Symptom Information: Sort according to HPO 

1
 (HPO:0001252) Muscular hypotonia Very frequent [IBIS] 17033963 IBIS 990 / 7739
2
 (HPO:0003128) Lactic acidosis Very frequent [IBIS] 17033963 IBIS 116 / 7739
3
 (HPO:0005157) Concentric hypertrophic cardiomyopathy Very frequent [IBIS] 17033963 IBIS 5 / 7739
4
 (HPO:0008947) Infantile muscular hypotonia Very frequent [IBIS] 17033963 IBIS 482 / 7739
5
 (MedDRA:10058799) Mitochondrial encephalomyopathy Very frequent [IBIS] 17033963 IBIS 5 / 7739
6
 (HPO:0002878) Respiratory failure Very frequent [IBIS] 17033963 IBIS 57 / 7739
7
 (HPO:0001250) Seizures 17033963 IBIS 1245 / 7739
8
 (HPO:0001298) Encephalopathy 17033963 IBIS 72 / 7739
9
 (HPO:0001319) Neonatal hypotonia 17033963 IBIS 101 / 7739
10
 (HPO:0001324) Muscle weakness 25037205 IBIS 859 / 7739
11
 (HPO:0001511) Intrauterine growth retardation 25037205 IBIS 358 / 7739
12
 (HPO:0001558) Decreased fetal movement 17033963 IBIS 74 / 7739
13
 (HPO:0001643) Patent ductus arteriosus 17033963 IBIS 228 / 7739
14
 (HPO:0011648) Patent ductus arteriosus after birth at term 17033963 IBIS 18 / 7739
15
 (HPO:0001655) Patent foramen ovale 17033963 IBIS 31 / 7739
16
 (HPO:0002093) Respiratory insufficiency 17033963 IBIS 410 / 7739
17
 (HPO:0002119) Ventriculomegaly 17033963 IBIS 253 / 7739
18
 (HPO:0002151) Increased serum lactate 17033963 IBIS 92 / 7739
19
 (HPO:0003201) Rhabdomyolysis 17033963 IBIS 27 / 7739
20
 (HPO:0003236) Elevated serum creatine phosphokinase 17033963 IBIS 214 / 7739
21
 (HPO:0008347) Decreased activity of mitochondrial complex IV 17033963 IBIS 31 / 7739
22
 (HPO:0008872) Feeding difficulties in infancy 17033963 IBIS 153 / 7739
23
 (HPO:0011923) Decreased activity of mitochondrial complex I 17033963 IBIS 35 / 7739
24
 (HPO:0011924) Decreased activity of mitochondrial complex III 17033963 IBIS 22 / 7739
25
 (HPO:0011968) Feeding difficulties 17033963 IBIS 240 / 7739
26
 (OMIM) COX-deficient fibers 25037205 IBIS 3 / 7739
27
 (OMIM) Reduced brain gyri 17033963 IBIS 1 / 7739
28
 (OMIM) Abnormal signals in the thalami seen on MRI 17033963 IBIS 1 / 7739
29
 (OMIM) Increased serum ketones 17033963 IBIS 1 / 7739
30
 (OMIM) Increased serum ammonia 17033963 IBIS 5 / 7739
31
 (OMIM) Decreased activity of mitochondrial respiratory complexes I, III, and IV 17033963 IBIS 1 / 7739
32
 (OMIM) Early death 17033963 IBIS 13 / 7739
33
 (HPO:0003198) Myopathy 17033963 IBIS 151 / 7739
34
 (HPO:0006789) Mitochondrial encephalopathy 17033963 IBIS 5 / 7739
35
 (HPO:0003737) Mitochondrial myopathy 17033963 IBIS 18 / 7739
36
 (HPO:0001639) Hypertrophic cardiomyopathy 17033963 IBIS 137 / 7739
37
 (HPO:0002033) Poor suck 17033963 IBIS 37 / 7739
38
 (MedDRA:10057977) Lactate pyruvate ratio increased 17033963 IBIS 3 / 7739
39
 (MedDRA:10067221) Mechanical ventilation 17033963 IBIS 1 / 7739
40
 (HPO:0002094) Dyspnea 17033963 IBIS 132 / 7739
41
 (HPO:0001522) Death in infancy 17033963 IBIS 275 / 7739
42
 (HPO:0000741) Apathy 17033963 IBIS 42 / 7739
43
 (OMIM) Irregular breathing 17033963 IBIS 2 / 7739
44
 (HPO:0005957) Breathing dysregulation 17033963 IBIS 6 / 7739
45
 (HPO:0001942) Metabolic acidosis 17033963 IBIS 81 / 7739
46
 (HPO:0001946) Ketosis 17033963 IBIS 17 / 7739
47
 (HPO:0001987) Hyperammonemia 17033963 IBIS 50 / 7739
48
 (HPO:0001399) Hepatic failure 21741925 IBIS 80 / 7739
49
 (HPO:0001268) Mental deterioration 25037205 IBIS 88 / 7739
50
 (HPO:0007141) Sensorimotor neuropathy 25037205 IBIS 27 / 7739
51
 (HPO:0011804) Abnormality of muscle physiology 25037205 IBIS 1 / 7739
52
 (HPO:0003554) Type 2 muscle fiber atrophy 25037205 IBIS 14 / 7739
53
 (HPO:0002353) EEG abnormality 17033963 IBIS 188 / 7739
54
 (HPO:0003688) Decreased activity of cytochrome C oxidase in muscle tissue 17033963 IBIS 20 / 7739
55
 (HPO:0002902) Hyponatremia 17033963 IBIS 37 / 7739
56
 (HPO:0012378) Fatigue 25037205 IBIS 50 / 7739
57
 (HPO:0003458) EMG: myopathic abnormalities 25037205 IBIS 38 / 7739
58
 (HPO:0003447) Axonal loss 25037205 IBIS 11 / 7739
59
 (OMIM) Nerve hypertrophy 25037205 IBIS 2 / 7739
60
 (HPO:0100660) Dyskinesia 25037205 IBIS 19 / 7739