Lactic acidosis

Symptom Information:

Symptom ID: HPO:0003128
Synonyms:
Hyperlacticacidemia [HPO:0003128]
Lactic acidemia [HPO:0003128]
Lacticacidemia [HPO:0003128]
Lacticacidosis [HPO:0003128]
Hyperlacticacidemia [OMIM:Hyperlacticacidemia]
Lactic acidemia [OMIM:Lactic acidemia]
Lactic acidosis [OMIM:Lactic acidosis]
Lacticacidemia [OMIM:Lacticacidemia]
Lacticacidosis [OMIM:Lacticacidosis]
Lactic acidemia (2p21del) [OMIM:Lactic acidemia (2p21del)]
Lactic acidosis [MedDRA:10023676]
Quality:
Cross references:
OMIM: "Hyperlacticacidemia" [OMIM:Hyperlacticacidemia]
OMIM: "Lactic acidemia" [OMIM:Lactic acidemia]
OMIM: "Lactic acidosis" [OMIM:Lactic acidosis]
OMIM: "Lacticacidemia" [OMIM:Lacticacidemia]
OMIM: "Lacticacidosis" [OMIM:Lacticacidosis]
OMIM: "Lactic acidemia (2p21del)" [OMIM:Lactic acidemia (2p21del)]
UMLS:C1855560 "Lacticacidemia" [HPO:0003128]
Is a (Direct Parents):
MedDRA Metabolic acidoses (excl diabetic acidoses)
HPO         Acidosis
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of metabolism/homeostasis(HPO:0001939)
          Abnormality of acid-base homeostasis(HPO:0004360)
             Acidosis(HPO:0001941)
                Lactic acidosis(HPO:0003128)
MedDRA:
Metabolism and nutrition disorders(MedDRA:10027433)
    Acid-base disorders(MedDRA:10000485)
       Metabolic acidoses (excl diabetic acidoses)(MedDRA:10027416)
          Lactic acidosis(HPO:0003128)
Database Frequency: 116 / 7739
Resource:

All diseases associated with this symptom:

2p21 microdeletion syndrome (Orphanet:163693)
3-hydroxyisobutyric aciduria (Orphanet:939)
APNEA, CENTRAL SLEEP (OMIM:207720)
Acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins (Orphanet:217371)
Acute infantile liver failure-multisystemic involvement syndrome (Orphanet:370088)
Acyl-CoA dehydrogenase 9 deficiency (Orphanet:99901)
Amish lethal microcephaly (Orphanet:99742)
Atypical hypotonia - cystinuria syndrome (Orphanet:238523)
Autosomal recessive ataxia due to ubiquinone deficiency (Orphanet:139485)
Barth syndrome (Orphanet:111)
CARBONIC ANHYDRASE VA DEFICIENCY, HYPERAMMONEMIA DUE TO (OMIM:615751)
CARDIOENCEPHALOMYOPATHY, FATAL INFANTILE, DUE TO CYTOCHROME c OXIDASEDEFICIENCY 1 (OMIM:604377)
COENZYME Q10 DEFICIENCY, PRIMARY, 1 (OMIM:607426)
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 18 (OMIM:615578)
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 19 (OMIM:615595)
Cardiomyopathy-hypotonia-lactic acidosis syndrome (Orphanet:91130)
Childhood encephalopathy due to thiamine pyrophosphokinase deficiency (Orphanet:293955)
Classic maple syrup urine disease (Orphanet:268145)
Combined oxidative phosphorylation defect type 11 (Orphanet:324535)
Combined oxidative phosphorylation defect type 14 (Orphanet:319519)
Combined oxidative phosphorylation defect type 15 (Orphanet:319524)
Combined oxidative phosphorylation defect type 17 (Orphanet:369913)
Combined oxidative phosphorylation defect type 2 (Orphanet:254920)
Combined oxidative phosphorylation defect type 4 (Orphanet:254925)
Combined oxidative phosphorylation defect type 8 (Orphanet:319504)
Combined oxidative phosphorylation deficiency type 23 (ORPHA:444013)
Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome (Orphanet:1369)
Congenital lactic acidosis, Saguenay-Lac-St. Jean type (Orphanet:70472)
ENCEPHALOMYOPATHY, MITOCHONDRIAL, DUE TO VOLTAGE-DEPENDENT ANION CHANNELDEFICIENCY (OMIM:614520)
Encephalopathy-hypertrophic cardiomyopathy-renal tubular disease syndrome (Orphanet:319678)
Ethylmalonic encephalopathy (Orphanet:51188)
Fatal infantile cytochrome C oxidase deficiency (Orphanet:1561)
Fatal infantile hypertrophic cardiomyopathy due to mitochondrial complex I deficiency (Orphanet:289527)
Fatal infantile lactic acidosis with methylmalonic aciduria (Orphanet:17)
Fatal mitochondrial disease due to combined oxidative phosphorylation deficiency 3 (Orphanet:168566)
Fatal multiple mitochondrial dysfunction syndrome (Orphanet:289573)
Fumaric aciduria (Orphanet:24)
GLYCOGEN STORAGE DISEASE IXc (OMIM:613027)
GLYCOGEN STORAGE DISEASE Ic (OMIM:232240)
GRACILE syndrome (Orphanet:53693)
Glycogen storage disease due to glucose-6-phosphatase deficiency (Orphanet:364)
Glycogen storage disease due to glucose-6-phosphatase deficiency type a (Orphanet:79258)
Glycogen storage disease due to glucose-6-phosphatase deficiency type b (Orphanet:79259)
Glycogen storage disease due to glycogen debranching enzyme deficiency (Orphanet:366)
Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1 (Orphanet:137681)
Hereditary fructose intolerance (Orphanet:469)
Hereditary myopathy with lactic acidosis due to ISCU deficiency (Orphanet:43115)
Hypotonia - cystinuria syndrome (Orphanet:163690)
Hypotonia with lactic acidemia and hyperammonemia (Orphanet:137908)
Hypotonia-cerebral atrophy-hyperglycinemia syndrome (Orphanet:363424)
Isolated ATP synthase deficiency (Orphanet:254913)
Isolated CoQ-cytochrome C reductase deficiency (Orphanet:1460)
Isolated NADH-CoQ reductase deficiency (Orphanet:2609)
Isolated cytochrome C oxidase deficiency (Orphanet:254905)
Kearns-Sayre syndrome (Orphanet:480)
LIPOYLTRANSFERASE 1 DEFICIENCY (OMIM:616299)
Leber plus disease (Orphanet:99718)
Leigh syndrome (Orphanet:506)
Leigh syndrome with leukodystrophy (Orphanet:255241)
Lethal encephalopathy due to mitochondrial and peroxisomal fission defect (Orphanet:330050)
Lethal infantile mitochondrial myopathy (Orphanet:254857)
Leukoencephalopathy - thalamus and brainstem anomalies - high lactate (Orphanet:314051)
MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 2 (OMIM:154275)
MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 3 (OMIM:154276)
MEGDEL syndrome (Orphanet:352328)
MELAS (Orphanet:550)
MERRF (Orphanet:551)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 6 (OMIM:615453)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 8 (OMIM:615838)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 9 (OMIM:616111)
MITOCHONDRIAL COMPLEX V (ATP SYNTHASE) DEFICIENCY, NUCLEAR TYPE 1 (OMIM:604273)
MITOCHONDRIAL COMPLEX V (ATP SYNTHASE) DEFICIENCY, NUCLEAR TYPE 3 (OMIM:614053)
MITOCHONDRIAL DNA DEPLETION SYNDROME 1 (MNGIE TYPE) (OMIM:603041)
MITOCHONDRIAL DNA DEPLETION SYNDROME 12 (CARDIOMYOPATHIC TYPE) (OMIM:615418)
MITOCHONDRIAL PYRUVATE CARRIER DEFICIENCY (OMIM:614741)
MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 1 (OMIM:605711)
MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 2 (OMIM:614299)
Malonic aciduria (Orphanet:943)
Maternally-inherited Leigh syndrome (Orphanet:255210)
Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria (Orphanet:1933)
Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy (Orphanet:255235)
Mitochondrial DNA depletion syndrome, encephalomyopathic form with variable craniofacial anomalies (Orphanet:369897)
Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency (Orphanet:279934)
Mitochondrial DNA depletion syndrome, myopathic form (Orphanet:254875)
Mitochondrial encephalo-cardio-myopathy due to TMEM70 deficiency (Orphanet:1194)
Mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to MTO1 deficiency (Orphanet:314637)
Mitochondrial myopathy - lactic acidosis - deafness (Orphanet:2597)
Mitochondrial myopathy with reversible cytochrome C oxidase deficiency (Orphanet:254864)
Mitochondrial neurogastrointestinal encephalomyopathy (Orphanet:298)
Mitochondrial trifunctional protein deficiency (Orphanet:746)
Multiple acyl-CoA dehydrogenase deficiency (Orphanet:26791)
Myopathy, lactic acidosis, and sideroblastic anemia 1; MLASA1 (OMIM:600462)
Myopathy, lactic acidosis, and sideroblastic anemia 2; MLASA2 (OMIM:613561)
Navajo neurohepatopathy (Orphanet:255229)
PHENFORMIN 4-HYDROXYLATION (OMIM:261590)
Pearson syndrome (Orphanet:699)
Propionic acidemia (Orphanet:35)
Pyruvate carboxylase deficiency (Orphanet:3008)
Pyruvate dehydrogenase E1-alpha deficiency (Orphanet:79243)
Pyruvate dehydrogenase E1-beta deficiency (Orphanet:255138)
Pyruvate dehydrogenase E2 deficiency (Orphanet:79244)
Pyruvate dehydrogenase E3 deficiency (Orphanet:2394)
Pyruvate dehydrogenase E3-binding protein deficiency (Orphanet:255182)
Pyruvate dehydrogenase deficiency (Orphanet:765)
Pyruvate dehydrogenase lipoic acid synthetase deficiency (OMIM:614462)
Pyruvate dehydrogenase phosphatase deficiency (Orphanet:79246)
Renal tubulopathy - encephalopathy - liver failure (Orphanet:254902)
SIDEROBLASTIC ANEMIA WITH B-CELL IMMUNODEFICIENCY, PERIODIC FEVERS,AND DEVELOPMENTAL DELAY (OMIM:616084)
SUCCINIC ACIDEMIA (OMIM:600335)
Short chain 3-hydroxyacyl-CoA dehydrogenase deficiency (Orphanet:35123)
Sporadic Leigh syndrome (Orphanet:255199)
Stimmler syndrome (Orphanet:3199)
[DEL] COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 23 (OMIM:616198)
[DEL] GLYCOGEN STORAGE DISEASE Ib (OMIM:232220)
[DEL] LEIGH SYNDROME, X-LINKED (OMIM:308930)
[DEL] SENGERS SYNDROME (OMIM:212350)