Malar flattening

Symptom Information:

Symptom ID: HPO:0000272
Synonyms:
Depressed malar region [HPO:0000272]
Flat midface [HPO:0000272]
Malar hypoplasia [HPO:0000272]
Mid-face hypoplasia [HPO:0000272]
Flat midface [OMIM:Flat midface]
Malar flattening [OMIM:Malar flattening]
Malar hypoplasia [OMIM:Malar hypoplasia]
Mid-face hypoplasia [OMIM:Mid-face hypoplasia]
Flat cheek bones/malar hypoplasia [Orphanet:3580]
Malar hypoplasia (in one family) [OMIM:Malar hypoplasia (in one family)]
Quality:
Cross references:
Orphanet:3580 "Flat cheek bones/malar hypoplasia" [Orphanet:3580]
OMIM: "Flat midface" [OMIM:Flat midface]
OMIM: "Malar flattening" [OMIM:Malar flattening]
OMIM: "Malar hypoplasia" [OMIM:Malar hypoplasia]
OMIM: "Mid-face hypoplasia" [OMIM:Mid-face hypoplasia]
OMIM: "Malar hypoplasia (in one family)" [OMIM:Malar hypoplasia (in one family)]
Is a (Direct Parents):
Orphanet Abnormal facial shape
HPO         Abnormality of malar bones
HPO         Abnormal facial shape
HPO         Abnormality of the zygomatic arch
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of head or neck(HPO:0000152)
          Abnormality of the head(HPO:0000234)
             Abnormality of the face(HPO:0000271)
                Abnormality of the midface(HPO:0000309)
                   Abnormality of malar bones(HPO:0012369)
                      Malar flattening(HPO:0000272)
                   Abnormality of the zygomatic arch(HPO:0005557)
                      Malar flattening(HPO:0000272)
                Abnormal facial shape(HPO:0001999)
                   Malar flattening(HPO:0000272)
MedDRA:
Database Frequency: 277 / 7739
Resource:

All diseases associated with this symptom:

16p13.3 microduplication syndrome (Orphanet:96078)
17q11.2 microduplication syndrome (Orphanet:139474)
17q12 microdeletion syndrome (Orphanet:261265)
1p36 deletion syndrome (Orphanet:1606)
20p12.3 microdeletion syndrome (Orphanet:261295)
22q11.2 deletion syndrome (Orphanet:567)
2q32q33 microdeletion syndrome (Orphanet:251019)
2q37 microdeletion syndrome (Orphanet:1001)
3M syndrome (Orphanet:2616)
ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE (OMIM:614613)
ANTLEY-BIXLER SYNDROME WITH GENITAL ANOMALIES AND DISORDERED STEROIDOGENESIS (OMIM:201750)
ATP-BINDING CASSETTE, SUBFAMILY D, MEMBER 3 (OMIM:170995)
AXENFELD-RIEGER ANOMALY WITH PARTIALLY ABSENT EYE MUSCLES, DISTINCTIVEFACE, HYDROCEPHALY, AND SKELETAL ABNORMALITIES (OMIM:109120)
AXENFELD-RIEGER SYNDROME, TYPE 3 (OMIM:602482)
Ablepharon macrostomia syndrome (Orphanet:920)
Abruzzo-Erickson syndrome (Orphanet:921)
Achondrogenesis type 1B (Orphanet:93298)
Achondroplasia (Orphanet:15)
Acro-fronto-facio-nasal dysostosis (Orphanet:1784)
Acrofacial dysostosis, Catania type (Orphanet:1786)
Acrofacial dysostosis, Palagonia type (Orphanet:1787)
Acrofacial dysostosis, Rodriguez type (Orphanet:1788)
Acroosteolysis, dominant type (Orphanet:955)
Allan-Herndon-Dudley syndrome (Orphanet:59)
Alpha-mannosidosis (Orphanet:61)
Alpha-thalassemia - X-linked intellectual deficit syndrome (Orphanet:847)
Antley-Bixler syndrome (Orphanet:83)
Aortic arch anomaly - peculiar facies - intellectual deficit (Orphanet:1110)
Apert syndrome (Orphanet:87)
Arachnodactyly - abnormal ossification - intellectual deficit (Orphanet:1129)
