Hyporeflexia

Symptom Information:

Symptom ID: HPO:0001265
Synonyms:
Decreased deep tendon reflexes [HPO:0001265]
Decreased tendon reflexes [HPO:0001265]
Depressed tendon reflexes [HPO:0001265]
Diminished deep tendon reflexes [HPO:0001265]
Absent reflex (finding) [Orphanet:43350]
Hyporeflexia (finding) [Orphanet:43350]
Hyporeflexia [Orphanet:43350]
Absent reflex [Orphanet:43350]
Decreased deep tendon reflexes [OMIM:Decreased deep tendon reflexes]
Depressed tendon reflexes [OMIM:Depressed tendon reflexes]
Hyporeflexia [OMIM:Hyporeflexia]
Areflexia/hyporeflexia [Orphanet:43350]
Areflexia [Orphanet:43350]
Areflexia [MedDRA:10003084]
Absent ankle jerk [MedDRA:10003084]
Absent ankle jerks [MedDRA:10003084]
Absent reflex [MedDRA:10003084]
Absent reflexes [MedDRA:10003084]
PSR/ASR loss [MedDRA:10003084]
Reflex loss [MedDRA:10003084]
Reflexes absent [MedDRA:10003084]
Loss of gag reflex [MedDRA:10003084]
Patellar tendon reflex absent [MedDRA:10003084]
Tendon reflex absent [MedDRA:10003084]
Cremasteric reflex absent [MedDRA:10003084]
Hyporeflexia [MedDRA:10021089]
Achilles tendon reflex decreased [MedDRA:10021089]
Diminished reflexes [MedDRA:10021089]
Lower extremities deep decreased reflex test [MedDRA:10021089]
Patellar tendon reflex decreased [MedDRA:10021089]
Reflexes decreased [MedDRA:10021089]
Reflexes tendon decreased absent [MedDRA:10021089]
Tendon reflex decreased [MedDRA:10021089]
Retching reflex decreased [MedDRA:10021089]
Poor swallowing reflex [MedDRA:10021089]
Absent ankle jerks [OMIM:Absent ankle jerks]
Absent reflexes [OMIM:Absent reflexes]
Areflexia (30%) [OMIM:Areflexia (30%)]
Areflexia (common) [OMIM:Areflexia (common)]
Areflexia (in some patients) [OMIM:Areflexia (in some patients)]
Areflexia (in some) [OMIM:Areflexia (in some)]
Hyporeflexia (90%) [OMIM:Hyporeflexia (90%)]
Hyporeflexia (early) [OMIM:Hyporeflexia (early)]
Hyporeflexia (in some patients) [OMIM:Hyporeflexia (in some patients)]
Hyporeflexia (in some) [OMIM:Hyporeflexia (in some)]
Hyporeflexia (later in disease course) [OMIM:Hyporeflexia (later in disease course)]
Hyporeflexia (less common) [OMIM:Hyporeflexia (less common)]
Hyporeflexia (occurs later) [OMIM:Hyporeflexia (occurs later)]
Hyporeflexia (rare) [OMIM:Hyporeflexia (rare)]
Hyporeflexia/areflexia [OMIM:Hyporeflexia/areflexia]
Quality:
Cross references:
HPO:0001315 "Reduced tendon reflexes" [Orphanet:43350]
HPO:0001284 "Areflexia" [Orphanet:43350]
Orphanet:43350 "Areflexia/hyporeflexia" [Orphanet:43350]
OMIM: "Decreased deep tendon reflexes" [OMIM:Decreased deep tendon reflexes]
OMIM: "Depressed tendon reflexes" [OMIM:Depressed tendon reflexes]
OMIM: "Hyporeflexia" [OMIM:Hyporeflexia]
OMIM: "Absent ankle jerks" [OMIM:Absent ankle jerks]
OMIM: "Absent reflexes" [OMIM:Absent reflexes]
OMIM: "Areflexia (30%)" [OMIM:Areflexia (30%)]
OMIM: "Areflexia (common)" [OMIM:Areflexia (common)]
OMIM: "Areflexia (in some patients)" [OMIM:Areflexia (in some patients)]
OMIM: "Areflexia (in some)" [OMIM:Areflexia (in some)]
OMIM: "Hyporeflexia (90%)" [OMIM:Hyporeflexia (90%)]
OMIM: "Hyporeflexia (early)" [OMIM:Hyporeflexia (early)]
OMIM: "Hyporeflexia (in some patients)" [OMIM:Hyporeflexia (in some patients)]
OMIM: "Hyporeflexia (in some)" [OMIM:Hyporeflexia (in some)]
OMIM: "Hyporeflexia (later in disease course)" [OMIM:Hyporeflexia (later in disease course)]
