Spastic paraplegia

Symptom Information:

Symptom ID: HPO:0001258
Synonyms:
Spastic paraplegia, lower limb [HPO:0001258]
Spastic paraplegia [OMIM:Spastic paraplegia]
Spastic paraplegia, lower limb [OMIM:Spastic paraplegia, lower limb]
Spastic paraplegia [MedDRA:10048792]
Quality:
Cross references:
OMIM: "Spastic paraplegia" [OMIM:Spastic paraplegia]
OMIM: "Spastic paraplegia, lower limb" [OMIM:Spastic paraplegia, lower limb]
Is a (Direct Parents):
HPO         Paraplegia
MedDRA Paralysis and paresis (excl cranial nerve)
HPO         Lower limb spasticity
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Abnormality of central motor function(HPO:0011442)
                Abnormal pyramidal signs(HPO:0007256)
                   Hypertonia(HPO:0001276)
                      Spasticity(HPO:0001257)
                         Lower limb spasticity(HPO:0002061)
                            Spastic paraplegia(HPO:0001258)
                   Weakness due to upper motor neuron dysfunction(HPO:0010549)
                      Paraplegia/paraparesis(HPO:0010551)
                         Paraplegia(HPO:0010550)
                            Spastic paraplegia(HPO:0001258)
MedDRA:
Nervous system disorders(MedDRA:10029205)
    Abnormality of movement(HPO:0100022)
       Paralysis and paresis (excl cranial nerve)(MedDRA:10033800)
          Spastic paraplegia(HPO:0001258)
Database Frequency: 97 / 7739
Resource:

All diseases associated with this symptom:

AICARDI-GOUTIERES SYNDROME 2 (OMIM:610181)
AMYOTROPHIC DYSTONIC PARAPLEGIA (OMIM:105300)
Allan-Herndon-Dudley syndrome (Orphanet:59)
Argininemia (Orphanet:90)
Autosomal dominant spastic ataxia 1 (Orphanet:251282)
Autosomal dominant spastic paraplegia type 10 (Orphanet:100991)
Autosomal dominant spastic paraplegia type 12 (Orphanet:100993)
Autosomal dominant spastic paraplegia type 13 (Orphanet:100994)
Autosomal dominant spastic paraplegia type 17 (Orphanet:100998)
Autosomal dominant spastic paraplegia type 19 (Orphanet:100999)
Autosomal dominant spastic paraplegia type 29 (Orphanet:101009)
Autosomal dominant spastic paraplegia type 3 (Orphanet:100984)
Autosomal dominant spastic paraplegia type 31 (Orphanet:101011)
Autosomal dominant spastic paraplegia type 36 (Orphanet:320365)
Autosomal dominant spastic paraplegia type 37 (Orphanet:171612)
Autosomal dominant spastic paraplegia type 38 (Orphanet:171617)
Autosomal dominant spastic paraplegia type 4 (Orphanet:100985)
Autosomal dominant spastic paraplegia type 41 (Orphanet:320355)
Autosomal dominant spastic paraplegia type 42 (Orphanet:171863)
Autosomal dominant spastic paraplegia type 6 (Orphanet:100988)
Autosomal dominant spastic paraplegia type 8 (Orphanet:100989)
Autosomal dominant spastic paraplegia type 9 (Orphanet:100990)
Autosomal recessive spastic paraplegia type 11 (Orphanet:2822)
Autosomal recessive spastic paraplegia type 14 (Orphanet:100995)
Autosomal recessive spastic paraplegia type 15 (Orphanet:100996)
Autosomal recessive spastic paraplegia type 18 (Orphanet:209951)
Autosomal recessive spastic paraplegia type 20 (Orphanet:101000)
Autosomal recessive spastic paraplegia type 21 (Orphanet:101001)
Autosomal recessive spastic paraplegia type 23 (Orphanet:101003)
Autosomal recessive spastic paraplegia type 24 (Orphanet:101004)
Autosomal recessive spastic paraplegia type 26 (Orphanet:101006)
Autosomal recessive spastic paraplegia type 27 (Orphanet:101007)
Autosomal recessive spastic paraplegia type 28 (Orphanet:101008)
Autosomal recessive spastic paraplegia type 30 (Orphanet:101010)
Autosomal recessive spastic paraplegia type 32 (Orphanet:171622)
Autosomal recessive spastic paraplegia type 35 (Orphanet:171629)
Autosomal recessive spastic paraplegia type 43 (Orphanet:320370)
Autosomal recessive spastic paraplegia type 44 (Orphanet:320401)
Autosomal recessive spastic paraplegia type 45 (Orphanet:320396)
Autosomal recessive spastic paraplegia type 46 (Orphanet:320391)
Autosomal recessive spastic paraplegia type 48 (Orphanet:306511)
Autosomal recessive spastic paraplegia type 49 (Orphanet:320385)
Autosomal recessive spastic paraplegia type 53 (Orphanet:319199)
Autosomal recessive spastic paraplegia type 54 (Orphanet:320380)
Autosomal recessive spastic paraplegia type 55 (Orphanet:320375)
Autosomal recessive spastic paraplegia type 56 (Orphanet:320411)
Autosomal recessive spastic paraplegia type 5A (Orphanet:100986)
Autosomal recessive spastic paraplegia type 7 (Orphanet:99013)
Behr syndrome (Orphanet:1239)
CEREBRAL SCLEROSIS, DIFFUSE, SCHOLZ TYPE (OMIM:302700)
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 4 (OMIM:612164)
Generalized congenital lipodystrophy with myopathy (Orphanet:228429)
Giant axonal neuropathy (Orphanet:643)
Hereditary sensory and autonomic neuropathy with spastic paraplegia (Orphanet:139578)
Homocarnosinosis (Orphanet:2168)
Hydrocephalus with stenosis of aqueduct of Sylvius (Orphanet:2182)
Infantile-onset ascending hereditary spastic paralysis (Orphanet:293168)
Intellectual deficit - spasticity - ectrodactyly (Orphanet:1891)
KALLMANN SYNDROME WITH SPASTIC PARAPLEGIA (OMIM:308750)
Laurence-Moon syndrome (Orphanet:2377)
Leukoencephalopathy - metaphyseal chondrodysplasia (Orphanet:83629)
MASA syndrome (Orphanet:2466)
METAPHYSEAL MODELING ABNORMALITY, SKIN LESIONS, AND SPASTIC PARAPLEGIA (OMIM:250500)
Macrocephaly - spastic paraplegia - dysmorphism (Orphanet:2429)
OPTIC ATROPHY--SPASTIC PARAPLEGIA SYNDROME (OMIM:311100)
Paraplegia - intellectual deficit - hyperkeratosis (Orphanet:2824)
Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity (Orphanet:53583)
Pontocerebellar hypoplasia type 7 (Orphanet:284339)
Pyruvate dehydrogenase E3-binding protein deficiency (Orphanet:255182)
SPASTIC PARAPLEGIA 47, AUTOSOMAL RECESSIVE (OMIM:614066)
SPASTIC PARAPLEGIA 51, AUTOSOMAL RECESSIVE (OMIM:613744)
SPASTIC PARAPLEGIA 52, AUTOSOMAL RECESSIVE (OMIM:614067)
SPASTIC PARAPLEGIA 57, AUTOSOMAL RECESSIVE (OMIM:615658)
SPASTIC PARAPLEGIA 61, AUTOSOMAL RECESSIVE (OMIM:615685)
SPASTIC PARAPLEGIA 72, AUTOSOMAL RECESSIVE (OMIM:615625)
SPASTIC PARAPLEGIA 73, AUTOSOMAL DOMINANT (OMIM:616282)
SPASTIC PARAPLEGIA AND EVANS SYNDROME (OMIM:601608)
SPASTIC PARAPLEGIA WITH ASSOCIATED EXTRAPYRAMIDAL SIGNS (OMIM:182800)
SPASTIC PARAPLEGIA, ATAXIA, AND MENTAL RETARDATION (OMIM:607565)
SPASTIC PARAPLEGIA, OPTIC ATROPHY, AND DEMENTIA (OMIM:182830)
Severe intellectual deficit and progressive spastic paraplegia (Orphanet:280763)
Spastic paraplegia - epilepsy - intellectual deficit (Orphanet:2816)
Spastic paraplegia - glaucoma - intellectual deficit (Orphanet:2818)
Spastic paraplegia - nephritis - deafness (Orphanet:2820)
Spastic paraplegia - neuropathy - poikiloderma (Orphanet:2821)
Spastic paraplegia - precocious puberty (Orphanet:2826)
Spastic paraplegia 33, autosomal dominant (OMIM:610244)
Spastic paraplegia 63, autosomal recessive (OMIM:615686)
Spastic paraplegia 64, autosomal recessive (OMIM:615683)
Spastic paraplegia type 2 (Orphanet:99015)
Spastic paraplegia-optic atrophy-neuropathy syndrome (Orphanet:320406)
Waardenburg syndrome (Orphanet:3440)
X-linked cerebral adrenoleukodystrophy (Orphanet:139396)
X-linked immunoneurologic disorder (Orphanet:2571)
X-linked spastic paraplegia type 16 (Orphanet:100997)
X-linked spastic paraplegia type 34 (Orphanet:171607)
[DEL] SPASTIC PARAPLEGIA 7, AUTOSOMAL RECESSIVE (OMIM:607259)