Arterial tortuosity syndrome (Orphanet:3342)
Atelosteogenesis type I (Orphanet:1190)
Atelosteogenesis type II (Orphanet:56304)
Atelosteogenesis type III (Orphanet:56305)
Autosomal dominant Larsen syndrome (Orphanet:503)
Autosomal dominant Robinow syndrome (Orphanet:3107)
Autosomal recessive Robinow syndrome (Orphanet:1507)
Autosomal recessive cutis laxa type 2A (Orphanet:357058)
Autosomal recessive cutis laxa type 2B (Orphanet:357064)
Autosomal recessive omodysplasia (Orphanet:93329)
Autosomal recessive severe congenital neutropenia due to G6PC3 deficiency (Orphanet:331176)
BARATELA-SCOTT SYNDROME (OMIM:300881)
Beckwith-Wiedemann syndrome due to 11p15 microdeletion (Orphanet:231127)
Blepharophimosis-intellectual deficit syndrome, Verloes type (Orphanet:293725)
Bloom syndrome (Orphanet:125)
Brachymorphism - onychodysplasia - dysphalangism (Orphanet:1292)
Brachytelephalangy - dysmorphism - Kallmann syndrome (Orphanet:1295)
Branchio-oculo-facial syndrome (Orphanet:1297)
CAMPTODACTYLY SYNDROME, GUADALAJARA, TYPE III (OMIM:611929)
CATARACTS, CONGENITAL, WITH SENSORINEURAL DEAFNESS, DOWN SYNDROME-LIKEFACIAL APPEARANCE, SHORT STATURE, AND MENTAL RETARDATION (OMIM:601088)
CHARGE syndrome (Orphanet:138)
CK syndrome (Orphanet:251383)
CRANIOMETADIAPHYSEAL DYSPLASIA (OMIM:269300)
CRANIOSYNOSTOSIS-MENTAL RETARDATION SYNDROME OF LIN AND GETTIG (OMIM:218649)
Camptodactyly syndrome, Guadalajara type 1 (Orphanet:1327)
Cardiodysrhythmic potassium-sensitive periodic paralysis (Orphanet:37553)
Cardiofaciocutaneous syndrome (Orphanet:1340)
Carpenter syndrome (Orphanet:65759)
Cataract - intellectual deficit - hypogonadism (Orphanet:1387)
Cenani-Lenz syndrome (Orphanet:3258)
Cerebro-costo-mandibular syndrome (Orphanet:1393)
Cerebro-facio-articular syndrome (Orphanet:314679)
Cerebro-oculo-nasal syndrome (Orphanet:66625)
Chondrodysplasia punctata, tibial-metacarpal type (Orphanet:79346)
Chondrodysplasia, Blomstrand type (Orphanet:50945)
Cleft lip/palate - intestinal malrotation - cardiopathy (Orphanet:2001)
Cleidocranial dysplasia (Orphanet:1452)
Cohen syndrome (Orphanet:193)
Congenital lactic acidosis, Saguenay-Lac-St. Jean type (Orphanet:70472)
Congenital pulmonary lymphangiectasia (Orphanet:2414)
Connective tissue disorder due to lysyl hydroxylase-3 deficiency (Orphanet:300284)
Corneal anesthesia - deafness - intellectual deficit (Orphanet:1051)
Craniofacial dyssynostosis (Orphanet:1516)
Craniofacial-deafness-hand syndrome (Orphanet:1529)
Craniolenticulosutural dysplasia (Orphanet:50814)
Craniometadiaphyseal dysplasia, wormian bone type (Orphanet:85184)
Craniosynostosis - anal anomalies - porokeratosis (Orphanet:85199)
Cutis gyrata - acanthosis nigricans - craniosynostosis (Orphanet:1555)
Cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies (Orphanet:221145)
DIAMOND-BLACKFAN ANEMIA 10 (OMIM:613309)
Deafness - intellectual deficit, Martin-Probst type (Orphanet:85321)
Desbuquois syndrome (Orphanet:1425)
Dislocation of the hip - dysmorphism (Orphanet:2412)
Distal 22q11.2 microdeletion syndrome (Orphanet:261330)
Distal monosomy 6p (Orphanet:96125)
Donnai-Barrow syndrome (Orphanet:2143)
Down syndrome (Orphanet:870)
Dysmorphism - pectus carinatum - joint laxity (Orphanet:2104)
Dysostosis, Stanescu type (Orphanet:1798)
