Downturned corners of mouth

Symptom Information:

Symptom ID: HPO:0002714
Synonyms:
Downturned corners of the mouth [HPO:0002714]
Downturned mouth [HPO:0002714]
Downturned corners of mouth [OMIM:Downturned corners of mouth]
Downturned corners of the mouth [OMIM:Downturned corners of the mouth]
Downturned mouth [OMIM:Downturned mouth]
Downturned mouth [Orphanet:9320]
Downturned corners of mouth (63%) [OMIM:Downturned corners of mouth (63%)]
Downturned corners of the mouth (deletion patients) [OMIM:Downturned corners of the mouth (deletion patients)]
Quality:
Cross references:
Orphanet:9320 "Downturned mouth" [Orphanet:9320]
OMIM: "Downturned corners of mouth" [OMIM:Downturned corners of mouth]
OMIM: "Downturned corners of the mouth" [OMIM:Downturned corners of the mouth]
OMIM: "Downturned mouth" [OMIM:Downturned mouth]
OMIM: "Downturned corners of mouth (63%)" [OMIM:Downturned corners of mouth (63%)]
OMIM: "Downturned corners of the mouth (deletion patients)" [OMIM:Downturned corners of the mouth (deletion patients)]
Is a (Direct Parents):
Orphanet Abnormality of the mouth
HPO         Abnormality of mouth shape
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of head or neck(HPO:0000152)
          Abnormality of the head(HPO:0000234)
             Abnormality of the face(HPO:0000271)
                Abnormality of the mouth(HPO:0000153)
                   Abnormality of mouth shape(HPO:0011338)
                      Downturned corners of mouth(HPO:0002714)
MedDRA:
Database Frequency: 98 / 7739
Resource:

All diseases associated with this symptom:

