hypodontia | 1 / 7739 |
Associated genes:
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
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Additional Information:
Clinical Description OMIM |
In 3 consanguineous Lebanese Muslim Shiite sibships, Fadhil et al. (1983) described an apparently 'new' form of ectodermal dysplasia with dystrophic nails, misshapen teeth, including peg-shaped incisors, and erythematous lesions of face and thickening of the palms and ... |
Molecular genetics OMIM |
In affected members of 3 consanguineous Lebanese Muslim Shiite families with odontoonychodermal dysplasia, Adaimy et al. (2007) found homozygosity for the same nonsense mutation in the WNT10A gene (E233X; 606268.0001). The mutation was predicted to result in a ... |