OMIM: "Hyporeflexia (less common)" [OMIM:Hyporeflexia (less common)]
OMIM: "Hyporeflexia (occurs later)" [OMIM:Hyporeflexia (occurs later)]
OMIM: "Hyporeflexia (rare)" [OMIM:Hyporeflexia (rare)]
OMIM: "Hyporeflexia/areflexia" [OMIM:Hyporeflexia/areflexia]
UMLS:C0151888 "Hyporeflexia" [HPO:0001265]
UMLS:C0151888 "Hyporeflexia" [Orphanet:43350]
UMLS:C0234146 "Absent reflex" [Orphanet:43350]
Is a (Direct Parents):
Orphanet [DEL]Motor deficit/trouble
MedDRA Abnormal reflexes
HPO         Reduced tendon reflexes
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Reduced tendon reflexes(HPO:0001315)
                Hyporeflexia(HPO:0001265)
MedDRA:
Nervous system disorders(MedDRA:10029205)
    Neurological disorders NEC(MedDRA:10029305)
       Abnormal reflexes(MedDRA:10000171)
          Hyporeflexia(HPO:0001265)
Database Frequency: 208 / 7739
Resource:

All diseases associated with this symptom:

2q37 microdeletion syndrome (Orphanet:1001)
3-methylglutaconic aciduria type 4 (Orphanet:67048)
4-hydroxybutyric aciduria (Orphanet:22)
ADIE PUPIL (OMIM:103100)
AMYOTROPHIC LATERAL SCLEROSIS 17 (OMIM:614696)
AMYOTROPHIC LATERAL SCLEROSIS 6, WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA (OMIM:608030)
ATAXIA, SENSORY, 1, AUTOSOMAL DOMINANT (OMIM:608984)
ATAXIA-OCULOMOTOR APRAXIA 3 (OMIM:615217)
ATTRV122I amyloidosis (Orphanet:85451)
Adult-onset proximal spinal muscular atrophy, autosomal dominant (Orphanet:209335)
Ataxia - hypogonadism - choroidal dystrophy (Orphanet:1180)
Ataxia - oculomotor apraxia type 1 (Orphanet:1168)
Ataxia-telangiectasia-like disorder (Orphanet:251347)
Autosomal dominant Charcot-Marie-Tooth disease type 2A1 (Orphanet:99946)
Autosomal dominant Charcot-Marie-Tooth disease type 2A2 (Orphanet:99947)
Autosomal dominant Charcot-Marie-Tooth disease type 2B (Orphanet:99936)
Autosomal dominant Charcot-Marie-Tooth disease type 2C (Orphanet:99937)
Autosomal dominant Charcot-Marie-Tooth disease type 2D (Orphanet:99938)
Autosomal dominant Charcot-Marie-Tooth disease type 2E (Orphanet:99939)
Autosomal dominant Charcot-Marie-Tooth disease type 2F (Orphanet:99940)
Autosomal dominant Charcot-Marie-Tooth disease type 2G (Orphanet:99941)
Autosomal dominant Charcot-Marie-Tooth disease type 2I (Orphanet:99942)
Autosomal dominant Charcot-Marie-Tooth disease type 2J (Orphanet:99943)
Autosomal dominant Charcot-Marie-Tooth disease type 2L (Orphanet:99945)
Autosomal dominant Charcot-Marie-Tooth disease type 2M (Orphanet:228179)
Autosomal dominant Charcot-Marie-Tooth disease type 2O (Orphanet:284232)
Autosomal dominant Charcot-Marie-Tooth disease type 2P (Orphanet:300319)
Autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures (Orphanet:363454)
Autosomal dominant congenital benign spinal muscular atrophy (Orphanet:1216)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type A (Orphanet:100043)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type B (Orphanet:100044)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type D (Orphanet:100046)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type E (Orphanet:93114)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type F (Orphanet:352670)
Autosomal dominant limb-girdle muscular dystrophy type 1A (Orphanet:266)
Autosomal dominant limb-girdle muscular dystrophy type 1H (Orphanet:238755)
Autosomal dominant progressive external ophthalmoplegia (Orphanet:254892)
