Symptom Information: Sort according to HPO 

1
 (HPO:0001387) Joint stiffness Very frequent [Orphanet] 322 / 7739
2
 (HPO:0001252) Muscular hypotonia Very frequent [Orphanet] 990 / 7739
3
 (HPO:0100678) Premature skin wrinkling Very frequent [Orphanet] 25 / 7739
4
 (HPO:0000951) Abnormality of the skin Very frequent [Orphanet] 147 / 7739
5
 (HPO:0000938) Osteopenia 138 / 7739
6
 (HPO:0001537) Umbilical hernia Very frequent [Orphanet] 206 / 7739
7
 (HPO:0001373) Joint dislocation Very frequent [Orphanet] 59 / 7739
8
 (HPO:0003010) Prolonged bleeding time Very frequent [Orphanet] 88 / 7739
9
 (HPO:0000974) Hyperextensible skin Very frequent [Orphanet] 59 / 7739
10
 (HPO:0000023) Inguinal hernia 181 / 7739
11
 (HPO:0000316) Hypertelorism Frequent [Orphanet] 644 / 7739
12
 (HPO:0000347) Micrognathia 426 / 7739
13
 (HPO:0004322) Short stature Very frequent [Orphanet] 1232 / 7739
14
 (HPO:0000963) Thin skin Very frequent [Orphanet] 96 / 7739
15
 (HPO:0000286) Epicanthus Frequent [Orphanet] 371 / 7739
16
 (HPO:0004299) Hernia of the abdominal wall Very frequent [Orphanet] 176 / 7739
17
 (HPO:0001382) Joint hypermobility Very frequent [Orphanet] 231 / 7739
18
 (HPO:0001388) Joint laxity 117 / 7739
19
 (HPO:0005280) Depressed nasal bridge Frequent [Orphanet] 381 / 7739
20
 (HPO:0002650) Scoliosis Frequent [Orphanet] 705 / 7739
21
 (HPO:0001385) Hip dysplasia Very frequent [Orphanet] 242 / 7739
22
 (HPO:0000212) Gingival overgrowth 43 / 7739
23
 (HPO:0000222) Gingival hyperkeratosis 2 / 7739
24
 (HPO:0000225) Gingival bleeding 28 / 7739
25
 (HPO:0000232) Everted lower lip vermilion 90 / 7739
26
 (HPO:0000260) Wide anterior fontanel 55 / 7739
27
 (HPO:0001476) Delayed closure of the anterior fontanelle 23 / 7739
28
 (HPO:0000494) Downslanted palpebral fissures 328 / 7739
29
 (HPO:0000545) Myopia 286 / 7739
30
 (HPO:0000592) Blue sclerae 85 / 7739
31
 (HPO:0000668) Hypodontia 81 / 7739
32
 (HPO:0000978) Bruising susceptibility 123 / 7739
33
 (HPO:0000987) Atypical scarring of skin Very frequent [Orphanet] 58 / 7739
34
 (HPO:0001007) Hirsutism 91 / 7739
35
 (HPO:0001027) Soft, doughy skin 3 / 7739
36
 (HPO:0001030) Fragile skin 25 / 7739
37
 (HPO:0001270) Motor delay 322 / 7739
38
 (HPO:0001582) Redundant skin 51 / 7739
39
 (HPO:0001622) Premature birth 100 / 7739
40
 (HPO:0001788) Premature rupture of membranes 5 / 7739
41
 (HPO:0001831) Short toe 52 / 7739
42
 (HPO:0002167) Neurological speech impairment Very frequent [Orphanet] 308 / 7739
43
 (HPO:0002983) Micromelia 130 / 7739
44
 (HPO:0004349) Reduced bone mineral density Very frequent [Orphanet] 165 / 7739
45
 (HPO:0004876) Spontaneous neonatal pneumothorax 2 / 7739
46
 (HPO:0005332) Recurrent mandibular subluxations 1 / 7739
47
 (HPO:0006344) Abnormality of primary molar morphology 1 / 7739
48
 (HPO:0009803) Short phalanx of finger 79 / 7739
49
 (HPO:0010749) Blepharochalasis 3 / 7739
50
 (HPO:0200094) Frontal open bite 1 / 7739
51
 (HPO:0100540) Palpebral edema 31 / 7739
52
 (OMIM) Excessive buccal mucosa 1 / 7739
53
 (OMIM) Prominent lips 7 / 7739
54
 (HPO:0011073) Abnormality of dental color 24 / 7739
55
 (OMIM) Deciduous molars show abnormal morphology 1 / 7739
56
 (OMIM) Deciduous dentition shows enamel attrition 1 / 7739
57
 (OMIM) Joint laxity, marked 1 / 7739
58
 (OMIM) Short limbs 17 / 7739
59
 (MedDRA:10070939) Wound healing normal 5 / 7739
60
 (OMIM) Collagen fibrils show hieroglyphic pattern 1 / 7739
61
 (OMIM) Hirsutism, mild 2 / 7739
62
 (HPO:0002577) Abnormality of the stomach Very frequent [Orphanet] 84 / 7739
63
 (HPO:0000277) Abnormality of the mandible Frequent [Orphanet] 394 / 7739
64
 (HPO:0000007) Autosomal recessive inheritance 2538 / 7739
65
 (HPO:0012471) Thick vermilion border 115 / 7739