Areflexia

Symptom Information:

Symptom ID: HPO:0001284
Synonyms:
Absent deep tendon reflexes [HPO:0001284]
Absent tendon reflexes [HPO:0001284]
Deep tendon reflexes absent [HPO:0001284]
Loss of deep tendon reflexes [HPO:0001284]
Hyporeflexia [Orphanet:43350]
Absent reflex (finding) [Orphanet:43350]
Hyporeflexia (finding) [Orphanet:43350]
Absent reflex [Orphanet:43350]
Absent deep tendon reflexes [OMIM:Absent deep tendon reflexes]
Absent tendon reflexes [OMIM:Absent tendon reflexes]
Areflexia [OMIM:Areflexia]
Deep tendon reflexes absent [OMIM:Deep tendon reflexes absent]
Loss of deep tendon reflexes [OMIM:Loss of deep tendon reflexes]
Areflexia/hyporeflexia [Orphanet:43350]
Areflexia [Orphanet:43350]
Areflexia [MedDRA:10003084]
Absent ankle jerk [MedDRA:10003084]
Absent ankle jerks [MedDRA:10003084]
Absent reflex [MedDRA:10003084]
Absent reflexes [MedDRA:10003084]
PSR/ASR loss [MedDRA:10003084]
Reflex loss [MedDRA:10003084]
Reflexes absent [MedDRA:10003084]
Loss of gag reflex [MedDRA:10003084]
Patellar tendon reflex absent [MedDRA:10003084]
Tendon reflex absent [MedDRA:10003084]
Cremasteric reflex absent [MedDRA:10003084]
Hyporeflexia [MedDRA:10021089]
Achilles tendon reflex decreased [MedDRA:10021089]
Diminished reflexes [MedDRA:10021089]
Lower extremities deep decreased reflex test [MedDRA:10021089]
Patellar tendon reflex decreased [MedDRA:10021089]
Reflexes decreased [MedDRA:10021089]
Reflexes tendon decreased absent [MedDRA:10021089]
Tendon reflex decreased [MedDRA:10021089]
Retching reflex decreased [MedDRA:10021089]
Poor swallowing reflex [MedDRA:10021089]
Absent ankle jerks [OMIM:Absent ankle jerks]
Absent reflexes [OMIM:Absent reflexes]
Areflexia (30%) [OMIM:Areflexia (30%)]
Areflexia (common) [OMIM:Areflexia (common)]
Areflexia (in some patients) [OMIM:Areflexia (in some patients)]
Areflexia (in some) [OMIM:Areflexia (in some)]
Hyporeflexia (90%) [OMIM:Hyporeflexia (90%)]
Hyporeflexia (early) [OMIM:Hyporeflexia (early)]
Hyporeflexia (in some patients) [OMIM:Hyporeflexia (in some patients)]
Hyporeflexia (in some) [OMIM:Hyporeflexia (in some)]
Hyporeflexia (later in disease course) [OMIM:Hyporeflexia (later in disease course)]
Hyporeflexia (less common) [OMIM:Hyporeflexia (less common)]
Hyporeflexia (occurs later) [OMIM:Hyporeflexia (occurs later)]
Hyporeflexia (rare) [OMIM:Hyporeflexia (rare)]
Hyporeflexia/areflexia [OMIM:Hyporeflexia/areflexia]
Loss of deep tendon reflexes (later) [OMIM:Loss of deep tendon reflexes (later)]
Quality:
Cross references:
HPO:0001265 "Hyporeflexia" [Orphanet:43350]
HPO:0001315 "Reduced tendon reflexes" [Orphanet:43350]
Orphanet:43350 "Areflexia/hyporeflexia" [Orphanet:43350]
OMIM: "Absent deep tendon reflexes" [OMIM:Absent deep tendon reflexes]
OMIM: "Absent tendon reflexes" [OMIM:Absent tendon reflexes]
OMIM: "Areflexia" [OMIM:Areflexia]
OMIM: "Deep tendon reflexes absent" [OMIM:Deep tendon reflexes absent]
OMIM: "Loss of deep tendon reflexes" [OMIM:Loss of deep tendon reflexes]
OMIM: "Absent ankle jerks" [OMIM:Absent ankle jerks]
OMIM: "Absent reflexes" [OMIM:Absent reflexes]
OMIM: "Areflexia (30%)" [OMIM:Areflexia (30%)]
OMIM: "Areflexia (common)" [OMIM:Areflexia (common)]
OMIM: "Areflexia (in some patients)" [OMIM:Areflexia (in some patients)]
OMIM: "Areflexia (in some)" [OMIM:Areflexia (in some)]
