Symptom Information: Sort according to HPO 

1
 (HPO:0001387) Joint stiffness Occasional [Orphanet] 322 / 7739
2
 (HPO:0001347) Hyperreflexia Very frequent [Orphanet] 363 / 7739
3
 (HPO:0001260) Dysarthria 329 / 7739
4
 (HPO:0002607) Bowel incontinence Frequent [Orphanet] 33 / 7739
5
 (HPO:0002205) Recurrent respiratory infections Occasional [Orphanet] 254 / 7739
6
 (HPO:0002071) Abnormality of extrapyramidal motor function Frequent [Orphanet] 76 / 7739
7
 (HPO:0002204) Pulmonary embolism Occasional [Orphanet] 26 / 7739
8
 (HPO:0001288) Gait disturbance Very frequent [Orphanet] 318 / 7739
9
 (HPO:0001276) Hypertonia Very frequent [Orphanet] 317 / 7739
10
 (HPO:0001324) Muscle weakness Very frequent [Orphanet] 859 / 7739
11
 (HPO:0001251) Ataxia 24954637 IBIS 413 / 7739
12
 (HPO:0002066) Gait ataxia Occasional [Orphanet] 327 / 7739
13
 (HPO:0000648) Optic atrophy 238 / 7739
14
 (HPO:0001249) Intellectual disability 24954637 IBIS 1089 / 7739
15
 (HPO:0000639) Nystagmus Occasional [Orphanet] 24954637 IBIS 555 / 7739
16
 (HPO:0001258) Spastic paraplegia 97 / 7739
17
 (HPO:0001310) Dysmetria 76 / 7739
18
 (HPO:0001371) Flexion contracture 220 / 7739
19
 (HPO:0001761) Pes cavus 225 / 7739
20
 (HPO:0002061) Lower limb spasticity 56 / 7739
21
 (HPO:0002064) Spastic gait 46 / 7739
22
 (HPO:0002167) Neurological speech impairment Occasional [Orphanet] 308 / 7739
23
 (HPO:0002314) Degeneration of the lateral corticospinal tracts 9 / 7739
24
 (HPO:0002503) Spinocerebellar tract degeneration 8 / 7739
25
 (HPO:0003202) Skeletal muscle atrophy 281 / 7739
26
 (HPO:0003487) Babinski sign 179 / 7739
27
 (HPO:0007340) Lower limb muscle weakness 61 / 7739
28
 (MedDRA:10003694) Atrophy 7 / 7739
29
 (HPO:0001317) Abnormality of the cerebellum 36 / 7739
30
 (OMIM) Upper limb involvement 4 / 7739
31
 (HPO:0000079) Abnormality of the urinary system Frequent [Orphanet] 88 / 7739
32
 (HPO:0011442) Abnormality of central motor function Frequent [Orphanet] 76 / 7739
33
 (HPO:0012758) Neurodevelopmental delay Frequent [Orphanet] 949 / 7739
34
 (HPO:0011037) Decreased urine output Frequent [Orphanet] 47 / 7739
35
 (HPO:0003474) Sensory impairment Occasional [Orphanet] 54 / 7739
36
 (HPO:0012795) Abnormality of the optic disc Frequent [Orphanet] 187 / 7739
37
 (HPO:0002313) Spastic paraparesis 33 / 7739
38
 (HPO:0003812) Phenotypic variability 129 / 7739
39
 (HPO:0001250) Seizures 24954637 IBIS 1245 / 7739
40
 (HPO:0001271) Polyneuropathy 24954637 IBIS 56 / 7739
41
 (HPO:0002500) Abnormality of the cerebral white matter 24954637 IBIS 73 / 7739