Valente et al. (2002) reported an Italian family in which 10 members in 3 consecutive generations had spastic paraplegia. Mean age of onset was 47 years (range, 36-55) and clinical findings included lower limb hyperreflexia, progressive spastic gait ... Valente et al. (2002) reported an Italian family in which 10 members in 3 consecutive generations had spastic paraplegia. Mean age of onset was 47 years (range, 36-55) and clinical findings included lower limb hyperreflexia, progressive spastic gait abnormality, extensor plantar responses, ankle or knee clonus, and urinary urgency. Spasticity was exacerbated by stress, anxiety, and walking after rest. Nerve conduction studies on some of the individuals revealed slowing of motor and sensory conduction velocities localized to the lower limbs. In general, however, the disorder followed a slow progression and was relatively benign, with only 1 patient confined to a wheelchair.