OMIM: "Hyporeflexia (90%)" [OMIM:Hyporeflexia (90%)]
OMIM: "Hyporeflexia (early)" [OMIM:Hyporeflexia (early)]
OMIM: "Hyporeflexia (in some patients)" [OMIM:Hyporeflexia (in some patients)]
OMIM: "Hyporeflexia (in some)" [OMIM:Hyporeflexia (in some)]
OMIM: "Hyporeflexia (later in disease course)" [OMIM:Hyporeflexia (later in disease course)]
OMIM: "Hyporeflexia (less common)" [OMIM:Hyporeflexia (less common)]
OMIM: "Hyporeflexia (occurs later)" [OMIM:Hyporeflexia (occurs later)]
OMIM: "Hyporeflexia (rare)" [OMIM:Hyporeflexia (rare)]
OMIM: "Hyporeflexia/areflexia" [OMIM:Hyporeflexia/areflexia]
OMIM: "Loss of deep tendon reflexes (later)" [OMIM:Loss of deep tendon reflexes (later)]
UMLS:C0234146 "Areflexia" [HPO:0001284]
UMLS:C0151888 "Hyporeflexia" [Orphanet:43350]
UMLS:C0234146 "Absent reflex" [Orphanet:43350]
Is a (Direct Parents):
MedDRA Abnormal reflexes
HPO         Reduced tendon reflexes
Orphanet [DEL]Motor deficit/trouble
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Reduced tendon reflexes(HPO:0001315)
                Areflexia(HPO:0001284)
MedDRA:
Nervous system disorders(MedDRA:10029205)
    Neurological disorders NEC(MedDRA:10029305)
       Abnormal reflexes(MedDRA:10000171)
          Areflexia(HPO:0001284)
Database Frequency: 198 / 7739
Resource:

All diseases associated with this symptom:

3-methylglutaconic aciduria type 4 (Orphanet:67048)
ALG1-CDG (Orphanet:79327)
ALG6-CDG (Orphanet:79320)
AMYOTROPHIC LATERAL SCLEROSIS 17 (OMIM:614696)
AMYOTROPHIC LATERAL SCLEROSIS 8 (OMIM:608627)
ATAXIA, SENSORY, 1, AUTOSOMAL DOMINANT (OMIM:608984)
ATAXIA-OCULOMOTOR APRAXIA 3 (OMIM:615217)
ATAXIA-OCULOMOTOR APRAXIA 4 (OMIM:616267)
ATP-BINDING CASSETTE, SUBFAMILY D, MEMBER 3 (OMIM:170995)
Alagille syndrome due to 20p12 microdeletion (Orphanet:261600)
Alagille syndrome due to a JAG1 point mutation (Orphanet:261619)
Alpha-mannosidosis (Orphanet:61)
Ataxia - hypogonadism - choroidal dystrophy (Orphanet:1180)
Ataxia - oculomotor apraxia type 1 (Orphanet:1168)
Ataxia with vitamin E deficiency (Orphanet:96)
Autosomal dominant Charcot-Marie-Tooth disease type 2A1 (Orphanet:99946)
Autosomal dominant Charcot-Marie-Tooth disease type 2A2 (Orphanet:99947)
Autosomal dominant Charcot-Marie-Tooth disease type 2B (Orphanet:99936)
Autosomal dominant Charcot-Marie-Tooth disease type 2C (Orphanet:99937)
Autosomal dominant Charcot-Marie-Tooth disease type 2E (Orphanet:99939)
Autosomal dominant Charcot-Marie-Tooth disease type 2F (Orphanet:99940)
Autosomal dominant Charcot-Marie-Tooth disease type 2G (Orphanet:99941)
Autosomal dominant Charcot-Marie-Tooth disease type 2I (Orphanet:99942)
Autosomal dominant Charcot-Marie-Tooth disease type 2J (Orphanet:99943)
Autosomal dominant Charcot-Marie-Tooth disease type 2K (Orphanet:99944)
Autosomal dominant Charcot-Marie-Tooth disease type 2L (Orphanet:99945)
Autosomal dominant Charcot-Marie-Tooth disease type 2M (Orphanet:228179)
Autosomal dominant Charcot-Marie-Tooth disease type 2N (Orphanet:228174)
Autosomal dominant Charcot-Marie-Tooth disease type 2P (Orphanet:300319)
Autosomal dominant centronuclear myopathy (Orphanet:169189)
Autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures (Orphanet:363454)
