Ehlers-Danlos syndrome, dermatosparaxis type
General Information (adopted from Orphanet):
Synonyms, Signs: |
EDS VIIC EHLERS-DANLOS SYNDROME, DERMATOSPARAXIS TYPE DERMATOSPARAXIS EDS7C Ehlers-Danlos syndrome type 7C |
Number of Symptoms | 65 |
OrphanetNr: | 1901 |
OMIM Id: |
225410
|
ICD-10: |
Q79.6 |
UMLs: |
C2700425 |
MeSH: |
|
MedDRA: |
|
Snomed: |
55711009 |
Prevalence, inheritance and age of onset:
Prevalence: | 7 cases [Orphanet] |
Inheritance: |
Autosomal recessive [Orphanet] |
Age of onset: |
Neonatal Infancy [Orphanet] |
Disease classification (adopted from Orphanet):
Parent Diseases: |
Ehlers-Danlos syndrome
-Rare developmental defect during embryogenesis -Rare genetic disease -Rare skin disease -Rare systemic or rheumatologic disease |
Symptom Information:
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(HPO:0000494) | Downslanted palpebral fissures | 328 / 7739 | ||||
|
(HPO:0000225) | Gingival bleeding | 28 / 7739 | ||||
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(HPO:0000277) | Abnormality of the mandible | Frequent [Orphanet] | 394 / 7739 | |||
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(HPO:0000286) | Epicanthus | Frequent [Orphanet] | 371 / 7739 | |||
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(HPO:0000212) | Gingival overgrowth | 43 / 7739 | ||||
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(HPO:0001476) | Delayed closure of the anterior fontanelle | 23 / 7739 | ||||
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(HPO:0000260) | Wide anterior fontanel | 55 / 7739 | ||||
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(HPO:0200094) | Frontal open bite | 1 / 7739 | ||||
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(HPO:0012471) | Thick vermilion border | 115 / 7739 | ||||
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(HPO:0100540) | Palpebral edema | 31 / 7739 | ||||
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(HPO:0010749) | Blepharochalasis | 3 / 7739 | ||||
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(HPO:0000347) | Micrognathia | 426 / 7739 | ||||
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(HPO:0000668) | Hypodontia | 81 / 7739 | ||||
|
(HPO:0005280) | Depressed nasal bridge | Frequent [Orphanet] | 381 / 7739 | |||
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(HPO:0011073) | Abnormality of dental color | 24 / 7739 | ||||
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(HPO:0000232) | Everted lower lip vermilion | 90 / 7739 | ||||
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(HPO:0000222) | Gingival hyperkeratosis | 2 / 7739 | ||||
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(HPO:0000316) | Hypertelorism | Frequent [Orphanet] | 644 / 7739 | |||
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(HPO:0006344) | Abnormality of primary molar morphology | 1 / 7739 | ||||
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(HPO:0005332) | Recurrent mandibular subluxations | 1 / 7739 | ||||
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(HPO:0000592) | Blue sclerae | 85 / 7739 | ||||
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(HPO:0000545) | Myopia | 286 / 7739 | ||||
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(HPO:0002167) | Neurological speech impairment | Very frequent [Orphanet] | 308 / 7739 | |||
|
(HPO:0001270) | Motor delay | 322 / 7739 | ||||
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(HPO:0004349) | Reduced bone mineral density | Very frequent [Orphanet] | 165 / 7739 | |||
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(HPO:0001373) | Joint dislocation | Very frequent [Orphanet] | 59 / 7739 | |||
|
(HPO:0002650) | Scoliosis | Frequent [Orphanet] | 705 / 7739 | |||
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(HPO:0001387) | Joint stiffness | Very frequent [Orphanet] | 322 / 7739 | |||
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(HPO:0000938) | Osteopenia | 138 / 7739 | ||||
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(HPO:0001382) | Joint hypermobility | Very frequent [Orphanet] | 231 / 7739 | |||
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(HPO:0002983) | Micromelia | 130 / 7739 | ||||
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(HPO:0001385) | Hip dysplasia | Very frequent [Orphanet] | 242 / 7739 | |||
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(HPO:0001388) | Joint laxity | 117 / 7739 | ||||
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(HPO:0001831) | Short toe | 52 / 7739 | ||||
