Tutuncuoglu et al. (1996) described a 46,XY Turkish male infant with microcephaly, severe hypoplasia of the corpus callosum, exophthalmos, cleft lip and palate, seizures, and psychomotor retardation. His parents were first cousins. A similar case was reported by ... Tutuncuoglu et al. (1996) described a 46,XY Turkish male infant with microcephaly, severe hypoplasia of the corpus callosum, exophthalmos, cleft lip and palate, seizures, and psychomotor retardation. His parents were first cousins. A similar case was reported by Howard and Young (1988), but their patient also had preaxial polydactyly. Marles and Chudley (1990) described similar findings in a 9-month-old boy: failure to thrive, developmental delay, bilateral cleft lip and palate, and left preaxial polydactyly. The boy had a broad nasal bridge and bilateral epicanthic folds. A right inguinal hernia was repaired surgically. The parents were not related.