Cleft upper lip

Symptom Information:

Symptom ID: HPO:0000204
Synonyms:
Cleft lip [HPO:0000204]
Cleft of upper lip [HPO:0000204]
Cleft lip [OMIM:Cleft lip]
Cleft lip (1 patient, WWS) [OMIM:Cleft lip (1 patient, WWS)]
Cleft lip (27%) [OMIM:Cleft lip (27%)]
Cleft lip (4%) [OMIM:Cleft lip (4%)]
Cleft lip (WWS) [OMIM:Cleft lip (WWS)]
Cleft lip (in some patients) [OMIM:Cleft lip (in some patients)]
Cleft lip (rare) [OMIM:Cleft lip (rare)]
Cleft lip. [OMIM:Cleft lip.]
Cleft lip [MedDRA:10009259]
Cleft lip (disorder) [Orphanet:9800]
Cleft Lip [Orphanet:9800]
Cleft lip [Orphanet:9800]
Quality:
Cross references:
Orphanet:9800 "Cleft lip" [Orphanet:9800]
OMIM: "Cleft lip" [OMIM:Cleft lip]
OMIM: "Cleft lip (1 patient, WWS)" [OMIM:Cleft lip (1 patient, WWS)]
OMIM: "Cleft lip (27%)" [OMIM:Cleft lip (27%)]
OMIM: "Cleft lip (4%)" [OMIM:Cleft lip (4%)]
OMIM: "Cleft lip (WWS)" [OMIM:Cleft lip (WWS)]
OMIM: "Cleft lip (in some patients)" [OMIM:Cleft lip (in some patients)]
OMIM: "Cleft lip (rare)" [OMIM:Cleft lip (rare)]
OMIM: "Cleft lip." [OMIM:Cleft lip.]
UMLS:C0008924 "Cleft Lip" [Orphanet:9800]
Is a (Direct Parents):
HPO         Oral cleft
Orphanet Abnormality of the mouth
HPO         Abnormality of upper lip
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of head or neck(HPO:0000152)
          Abnormality of the head(HPO:0000234)
             Abnormality of the face(HPO:0000271)
                Abnormality of the mouth(HPO:0000153)
                   Oral cleft(HPO:0000202)
                      Cleft upper lip(HPO:0000204)
                   Abnormality of the lip(HPO:0000159)
                      Abnormality of upper lip(HPO:0000177)
                         Cleft upper lip(HPO:0000204)
MedDRA:
Database Frequency: 193 / 7739
Resource:

All diseases associated with this symptom:

16p13.11 microdeletion syndrome (Orphanet:261236)
1p36 deletion syndrome (Orphanet:1606)
1q41q42 microdeletion syndrome (Orphanet:250999)
3MC SYNDROME 1 (OMIM:257920)
3MC SYNDROME 2 (OMIM:265050)
3MC SYNDROME 3 (OMIM:248340)
AARSKOG-SCOTT SYNDROME (OMIM:305400)
ADAMS-OLIVER SYNDROME 1 (OMIM:100300)
Aarskog-Scott syndrome (Orphanet:915)
Absent tibia - polydactyly - arachnoid cyst (Orphanet:3328)
Acro-cardio-facial syndrome (Orphanet:2008)
Acro-fronto-facio-nasal dysostosis (Orphanet:1784)
Acrocallosal syndrome (Orphanet:36)
Acrofacial dysostosis, Palagonia type (Orphanet:1787)
Acromelic frontonasal dysplasia (Orphanet:1827)
Adams-Oliver syndrome (Orphanet:974)
Aicardi syndrome (Orphanet:50)
Alar cartilages hypoplasia - coloboma - telecanthus (Orphanet:2007)
Aminopterin/methotrexate embryofetopathy (Orphanet:1908)
Ankyloblepharon - ectodermal defects - cleft lip/palate (Orphanet:1071)
Ankyloblepharon filiforme - imperforate anus (Orphanet:1074)
Ankyloblepharon filiforme adnatum - cleft palate (Orphanet:1072)
Anophthalmia plus syndrome (Orphanet:1104)
Auriculoocular anomalies - cleft lip (Orphanet:71270)
Autosomal dominant Larsen syndrome (Orphanet:503)
Autosomal dominant Opitz G/BBB syndrome (Orphanet:306588)
Autosomal dominant popliteal pterygium syndrome (Orphanet:1300)
Autosomal recessive amelia (Orphanet:1027)
Bartsocas-Papas syndrome (Orphanet:1234)
Bilateral renal agenesis (Orphanet:1848)
Blackfan-Diamond anemia (Orphanet:124)
Blepharo-cheilo-odontic syndrome (Orphanet:1997)
Blepharonasofacial malformation syndrome (Orphanet:1252)
Bohring-Opitz syndrome (Orphanet:97297)
Branchio-oculo-facial syndrome (Orphanet:1297)
CARDIAC MALFORMATION, CLEFT LIP/PALATE, MICROCEPHALY AND DIGITAL ANOMALIES (OMIM:600987)
CATEL-MANZKE SYNDROME (OMIM:616145)
