Distal muscle weakness

Symptom Information:

Symptom ID: HPO:0002460
Synonyms:
Distal limb muscle weakness [HPO:0002460]
DISTAL LIMB MUSCLE WEAKNESS DUE TO PERIPHERAL NEUROPATHY [HPO:0002460]
Distal limb weakness [HPO:0002460]
Distal muscular weakness [HPO:0002460]
Muscle weakness, distal [HPO:0002460]
Muscle weakness, distal limbs, due to neuronopathy [HPO:0002460]
Weakness of distal muscles [HPO:0002460]
Distal limb muscle weakness [OMIM:Distal limb muscle weakness]
Distal limb muscle weakness due to peripheral neuropathy [OMIM:Distal limb muscle weakness due to peripheral neuropathy]
Distal limb weakness [OMIM:Distal limb weakness]
Distal muscle weakness [OMIM:Distal muscle weakness]
Distal muscular weakness [OMIM:Distal muscular weakness]
Muscle weakness, distal [OMIM:Muscle weakness, distal]
Muscle weakness, distal limbs, due to neuronopathy [OMIM:Muscle weakness, distal limbs, due to neuronopathy]
Distal limb muscle weakness (less common) [OMIM:Distal limb muscle weakness (less common)]
Distal limb muscle weakness due to peripheral neuropathy (lower and sometimes upper limbs are affected) [OMIM:Distal limb muscle weakness due to peripheral neuropathy (lower and sometimes upper limbs are affected)]
Distal limb muscle weakness due to peripheral neuropathy (lower limbs are more affected than upper limbs) [OMIM:Distal limb muscle weakness due to peripheral neuropathy (lower limbs are more affected than upper limbs)]
Distal muscle weakness (first affects anterior leg muscles, then posterior leg muscles) [OMIM:Distal muscle weakness (first affects anterior leg muscles, then posterior leg muscles)]
Weakness of distal muscles (upper and lower limb) [OMIM:Weakness of distal muscles (upper and lower limb)]
Quality:
Cross references:
OMIM: "Distal limb muscle weakness" [OMIM:Distal limb muscle weakness]
OMIM: "Distal limb muscle weakness due to peripheral neuropathy" [OMIM:Distal limb muscle weakness due to peripheral neuropathy]
OMIM: "Distal limb weakness" [OMIM:Distal limb weakness]
OMIM: "Distal muscle weakness" [OMIM:Distal muscle weakness]
OMIM: "Distal muscular weakness" [OMIM:Distal muscular weakness]
OMIM: "Muscle weakness, distal" [OMIM:Muscle weakness, distal]
OMIM: "Muscle weakness, distal limbs, due to neuronopathy" [OMIM:Muscle weakness, distal limbs, due to neuronopathy]
OMIM: "Distal limb muscle weakness (less common)" [OMIM:Distal limb muscle weakness (less common)]
OMIM: "Distal limb muscle weakness due to peripheral neuropathy (lower and sometimes upper limbs are affected)" [OMIM:Distal limb muscle weakness due to peripheral neuropathy (lower and sometimes upper limbs are affected)]
OMIM: "Distal limb muscle weakness due to peripheral neuropathy (lower limbs are more affected than upper limbs)" [OMIM:Distal limb muscle weakness due to peripheral neuropathy (lower limbs are more affected than upper limbs)]
OMIM: "Distal muscle weakness (first affects anterior leg muscles, then posterior leg muscles)" [OMIM:Distal muscle weakness (first affects anterior leg muscles, then posterior leg muscles)]
OMIM: "Weakness of distal muscles (upper and lower limb)" [OMIM:Weakness of distal muscles (upper and lower limb)]
Is a (Direct Parents):
HPO         Muscle weakness
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the musculature(HPO:0003011)
          Abnormality of muscle physiology(HPO:0011804)
             Muscle weakness(HPO:0001324)
                Distal muscle weakness(HPO:0002460)
MedDRA:
Database Frequency: 122 / 7739
Resource:

All diseases associated with this symptom:

AMYOTROPHIC LATERAL SCLEROSIS 5 (OMIM:602099)
AMYOTROPHIC LATERAL SCLEROSIS 8 (OMIM:608627)
AMYOTROPHIC LATERAL SCLEROSIS 9 (OMIM:611895)
