Solitary median maxillary central incisor syndrome
General Information (adopted from Orphanet):
Synonyms, Signs: |
FUSED INCISORS SMMCI SYNDROME, INCLUDED SINGLE CENTRAL MAXILLARY INCISOR SOLITARY MEDIAN MAXILLARY CENTRAL INCISOR SYNDROME, INCLUDED INCISORS, FUSED SMMCI single upper central incisor |
Number of Symptoms | 55 |
OrphanetNr: | 2286 |
OMIM Id: |
147250
|
ICD-10: |
K00.2 |
UMLs: |
C1840235 |
MeSH: |
C537342 |
MedDRA: |
|
Snomed: |
8654005 |
Prevalence, inheritance and age of onset:
Prevalence: | No data available. |
Inheritance: |
Multifactorial [Orphanet] |
Age of onset: |
Childhood [Orphanet] |
Disease classification (adopted from Orphanet):
Parent Diseases: |
Genetic malformation syndrome with odontal and/or periodontal component
-Rare genetic disease Malformation syndrome with odontal and/or periodontal component -Rare developmental defect during embryogenesis -Rare odontologic disease Microform holoprosencephaly -Rare developmental defect during embryogenesis -Rare endocrine disease -Rare genetic disease -Rare neurologic disease Rare genetic intellectual deficit with developmental anomaly -Rare genetic disease |
Symptom Information:
|
(HPO:0000054) | Micropenis | Occasional [Orphanet] | 257 / 7739 | |||
|
(HPO:0008678) | Renal hypoplasia/aplasia | Occasional [Orphanet] | 127 / 7739 | |||
|
(HPO:0000062) | Ambiguous genitalia | Occasional [Orphanet] | 74 / 7739 | |||
|
(HPO:0000252) | Microcephaly | Frequent [Orphanet] occasional [HPO] | 832 / 7739 | |||
|
(HPO:0010804) | Tented upper lip vermilion | Frequent [Orphanet] | 47 / 7739 | |||
|
(HPO:0010644) | Midnasal stenosis | 9/14 [HPO] | 11471164 | IBIS | 2 / 7739 | |
|
(HPO:0000528) | Anophthalmia | rare [HPO] | 12503095 | IBIS | 42 / 7739 | |
|
(HPO:0000601) | Hypotelorism | Frequent [Orphanet] 8/14 [HPO] | 11471164 | IBIS | 83 / 7739 | |
|
(HPO:0006315) | Single median maxillary incisor | Very frequent [Orphanet] 100% [HPO] | 13 / 7739 | |||
|
(HPO:0000463) | Anteverted nares | Occasional [Orphanet] | 305 / 7739 | |||
|
(HPO:0000366) | Abnormality of the nose | Very frequent [Orphanet] | 56 / 7739 | |||
|
(HPO:0000174) | Abnormality of the palate | Occasional [Orphanet] | 298 / 7739 | |||
|
(HPO:0000446) | Narrow nasal bridge | Frequent [Orphanet] | 29 / 7739 | |||
|
(HPO:0000453) | Choanal atresia | Very frequent [Orphanet] 8/14 [HPO] | 11471164 | IBIS | 76 / 7739 | |
|
(HPO:0000322) | Short philtrum | Frequent [Orphanet] | 130 / 7739 | |||
|
(HPO:0001739) | Abnormality of the nasopharynx | 1/14 [HPO] | 11471164 | IBIS | 16 / 7739 | |
|
(HPO:0003196) | Short nose | Occasional [Orphanet] | 264 / 7739 | |||
|
(HPO:0000204) | Cleft upper lip | 1/14 [HPO] | 11471164 | IBIS | 193 / 7739 | |
|
(HPO:0000202) | Oral cleft | Occasional [Orphanet] | 120 / 7739 | |||
|
(HPO:0000568) | Microphthalmia | rare [HPO] | 12503095 | IBIS | 183 / 7739 | |
|
(HPO:0000458) | Anosmia | occasional [HPO] | 49 / 7739 | |||
|
(HPO:0100789) | Torus palatinus | 6 / 7739 | ||||
|
(HPO:0002708) | Prominent median palatal raphe | 14/14 [HPO] | 11471164 | IBIS | 4 / 7739 | |
|
(HPO:0009914) | Cyclopia | Occasional [Orphanet] rare [HPO] | 12503095 | IBIS | 11 / 7739 | |
|
