Hanein et al. (2007) reported a large 4-generation French family in which at least 13 members had spastic paraplegia inherited in an autosomal dominant pattern. The age at onset varied from 8 to 60 years with a mean ... Hanein et al. (2007) reported a large 4-generation French family in which at least 13 members had spastic paraplegia inherited in an autosomal dominant pattern. The age at onset varied from 8 to 60 years with a mean of 31.6 years. Clinical features included spastic gait and extensor plantar responses. Variable features included hyperreflexia of the upper limbs, weakness of the iliopsoas muscle, decreased vibration sense, and bladder disturbances. The disorder appeared to be slowly progressive. None required a walking aid, and brain imaging was normal in those tested. Several individuals were probably or possibly affected, suggesting incomplete penetrance.