Autosomal dominant congenital benign spinal muscular atrophy (Orphanet:1216)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type A (Orphanet:100043)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type B (Orphanet:100044)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type D (Orphanet:100046)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type E (Orphanet:93114)
Autosomal dominant limb-girdle muscular dystrophy type 1A (Orphanet:266)
Autosomal recessive Charcot-Marie-Tooth disease with hoarseness (Orphanet:101097)
Autosomal recessive centronuclear myopathy (Orphanet:169186)
Autosomal recessive cerebelloparenchymal disorder type 3 (Orphanet:1170)
Autosomal recessive intermediate Charcot-Marie-Tooth disease type A (Orphanet:217055)
Autosomal recessive intermediate Charcot-Marie-Tooth disease type B (Orphanet:254334)
Autosomal recessive intermediate Charcot-Marie-Tooth disease type C (Orphanet:369867)
Autosomal recessive limb-girdle muscular dystrophy type 2H (Orphanet:1878)
Autosomal recessive limb-girdle muscular dystrophy type 2M (Orphanet:206554)
Autosomal recessive lower motor neuron disease with childhood onset (Orphanet:206580)
Autosomal recessive progressive external ophthalmoplegia (Orphanet:254886)
Autosomal recessive spastic ataxia - optic atrophy - dysarthria (Orphanet:254343)
Autosomal recessive spastic paraplegia type 26 (Orphanet:101006)
Autosomal recessive spastic paraplegia type 43 (Orphanet:320370)
Autosomal recessive spastic paraplegia type 49 (Orphanet:320385)
BROWN-VIALETTO-VAN LAERE SYNDROME 2 (OMIM:614707)
CARDIONEUROMYOPATHY WITH HYALINE MASSES AND NEMALINE RODS (OMIM:606842)
CEDNIK syndrome (Orphanet:66631)
CEREBELLAR ATAXIA, AREFLEXIA, PES CAVUS, OPTIC ATROPHY, AND SENSORINEURALHEARING LOSS (OMIM:601338)
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R (OMIM:615490)
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2S (OMIM:616155)
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2U (OMIM:616280)
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, WITH VOCAL CORD PARESIS, AUTOSOMALRECESSIVE (OMIM:607706)
CHARCOT-MARIE-TOOTH DISEASE, RECESSIVE INTERMEDIATE D (OMIM:616039)
CHARCOT-MARIE-TOOTH PERONEAL MUSCULAR ATROPHY AND FRIEDREICH ATAXIA,COMBINED (OMIM:302900)
Cataract - ataxia - deafness (Orphanet:1368)
Charcot-Marie-Tooth disease type 1A (Orphanet:101081)
Charcot-Marie-Tooth disease type 1B (Orphanet:101082)
Charcot-Marie-Tooth disease type 1E (Orphanet:90658)
Charcot-Marie-Tooth disease type 1F (Orphanet:101085)
Charcot-Marie-Tooth disease type 2B1 (Orphanet:98856)
Charcot-Marie-Tooth disease type 2B2 (Orphanet:101101)
Charcot-Marie-Tooth disease type 4A (Orphanet:99948)
Charcot-Marie-Tooth disease type 4B2 (Orphanet:99956)
Charcot-Marie-Tooth disease type 4B3 (Orphanet:363981)
Charcot-Marie-Tooth disease type 4D (Orphanet:99950)
Charcot-Marie-Tooth disease type 4E (Orphanet:99951)
Charcot-Marie-Tooth disease type 4F (Orphanet:99952)
Charcot-Marie-Tooth disease type 4H (Orphanet:99954)
Charcot-Marie-Tooth disease type 4J (Orphanet:139515)
Choreoacanthocytosis (Orphanet:2388)
Chronic intestinal pseudo-obstruction (Orphanet:2978)
Combined oxidative phosphorylation defect type 11 (Orphanet:324535)
Combined oxidative phosphorylation defect type 7 (Orphanet:254930)
Congenital lethal myopathy, Compton-North type (Orphanet:210163)
Congenital multicore myopathy with external ophthalmoplegia (Orphanet:98905)
Congenital muscular dystrophy type 1A (Orphanet:258)
