Nocturnal frontal lobe epilepsy-5 is an autosomal dominant focal epilepsy syndrome characterized by childhood onset of clusters of motor seizures during sleep. Some patients may develop behavioral or psychiatric manifestations and/or intellectual disability. The phenotype is more severe ... Nocturnal frontal lobe epilepsy-5 is an autosomal dominant focal epilepsy syndrome characterized by childhood onset of clusters of motor seizures during sleep. Some patients may develop behavioral or psychiatric manifestations and/or intellectual disability. The phenotype is more severe than observed in other genetic forms of ENFL (summary by Heron et al., 2012). For a general description and a discussion of genetic heterogeneity of ENFL, see ENFL1 (600513).
Derry et al. (2008) reported a family (family B) in which 6 individuals had childhood onset of partial nocturnal seizures associated with psychiatric disorders and cognitive impairment. Age at seizure onset ranged between 1 and 15 years, and ... Derry et al. (2008) reported a family (family B) in which 6 individuals had childhood onset of partial nocturnal seizures associated with psychiatric disorders and cognitive impairment. Age at seizure onset ranged between 1 and 15 years, and all had partial nocturnal seizures. Seizures were typical of frontal lobe epilepsy, with dystonic posturing, prominent vocalization, and hypermotor automatisms. Two also had partial diurnal seizures, and 1 also had rare generalized tonic-clonic seizures. Four patients had refractory seizures and 2 had a history of status epilepticus. Five had a personality/behavioral disorder or depression, and 3 had intellectual disability. One patient, aged 21 years, showed developmental regression; seizure frequency in this patient was between 40 and 60 per night. Derry et al. (2008) excluded linkage to or mutations in several candidate genes, including CHRNA4 (118504), CHRNB2 (118507), and CHRNA2 (118502), all of which encode proteins involved in nicotinic acetylcholine receptors (nAChR). Heron et al. (2012) reported 4 unrelated families with ENFL5, including the family reported by Derry et al. (2008). Affected individuals had a more severe phenotype compared to patients with other genetic forms of ENFL. Those with ENFL5 had an earlier mean age of onset at 6 years of age (compared to 10 years of age in other forms), as well as a significantly higher frequency of psychiatric or behavioral problems, including psychosis, catatonia, and aggression. In addition, 6 individuals from 2 families had varying degrees of intellectual disability.
By whole-exome capture and sequencing of patients from the family with ENFL reported by Derry et al. (2008), Heron et al. (2012) identified a heterozygous mutation in the KCNT1 gene (R928C; 608167.0005). The mutation, which was confirmed by ... By whole-exome capture and sequencing of patients from the family with ENFL reported by Derry et al. (2008), Heron et al. (2012) identified a heterozygous mutation in the KCNT1 gene (R928C; 608167.0005). The mutation, which was confirmed by Sanger sequencing and not identified in multiple control samples, segregated with the disorder. Subsequent analysis of this gene in 108 additional unrelated cases with a similar disorder identified 3 more pathogenic mutations in 3 families (608167.0006-608167.0008).