AMYOTROPHIC LATERAL SCLEROSIS WITH POLYGLUCOSAN BODIES (OMIM:205250)
Alpha-N-acetylgalactosaminidase deficiency type 2 (Orphanet:79280)
Alpha-crystallinopathy (Orphanet:98910)
Amyotrophic lateral sclerosis type 4 (Orphanet:357043)
Autosomal dominant Charcot-Marie-Tooth disease type 2A1 (Orphanet:99946)
Autosomal dominant Charcot-Marie-Tooth disease type 2A2 (Orphanet:99947)
Autosomal dominant Charcot-Marie-Tooth disease type 2B (Orphanet:99936)
Autosomal dominant Charcot-Marie-Tooth disease type 2C (Orphanet:99937)
Autosomal dominant Charcot-Marie-Tooth disease type 2D (Orphanet:99938)
Autosomal dominant Charcot-Marie-Tooth disease type 2E (Orphanet:99939)
Autosomal dominant Charcot-Marie-Tooth disease type 2F (Orphanet:99940)
Autosomal dominant Charcot-Marie-Tooth disease type 2G (Orphanet:99941)
Autosomal dominant Charcot-Marie-Tooth disease type 2I (Orphanet:99942)
Autosomal dominant Charcot-Marie-Tooth disease type 2J (Orphanet:99943)
Autosomal dominant Charcot-Marie-Tooth disease type 2K (Orphanet:99944)
Autosomal dominant Charcot-Marie-Tooth disease type 2L (Orphanet:99945)
Autosomal dominant Charcot-Marie-Tooth disease type 2M (Orphanet:228179)
Autosomal dominant Charcot-Marie-Tooth disease type 2N (Orphanet:228174)
Autosomal dominant Charcot-Marie-Tooth disease type 2O (Orphanet:284232)
Autosomal dominant Charcot-Marie-Tooth disease type 2P (Orphanet:300319)
Autosomal dominant congenital benign spinal muscular atrophy (Orphanet:1216)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type A (Orphanet:100043)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type B (Orphanet:100044)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type C (Orphanet:100045)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type D (Orphanet:100046)
Autosomal dominant intermediate Charcot-Marie-Tooth disease type E (Orphanet:93114)
Autosomal dominant spastic paraplegia type 17 (Orphanet:100998)
Autosomal dominant spastic paraplegia type 38 (Orphanet:171617)
Autosomal dominant spastic paraplegia type 9 (Orphanet:100990)
Autosomal recessive Charcot-Marie-Tooth disease with hoarseness (Orphanet:101097)
Autosomal recessive centronuclear myopathy (Orphanet:169186)
Autosomal recessive intermediate Charcot-Marie-Tooth disease type C (Orphanet:369867)
Autosomal recessive limb-girdle muscular dystrophy type 2E (Orphanet:119)
Autosomal recessive limb-girdle muscular dystrophy type 2I (Orphanet:34515)
Autosomal recessive limb-girdle muscular dystrophy type 2J (Orphanet:140922)
Autosomal recessive lower motor neuron disease with childhood onset (Orphanet:206580)
Autosomal recessive progressive external ophthalmoplegia (Orphanet:254886)
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (Orphanet:98)
Autosomal recessive spastic paraplegia type 48 (Orphanet:306511)
Bethlem myopathy (Orphanet:610)
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, WITH VOCAL CORD PARESIS, AUTOSOMALRECESSIVE (OMIM:607706)
CYSTINOSIS, NEPHROPATHIC (OMIM:219800)
Charcot-Marie-Tooth disease type 1A (Orphanet:101081)
Charcot-Marie-Tooth disease type 1B (Orphanet:101082)
Charcot-Marie-Tooth disease type 1C (Orphanet:101083)
Charcot-Marie-Tooth disease type 1D (Orphanet:101084)
Charcot-Marie-Tooth disease type 1E (Orphanet:90658)
Charcot-Marie-Tooth disease type 1F (Orphanet:101085)
Charcot-Marie-Tooth disease type 2B1 (Orphanet:98856)
Charcot-Marie-Tooth disease type 2B2 (Orphanet:101101)
Charcot-Marie-Tooth disease type 2H (Orphanet:101102)
Charcot-Marie-Tooth disease type 4A (Orphanet:99948)
Charcot-Marie-Tooth disease type 4B1 (Orphanet:99955)
Charcot-Marie-Tooth disease type 4B2 (Orphanet:99956)
Charcot-Marie-Tooth disease type 4C (Orphanet:99949)
Charcot-Marie-Tooth disease type 4D (Orphanet:99950)