CHARGE syndrome (Orphanet:138)
CHILD syndrome (Orphanet:139)
CHROMOSOME 15q25 DELETION SYNDROME (OMIM:614294)
CULLER-JONES SYNDROME (OMIM:615849)
Cantrell pentalogy (Orphanet:1335)
Catel-Manzke syndrome (Orphanet:1388)
Central congenital hypothyroidism (Orphanet:226298)
Cerebro-facio-thoracic dysplasia (Orphanet:1394)
Charlie M syndrome (Orphanet:1406)
Choanal atresia - deafness - cardiac defects - dysmorphism (Orphanet:1200)
Cholestasis - pigmentary retinopathy - cleft palate (Orphanet:1415)
Cleft lip - retinopathy (Orphanet:1995)
Cleft lip/palate - deafness - sacral lipoma (Orphanet:2003)
Cleft lip/palate - intestinal malrotation - cardiopathy (Orphanet:2001)
Cleft palate (Orphanet:2014)
Congenital laryngomalacia (Orphanet:2373)
Constriction rings syndrome (Orphanet:295000)
Contractures - ectodermal dysplasia - cleft lip/palate (Orphanet:1484)
Cornelia de Lange syndrome (Orphanet:199)
Craniofacial-ulnar-renal syndrome (Orphanet:293843)
Craniofrontonasal dysplasia (Orphanet:1520)
DIAMOND-BLACKFAN ANEMIA 1 (OMIM:105650)
DIAMOND-BLACKFAN ANEMIA 6 (OMIM:612561)
DISORGANIZATION, MOUSE, HOMOLOG OF (OMIM:223200)
Developmental malformations - deafness - dystonia (Orphanet:79107)
Diabetic embryopathy (Orphanet:1926)
Diprosopia (Orphanet:1681)
Distal monosomy 10p (Orphanet:1580)
Distal monosomy 6p (Orphanet:96125)
Distal monosomy 7q36 (Orphanet:1636)
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME1 (OMIM:129900)
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME3 (OMIM:604292)
EEC syndrome (Orphanet:1896)
Ellis Van Creveld syndrome (Orphanet:289)
Endocrine-cerebro-osteodysplasia syndrome (Orphanet:199332)
Eye defects - arachnodactyly - cardiopathy (Orphanet:2725)
Familial gastric cancer (Orphanet:26106)
Fetal alcohol syndrome (Orphanet:1915)
Focal dermal hypoplasia (Orphanet:2092)
Fraser syndrome (Orphanet:2052)
Fronto-facio-nasal dysostosis (Orphanet:1791)
Fryns syndrome (Orphanet:2059)
Genito-palato-cardiac syndrome (Orphanet:2075)
Goldenhar syndrome (Orphanet:374)
Gonadal dysgenesis, XY type - associated anomalies (Orphanet:1770)
Gorlin syndrome (Orphanet:377)
HYPOGONADOTROPIC HYPOGONADISM 3 WITH OR WITHOUT ANOSMIA (OMIM:244200)
Hartsfield-Bixler-Demyer syndrome (Orphanet:2117)
Hemimelia (Orphanet:2130)
Holoprosencephaly (Orphanet:2162)
Holzgreve-Wagner-Rehder syndrome (Orphanet:2167)
Hydrolethalus (Orphanet:2189)
Hyperphosphatasia-intellectual deficiency syndrome (Orphanet:247262)
Hypertelorism-microtia-facial clefting syndrome (Orphanet:2213)
Intellectual deficit, Wolff type (Orphanet:3080)
Intellectual deficit, X-linked, Abidi type (Orphanet:85273)
Intellectual deficit, X-linked, Siderius type (Orphanet:85287)
Joubert syndrome with orofaciodigital defect (Orphanet:2754)
Juberg-Hayward syndrome (Orphanet:2319)
KERATOCONUS POSTICUS CIRCUMSCRIPTUS (OMIM:244600)
KLIPPEL-FEIL SYNDROME 2, AUTOSOMAL RECESSIVE (OMIM:214300)
Kabuki syndrome (Orphanet:2322)
Kallmann syndrome (Orphanet:478)
Kapur-Toriello syndrome (Orphanet:2328)
Koolen-De Vries syndrome (Orphanet:96169)
Kyphomelic dysplasia (Orphanet:1801)
Lymphedema - distichiasis (Orphanet:33001)
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 13 (OMIM:613192)
MICROCEPHALY, CORPUS CALLOSUM DYSGENESIS, AND CLEFT LIP/PALATE (OMIM:601420)
MICROPHTHALMIA WITH CYST, BILATERAL FACIAL CLEFTS, AND LIMB ANOMALIES (OMIM:607597)
MICROPHTHALMIA, SYNDROMIC 1 (OMIM:309800)
MICROPHTHALMIA, SYNDROMIC 11 (OMIM:614402)
MIDLINE MALFORMATIONS, MULTIPLE, WITH LIMB ABNORMALITIES AND HYPOPITUITARISM (OMIM:601016)
