Symptom Information: Sort according to HPO 

1
 (HPO:0002497) Spastic ataxia Very frequent [IBIS] 100% (n=9) 20108356 IBIS 13 / 7739
2
 (HPO:0001258) Spastic paraplegia Very frequent [IBIS] 22266886 IBIS 97 / 7739
3
 (HPO:0001260) Dysarthria Frequent [IBIS] 44% (n=9) 24727571 IBIS 329 / 7739
4
 (HPO:0002839) Urinary bladder sphincter dysfunction Frequent [IBIS] 33% (n=9) 24727571 IBIS 34 / 7739
5
 (HPO:0007340) Lower limb muscle weakness Frequent [IBIS] 11377972 IBIS 61 / 7739
6
 (HPO:0001272) Cerebellar atrophy Frequent [IBIS] 24466038 IBIS 197 / 7739
7
 (HPO:0003200) Ragged-red muscle fibers Occasional [IBIS] 22266886 IBIS 37 / 7739
8
 (HPO:0003688) Decreased activity of cytochrome C oxidase in muscle tissue Occasional [IBIS] 22266886 IBIS 20 / 7739
9
 (HPO:0011923) Decreased activity of mitochondrial complex I Occasional [IBIS] 22266886 IBIS 35 / 7739
10
 (HPO:0008972) Decreased activity of mitochondrial respiratory chain Occasional [IBIS] 22266886 IBIS 34 / 7739
11
 (HPO:0009830) Peripheral neuropathy Occasional [IBIS] 22266886 IBIS 206 / 7739
12
 (HPO:0000012) Urinary urgency 24466038 IBIS 35 / 7739
13
 (HPO:0000020) Urinary incontinence 24466038 IBIS 75 / 7739
14
 (HPO:0000648) Optic atrophy 22266886 IBIS 238 / 7739
15
 (HPO:0000639) Nystagmus 20108356 IBIS 555 / 7739
16
 (HPO:0002166) Impaired vibration sensation in the lower limbs 11377972 IBIS 26 / 7739
17
 (HPO:0001347) Hyperreflexia 20108356 IBIS 363 / 7739
18
 (HPO:0007256) Abnormal pyramidal signs 20108356 IBIS 116 / 7739
19
 (HPO:0002066) Gait ataxia 24727571 IBIS 327 / 7739
20
 (HPO:0002015) Dysphagia 20108356 IBIS 301 / 7739
21
 (HPO:0003487) Babinski sign 24466038 IBIS 179 / 7739
22
 (HPO:0002061) Lower limb spasticity 20108356 IBIS 56 / 7739
23
 (HPO:0002064) Spastic gait 24727571 IBIS 46 / 7739
24
 (HPO:0001761) Pes cavus 24466038 IBIS 225 / 7739
25
 (HPO:0002650) Scoliosis 24466038 IBIS 705 / 7739
26
 (HPO:0002314) Degeneration of the lateral corticospinal tracts 24727571 IBIS 9 / 7739
27
 (MedDRA:10048327) Supranuclear palsy 22266886 IBIS 2 / 7739
28
 (HPO:0100543) Cognitive impairment 24466038 IBIS 230 / 7739
29
 (HPO:0001273) Abnormality of the corpus callosum 20108356 IBIS 20 / 7739
30
 (HPO:0003474) Sensory impairment 20108356 IBIS 54 / 7739
31
 (HPO:0002313) Spastic paraparesis 20108356 IBIS 33 / 7739
32
 (HPO:0008969) Leg muscle stiffness 20108356 IBIS 5 / 7739
33
 (HPO:0001488) Bilateral ptosis 20108356 IBIS 42 / 7739
34
 (HPO:0007838) Progressive ptosis 20108356 IBIS 2 / 7739
35
 (HPO:0000492) Abnormality of the eyelid 20108356 IBIS 41 / 7739
36
 (HPO:0002500) Abnormality of the cerebral white matter 20108356 IBIS 73 / 7739
37
 (HPO:0000590) Progressive external ophthalmoplegia 24727571 IBIS 23 / 7739
38
 (HPO:0007370) Aplasia/Hypoplasia of the corpus callosum 24466038 IBIS 180 / 7739
39
 (HPO:0000488) Retinopathy 24466038 IBIS 75 / 7739
40
 (HPO:0001332) Dystonia 24466038 IBIS 197 / 7739
41
 (HPO:0006986) Upper limb spasticity 24466038 IBIS 15 / 7739
42
 (HPO:0003484) Upper limb muscle weakness 24466038 IBIS 19 / 7739
43
 (HPO:0002070) Limb ataxia 24466038 IBIS 41 / 7739
44
 (HPO:0002078) Truncal ataxia 24466038 IBIS 41 / 7739
45
 (MedDRA:10046494) Urge incontinence 24466038 IBIS 2 / 7739
46
 (HPO:0002495) Impaired vibratory sensation 24466038 IBIS 26 / 7739
47
 (HPO:0000365) Hearing impairment 24466038 IBIS 539 / 7739
48
 (HPO:0003202) Skeletal muscle atrophy 24466038 IBIS 281 / 7739
49
 (HPO:0011924) Decreased activity of mitochondrial complex III 24466038 IBIS 22 / 7739
50
 (HPO:0008347) Decreased activity of mitochondrial complex IV 24466038 IBIS 31 / 7739
51
 (HPO:0001271) Polyneuropathy 24954637 IBIS 56 / 7739