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(HPO:0009803) | Short phalanx of finger | 79 / 7739 | ||||
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(HPO:0001622) | Premature birth | 100 / 7739 | ||||
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(HPO:0001788) | Premature rupture of membranes | 5 / 7739 | ||||
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(HPO:0004299) | Hernia of the abdominal wall | Very frequent [Orphanet] | 176 / 7739 | |||
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(HPO:0001537) | Umbilical hernia | Very frequent [Orphanet] | 206 / 7739 | |||
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(HPO:0002577) | Abnormality of the stomach | Very frequent [Orphanet] | 84 / 7739 | |||
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(HPO:0000023) | Inguinal hernia | 181 / 7739 | ||||
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(HPO:0004322) | Short stature | Very frequent [Orphanet] | 1232 / 7739 | |||
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(HPO:0000963) | Thin skin | Very frequent [Orphanet] | 96 / 7739 | |||
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(HPO:0100678) | Premature skin wrinkling | Very frequent [Orphanet] | 25 / 7739 | |||
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(HPO:0000951) | Abnormality of the skin | Very frequent [Orphanet] | 147 / 7739 | |||
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(HPO:0001007) | Hirsutism | 91 / 7739 | ||||
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(HPO:0000987) | Atypical scarring of skin | Very frequent [Orphanet] | 58 / 7739 | |||
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(HPO:0000978) | Bruising susceptibility | 123 / 7739 | ||||
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(HPO:0001027) | Soft, doughy skin | 3 / 7739 | ||||
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(HPO:0001030) | Fragile skin | 25 / 7739 | ||||
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(HPO:0000974) | Hyperextensible skin | Very frequent [Orphanet] | 59 / 7739 | |||
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(HPO:0001582) | Redundant skin | 51 / 7739 | ||||
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(HPO:0003010) | Prolonged bleeding time | Very frequent [Orphanet] | 88 / 7739 | |||
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(HPO:0004876) | Spontaneous neonatal pneumothorax | 2 / 7739 | ||||
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(HPO:0001252) | Muscular hypotonia | Very frequent [Orphanet] | 990 / 7739 | |||
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(OMIM) | Joint laxity, marked | 1 / 7739 | ||||
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(OMIM) | Prominent lips | 7 / 7739 | ||||
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(MedDRA:10070939) | Wound healing normal | 5 / 7739 | ||||
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(OMIM) | Short limbs | 17 / 7739 | ||||
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(HPO:0000007) | Autosomal recessive inheritance | 2538 / 7739 | ||||
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(OMIM) | Collagen fibrils show hieroglyphic pattern | 1 / 7739 | ||||
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(OMIM) | Deciduous molars show abnormal morphology | 1 / 7739 | ||||
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(OMIM) | Deciduous dentition shows enamel attrition | 1 / 7739 | ||||
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(OMIM) | Excessive buccal mucosa | 1 / 7739 | ||||
|
(OMIM) | Hirsutism, mild | 2 / 7739 |
Associated genes:
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
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Additional Information:
Description: (OMIM) |
Dermatosparaxis (meaning 'tearing of skin') is an autosomal recessive disorder of connective tissue resulting from deficiency of procollagen peptidase, an enzyme that aids in the processing of type I procollagen. The disorder and the responsible biochemical defect was ... |
Clinical Description OMIM |
Lichtenstein et al. (1973) reported 2 patients with severe joint hyperextensibility and mild stretchability and bruisability of the skin similar to that seen in dermatosparaxis in cattle. Other clinical features in the patients included short stature, epicanthal folds, ... |
Molecular genetics OMIM |
Colige et al. (1999) identified mutations in the ADAMTS2 gene causing EDS type VIIC in the 6 known affected individuals and also in 1 strain of dermatosparactic calf. Five of the individuals with EDS type VIIC were homozygous ... |