Congenital myopathy with excess of thin filaments (Orphanet:98904)
Corpus callosum agenesis - neuronopathy (Orphanet:1496)
DE SANCTIS-CACCHIONE SYNDROME (OMIM:278800)
Deafness - encephaloneuropathy - obesity - valvulopathy (Orphanet:254898)
Dejerine-Sottas syndrome (Orphanet:64748)
ENCEPHALOPATHY, RECURRENT, OF CHILDHOOD (OMIM:130950)
EPILEPSY, PROGRESSIVE MYOCLONIC, 5 (OMIM:613832)
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 29 (OMIM:616339)
Early-onset X-linked optic atrophy (Orphanet:98890)
FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 2 (OMIM:615911)
Fetal akinesia-cerebral and retinal hemorrhage syndrome (Orphanet:363409)
Friedreich ataxia 2 (OMIM:601992)
GIANT AXONAL NEUROPATHY 2, AUTOSOMAL DOMINANT (OMIM:610100)
Genetic recurrent myoglobinuria (Orphanet:99845)
Gerstmann-Straussler-Scheinker syndrome (Orphanet:356)
Glycogen storage disease due to acid maltase deficiency (Orphanet:365)
Glycogen storage disease due to glycogen branching enzyme deficiency (Orphanet:367)
Hereditary motor and sensory neuropathy type 6 (Orphanet:90120)
Hereditary myoclonus - progressive distal muscular atrophy (Orphanet:2590)
Hereditary sensory and autonomic neuropathy type 1 (Orphanet:36386)
Hereditary sensory and autonomic neuropathy type 2 (Orphanet:970)
Hereditary sensory and autonomic neuropathy type 6 (Orphanet:314381)
Hereditary thermosensitive neuropathy (Orphanet:84093)
Infantile cerebellar-retinal degeneration (Orphanet:313850)
Infantile neuroaxonal dystrophy (Orphanet:35069)
Infantile onset spinocerebellar ataxia (Orphanet:1186)
Intellectual disability-developmental delay-contractures syndrome (Orphanet:3454)
Kearns-Sayre syndrome (Orphanet:480)
LETHAL CONGENITAL CONTRACTURE SYNDROME 7 (OMIM:616286)
LETHAL CONGENITAL CONTRACTURE SYNDROME 8 (OMIM:616287)
LISSENCEPHALY 7 WITH CEREBELLAR HYPOPLASIA (OMIM:616342)
Lethal ataxia with deafness and optic atrophy (Orphanet:1187)
Lethal encephalopathy due to mitochondrial and peroxisomal fission defect (Orphanet:330050)
Lower motor neuron syndrome with late-adult onset (Orphanet:276435)
MELAS (Orphanet:550)
MENTAL RETARDATION, AUTOSOMAL DOMINANT 13 (OMIM:614563)
METACHROMATIC LEUKODYSTROPHY (OMIM:250100)
MITOCHONDRIAL DNA DEPLETION SYNDROME 1 (MNGIE TYPE) (OMIM:603041)
MITOCHONDRIAL MYOPATHY (OMIM:251900)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYEANOMALIES), TYPE A, 4 (OMIM:253800)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYEANOMALIES), TYPE A, 6 (OMIM:613154)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYEANOMALIES), TYPE A, 7 (OMIM:614643)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH MENTAL RETARDATION),TYPE B, 2 (OMIM:613156)
MYASTHENIC SYNDROME, CONGENITAL, 18 (OMIM:616330)
MYASTHENIC SYNDROME, CONGENITAL, 7, PRESYNAPTIC (OMIM:616040)
MYOGLOBINURIA, ACUTE RECURRENT, AUTOSOMAL RECESSIVE (OMIM:268200)
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET (OMIM:614399)
MYOPATHY, CENTRONUCLEAR, 1 (OMIM:160150)
MYOPATHY, CENTRONUCLEAR, 5 (OMIM:615959)
MYOPATHY, REDUCING BODY, X-LINKED, EARLY-ONSET, SEVERE (OMIM:300717)
Maple syrup urine disease (Orphanet:511)
McLeod neuroacanthocytosis syndrome (Orphanet:59306)
Mitochondrial myopathy with reversible cytochrome C oxidase deficiency (Orphanet:254864)
Mitochondrial neurogastrointestinal encephalomyopathy (Orphanet:298)
