Increased serum lactate
Symptom Information:
Symptom ID: | HPO:0002151 | |||||
Synonyms: |
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Cross references: |
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Is a (Direct Parents): |
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Is a (Whole tree): |
HPO:
All(HPO:0000001) Phenotypic abnormality(HPO:0000118) Abnormality of metabolism/homeostasis(HPO:0001939) Abnormality of acid-base homeostasis(HPO:0004360) Acidosis(HPO:0001941) Increased serum lactate(HPO:0002151) MedDRA: |
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Database Frequency: | 92 / 7739 | |||||
Resource: |
All diseases associated with this symptom:
ACETYL-CoA ACETYLTRANSFERASE-2 DEFICIENCY | (OMIM:614055) |
Acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins | (Orphanet:217371) |
Alpers syndrome | (Orphanet:726) |
Autosomal dominant progressive external ophthalmoplegia | (Orphanet:254892) |
CARBONIC ANHYDRASE VA DEFICIENCY, HYPERAMMONEMIA DUE TO | (OMIM:615751) |
CARDIOENCEPHALOMYOPATHY, FATAL INFANTILE, DUE TO CYTOCHROME c OXIDASEDEFICIENCY 1 | (OMIM:604377) |
COENZYME Q10 DEFICIENCY, PRIMARY, 3 | (OMIM:614652) |
COENZYME Q10 DEFICIENCY, PRIMARY, 7 | (OMIM:616276) |
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 18 | (OMIM:615578) |
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 21 | (OMIM:615918) |
Citrullinemia type II | (Orphanet:247585) |
Combined oxidative phosphorylation defect type 11 | (Orphanet:324535) |
Combined oxidative phosphorylation defect type 13 | (Orphanet:319514) |
Combined oxidative phosphorylation defect type 14 | (Orphanet:319519) |
Combined oxidative phosphorylation defect type 15 | (Orphanet:319524) |
Combined oxidative phosphorylation defect type 17 | (Orphanet:369913) |
Combined oxidative phosphorylation defect type 2 | (Orphanet:254920) |
Combined oxidative phosphorylation defect type 7 | (Orphanet:254930) |
Combined oxidative phosphorylation defect type 8 | (Orphanet:319504) |
Combined oxidative phosphorylation defect type 9 | (Orphanet:319509) |
Combined oxidative phosphorylation deficiency type 23 | (ORPHA:444013) |
Congenital lactic acidosis, Saguenay-Lac-St. Jean type | (Orphanet:70472) |
Deafness - encephaloneuropathy - obesity - valvulopathy | (Orphanet:254898) |
Encephalopathy-hypertrophic cardiomyopathy-renal tubular disease syndrome | (Orphanet:319678) |
Fatal infantile cytochrome C oxidase deficiency | (Orphanet:1561) |
Fatal infantile hypertrophic cardiomyopathy due to mitochondrial complex I deficiency | (Orphanet:289527) |
Fatal mitochondrial disease due to combined oxidative phosphorylation deficiency 3 | (Orphanet:168566) |
GRACILE syndrome | (Orphanet:53693) |
Glycogen storage disease due to hepatic glycogen synthase deficiency | (Orphanet:2089) |
Glycogen storage disease due to lactate dehydrogenase M-subunit deficiency | (Orphanet:284426) |
Glycogen storage disease due to lactate dehydrogenase deficiency | (Orphanet:2364) |
Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1 | (Orphanet:137681) |
Hereditary myopathy with lactic acidosis due to ISCU deficiency | (Orphanet:43115) |
Hyperammonemic encephalopathy due to carbonic anhydrase VA deficiency | (Orphanet:401948) |
Hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome | (Orphanet:363694) |
Hypotonia with lactic acidemia and hyperammonemia | (Orphanet:137908) |
Infantile hypertrophic cardiomyopathy due to MRPL44 deficiency | (Orphanet:352563) |
Intellectual deficit, X-linked, Brooks type | (Orphanet:3056) |
