Babinski sign

Symptom Information:

Symptom ID: HPO:0003487
Synonyms:
Extensor plantar reflexes [HPO:0003487]
Extensor plantar response [HPO:0003487]
Extensor plantar responses [HPO:0003487]
Babinski sign [OMIM:Babinski sign]
Extensor plantar reflexes [OMIM:Extensor plantar reflexes]
Extensor plantar response [OMIM:Extensor plantar response]
Extensor plantar responses [OMIM:Extensor plantar responses]
Extensor plantar responses (1 patient) [OMIM:Extensor plantar responses (1 patient)]
Extensor plantar responses (early-on) [OMIM:Extensor plantar responses (early-on)]
Extensor plantar responses (in some patients) [OMIM:Extensor plantar responses (in some patients)]
Extensor plantar responses (later) [OMIM:Extensor plantar responses (later)]
Extensor plantar responses (less common) [OMIM:Extensor plantar responses (less common)]
Extensor plantar responses (reported in 1 family) [OMIM:Extensor plantar responses (reported in 1 family)]
Extensor plantar responses (reported in 1 patient) [OMIM:Extensor plantar responses (reported in 1 patient)]
Extensor plantar responses (variable) [OMIM:Extensor plantar responses (variable)]
Extensor plantar response [MedDRA:10015727]
Quality:
Cross references:
OMIM: "Babinski sign" [OMIM:Babinski sign]
OMIM: "Extensor plantar reflexes" [OMIM:Extensor plantar reflexes]
OMIM: "Extensor plantar response" [OMIM:Extensor plantar response]
OMIM: "Extensor plantar responses" [OMIM:Extensor plantar responses]
OMIM: "Extensor plantar responses (1 patient)" [OMIM:Extensor plantar responses (1 patient)]
OMIM: "Extensor plantar responses (early-on)" [OMIM:Extensor plantar responses (early-on)]
OMIM: "Extensor plantar responses (in some patients)" [OMIM:Extensor plantar responses (in some patients)]
OMIM: "Extensor plantar responses (later)" [OMIM:Extensor plantar responses (later)]
OMIM: "Extensor plantar responses (less common)" [OMIM:Extensor plantar responses (less common)]
OMIM: "Extensor plantar responses (reported in 1 family)" [OMIM:Extensor plantar responses (reported in 1 family)]
OMIM: "Extensor plantar responses (reported in 1 patient)" [OMIM:Extensor plantar responses (reported in 1 patient)]
OMIM: "Extensor plantar responses (variable)" [OMIM:Extensor plantar responses (variable)]
Is a (Direct Parents):
HPO         Abnormal pyramidal signs
MedDRA Abnormal reflexes
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Abnormality of central motor function(HPO:0011442)
                Abnormal pyramidal signs(HPO:0007256)
                   Babinski sign(HPO:0003487)
MedDRA:
Nervous system disorders(MedDRA:10029205)
    Neurological disorders NEC(MedDRA:10029305)
       Abnormal reflexes(MedDRA:10000171)
          Babinski sign(HPO:0003487)
Database Frequency: 179 / 7739
Resource:

All diseases associated with this symptom:

3-methylglutaconic aciduria type 3 (Orphanet:67047)
ACHALASIA-ADDISONIANISM-ALACRIMA SYNDROME (OMIM:231550)
ALZHEIMER DISEASE 3 (OMIM:607822)
AMYOTROPHIC LATERAL SCLEROSIS 10 WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA (OMIM:612069)
AMYOTROPHIC LATERAL SCLEROSIS 17 (OMIM:614696)
AMYOTROPHIC LATERAL SCLEROSIS 2, JUVENILE (OMIM:205100)
AMYOTROPHIC LATERAL SCLEROSIS 5 (OMIM:602099)
ATAXIA, COMBINED CEREBELLAR AND PERIPHERAL, WITH HEARING LOSS ANDDIABETES MELLITUS (OMIM:616192)
ATAXIA, SENSORY, 1, AUTOSOMAL DOMINANT (OMIM:608984)