Autosomal recessive cerebellar ataxia - epilepsy - intellectual deficit (Orphanet:284282)
Autosomal recessive cerebelloparenchymal disorder type 3 (Orphanet:1170)
Autosomal recessive deafness-onychodystrophy syndrome (Orphanet:79500)
Autosomal recessive intermediate Charcot-Marie-Tooth disease type A (Orphanet:217055)
Autosomal recessive intermediate Charcot-Marie-Tooth disease type B (Orphanet:254334)
Autosomal recessive limb-girdle muscular dystrophy type 2H (Orphanet:1878)
Autosomal recessive limb-girdle muscular dystrophy type 2M (Orphanet:206554)
Autosomal recessive progressive external ophthalmoplegia (Orphanet:254886)
Autosomal recessive spastic ataxia - optic atrophy - dysarthria (Orphanet:254343)
Autosomal recessive spastic paraplegia type 26 (Orphanet:101006)
Autosomal recessive spastic paraplegia type 43 (Orphanet:320370)
BARTTER SYNDROME, TYPE 4A (OMIM:602522)
BARTTER SYNDROME, TYPE 4B (OMIM:613090)
CARDIONEUROMYOPATHY WITH HYALINE MASSES AND NEMALINE RODS (OMIM:606842)
CATARACTS, GROWTH HORMONE DEFICIENCY, SENSORY NEUROPATHY, SENSORINEURALHEARING LOSS, AND SKELETAL DYSPLASIA (OMIM:616007)
CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME2 (OMIM:610185)
CEREBELLAR ATAXIA, NEUROPATHY, AND VESTIBULAR AREFLEXIA SYNDROME (OMIM:614575)
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2S (OMIM:616155)
CHARCOT-MARIE-TOOTH DISEASE, RECESSIVE INTERMEDIATE D (OMIM:616039)
Channelopathy-associated congenital insensitivity to pain (Orphanet:88642)
Charcot-Marie-Tooth disease type 1A (Orphanet:101081)
Charcot-Marie-Tooth disease type 1B (Orphanet:101082)
Charcot-Marie-Tooth disease type 1C (Orphanet:101083)
Charcot-Marie-Tooth disease type 1E (Orphanet:90658)
Charcot-Marie-Tooth disease type 1F (Orphanet:101085)
Charcot-Marie-Tooth disease type 2B1 (Orphanet:98856)
Charcot-Marie-Tooth disease type 2B2 (Orphanet:101101)
Charcot-Marie-Tooth disease type 4A (Orphanet:99948)
Charcot-Marie-Tooth disease type 4B2 (Orphanet:99956)
Charcot-Marie-Tooth disease type 4D (Orphanet:99950)
Charcot-Marie-Tooth disease type 4G (Orphanet:99953)
Charcot-Marie-Tooth disease type 4H (Orphanet:99954)
Charcot-Marie-Tooth disease type 4J (Orphanet:139515)
Choreoacanthocytosis (Orphanet:2388)
Chédiak-Higashi syndrome (Orphanet:167)
Combined oxidative phosphorylation defect type 11 (Orphanet:324535)
Combined oxidative phosphorylation defect type 13 (Orphanet:319514)
Congenital muscular dystrophy type 1A (Orphanet:258)
Congenital myopathy with excess of thin filaments (Orphanet:98904)
DE SANCTIS-CACCHIONE SYNDROME (OMIM:278800)
Dejerine-Sottas syndrome (Orphanet:64748)
Distal hereditary motor neuropathy type 7 (Orphanet:139589)
Distal hereditary motor neuropathy, Jerash type (Orphanet:139552)
Distal myopathy with posterior leg and anterior hand involvement (Orphanet:63273)
Dopa-responsive dystonia due to sepiapterin reductase deficiency (Orphanet:70594)
Duchenne muscular dystrophy (Orphanet:98896)
Early infantile epileptic encephalopathy without suppression burst (Orphanet:369894)
Early-onset X-linked optic atrophy (Orphanet:98890)
Erythrokeratodermia - ataxia (Orphanet:1955)
FACIAL SPASM (OMIM:134300)
FRIEDREICH ATAXIA, SO-CALLED, WITH OPTIC ATROPHY AND SENSORINEURALDEAFNESS (OMIM:136600)
FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 2 (OMIM:615911)
Familial amyloid polyneuropathy (Orphanet:85447)
