Lethargy

Symptom Information:

Symptom ID: HPO:0001254
Synonyms:
Lethargy (finding) [Orphanet:43470]
Lethargy [Orphanet:43470]
Lethargy [OMIM:Lethargy]
Obnubilation/coma/lethargia/desorientation [Orphanet:43470]
Lethargy [MedDRA:10024264]
Lethargic [MedDRA:10024264]
Lethargic tendency [MedDRA:10024264]
Lethargy (when taken off of medication) [OMIM:Lethargy (when taken off of medication)]
Quality:
Cross references:
Orphanet:43470 "Obnubilation/coma/lethargia/desorientation" [Orphanet:43470]
OMIM: "Lethargy" [OMIM:Lethargy]
OMIM: "Lethargy (when taken off of medication)" [OMIM:Lethargy (when taken off of medication)]
UMLS:C0023380 "Lethargy" [HPO:0001254]
UMLS:C0023380 "Lethargy" [Orphanet:43470]
Is a (Direct Parents):
HPO         Reduced consciousness/confusion
Orphanet Sleep disturbance
MedDRA Mood disorders NEC
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Abnormality of higher mental function(HPO:0011446)
                Reduced consciousness/confusion(HPO:0004372)
                   Lethargy(HPO:0001254)
MedDRA:
Database Frequency: 104 / 7739
Resource:

All diseases associated with this symptom:

2-methylbutyryl-CoA dehydrogenase deficiency (Orphanet:79157)
3-@METHYLCROTONYL-CoA CARBOXYLASE 1 DEFICIENCY (OMIM:210200)
Acrodermatitis enteropathica, zinc deficiency type (Orphanet:37)
Adenylosuccinate lyase deficiency (Orphanet:46)
Argininemia (Orphanet:90)
Argininosuccinic aciduria (Orphanet:23)
Autosomal recessive infantile hypercalcemia (Orphanet:300547)
Barth syndrome (Orphanet:111)
Biotinidase deficiency (Orphanet:79241)
CACH syndrome (Orphanet:135)
CADASIL (Orphanet:136)
CARBONIC ANHYDRASE VA DEFICIENCY, HYPERAMMONEMIA DUE TO (OMIM:615751)
CYCLIC VOMITING SYNDROME (OMIM:500007)
Carbamoylphosphate synthetase deficiency (Orphanet:147)
Carnitine palmitoyl transferase 1A deficiency (Orphanet:156)
Carnitine palmitoyl transferase II deficiency, neonatal form (Orphanet:228308)
Carnitine palmitoyl transferase II deficiency, severe infantile form (Orphanet:228305)
Carnitine uptake deficiency (Orphanet:158)
Carnitine-acylcarnitine translocase deficiency (Orphanet:159)
Citrullinemia type I (Orphanet:247525)
Citrullinemia type II (Orphanet:247585)
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (Orphanet:90794)
Classic maple syrup urine disease (Orphanet:268145)
Combined oxidative phosphorylation defect type 11 (Orphanet:324535)
Combined oxidative phosphorylation defect type 2 (Orphanet:254920)
Combined oxidative phosphorylation defect type 4 (Orphanet:254925)
Congenital lipoid adrenal hyperplasia due to STAR deficency (Orphanet:90790)
Congenital or early infantile CACH syndrome (Orphanet:157713)
Cree leukoencephalopathy (Orphanet:99854)
Cushing disease (Orphanet:96253)
Cushing syndrome (Orphanet:553)
Cytomegalic congenital adrenal hypoplasia (Orphanet:95702)
Dihydropyrimidine dehydrogenase deficiency (Orphanet:1675)
Dihydropyrimidinuria (Orphanet:38874)
ENCEPHALOPATHY, RECURRENT, OF CHILDHOOD (OMIM:130950)
Familial thyroid dyshormonogenesis (Orphanet:95716)
Fatal multiple mitochondrial dysfunction syndrome (Orphanet:289573)
Fructose-1,6-bisphosphatase deficiency (Orphanet:348)
GTP cyclohydrolase I deficiency (Orphanet:2102)
Gamma-aminobutyric acid transaminase deficiency (Orphanet:2066)
Gaucher disease type 2 (Orphanet:77260)
Glycine encephalopathy (Orphanet:407)
HYPERLYSINURIA WITH HYPERAMMONEMIA (OMIM:238750)
Hemochromatosis, type 1 (OMIM:235200)
Hemochromatosis, type 2A (OMIM:602390)
Hereditary fructose intolerance (Orphanet:469)
Heritable pulmonary arterial hypertension (Orphanet:275777)
His bundle tachycardia (Orphanet:3283)
Holocarboxylase synthetase deficiency (Orphanet:79242)
Hyperammonemia due to N-acetylglutamate synthetase deficiency (Orphanet:927)
Hyperammonemic encephalopathy due to carbonic anhydrase VA deficiency (Orphanet:401948)
Hyperornithinemia-hyperammonemia-homocitrullinuria (Orphanet:415)
Idiopathic copper-associated cirrhosis (Orphanet:209919)
Idiopathic pulmonary arterial hypertension (Orphanet:275766)
Intermittent maple syrup urine disease (Orphanet:268173)
Isolated 3-methylcrotonyl-CoA carboxylase deficiency (Orphanet:6)
Isolated NADH-CoQ reductase deficiency (Orphanet:2609)
Isolated glycerol kinase deficiency (Orphanet:408)
Isovaleric acidemia (Orphanet:33)
Juvenile or adult CACH syndrome (Orphanet:157719)
Late infantile CACH syndrome (Orphanet:157716)
MEGDEL syndrome (Orphanet:352328)
MELAS (Orphanet:550)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 8 (OMIM:615838)
MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 1 (OMIM:605711)
MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 2 (OMIM:614299)
MYXEDEMA (OMIM:255900)
Medium chain acyl-CoA dehydrogenase deficiency (Orphanet:42)
Methylcobalamin deficiency type cblDv1 (Orphanet:308380)
Methylcobalamin deficiency type cblE (Orphanet:2169)
Methylmalonic acidemia with homocystinuria (Orphanet:26)
Methylmalonic acidemia with homocystinuria, type cblC (Orphanet:79282)
Methylmalonic acidemia with homocystinuria, type cblD (Orphanet:79283)
Methylmalonic acidemia with homocystinuria, type cblF (Orphanet:79284)
Methylmalonic acidemia with homocystinuria, type cblJ (Orphanet:369955)
Mitochondrial encephalo-cardio-myopathy due to TMEM70 deficiency (Orphanet:1194)
Mitochondrial trifunctional protein deficiency (Orphanet:746)
Multiple acyl-CoA dehydrogenase deficiency (Orphanet:26791)
Neonatal hemochromatosis (Orphanet:446)
Neonatal intrahepatic cholestasis due to citrin deficiency (Orphanet:247598)
Ornithine transcarbamylase deficiency (Orphanet:664)
Ovarioleukodystrophy (Orphanet:99853)
Pearson syndrome (Orphanet:699)
Progressive demyelinating neuropathy with bilateral striatal necrosis (Orphanet:217396)
Propionic acidemia (Orphanet:35)
Pyruvate dehydrogenase E1-alpha deficiency (Orphanet:79243)
Pyruvate dehydrogenase E3 deficiency (Orphanet:2394)
Pyruvate dehydrogenase phosphatase deficiency (Orphanet:79246)
Short chain acyl-CoA dehydrogenase deficiency (Orphanet:26792)
THYROID DYSHORMONOGENESIS 1 (OMIM:274400)
Thiamine-responsive maple syrup urine disease (Orphanet:268184)
Thyroid ectopia (Orphanet:95712)
Thyroid hemiagenesis (Orphanet:95719)
Transcobalamin deficiency (Orphanet:859)
VISCERAL STEATOSIS, CONGENITAL (OMIM:228100)
Very long chain acyl-CoA dehydrogenase deficiency (Orphanet:26793)
Vitamin B12-responsive methylmalonic acidemia (Orphanet:28)
Vitamin B12-responsive methylmalonic acidemia type cblA (Orphanet:79310)
Vitamin B12-responsive methylmalonic acidemia type cblB (Orphanet:79311)
Vitamin B12-responsive methylmalonic acidemia, type cblDv2 (Orphanet:308442)
Vitamin B12-unresponsive methylmalonic acidemia (Orphanet:27)
Vitamin B12-unresponsive methylmalonic acidemia type mut- (Orphanet:79312)
Vitamin B12-unresponsive methylmalonic acidemia type mut0 (Orphanet:289916)
X-linked spinocerebellar ataxia type 3 (Orphanet:85297)