(HPO:0000486) | Strabismus | Occasional [Orphanet] | 576 / 7739 | |||
|
(HPO:0000612) | Iris coloboma | Occasional [Orphanet] | 116 / 7739 | |||
|
(HPO:0000589) | Coloboma | occasional [HPO] | 12503095 | IBIS | 47 / 7739 | |
|
(HPO:0001256) | Intellectual disability, mild | 3/14 [HPO] | 11471164 | IBIS | 141 / 7739 | |
|
(HPO:0001328) | Specific learning disability | 5/14 [HPO] | 11471164 | IBIS | 114 / 7739 | |
|
(HPO:0001250) | Seizures | Occasional [Orphanet] | 1245 / 7739 | |||
|
(HPO:0000830) | Anterior hypopituitarism | 9 / 7739 | ||||
|
(HPO:0009800) | Maternal diabetes | Occasional [Orphanet] | 14 / 7739 | |||
|
(HPO:0000821) | Hypothyroidism | Occasional [Orphanet] | 141 / 7739 | |||
|
(HPO:0000824) | Growth hormone deficiency | 5/7 [HPO] | 925821 | IBIS | 56 / 7739 | |
|
(HPO:0002650) | Scoliosis | Occasional [Orphanet] | 705 / 7739 | |||
|
(HPO:0003422) | Vertebral segmentation defect | Occasional [Orphanet] | 95 / 7739 | |||
|
(HPO:0001622) | Premature birth | Frequent [Orphanet] | 100 / 7739 | |||
|
(HPO:0100867) | Duodenal stenosis | Occasional [Orphanet] | 29 / 7739 | |||
|
(HPO:0001511) | Intrauterine growth retardation | Frequent [Orphanet] | 358 / 7739 | |||
|
(HPO:0004322) | Short stature | Very frequent [Orphanet] 7/14 [HPO] | 11471164 | IBIS | 1232 / 7739 | |
|
(HPO:0001052) | Nevus flammeus | Occasional [Orphanet] | 88 / 7739 | |||
|
(HPO:0030680) | Abnormality of cardiovascular system morphology | Occasional [Orphanet] | 355 / 7739 | |||
|
(HPO:0001636) | Tetralogy of Fallot | Occasional [Orphanet] | 104 / 7739 | |||
|
(HPO:0003220) | Abnormality of chromosome stability | Occasional [Orphanet] | 98 / 7739 | |||
|
(HPO:0002916) | Abnormality of chromosome segregation | 2/14 [HPO] | 11471164 | IBIS | 5 / 7739 | |
|
(HPO:0002099) | Asthma | Occasional [Orphanet] | 62 / 7739 | |||
|
(HPO:0003828) | Variable expressivity | 130 / 7739 | ||||
|
(HPO:0000006) | Autosomal dominant inheritance | 2518 / 7739 | ||||
|
(HPO:0007370) | Aplasia/Hypoplasia of the corpus callosum | Occasional [Orphanet] | 180 / 7739 | |||
|
(HPO:0001360) | Holoprosencephaly | frequent [HPO] | 29 / 7739 | |||
|
(OMIM) | Isolated growth hormone deficiency | 4 / 7739 | ||||
|
(OMIM) | Congenital nasal pyriform aperture stenosis | 2 / 7739 | ||||
|
(HPO:0012758) | Neurodevelopmental delay | Frequent [Orphanet] | 949 / 7739 | |||
|
(HPO:0040075) | Hypopituitarism | Occasional [Orphanet] | 32 / 7739 | |||
|
(HPO:0012443) | Abnormality of brain morphology | Occasional [Orphanet] | 45 / 7739 |
Associated genes:
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
---|
Additional Information:
Clinical Description OMIM |
Rappaport et al. (1976, 1977) reported 7 unrelated patients with single (unpaired) deciduous and permanent maxillary central incisors and short stature. Five of them had isolated growth hormone deficiency. The other 2 had normal growth hormone responses but ... |
Molecular genetics OMIM |
Nanni et al. (2001) performed a molecular study of 13 patients with solitary median maxillary central incisor who did not have holoprosencephaly. They studied 2 genes, SHH (600725) and SIX3 (603714), in which mutations had been reported in ... |