Dyssegmental dysplasia - glaucoma (Orphanet:1804)
Dyssegmental dysplasia, Rolland-Desbuquois type (Orphanet:156731)
Dyssegmental dysplasia, Silverman-Handmaker type (Orphanet:1865)
ECTODERMAL DYSPLASIA SYNDROME WITH DISTINCTIVE FACIAL APPEARANCE ANDPREAXIAL POLYDACTYLY OF FEET (OMIM:129540)
ECTODERMAL DYSPLASIA, SENSORINEURAL HEARING LOSS, AND DISTINCTIVEFACIAL FEATURES (OMIM:609944)
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME3 (OMIM:604292)
EEC syndrome (Orphanet:1896)
Ectodermal dysplasia - intellectual deficit - central nervous system malformation (Orphanet:1812)
Ehlers-Danlos syndrome, arthrochalasic type (Orphanet:1899)
Emery-Nelson syndrome (Orphanet:1927)
Endocrine-cerebro-osteodysplasia syndrome (Orphanet:199332)
FGFR2-related bent bone dysplasia (Orphanet:313855)
FIBROCHONDROGENESIS 2 (OMIM:614524)
Facial dysmorphism - immunodeficiency - livedo - short stature (Orphanet:352712)
Facial dysmorphism - shawl scrotum - joint laxity (Orphanet:1778)
Faciocardiorenal syndrome (Orphanet:1973)
Familial lambdoid synostosis (Orphanet:3267)
Familial osteodysplasia, Anderson type (Orphanet:2769)
Fibrochondrogenesis (Orphanet:2021)
Fine-Lubinsky syndrome (Orphanet:1272)
Flat face - microstomia - ear anomaly (Orphanet:1968)
Freeman-Sheldon syndrome (Orphanet:2053)
Fronto-facio-nasal dysostosis (Orphanet:1791)
Geroderma osteodysplastica (Orphanet:2078)
Glycogen storage disease due to glycogen debranching enzyme deficiency (Orphanet:366)
Goldenhar syndrome (Orphanet:374)
Gorlin-Chaudhry-Moss syndrome (Orphanet:2095)
Greenberg dysplasia (Orphanet:1426)
Gómez-López-Hernández syndrome (Orphanet:1532)
HOLOPROSENCEPHALY 2 (OMIM:157170)
HOLOPROSENCEPHALY 9 (OMIM:610829)
HUNTER-MACDONALD SYNDROME (OMIM:611962)
Hallermann-Streiff syndrome (Orphanet:2108)
Hennekam syndrome (Orphanet:2136)
Holoprosencephaly (Orphanet:2162)
Hutchinson-Gilford progeria syndrome (Orphanet:740)
Hydrocephalus - blue sclerae - nephropathy (Orphanet:2186)
Hydrocephalus - costovertebral dysplasia - Sprengel anomaly (Orphanet:2180)
Hyperphosphatasia-intellectual deficiency syndrome (Orphanet:247262)
Hypochondroplasia (Orphanet:429)
Hypomandibular faciocranial dysostosis (Orphanet:1790)
Hypospadias - hypertelorism - coloboma and deafness (Orphanet:157788)
ICF syndrome (Orphanet:2268)
Intellectual deficit - cataracts - calcified pinnae - myopathy (Orphanet:3042)
Intellectual deficit - short stature - hypertelorism (Orphanet:3074)
Intellectual deficit, X-linked - cubitus valgus - dysmorphism (Orphanet:85280)
Intellectual deficit, X-linked, Armfield type (Orphanet:85276)
Intellectual deficit, X-linked, Nascimento type (Orphanet:163956)
Jackson-Weiss syndrome (Orphanet:1540)
Joubert syndrome 14 (OMIM:614424)
Keutel syndrome (Orphanet:85202)
Kleefstra syndrome (Orphanet:261494)
Kniest dysplasia (Orphanet:485)
LOEYS-DIETZ SYNDROME 1 (OMIM:609192)
LOEYS-DIETZ SYNDROME 2 (OMIM:610168)
LUBS X-LINKED MENTAL RETARDATION SYNDROME (OMIM:300260)
Lambert syndrome (Orphanet:1296)
Larsen-like osseous dysplasia - short stature (Orphanet:2370)
Lateral meningocele syndrome (Orphanet:2789)
Lethal Kniest-like dysplasia (Orphanet:2347)
Lethal osteosclerotic bone dysplasia (Orphanet:1832)
Leukoencephalopathy - metaphyseal chondrodysplasia (Orphanet:83629)
Loeys-Dietz syndrome type 1 (Orphanet:60030)
