Symptom Information: Sort according to HPO 

1
 (OMIM) Hyperarginemia Very frequent [IBIS] 100% (n=27) 22633632 IBIS 3 / 7739
2
 (HPO:0010909) Abnormality of arginine metabolism Very frequent [IBIS] 100% (n=27) 15694174 IBIS 3 / 7739
3
 (HPO:0001263) Global developmental delay Very frequent [IBIS] Very frequent [Orphanet] 96% (n=25) 15694174 IBIS 853 / 7739
4
 (HPO:0002353) EEG abnormality Frequent [Orphanet] Very frequent [IBIS] 95% (n=21) 15694174 IBIS 188 / 7739
5
 (HPO:0001264) Spastic diplegia Very frequent [IBIS] 91% (n=23) 15694174 IBIS 24 / 7739
6
 (HPO:0004337) Abnormality of amino acid metabolism Very frequent [IBIS] Very frequent [Orphanet] 15694174 IBIS 45 / 7739
7
 (MedDRA:10062695) Arginase deficiency Very frequent [IBIS] 15694174 IBIS 1 / 7739
8
 (HPO:0001987) Hyperammonemia Frequent [Orphanet] Frequent [IBIS] 88% (n=26) 15694174 IBIS 50 / 7739
9
 (HPO:0001270) Motor delay Very frequent [Orphanet] Frequent [IBIS] 85% (n=23) 15694174 IBIS 322 / 7739
10
 (HPO:0002013) Vomiting Frequent [IBIS] 83% (n=24) 15694174 IBIS 191 / 7739
11
 (HPO:0001510) Growth delay Frequent [IBIS] 81% (n=21) 15694174 IBIS 295 / 7739
12
 (HPO:0001250) Seizures Frequent [Orphanet] Frequent [IBIS] 62% (n=26) 15694174 IBIS 1245 / 7739
13
 (HPO:0002059) Cerebral atrophy Frequent [IBIS] 55% (n=11) 15694174 IBIS 171 / 7739
14
 (HPO:0000252) Microcephaly Frequent [IBIS] 41% (n=17) 9378897 IBIS 832 / 7739
15
 (HPO:0002038) Protein avoidance Frequent [IBIS] 40% (n=25) 15694174 IBIS 7 / 7739
16
 (HPO:0011097) Epileptic spasms Frequent [IBIS] Frequent [Orphanet] 22964440 IBIS 45 / 7739
17
 (HPO:0003355) Aminoaciduria Frequent [IBIS] Very frequent [Orphanet] 10771848 IBIS 65 / 7739
18
 (HPO:0000708) Behavioral abnormality Frequent [IBIS] Very frequent [Orphanet] 15694174 IBIS 212 / 7739
19
 (HPO:0001249) Intellectual disability Frequent [IBIS] Very frequent [Orphanet] 15694174 IBIS 1089 / 7739
20
 (HPO:0001269) Hemiparesis Frequent [IBIS] Frequent [Orphanet] typical [HPO] 15694174 IBIS 51 / 7739
21
 (HPO:0002167) Neurological speech impairment Frequent [IBIS] Very frequent [Orphanet] 15694174 IBIS 308 / 7739
22
 (HPO:0003218) Oroticaciduria Frequent [IBIS] 15694174 IBIS 10 / 7739
23
 (HPO:0008339) Diaminoaciduria Frequent [IBIS] 14605507 IBIS 1 / 7739
24
 (HPO:0008897) Postnatal growth retardation Frequent [IBIS] 15694174 IBIS 113 / 7739
25
 (HPO:0100543) Cognitive impairment Frequent [IBIS] Very frequent [Orphanet] 15694174 IBIS 230 / 7739
26
 (HPO:0001258) Spastic paraplegia Frequent [IBIS] 22964440 IBIS 97 / 7739
27
 (HPO:0007307) Rapid neurologic deterioration Occasional [IBIS] 22% (n=27) 9378897 IBIS 3 / 7739
28
 (HPO:0002478) Progressive spastic quadriplegia Occasional [IBIS] 9% (n=23) 15694174 IBIS 7 / 7739
29
 (HPO:0001298) Encephalopathy Occasional [IBIS] 22633632 IBIS 72 / 7739