ATAXIA, SPASTIC, CHILDHOOD-ONSET, AUTOSOMAL RECESSIVE, WITH OPTICATROPHY AND MENTAL RETARDATION (OMIM:270500)
Adult polyglucosan body disease (Orphanet:206583)
Adult-onset autosomal dominant leukodystrophy (Orphanet:99027)
Allan-Herndon-Dudley syndrome (Orphanet:59)
Alpha-mannosidosis (Orphanet:61)
Amyotrophic lateral sclerosis type 4 (Orphanet:357043)
Arnold-Chiari malformation type I (Orphanet:268882)
Aromatic L-amino acid decarboxylase deficiency (Orphanet:35708)
Autosomal dominant Charcot-Marie-Tooth disease type 2A2 (Orphanet:99947)
Autosomal dominant dopa-responsive dystonia (Orphanet:98808)
Autosomal dominant spastic paraplegia type 10 (Orphanet:100991)
Autosomal dominant spastic paraplegia type 12 (Orphanet:100993)
Autosomal dominant spastic paraplegia type 13 (Orphanet:100994)
Autosomal dominant spastic paraplegia type 17 (Orphanet:100998)
Autosomal dominant spastic paraplegia type 19 (Orphanet:100999)
Autosomal dominant spastic paraplegia type 29 (Orphanet:101009)
Autosomal dominant spastic paraplegia type 3 (Orphanet:100984)
Autosomal dominant spastic paraplegia type 31 (Orphanet:101011)
Autosomal dominant spastic paraplegia type 36 (Orphanet:320365)
Autosomal dominant spastic paraplegia type 37 (Orphanet:171612)
Autosomal dominant spastic paraplegia type 38 (Orphanet:171617)
Autosomal dominant spastic paraplegia type 4 (Orphanet:100985)
Autosomal dominant spastic paraplegia type 42 (Orphanet:171863)
Autosomal dominant spastic paraplegia type 6 (Orphanet:100988)
Autosomal dominant spastic paraplegia type 8 (Orphanet:100989)
Autosomal dominant spastic paraplegia type 9 (Orphanet:100990)
Autosomal recessive cerebellar ataxia - epilepsy - intellectual deficit (Orphanet:284282)
Autosomal recessive cerebellar ataxia - saccadic intrusion (Orphanet:95434)
Autosomal recessive nonsyndromic intellectual deficit (Orphanet:88616)
Autosomal recessive spastic ataxia - optic atrophy - dysarthria (Orphanet:254343)
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (Orphanet:98)
Autosomal recessive spastic paraplegia type 11 (Orphanet:2822)
Autosomal recessive spastic paraplegia type 14 (Orphanet:100995)
Autosomal recessive spastic paraplegia type 15 (Orphanet:100996)
Autosomal recessive spastic paraplegia type 18 (Orphanet:209951)
Autosomal recessive spastic paraplegia type 20 (Orphanet:101000)
Autosomal recessive spastic paraplegia type 21 (Orphanet:101001)
Autosomal recessive spastic paraplegia type 23 (Orphanet:101003)
Autosomal recessive spastic paraplegia type 26 (Orphanet:101006)
Autosomal recessive spastic paraplegia type 27 (Orphanet:101007)
Autosomal recessive spastic paraplegia type 28 (Orphanet:101008)
Autosomal recessive spastic paraplegia type 30 (Orphanet:101010)
Autosomal recessive spastic paraplegia type 32 (Orphanet:171622)
Autosomal recessive spastic paraplegia type 35 (Orphanet:171629)
Autosomal recessive spastic paraplegia type 39 (Orphanet:139480)
Autosomal recessive spastic paraplegia type 43 (Orphanet:320370)
Autosomal recessive spastic paraplegia type 44 (Orphanet:320401)
Autosomal recessive spastic paraplegia type 45 (Orphanet:320396)
Autosomal recessive spastic paraplegia type 46 (Orphanet:320391)
Autosomal recessive spastic paraplegia type 48 (Orphanet:306511)
Autosomal recessive spastic paraplegia type 54 (Orphanet:320380)
Autosomal recessive spastic paraplegia type 55 (Orphanet:320375)