MANDIBULOFACIAL DYSOSTOSIS WITH MENTAL DEFICIENCY (OMIM:248400)
MANDIBULOFACIAL DYSOSTOSIS WITH PTOSIS, AUTOSOMAL DOMINANT (OMIM:608257)
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 15 (OMIM:614202)
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 35 (OMIM:615162)
MIDFACE HYPOPLASIA, OBESITY, DEVELOPMENTAL DELAY, AND NEONATAL HYPOTONIA (OMIM:608624)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYEANOMALIES), TYPE A, 3 (OMIM:253280)
MYELODYSPLASIA, IMMUNODEFICIENCY, FACIAL DYSMORPHISM, SHORT STATURE,AND PSYCHOMOTOR DELAY (OMIM:601347)
Mandibulofacial dysostosis-microcephaly syndrome (Orphanet:79113)
Marden-Walker syndrome (Orphanet:2461)
Marfan syndrome (Orphanet:558)
Marfan syndrome type 1 (Orphanet:284963)
Marfanoid habitus - intellectual deficit, autosomal recessive (Orphanet:2463)
Marshall syndrome (Orphanet:560)
Marshall-Smith syndrome (Orphanet:561)
Mesomelia-synostoses syndrome (Orphanet:2496)
Metaphyseal acroscyphodysplasia (Orphanet:1240)
Microbrachycephaly - ptosis - cleft lip (Orphanet:2511)
Microcephalic osteodysplastic dysplasia, Saul-Wilson type (Orphanet:85172)
Microcephalic osteodysplastic primordial dwarfism types 1 and 3 (Orphanet:2636)
Microcephalic primordial dwarfism, Alazami type (Orphanet:319671)
Microcephaly - brachydactyly - kyphoscoliosis (Orphanet:3433)
Microcephaly - cervical spine fusion anomalies (Orphanet:2522)
Microphthalmia with brain and digit anomalies (Orphanet:139471)
Monosomy 18q (Orphanet:1600)
Monosomy 22q13 (Orphanet:48652)
Monosomy 9p (Orphanet:261112)
Mosaic variegated aneuploidy syndrome (Orphanet:1052)
Muenke syndrome (Orphanet:53271)
Mullerian derivatives - lymphangiectasia - polydactyly (Orphanet:1655)
Multiple congenital anomalies-hypotonia-seizures syndrome type 2 (Orphanet:300496)
Multiple epiphyseal dysplasia, Al-Gazali type (Orphanet:166024)
Myhre syndrome (Orphanet:2588)
Nager syndrome (Orphanet:245)
Nephrogenic diabetes insipidus - intracranial calcification (Orphanet:3145)
Nestor-Guillermo progeria syndrome (Orphanet:280576)
Night blindness - skeletal anomalies - dysmorphism (Orphanet:1390)
Non-eruption of teeth - maxillary hypoplasia - genu valgum (Orphanet:2972)
Non-rhizomelic chondrodysplasia punctata (Orphanet:176)
Norrie disease (Orphanet:649)
OSTEOGENESIS IMPERFECTA, TYPE X (OMIM:613848)
OSTEOGENESIS IMPERFECTA, TYPE XII (OMIM:613849)
OTOFACIOOSSEOUS-GONADAL SYNDROME (OMIM:601976)
Oculo-reno-cerebellar syndrome (Orphanet:2715)
Orofaciodigital syndrome type 1 (Orphanet:2750)
Orofaciodigital syndrome type 2 (Orphanet:2751)
Osteoglophonic dwarfism (Orphanet:2645)
Otopalatodigital syndrome (Orphanet:669)
Otopalatodigital syndrome type 1 (Orphanet:90650)
Otospondylomegaepiphyseal dysplasia (Orphanet:1427)
PECTUS EXCAVATUM, MACROCEPHALY, SHORT STATURE, AND DYSPLASTIC NAILS (OMIM:600399)
PEROXISOME BIOGENESIS DISORDER 3B (OMIM:266510)
PITUITARY HORMONE DEFICIENCY, COMBINED, 1 (OMIM:613038)
PLANTAR LIPOMATOSIS, UNUSUAL FACIES, AND DEVELOPMENTAL DELAY (OMIM:602342)
Paraplegia - brachydactyly - cone-shaped epiphysis (Orphanet:2823)
Patterson-Stevenson-Fontaine syndrome (Orphanet:2439)
Pectus excavatum - macrocephaly - dysplastic nails (Orphanet:2835)
Pfeiffer syndrome (Orphanet:710)
Phocomelia - ectrodactyly - deafness - sinus arrhythmia (Orphanet:2878)