Familial dysautonomia (Orphanet:1764)
Fragile X-associated tremor/ataxia syndrome (Orphanet:93256)
Friedreich ataxia 2 (OMIM:601992)
GIANT AXONAL NEUROPATHY 2, AUTOSOMAL DOMINANT (OMIM:610100)
Gaucher disease - ophthalmoplegia - cardiovascular calcification (Orphanet:2072)
Genetic recurrent myoglobinuria (Orphanet:99845)
Glycogen storage disease due to acid maltase deficiency (Orphanet:365)
Hereditary motor and sensory neuropathy type 6 (Orphanet:90120)
Hereditary neuropathy with liability to pressure palsies (Orphanet:640)
Hereditary sensory and autonomic neuropathy type 1 (Orphanet:36386)
Hereditary sensory and autonomic neuropathy type 2 (Orphanet:970)
Inclusion body myositis (Orphanet:611)
Infantile Bartter syndrome with deafness (Orphanet:89938)
Infantile cerebellar-retinal degeneration (Orphanet:313850)
Infantile onset spinocerebellar ataxia (Orphanet:1186)
Isolated NADH-CoQ reductase deficiency (Orphanet:2609)
KRABBE DISEASE, ATYPICAL, DUE TO SAPOSIN A DEFICIENCY (OMIM:611722)
Kearns-Sayre syndrome (Orphanet:480)
Kennedy disease (Orphanet:481)
Leigh syndrome (Orphanet:506)
Leukoencephalopathy with brain stem and spinal cord involvement - lactate elevation (Orphanet:137898)
Lower motor neuron syndrome with late-adult onset (Orphanet:276435)
MELAS (Orphanet:550)
MENTAL RETARDATION, AUTOSOMAL DOMINANT 13 (OMIM:614563)
METACHROMATIC LEUKODYSTROPHY (OMIM:250100)
METACHROMATIC LEUKODYSTROPHY DUE TO SAPOSIN B DEFICIENCY (OMIM:249900)
MITOCHONDRIAL MYOPATHY (OMIM:251900)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH MENTAL RETARDATION),TYPE B, 2 (OMIM:613156)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (LIMB-GIRDLE), TYPE C, 12 (OMIM:616094)
MYASTHENIC SYNDROME, CONGENITAL, 17 (OMIM:616304)
MYASTHENIC SYNDROME, CONGENITAL, 7, PRESYNAPTIC (OMIM:616040)
MYOGLOBINURIA, ACUTE RECURRENT, AUTOSOMAL RECESSIVE (OMIM:268200)
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET (OMIM:614399)
MYOPATHY, REDUCING BODY, X-LINKED, CHILDHOOD-ONSET (OMIM:300718)
MYOPATHY, REDUCING BODY, X-LINKED, EARLY-ONSET, SEVERE (OMIM:300717)
Maple syrup urine disease (Orphanet:511)
Maternally-inherited Leigh syndrome (Orphanet:255210)
Microcephaly - seizures - developmental delay (Orphanet:228418)
Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria (Orphanet:1933)
Mitochondrial encephalo-cardio-myopathy due to TMEM70 deficiency (Orphanet:1194)
Mitochondrial myopathy with reversible cytochrome C oxidase deficiency (Orphanet:254864)
Monosomy 22q13 (Orphanet:48652)
Multiple congenital anomalies - hypotonia - seizures syndrome (Orphanet:280633)
Muscular dystrophy, Selcen type (Orphanet:199340)
Myopathy and diabetes mellitus (Orphanet:2596)
NEMALINE MYOPATHY 2 (OMIM:256030)
NEMALINE MYOPATHY 4 (OMIM:609285)
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2A (OMIM:256600)
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 6 (OMIM:615643)
NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE VB (OMIM:614751)
NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE VIIA (OMIM:158580)
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IIA (OMIM:201300)
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IIB (OMIM:613115)
NEUROPATHY, HEREDITARY SENSORY, TYPE IE (OMIM:614116)
NEUROPATHY, HEREDITARY SENSORY, TYPE IIC (OMIM:614213)
Native American myopathy (Orphanet:168572)
Navajo neurohepatopathy (Orphanet:255229)