Autosomal recessive spastic paraplegia type 56 (Orphanet:320411)
Autosomal recessive spastic paraplegia type 5A (Orphanet:100986)
Autosomal recessive spastic paraplegia type 7 (Orphanet:99013)
Behavioral variant of frontotemporal dementia (Orphanet:275864)
Behr syndrome (Orphanet:1239)
Beta-mannosidosis (Orphanet:118)
Bilateral frontoparietal polymicrogyria (Orphanet:101070)
CAMOS syndrome (Orphanet:83472)
CARASIL (Orphanet:199354)
CEREBRAL PALSY, SPASTIC QUADRIPLEGIC, 1 (OMIM:603513)
CHARCOT-MARIE-TOOTH PERONEAL MUSCULAR ATROPHY AND FRIEDREICH ATAXIA,COMBINED (OMIM:302900)
CHOROID PLEXUS CALCIFICATION AND MENTAL RETARDATION (OMIM:215480)
Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia (Orphanet:284324)
Christianson syndrome (Orphanet:85278)
Classical phenylketonuria (Orphanet:79254)
Congenital cataracts - facial dysmorphism - neuropathy (Orphanet:48431)
Congenital muscular dystrophy type 1A (Orphanet:258)
DPM3-CDG (Orphanet:263494)
Distal hereditary motor neuropathy type 1 (Orphanet:139518)
Distal hereditary motor neuropathy, Jerash type (Orphanet:139552)
ENCEPHALOPATHY, RECURRENT, OF CHILDHOOD (OMIM:130950)
EPILEPSY, PROGRESSIVE MYOCLONIC, 1B (OMIM:612437)
Early-onset X-linked optic atrophy (Orphanet:98890)
Early-onset progressive neurodegeneration - blindness - ataxia - spasticity (Orphanet:352654)
Encephalopathy due to GLUT1 deficiency (Orphanet:71277)
Encephalopathy due to prosaposin deficiency (Orphanet:139406)
Episodic ataxia type 1 (Orphanet:37612)
FRIEDREICH ATAXIA AND CONGENITAL GLAUCOMA (OMIM:229310)
FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 2 (OMIM:615911)
Friedreich ataxia 1 (OMIM:229300)
Friedreich ataxia 2 (OMIM:601992)
Hereditary continuous muscle fiber activity (Orphanet:972)
Hereditary motor and sensory neuropathy type 5 (Orphanet:64751)
Hereditary sensory and autonomic neuropathy with spastic paraplegia (Orphanet:139578)
Hypomyelination - congenital cataract (Orphanet:85163)
Hypomyelination with brain stem and spinal cord involvement and leg spasticity (Orphanet:363412)
Infantile-onset ascending hereditary spastic paralysis (Orphanet:293168)
Inherited congenital spastic tetraplegia (Orphanet:210141)
Intellectual deficit, X-linked - psychosis - macroorchidism (Orphanet:3077)
Isolated NADH-CoQ reductase deficiency (Orphanet:2609)
Isolated succinate-CoQ reductase deficiency (Orphanet:3208)
Juvenile amyotrophic lateral sclerosis (Orphanet:300605)
Juvenile primary lateral sclerosis (Orphanet:247604)
Kufor-Rakeb syndrome (Orphanet:306674)
Leber plus disease (Orphanet:99718)
Leigh syndrome (Orphanet:506)
Lesch-Nyhan syndrome (Orphanet:510)
Leukoencephalopathy - ataxia - hypodontia - hypomyelination (Orphanet:137639)
Leukoencephalopathy - metaphyseal chondrodysplasia (Orphanet:83629)
Leukoencephalopathy with brain stem and spinal cord involvement - lactate elevation (Orphanet:137898)
MENTAL RETARDATION, AUTOSOMAL DOMINANT 9 (OMIM:614255)
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 40 (OMIM:615599)
METACHROMATIC LEUKODYSTROPHY (OMIM:250100)
METACHROMATIC LEUKODYSTROPHY DUE TO SAPOSIN B DEFICIENCY (OMIM:249900)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 2 (OMIM:615157)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH MENTAL RETARDATION),TYPE B, 6 (OMIM:608840)
McLeod neuroacanthocytosis syndrome (Orphanet:59306)
Mucolipidosis type 4 (Orphanet:578)
Multiple system atrophy (Orphanet:102)