Pierre Robin syndrome - faciodigital anomaly (Orphanet:2888)
Poikiloderma with neutropenia (Orphanet:221046)
Postaxial acrofacial dysostosis (Orphanet:246)
Prolidase deficiency (Orphanet:742)
Pseudodiastrophic dysplasia (Orphanet:85174)
RETINAL DYSTROPHY, JUVENILE CATARACTS, AND SHORT STATURE SYNDROME (OMIM:616108)
ROBERTS SYNDROME (OMIM:268300)
ROBINOW-SORAUF SYNDROME (OMIM:180750)
Recombinant 8 syndrome (Orphanet:96167)
Renpenning syndrome (Orphanet:3242)
Rhizomelic chondrodysplasia punctata (Orphanet:177)
Roberts syndrome (Orphanet:3103)
SHORT STATURE, AUDITORY CANAL ATRESIA, MANDIBULAR HYPOPLASIA, ANDSKELETAL ABNORMALITIES (OMIM:602471)
SHORT syndrome (Orphanet:3163)
SIMOSA CRANIOFACIAL SYNDROME (OMIM:182150)
SKELETAL DYSPLASIA AND PROGRESSIVE CENTRAL NERVOUS SYSTEM DEGENERATION,LETHAL (OMIM:602613)
SPONASTRIME dysplasia (Orphanet:93357)
STICKLER SYNDROME, TYPE I (OMIM:108300)
Saethre-Chotzen syndrome (Orphanet:794)
Sakati-Nyhan syndrome (Orphanet:3128)
Schilbach-Rott syndrome (Orphanet:2353)
Schinzel-Giedion syndrome (Orphanet:798)
Schneckenbecken dysplasia (Orphanet:3144)
Schwartz-Jampel syndrome (Orphanet:800)
Sclerosteosis (Orphanet:3152)
Short stature - craniofacial anomalies - genital hypoplasia (Orphanet:2994)
Smith-Magenis syndrome (Orphanet:819)
Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification (Orphanet:93358)
Spondyloepimetaphyseal dysplasia with joint laxity (Orphanet:93359)
Spondyloepimetaphyseal dysplasia with multiple dislocations (Orphanet:93360)
Spondyloepimetaphyseal dysplasia, Bieganski type (Orphanet:168448)
Spondyloepimetaphyseal dysplasia, aggrecan type (Orphanet:171866)
Spondyloepiphyseal dysplasia congenita (Orphanet:94068)
Spondyloepiphyseal dysplasia tarda (Orphanet:93284)
Spondyloepiphyseal dysplasia, Cantu type (Orphanet:163654)
Spondyloperipheral dysplasia - short ulna (Orphanet:1856)
Stickler syndrome (Orphanet:828)
Stickler syndrome type 2 (Orphanet:90654)
Stickler syndrome type 3 (Orphanet:166100)
Stüve-Wiedemann syndrome (Orphanet:3206)
Subaortic stenosis - short stature (Orphanet:3191)
THREE M SYNDROME 2 (OMIM:612921)
THREE M SYNDROME 3 (OMIM:614205)
TMEM165-CDG (Orphanet:314667)
TREACHER COLLINS SYNDROME 1 (OMIM:154500)
TREACHER COLLINS SYNDROME 3 (OMIM:248390)
Terminal osseous dysplasia - pigmentary defects (Orphanet:88630)
Thrombocytopenia - absent radius (Orphanet:3320)
Toluene embryopathy (Orphanet:1920)
Treacher-Collins syndrome (Orphanet:861)
Tyrosinemia type 2 (Orphanet:28378)
Ulnar/fibula ray defect - brachydactyly (Orphanet:52056)
VAN MALDERGEM SYNDROME 1 (OMIM:601390)
VAN MALDERGEM SYNDROME 2 (OMIM:615546)
Van den Ende-Gupta syndrome (Orphanet:2460)
WHISTLING FACE SYNDROME, RECESSIVE FORM (OMIM:277720)
Wiedemann-Rautenstrauch syndrome (Orphanet:3455)
Williams syndrome (Orphanet:904)
X-linked creatine transporter deficiency (Orphanet:52503)
X-linked dominant chondrodysplasia punctata (Orphanet:35173)
X-linked intellectual deficit - hypotonic face (Orphanet:73220)
X-linked intellectual deficit with marfanoid habitus (Orphanet:776)
X-linked mandibulofacial dysostosis (Orphanet:1131)
Zechi-Ceide syndrome (Orphanet:217017)
Zellweger syndrome (Orphanet:912)
Zlotogora-Ogur syndrome (Orphanet:3253)
[DEL] NEUROFIBROMATOSIS-NOONAN SYNDROME (OMIM:601321)