Schule et al. (2009) reported a 3-generation German family with autosomal dominant complicated spastic paraplegia. The mean age at onset was 24 years (range, 14 to 33 years), and the phenotype included the core features of spastic gait, ... Schule et al. (2009) reported a 3-generation German family with autosomal dominant complicated spastic paraplegia. The mean age at onset was 24 years (range, 14 to 33 years), and the phenotype included the core features of spastic gait, spasticity, and lower limb weakness, as well as extensor plantar responses. Affected individuals also had lower extremity sensory deficits affecting vibration, touch, joint position, and temperature discrimination, suggesting a demyelinating type of pyramidal damage, which was confirmed by neurophysiologic studies. Two patients had pes cavus, and 2 became wheelchair-dependent late in the disease course. There were no neuropsychologic abnormalities, and brain MRI studies were unremarkable.