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2B (OMIM:610217)
NEUROPATHY, CONGENITAL, WITH ARTHROGRYPOSIS MULTIPLEX (OMIM:162370)
NEUROPATHY, HEREDITARY SENSORIMOTOR, WITH UPPER MOTOR NEURON, VISUALPATHWAY AND AUTONOMIC DISTURBANCE (OMIM:162380)
NEUROPATHY, HEREDITARY SENSORY, ATYPICAL (OMIM:256860)
Nasu-Hakola disease (Orphanet:2770)
Neurodegeneration with brain iron accumulation due to C19orf12 mutation (Orphanet:289560)
Neuroferritinopathy (Orphanet:157846)
Odontoleukodystrophy (Orphanet:77295)
PARKINSON DISEASE 15, AUTOSOMAL RECESSIVE EARLY-ONSET (OMIM:260300)
PARTIAL LIPODYSTROPHY, CONGENITAL CATARACTS, AND NEURODEGENERATIONSYNDROME (OMIM:606721)
PONTOCEREBELLAR HYPOPLASIA, TYPE 2B (OMIM:612389)
PORENCEPHALY 1 (OMIM:175780)
Paraplegia - brachydactyly - cone-shaped epiphysis (Orphanet:2823)
Parkinsonim due to ATP13A2 deficiency (Orphanet:314632)
Pelizaeus-Merzbacher-like due to GJC2 mutation (Orphanet:280282)
Pelizaeus-Merzbacher-like due to HSPD1 mutation (Orphanet:280288)
Peroxisomal acyl-CoA oxidase deficiency (Orphanet:2971)
Polyneuropathy - hearing loss - ataxia - retinitis pigmentosa - cataract (Orphanet:171848)
Porencephaly (Orphanet:2940)
Primary lateral sclerosis (Orphanet:35689)
RIGIDITY AND MULTIFOCAL SEIZURE SYNDROME, LETHAL NEONATAL (OMIM:614498)
SPASTIC ATAXIA 2, AUTOSOMAL RECESSIVE (OMIM:611302)
SPASTIC PARAPLEGIA 47, AUTOSOMAL RECESSIVE (OMIM:614066)
SPASTIC PARAPLEGIA 50, AUTOSOMAL RECESSIVE (OMIM:612936)
SPASTIC PARAPLEGIA 51, AUTOSOMAL RECESSIVE (OMIM:613744)
SPASTIC PARAPLEGIA 52, AUTOSOMAL RECESSIVE (OMIM:614067)
SPASTIC PARAPLEGIA 57, AUTOSOMAL RECESSIVE (OMIM:615658)
SPASTIC PARAPLEGIA 72, AUTOSOMAL RECESSIVE (OMIM:615625)
SPASTIC PARAPLEGIA 73, AUTOSOMAL DOMINANT (OMIM:616282)
SPASTIC PARAPLEGIA, ATAXIA, AND MENTAL RETARDATION (OMIM:607565)
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 18 (OMIM:616204)
STRIATONIGRAL DEGENERATION, INFANTILE, MITOCHONDRIAL (OMIM:500003)
Severe intellectual deficit and progressive spastic paraplegia (Orphanet:280763)
Spastic ataxia with congenital miosis (Orphanet:1182)
Spastic paraplegia 33, autosomal dominant (OMIM:610244)
Spastic paraplegia 64, autosomal recessive (OMIM:615683)
Spastic paraplegia type 2 (Orphanet:99015)
Spinocerebellar ataxia - dysmorphism (Orphanet:1185)
Spinocerebellar ataxia type 1 (Orphanet:98755)
Spinocerebellar ataxia type 18 (Orphanet:98771)
Spinocerebellar ataxia type 23 (Orphanet:101108)
Spinocerebellar ataxia type 25 (Orphanet:101111)
Spinocerebellar ataxia type 28 (Orphanet:101109)
Spinocerebellar ataxia type 3 (Orphanet:98757)
Spinocerebellar ataxia type 35 (Orphanet:276193)
Spinocerebellar ataxia type 36 (Orphanet:276198)
Spinocerebellar ataxia type 4 (Orphanet:98765)
Spinocerebellar ataxia type 7 (Orphanet:94147)
Syndromic X-linked intellectual deficit due to JARID1C mutation (Orphanet:85279)
Syringomyelia (Orphanet:3280)
TRICHORRHEXIS NODOSA SYNDROME (OMIM:275550)
Thiamine-responsive encephalopathy (Orphanet:199348)
Triple A syndrome (Orphanet:869)
X-linked Charcot-Marie-Tooth disease type 1 (Orphanet:101075)
X-linked parkinsonism-spasticity syndrome (Orphanet:363654)
X-linked sideroblastic anemia - ataxia (Orphanet:2802)
X-linked spastic paraplegia type 16 (Orphanet:100997)
X-linked spastic paraplegia type 34 (Orphanet:171607)
[DEL] SPASTIC PARAPLEGIA 7, AUTOSOMAL RECESSIVE (OMIM:607259)