Charcot-Marie-Tooth disease type 4E (Orphanet:99951)
Charcot-Marie-Tooth disease type 4G (Orphanet:99953)
Charcot-Marie-Tooth disease type 4J (Orphanet:139515)
Dejerine-Sottas syndrome (Orphanet:64748)
Desminopathy (Orphanet:98909)
Distal hereditary motor neuropathy type 1 (Orphanet:139518)
Distal hereditary motor neuropathy type 5 (Orphanet:139536)
Distal hereditary motor neuropathy type 7 (Orphanet:139589)
Distal hereditary motor neuropathy, Jerash type (Orphanet:139552)
Distal myopathy with anterior tibial onset (Orphanet:178400)
Distal myopathy with vocal cord weakness (Orphanet:600)
Distal myopathy, Welander type (Orphanet:603)
Distal spinal muscular atrophy type 3 (Orphanet:139547)
Duchenne muscular dystrophy (Orphanet:98896)
GIANT AXONAL NEUROPATHY 2, AUTOSOMAL DOMINANT (OMIM:610100)
Giant axonal neuropathy (Orphanet:643)
Hereditary inclusion body myopathy - joint contractures - ophthalmoplegia (Orphanet:79091)
Hereditary motor and sensory neuropathy type 5 (Orphanet:64751)
Hereditary motor and sensory neuropathy type 6 (Orphanet:90120)
Hereditary sensory and autonomic neuropathy type 1 (Orphanet:36386)
Inclusion body myositis (Orphanet:611)
Laing distal myopathy (Orphanet:59135)
MITOCHONDRIAL DNA DEPLETION SYNDROME 1 (MNGIE TYPE) (OMIM:603041)
MIYOSHI MUSCULAR DYSTROPHY 3 (OMIM:613319)
MYOPATHY, DISTAL, 3 (OMIM:610099)
MYOPATHY, DISTAL, INFANTILE-ONSET (OMIM:160300)
Mitochondrial neurogastrointestinal encephalomyopathy (Orphanet:298)
Miyoshi myopathy (Orphanet:45448)
Myosclerosis (Orphanet:289380)
NEUROLOGIC, ENDOCRINE, AND PANCREATIC DISEASE, MULTISYSTEM, INFANTILE-ONSET (OMIM:616263)
NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IIC (OMIM:613376)
NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE VA (OMIM:600794)
NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE VB (OMIM:614751)
NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE VIIA (OMIM:158580)
NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE VIIB (OMIM:607641)
NEUROPATHY, CONGENITAL, WITH ARTHROGRYPOSIS MULTIPLEX (OMIM:162370)
NEUROPATHY, HEREDITARY SENSORIMOTOR, WITH UPPER MOTOR NEURON, VISUALPATHWAY AND AUTONOMIC DISTURBANCE (OMIM:162380)
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IC (OMIM:613640)
NONAKA MYOPATHY (OMIM:605820)
Navajo neurohepatopathy (Orphanet:255229)
Neurodegeneration with brain iron accumulation due to C19orf12 mutation (Orphanet:289560)
Neurologic Waardenburg-Shah syndrome (Orphanet:163746)
OPTIC ATROPHY, HEARING LOSS, AND PERIPHERAL NEUROPATHY, AUTOSOMALRECESSIVE (OMIM:258650)
Oculopharyngeal muscular dystrophy (Orphanet:270)
Oculopharyngodistal myopathy (Orphanet:98897)
PERIPHERAL NEUROPATHY, MYOPATHY, HOARSENESS, AND HEARING LOSS (OMIM:614369)
POLYGLUCOSAN BODY MYOPATHY 2 (OMIM:616199)
Posterior column ataxia - retinitis pigmentosa (Orphanet:88628)
RADICULONEUROPATHY, FATAL NEONATAL (OMIM:266250)
Roussy-Lévy syndrome (Orphanet:3115)
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 1 (OMIM:606002)
Spheroid body myopathy (Orphanet:268129)
Spinal muscular atrophy with respiratory distress (Orphanet:98920)
Spinocerebellar ataxia with axonal neuropathy type 2 (Orphanet:64753)
Steinert myotonic dystrophy (Orphanet:273)
Trichomegaly - retina pigmentary degeneration - dwarfism (Orphanet:3363)
VACUOLAR NEUROMYOPATHY (OMIM:601846)
X-linked Charcot-Marie-Tooth disease type 1 (Orphanet:101075)
X-linked Charcot-Marie-Tooth disease type 2 (Orphanet:101076)
X-linked Charcot-Marie-Tooth disease type 3 (Orphanet:101077)
X-linked Charcot-Marie-Tooth disease type 5 (Orphanet:99014)
X-linked distal spinal muscular atrophy (Orphanet:139557)
X-linked intellectual disability due to GRIA3 anomalies (Orphanet:364028)