MURCS association (Orphanet:2578)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYEANOMALIES), TYPE A, 1 (OMIM:236670)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYEANOMALIES), TYPE A, 2 (OMIM:613150)
Meckel syndrome (Orphanet:564)
Meckel syndrome, type 1 (OMIM:249000)
Meckel syndrome, type 5 (OMIM:611561)
Meckel syndrome, type 6 (OMIM:612284)
Meckel syndrome, type 8 (OMIM:613885)
Medeira-Dennis-Donnai syndrome (Orphanet:2476)
Microbrachycephaly - ptosis - cleft lip (Orphanet:2511)
Microphthalmia with limb anomalies (Orphanet:1106)
Monosomy 18q (Orphanet:1600)
Mowat-Wilson syndrome (Orphanet:2152)
Muscle-eye-brain disease (Orphanet:588)
Myhre syndrome (Orphanet:2588)
Nager syndrome (Orphanet:245)
Nail-patella syndrome (Orphanet:2614)
Naxos disease (Orphanet:34217)
Neu-Laxova syndrome (Orphanet:2671)
Nijmegen breakage syndrome (Orphanet:647)
OCULODENTODIGITAL DYSPLASIA (OMIM:164200)
OPITZ-KAVEGGIA SYNDROME (OMIM:305450)
OROFACIAL CLEFT 1 (OMIM:119530)
OROFACIAL CLEFT 5 (OMIM:608874)
OROFACIAL CLEFT 6, SUSCEPTIBILITY TO (OMIM:608864)
OROFACIODIGITAL SYNDROME VI (OMIM:277170)
Oculoauriculovertebral spectrum with radial defects (Orphanet:2549)
Oculodentodigital dysplasia (Orphanet:2710)
Odontotrichomelic syndrome (Orphanet:2723)
Opitz G/BBB syndrome (Orphanet:2745)
Orofaciodigital syndrome type 1 (Orphanet:2750)
Orofaciodigital syndrome type 8 (Orphanet:2755)
Osteopathia striata - cranial sclerosis (Orphanet:2780)
PARIETAL FORAMINA (OMIM:168500)
Pallister-Hall syndrome (Orphanet:672)
Parietal foramina (Orphanet:60015)
Peters-plus syndrome (Orphanet:709)
Pilotto syndrome (Orphanet:2894)
Postaxial acrofacial dysostosis (Orphanet:246)
RADIUS, APLASIA OF, WITH CLEFT LIP/PALATE (OMIM:179400)
RAPP-HODGKIN SYNDROME (OMIM:129400)
ROBERTS SYNDROME (OMIM:268300)
Roberts syndrome (Orphanet:3103)
Rosselli-Gulienetti syndrome (Orphanet:90339)
SC PHOCOMELIA SYNDROME (OMIM:269000)
SHORT RIB-POLYDACTYLY SYNDROME, TYPE IIB (OMIM:615087)
SHORT STATURE AND FACIOAURICULOTHORACIC MALFORMATIONS (OMIM:609654)
Schisis association (Orphanet:63862)
Short rib-polydactyly syndrome (Orphanet:1505)
Short-rib thoracic dysplasia 3 with or without polydactyly (OMIM:613091)
Simpson-Golabi-Behmel syndrome (Orphanet:373)
Smith-Magenis syndrome (Orphanet:819)
Solitary median maxillary central incisor syndrome (Orphanet:2286)
Sternal malformation - vascular dysplasia (Orphanet:3195)
Stickler syndrome (Orphanet:828)
TMCO1 defect syndrome (Orphanet:228407)
Terminal transverse defects of arm (Orphanet:93937)
Tessier number 4 facial cleft (Orphanet:141258)
Tetraamelia - multiple malformations (Orphanet:3301)
Treacher-Collins syndrome (Orphanet:861)
Tricho-oculo-dermo-vertebral syndrome (Orphanet:3354)
Triploidy (Orphanet:3376)
Trisomy 17p (Orphanet:261290)
Trisomy 18 (Orphanet:3380)
Trisomy 8q (Orphanet:1752)
Trisomy 9p (Orphanet:236)
Ulbright-Hodes syndrome (Orphanet:3404)
Uveal coloboma - cleft lip and palate - intellectual deficit (Orphanet:1473)
VACTERL/VATER association (Orphanet:887)
VAN DER WOUDE SYNDROME 1 (OMIM:119300)
VAN DER WOUDE SYNDROME 2 (OMIM:606713)
Van der Woude syndrome (Orphanet:888)
Verloove Vanhorick-Brubakk syndrome (Orphanet:3429)
Vici syndrome (Orphanet:1493)
W syndrome (Orphanet:2804)
WEYERS ULNAR RAY/OLIGODACTYLY SYNDROME (OMIM:602418)
Waardenburg syndrome type 1 (Orphanet:894)
Walker-Warburg syndrome (Orphanet:899)
Wolf-Hirschhorn syndrome (Orphanet:280)
X-linked Opitz G/BBB syndrome (Orphanet:306597)
X-linked lethal multiple pterygium syndrome (Orphanet:79447)
Zechi-Ceide syndrome (Orphanet:217017)
Zlotogora-Ogur syndrome (Orphanet:3253)