Isolated ATP synthase deficiency | (Orphanet:254913) |
Isolated CoQ-cytochrome C reductase deficiency | (Orphanet:1460) |
Isolated cytochrome C oxidase deficiency | (Orphanet:254905) |
Isolated succinate-CoQ reductase deficiency | (Orphanet:3208) |
LEBER OPTIC ATROPHY AND DYSTONIA | (OMIM:500001) |
LIPOYLTRANSFERASE 1 DEFICIENCY | (OMIM:616299) |
Leigh syndrome | (Orphanet:506) |
Leigh syndrome with nephrotic syndrome | (Orphanet:255249) |
Leukoencephalopathy - thalamus and brainstem anomalies - high lactate | (Orphanet:314051) |
Leukoencephalopathy with brain stem and spinal cord involvement - lactate elevation | (Orphanet:137898) |
MEGDEL syndrome | (Orphanet:352328) |
MELAS | (Orphanet:550) |
MERRF | (Orphanet:551) |
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 4 | (OMIM:615159) |
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 5 | (OMIM:615160) |
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 6 | (OMIM:615453) |
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 8 | (OMIM:615838) |
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 9 | (OMIM:616111) |
MITOCHONDRIAL COMPLEX V (ATP SYNTHASE) DEFICIENCY, NUCLEAR TYPE 1 | (OMIM:604273) |
MITOCHONDRIAL PYRUVATE CARRIER DEFICIENCY | (OMIM:614741) |
MITOCHONDRIAL SHORT-CHAIN ENOYL-CoA HYDRATASE 1 DEFICIENCY | (OMIM:616277) |
MYOPATHY, ISOLATED MITOCHONDRIAL, AUTOSOMAL DOMINANT | (OMIM:616209) |
Maternally-inherited Leigh syndrome | (Orphanet:255210) |
Mitochondrial DNA depletion syndrome, encephalomyopathic form with variable craniofacial anomalies | (Orphanet:369897) |
Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency | (Orphanet:279934) |
Mitochondrial encephalo-cardio-myopathy due to TMEM70 deficiency | (Orphanet:1194) |
Mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to MTO1 deficiency | (Orphanet:314637) |
Mitochondrial myopathy - lactic acidosis - deafness | (Orphanet:2597) |
Mitochondrial myopathy with reversible cytochrome C oxidase deficiency | (Orphanet:254864) |
Myopathy, lactic acidosis, and sideroblastic anemia 1; MLASA1 | (OMIM:600462) |
Myopathy, lactic acidosis, and sideroblastic anemia 2; MLASA2 | (OMIM:613561) |
Neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndrome | (Orphanet:457185) |
Oxoglutaricaciduria | (Orphanet:31) |
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 1 | (OMIM:157640) |
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 3 | (OMIM:609286) |
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 4 | (OMIM:610131) |
Perrault Syndrome 5 | (OMIM:616138) |
Pontocerebellar hypoplasia type 6 | (Orphanet:166073) |
Pyridoxal phosphate-responsive seizures | (Orphanet:79096) |
Pyruvate carboxylase deficiency | (Orphanet:3008) |
Pyruvate dehydrogenase E1-alpha deficiency | (Orphanet:79243) |
Pyruvate dehydrogenase E1-beta deficiency | (Orphanet:255138) |
Pyruvate dehydrogenase E3 deficiency | (Orphanet:2394) |
Pyruvate dehydrogenase lipoic acid synthetase deficiency | (OMIM:614462) |
Pyruvate dehydrogenase phosphatase deficiency | (Orphanet:79246) |
Renal tubulopathy - encephalopathy - liver failure | (Orphanet:254902) |
Severe X-linked mitochondrial encephalomyopathy | (Orphanet:238329) |
Spinocerebellar ataxia with epilepsy | (Orphanet:254881) |
Sporadic Leigh syndrome | (Orphanet:255199) |
Thrombotic thrombocytopenic purpura | (Orphanet:54057) |
Zellweger-like syndrome without peroxisomal anomalies | (Orphanet:50812) |
[DEL] COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 23 | (OMIM:616198) |
[DEL] LEIGH SYNDROME, X-LINKED | (OMIM:308930) |
[DEL] SENGERS SYNDROME | (OMIM:212350) |