Increased serum lactate

Symptom Information:

Symptom ID: HPO:0002151
Synonyms:
Increased blood lactate [HPO:0002151]
Increased blood lactate [OMIM:Increased blood lactate]
Increased serum lactate [OMIM:Increased serum lactate]
Increased serum lactate (in some patients) [OMIM:Increased serum lactate (in some patients)]
Increased serum lactate (mild) [OMIM:Increased serum lactate (mild)]
Quality:
Cross references:
OMIM: "Increased blood lactate" [OMIM:Increased blood lactate]
OMIM: "Increased serum lactate" [OMIM:Increased serum lactate]
OMIM: "Increased serum lactate (in some patients)" [OMIM:Increased serum lactate (in some patients)]
OMIM: "Increased serum lactate (mild)" [OMIM:Increased serum lactate (mild)]
Is a (Direct Parents):
HPO         Acidosis
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of metabolism/homeostasis(HPO:0001939)
          Abnormality of acid-base homeostasis(HPO:0004360)
             Acidosis(HPO:0001941)
                Increased serum lactate(HPO:0002151)
MedDRA:
Database Frequency: 92 / 7739
Resource:

All diseases associated with this symptom:

ACETYL-CoA ACETYLTRANSFERASE-2 DEFICIENCY (OMIM:614055)
Acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins (Orphanet:217371)
Alpers syndrome (Orphanet:726)
Autosomal dominant progressive external ophthalmoplegia (Orphanet:254892)
CARBONIC ANHYDRASE VA DEFICIENCY, HYPERAMMONEMIA DUE TO (OMIM:615751)
CARDIOENCEPHALOMYOPATHY, FATAL INFANTILE, DUE TO CYTOCHROME c OXIDASEDEFICIENCY 1 (OMIM:604377)
COENZYME Q10 DEFICIENCY, PRIMARY, 3 (OMIM:614652)
COENZYME Q10 DEFICIENCY, PRIMARY, 7 (OMIM:616276)
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 18 (OMIM:615578)
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 21 (OMIM:615918)
Citrullinemia type II (Orphanet:247585)
Combined oxidative phosphorylation defect type 11 (Orphanet:324535)
Combined oxidative phosphorylation defect type 13 (Orphanet:319514)
Combined oxidative phosphorylation defect type 14 (Orphanet:319519)
Combined oxidative phosphorylation defect type 15 (Orphanet:319524)
Combined oxidative phosphorylation defect type 17 (Orphanet:369913)
Combined oxidative phosphorylation defect type 2 (Orphanet:254920)
Combined oxidative phosphorylation defect type 7 (Orphanet:254930)
Combined oxidative phosphorylation defect type 8 (Orphanet:319504)
Combined oxidative phosphorylation defect type 9 (Orphanet:319509)
Combined oxidative phosphorylation deficiency type 23 (ORPHA:444013)
Congenital lactic acidosis, Saguenay-Lac-St. Jean type (Orphanet:70472)
Deafness - encephaloneuropathy - obesity - valvulopathy (Orphanet:254898)
Encephalopathy-hypertrophic cardiomyopathy-renal tubular disease syndrome (Orphanet:319678)
Fatal infantile cytochrome C oxidase deficiency (Orphanet:1561)
Fatal infantile hypertrophic cardiomyopathy due to mitochondrial complex I deficiency (Orphanet:289527)
Fatal mitochondrial disease due to combined oxidative phosphorylation deficiency 3 (Orphanet:168566)
GRACILE syndrome (Orphanet:53693)
Glycogen storage disease due to hepatic glycogen synthase deficiency (Orphanet:2089)
Glycogen storage disease due to lactate dehydrogenase M-subunit deficiency (Orphanet:284426)
Glycogen storage disease due to lactate dehydrogenase deficiency (Orphanet:2364)
Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1 (Orphanet:137681)
Hereditary myopathy with lactic acidosis due to ISCU deficiency (Orphanet:43115)
Hyperammonemic encephalopathy due to carbonic anhydrase VA deficiency (Orphanet:401948)
Hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome (Orphanet:363694)