Mitochondrial trifunctional protein deficiency (Orphanet:746)
Myopathy and diabetes mellitus (Orphanet:2596)
Myotilin-related myofibrillar myopathy without spheroid body (Orphanet:98911)
NEMALINE MYOPATHY 2 (OMIM:256030)
NEMALINE MYOPATHY 7 (OMIM:610687)
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2A (OMIM:256600)
NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE VB (OMIM:614751)
NEUROPATHY, HEREDITARY SENSORIMOTOR, WITH UPPER MOTOR NEURON, VISUALPATHWAY AND AUTONOMIC DISTURBANCE (OMIM:162380)
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IIA (OMIM:201300)
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IIB (OMIM:613115)
NEUROPATHY, HEREDITARY SENSORY, TYPE IIC (OMIM:614213)
Navajo neurohepatopathy (Orphanet:255229)
Nemaline myopathy (Orphanet:607)
Neuralgic amyotrophy (Orphanet:2901)
Neurodegeneration with brain iron accumulation due to C19orf12 mutation (Orphanet:289560)
Neurologic Waardenburg-Shah syndrome (Orphanet:163746)
Neutral lipid storage myopathy (Orphanet:98908)
Niemann-Pick disease type A (Orphanet:77292)
OPTIC ATROPHY, HEARING LOSS, AND PERIPHERAL NEUROPATHY, AUTOSOMALRECESSIVE (OMIM:258650)
Oculocerebrorenal syndrome (Orphanet:534)
Oculopharyngodistal myopathy (Orphanet:98897)
PERIPHERAL NEUROPATHY, MYOPATHY, HOARSENESS, AND HEARING LOSS (OMIM:614369)
PEROXISOME BIOGENESIS DISORDER 2A (ZELLWEGER) (OMIM:214110)
PEROXISOME BIOGENESIS DISORDER 5A (ZELLWEGER) (OMIM:614866)
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 3 (OMIM:609286)
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 5 (OMIM:613077)
Perrault Syndrome (Orphanet:2855)
Perrault Syndrome 1 (OMIM:233400)
Pierson syndrome (Orphanet:2670)
Posterior column ataxia - retinitis pigmentosa (Orphanet:88628)
Primary CD59 deficiency (Orphanet:169464)
Progressive myoclonic epilepsy type 6 (Orphanet:280620)
Proximal spinal muscular atrophy (Orphanet:70)
Proximal spinal muscular atrophy type 1 (Orphanet:83330)
Pyruvate dehydrogenase E1-alpha deficiency (Orphanet:79243)
RADICULONEUROPATHY, FATAL NEONATAL (OMIM:266250)
Reducing body myopathy (Orphanet:97239)
Richards-Rundle syndrome (Orphanet:1399)
Roussy-Lévy syndrome (Orphanet:3115)
SCAPULOPERONEAL SPINAL MUSCULAR ATROPHY (OMIM:181405)
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 1 (OMIM:606002)
Sensory ataxic neuropathy-dysarthria-ophthalmoparesis (Orphanet:70595)
Severe X-linked mitochondrial encephalomyopathy (Orphanet:238329)
Smith-Magenis syndrome (Orphanet:819)
Spinocerebellar ataxia type 1 (Orphanet:98755)
Spinocerebellar ataxia type 18 (Orphanet:98771)
Spinocerebellar ataxia type 4 (Orphanet:98765)
Spinocerebellar ataxia with axonal neuropathy type 2 (Orphanet:64753)
Spinocerebellar ataxia with epilepsy (Orphanet:254881)
TMCO1 defect syndrome (Orphanet:228407)
TRICHORRHEXIS NODOSA SYNDROME (OMIM:275550)
Tangier disease (Orphanet:31150)
VISCERAL NEUROPATHY, FAMILIAL, AUTOSOMAL RECESSIVE (OMIM:243180)
Wolfram syndrome 1 (OMIM:222300)
X-linked Charcot-Marie-Tooth disease type 2 (Orphanet:101076)
X-linked Charcot-Marie-Tooth disease type 3 (Orphanet:101077)
X-linked centronuclear myopathy (Orphanet:596)
X-linked distal arthrogryposis multiplex congenita (Orphanet:1145)
X-linked spinocerebellar ataxia type 3 (Orphanet:85297)
Young adult-onset distal hereditary motor neuropathy (Orphanet:314485)
Zellweger syndrome (Orphanet:912)