Nemaline myopathy (Orphanet:607)
Neuralgic amyotrophy (Orphanet:2901)
Neurodegeneration with brain iron accumulation due to C19orf12 mutation (Orphanet:289560)
Neurologic Waardenburg-Shah syndrome (Orphanet:163746)
Neutral lipid storage myopathy (Orphanet:98908)
Niemann-Pick disease type A (Orphanet:77292)
PELIZAEUS-MERZBACHER DISEASE (OMIM:312080)
PERIPHERAL NEUROPATHY, MYOPATHY, HOARSENESS, AND HEARING LOSS (OMIM:614369)
PEROXISOME BIOGENESIS DISORDER 3B (OMIM:266510)
PEROXISOME BIOGENESIS DISORDER 5B (OMIM:614867)
PEROXISOME BIOGENESIS DISORDER 6B (OMIM:614871)
PMM2-CDG (Orphanet:79318)
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 1 (OMIM:157640)
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 3 (OMIM:609286)
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 5 (OMIM:613077)
PSYCHOMOTOR RETARDATION, EPILEPSY, AND CRANIOFACIAL DYSMORPHISM (OMIM:614501)
Perrault Syndrome (Orphanet:2855)
Perrault Syndrome 1 (OMIM:233400)
Perrault Syndrome 5 (OMIM:616138)
Polymicrogyria with optic nerve hypoplasia (Orphanet:250972)
Polyneuropathy - hearing loss - ataxia - retinitis pigmentosa - cataract (Orphanet:171848)
Progressive demyelinating neuropathy with bilateral striatal necrosis (Orphanet:217396)
Progressive external ophthalmoplegia - myopathy - emaciation (Orphanet:352447)
Proximal spinal muscular atrophy type 3 (Orphanet:83419)
Pyruvate dehydrogenase E1-alpha deficiency (Orphanet:79243)
Pyruvate dehydrogenase E1-beta deficiency (Orphanet:255138)
REFSUM DISEASE, CLASSIC (OMIM:266500)
RIENHOFF SYNDROME (OMIM:615582)
Reducing body myopathy (Orphanet:97239)
Refsum disease (Orphanet:773)
Roussy-Lévy syndrome (Orphanet:3115)
SCAPULOPERONEAL MYOPATHY, X-LINKED DOMINANT (OMIM:300695)
SCAPULOPERONEAL SPINAL MUSCULAR ATROPHY (OMIM:181405)
SPINAL MUSCULAR ATROPHY, DISTAL, AUTOSOMAL RECESSIVE, 1 (OMIM:604320)
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 15 (OMIM:615705)
Schwartz-Jampel syndrome (Orphanet:800)
Sensory ataxic neuropathy-dysarthria-ophthalmoparesis (Orphanet:70595)
Severe X-linked mitochondrial encephalomyopathy (Orphanet:238329)
Smith-Magenis syndrome (Orphanet:819)
Spastic paraplegia-optic atrophy-neuropathy syndrome (Orphanet:320406)
Spinal muscular atrophy with respiratory distress (Orphanet:98920)
Spinocerebellar ataxia - dysmorphism (Orphanet:1185)
Spinocerebellar ataxia type 18 (Orphanet:98771)
Spinocerebellar ataxia type 19/22 (Orphanet:98772)
Spinocerebellar ataxia type 2 (Orphanet:98756)
Spinocerebellar ataxia type 21 (Orphanet:98773)
Spinocerebellar ataxia type 4 (Orphanet:98765)
Spinocerebellar ataxia with axonal neuropathy type 2 (Orphanet:64753)
Spinocerebellar ataxia with epilepsy (Orphanet:254881)
TMCO1 defect syndrome (Orphanet:228407)
Tangier disease (Orphanet:31150)
Triose phosphate-isomerase deficiency (Orphanet:868)
X-linked Charcot-Marie-Tooth disease type 1 (Orphanet:101075)
X-linked distal spinal muscular atrophy (Orphanet:139557)
X-linked intellectual disability due to GRIA3 anomalies (Orphanet:364028)
X-linked spinocerebellar ataxia type 3 (Orphanet:85297)
Xeroderma pigmentosum complementation group A (Orphanet:276249)
Xeroderma pigmentosum complementation group D (Orphanet:276258)
Xeroderma pigmentosum/Cockayne syndrome complex (Orphanet:220295)
Zellweger syndrome (Orphanet:912)
[DEL] MUSCULAR DYSTROPHY, BECKER TYPE (OMIM:300376)