Hypotonia with lactic acidemia and hyperammonemia (Orphanet:137908)
Infantile hypertrophic cardiomyopathy due to MRPL44 deficiency (Orphanet:352563)
Intellectual deficit, X-linked, Brooks type (Orphanet:3056)
Isolated ATP synthase deficiency (Orphanet:254913)
Isolated CoQ-cytochrome C reductase deficiency (Orphanet:1460)
Isolated cytochrome C oxidase deficiency (Orphanet:254905)
Isolated succinate-CoQ reductase deficiency (Orphanet:3208)
LEBER OPTIC ATROPHY AND DYSTONIA (OMIM:500001)
LIPOYLTRANSFERASE 1 DEFICIENCY (OMIM:616299)
Leigh syndrome (Orphanet:506)
Leigh syndrome with nephrotic syndrome (Orphanet:255249)
Leukoencephalopathy - thalamus and brainstem anomalies - high lactate (Orphanet:314051)
Leukoencephalopathy with brain stem and spinal cord involvement - lactate elevation (Orphanet:137898)
MEGDEL syndrome (Orphanet:352328)
MELAS (Orphanet:550)
MERRF (Orphanet:551)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 4 (OMIM:615159)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 5 (OMIM:615160)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 6 (OMIM:615453)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 8 (OMIM:615838)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 9 (OMIM:616111)
MITOCHONDRIAL COMPLEX V (ATP SYNTHASE) DEFICIENCY, NUCLEAR TYPE 1 (OMIM:604273)
MITOCHONDRIAL PYRUVATE CARRIER DEFICIENCY (OMIM:614741)
MITOCHONDRIAL SHORT-CHAIN ENOYL-CoA HYDRATASE 1 DEFICIENCY (OMIM:616277)
MYOPATHY, ISOLATED MITOCHONDRIAL, AUTOSOMAL DOMINANT (OMIM:616209)
Maternally-inherited Leigh syndrome (Orphanet:255210)
Mitochondrial DNA depletion syndrome, encephalomyopathic form with variable craniofacial anomalies (Orphanet:369897)
Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency (Orphanet:279934)
Mitochondrial encephalo-cardio-myopathy due to TMEM70 deficiency (Orphanet:1194)
Mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to MTO1 deficiency (Orphanet:314637)
Mitochondrial myopathy - lactic acidosis - deafness (Orphanet:2597)
Mitochondrial myopathy with reversible cytochrome C oxidase deficiency (Orphanet:254864)
Myopathy, lactic acidosis, and sideroblastic anemia 1; MLASA1 (OMIM:600462)
Myopathy, lactic acidosis, and sideroblastic anemia 2; MLASA2 (OMIM:613561)
Neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndrome (Orphanet:457185)
Oxoglutaricaciduria (Orphanet:31)
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 1 (OMIM:157640)
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 3 (OMIM:609286)
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 4 (OMIM:610131)
Perrault Syndrome 5 (OMIM:616138)
Pontocerebellar hypoplasia type 6 (Orphanet:166073)
Pyridoxal phosphate-responsive seizures (Orphanet:79096)
Pyruvate carboxylase deficiency (Orphanet:3008)
Pyruvate dehydrogenase E1-alpha deficiency (Orphanet:79243)
Pyruvate dehydrogenase E1-beta deficiency (Orphanet:255138)
Pyruvate dehydrogenase E3 deficiency (Orphanet:2394)
Pyruvate dehydrogenase lipoic acid synthetase deficiency (OMIM:614462)
Pyruvate dehydrogenase phosphatase deficiency (Orphanet:79246)
Renal tubulopathy - encephalopathy - liver failure (Orphanet:254902)
Severe X-linked mitochondrial encephalomyopathy (Orphanet:238329)
Spinocerebellar ataxia with epilepsy (Orphanet:254881)
Sporadic Leigh syndrome (Orphanet:255199)
Thrombotic thrombocytopenic purpura (Orphanet:54057)
Zellweger-like syndrome without peroxisomal anomalies (Orphanet:50812)
[DEL] COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 23 (OMIM:616198)
[DEL] LEIGH SYNDROME, X-LINKED (OMIM:308930)
[DEL] SENGERS SYNDROME (OMIM:212350)