30
 (HPO:0002240) Hepatomegaly Occasional [IBIS] 15694174 IBIS 467 / 7739
31
 (HPO:0001395) Hepatic fibrosis Occasional [IBIS] 15694174 IBIS 67 / 7739
32
 (HPO:0000709) Psychosis Occasional [IBIS] 15694174 IBIS 61 / 7739
33
 (HPO:0006579) Prolonged neonatal jaundice Occasional [IBIS] 22964440 IBIS 25 / 7739
34
 (HPO:0002133) Status epilepticus Frequent [Orphanet] 24258525 IBIS 59 / 7739
35
 (HPO:0000737) Irritability 15694174 IBIS 93 / 7739
36
 (HPO:0000752) Hyperactivity 839367 IBIS 140 / 7739
37
 (HPO:0002039) Anorexia 15694174 IBIS 62 / 7739
38
 (OMIM) Protein intolerance 3104676 IBIS 2 / 7739
39
 (HPO:0001288) Gait disturbance 15694174 IBIS 318 / 7739
40
 (HPO:0002061) Lower limb spasticity 15694174 IBIS 56 / 7739
41
 (HPO:0001276) Hypertonia 15694174 IBIS 317 / 7739
42
 (HPO:0001347) Hyperreflexia 15694174 IBIS 363 / 7739
43
 (HPO:0011968) Feeding difficulties 15694174 IBIS 240 / 7739
44
 (HPO:0001291) Abnormality of the cranial nerves 15694174 IBIS 27 / 7739
45
 (HPO:0002181) Cerebral edema 15694174 IBIS 19 / 7739
46
 (MedDRA:10006126) Brain herniation 15694174 IBIS 1 / 7739
47
 (HPO:0002169) Clonus 15694174 IBIS 37 / 7739
48
 (HPO:0007064) Progressive language deterioration 15694174 IBIS 3 / 7739
49
 (HPO:0001262) Somnolence 15694174 IBIS 20 / 7739
50
 (HPO:0001289) Confusion 15694174 IBIS 36 / 7739
51
 (HPO:0002312) Clumsiness 15694174 IBIS 28 / 7739
52
 (HPO:0000716) Depression 15694174 IBIS 99 / 7739
53
 (HPO:0006466) Ankle contracture 15694174 IBIS 17 / 7739
54
 (HPO:0001771) Achilles tendon contracture 15694174 IBIS 27 / 7739
55
 (HPO:0006380) Knee flexion contracture 15694174 IBIS 56 / 7739
56
 (HPO:0001259) Coma 15694174 IBIS 65 / 7739
57
 (HPO:0002359) Frequent falls 15694174 IBIS 24 / 7739
58
 (HPO:0001251) Ataxia 15694174 IBIS 413 / 7739
59
 (HPO:0002018) Nausea 15694174 IBIS 44 / 7739
60
 (HPO:0001254) Lethargy 15694174 IBIS 104 / 7739
61
 (HPO:0001394) Cirrhosis 9106111 IBIS 102 / 7739
62
 (HPO:0001928) Abnormality of coagulation 15694174 IBIS 44 / 7739
63
 (HPO:0003259) Elevated serum creatinine 15694174 IBIS 31 / 7739
64
 (HPO:0001332) Dystonia 22964440 IBIS 197 / 7739
65
 (HPO:0009830) Peripheral neuropathy 22964440 IBIS 206 / 7739
66
 (HPO:0001402) Hepatocellular carcinoma 22964440 IBIS 25 / 7739
67
 (HPO:0030051) Tip-toe gait 22964440 IBIS 10 / 7739
68
 (HPO:0001257) Spasticity 15694174 IBIS 251 / 7739
69
 (HPO:0002311) Incoordination 15694174 IBIS 84 / 7739
70
 (HPO:0004386) Gastrointestinal inflammation 15694174 IBIS 5 / 7739
71
 (HPO:0002921) Abnormality of the cerebrospinal fluid 19052914 IBIS 6 / 7739
72
 (HPO:0002104) Apnea 12640389 IBIS 106 / 7739
73
 (HPO:0011966) Elevated plasma citrulline 24224027 IBIS 5 / 7739
74
 (HPO:0003268) Argininuria 22633632 IBIS 5 / 7739