12q14 microdeletion syndrome (Orphanet:94063)
14q22q23 microdeletion syndrome (Orphanet:264200)
2q23.1 microdeletion syndrome (Orphanet:228402)
2q31.1 microdeletion syndrome (Orphanet:251014)
2q37 microdeletion syndrome (Orphanet:1001)
3MC SYNDROME 2 (OMIM:265050)
4q21 microdeletion syndrome (Orphanet:238750)
5q14.3 microdeletion syndrome (Orphanet:228384)
8q21.11 microdeletion syndrome (Orphanet:284160)
Acroosteolysis, dominant type (Orphanet:955)
Aniridia - renal agenesis - psychomotor retardation (Orphanet:1064)
Aortic arch anomaly - peculiar facies - intellectual deficit (Orphanet:1110)
Arthrogryposis multiplex congenita - whistling face (Orphanet:1150)
Autosomal dominant Robinow syndrome (Orphanet:3107)
Autosomal dominant nonsyndromic intellectual deficit (Orphanet:178469)
Autosomal recessive Robinow syndrome (Orphanet:1507)
Autosomal recessive deafness-onychodystrophy syndrome (Orphanet:79500)
Autosomal recessive multiple pterygium syndrome (Orphanet:2990)
CORNELIA DE LANGE SYNDROME 1 (OMIM:122470)
CORNELIA DE LANGE SYNDROME 2 (OMIM:300590)
CORNELIA DE LANGE SYNDROME 5 (OMIM:300882)
Camptodactyly syndrome, Guadalajara type 1 (Orphanet:1327)
Cerebro-facio-articular syndrome (Orphanet:314679)
Cerebro-oculo-nasal syndrome (Orphanet:66625)
Cerebro-reno-digital syndrome (Orphanet:1396)
Cloverleaf skull - multiple congenital anomalies (Orphanet:93267)
Connective tissue disorder due to lysyl hydroxylase-3 deficiency (Orphanet:300284)
Cornelia de Lange syndrome (Orphanet:199)
DEND syndrome (Orphanet:79134)
Disorder of sex development - intellectual deficit (Orphanet:2983)
Distal monosomy 3p (Orphanet:1620)
Distal monosomy 6p (Orphanet:96125)
Distal trisomy 15q (Orphanet:1707)
Down syndrome (Orphanet:870)
Dysmorphism - multiple structural anomalies (Orphanet:1780)
Edinburgh malformation syndrome (Orphanet:1895)
Ehlers-Danlos syndrome, musculocontractural type (Orphanet:2953)
FACIAL DYSMORPHISM WITH MULTIPLE MALFORMATIONS (OMIM:227255)
Facial ectodermal dysplasia (Orphanet:1807)
Familial lambdoid synostosis (Orphanet:3267)
Fetal valproate syndrome (Orphanet:1906)
Flat face - microstomia - ear anomaly (Orphanet:1968)
Floating-Harbor syndrome (Orphanet:2044)
Fryns-Smeets-Thiry syndrome (Orphanet:2058)
Genito-palato-cardiac syndrome (Orphanet:2075)
HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 1 (OMIM:239300)
Hall-Riggs syndrome (Orphanet:2107)
Hunter-McAlpine craniosynostosis (Orphanet:97340)
Hyperphosphatasia-intellectual deficiency syndrome (Orphanet:247262)
Intellectual deficit, X-linked - cubitus valgus - dysmorphism (Orphanet:85280)
Intellectual deficit, X-linked, Armfield type (Orphanet:85276)
Intellectual deficit, X-linked, Nascimento type (Orphanet:163956)
Isolated glycerol kinase deficiency (Orphanet:408)
Kleefstra syndrome (Orphanet:261494)
Kleefstra syndrome due to 9q34 microdeletion (Orphanet:96147)
Lathosterolosis (Orphanet:46059)
Laurin-Sandrow syndrome (Orphanet:2378)
Lichstenstein syndrome (Orphanet:2390)
MEHMO syndrome (Orphanet:85282)
MENTAL RETARDATION, AUTOSOMAL DOMINANT 32 (OMIM:616268)
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 13 (OMIM:613192)
Malignant hyperthermia - arthrogryposis - torticollis (Orphanet:2215)
Microcephalic primordial dwarfism, Toriello type (Orphanet:2643)
Microcephaly-capillary malformation syndrome (Orphanet:294016)
Monosomy 18p (Orphanet:1598)
Monosomy 18q (Orphanet:1600)
Monosomy 5p (Orphanet:281)
Multicentric carpo-tarsal osteolysis with or without nephropathy (Orphanet:2774)
Multiple congenital anomalies-hypotonia-seizures syndrome type 2 (Orphanet:300496)
Native American myopathy (Orphanet:168572)
Okamoto syndrome (Orphanet:2729)
Omphalocele syndrome, Shprintzen-Goldberg type (Orphanet:3164)
Permanent neonatal diabetes mellitus (Orphanet:99885)
Pontocerebellar hypoplasia type 3 (Orphanet:97249)
Potocki-Shaffer syndrome (Orphanet:52022)
Prader-Willi syndrome (Orphanet:739)
Radio-renal syndrome (Orphanet:3015)
Recombinant 8 syndrome (Orphanet:96167)
Ring chromosome 1 (Orphanet:1437)
SILVER-RUSSELL SYNDROME (OMIM:180860)
STEVENSON-CAREY SYNDROME (OMIM:611961)
Severe intellectual deficit - epilepsy - anal anomalies - distal phalangeal hypoplasia (Orphanet:94066)
Short stature - heart defect - craniofacial anomalies (Orphanet:1088)
Silver-Russell syndrome (Orphanet:813)
Spinocerebellar ataxia - dysmorphism (Orphanet:1185)
TEMPLE-BARAITSER SYNDROME (OMIM:611816)
TETRAAMELIA WITH ECTODERMAL DYSPLASIA AND LACRIMAL DUCT ABNORMALITIES (OMIM:273390)
Tetrasomy 12p (Orphanet:884)
Toriello-Carey syndrome (Orphanet:3338)
Trisomy 12p (Orphanet:1699)
Trisomy 20p (Orphanet:261318)
Trisomy 9p (Orphanet:236)
VAN MALDERGEM SYNDROME 1 (OMIM:601390)
VAN MALDERGEM SYNDROME 2 (OMIM:615546)
Van Regemorter-Pierquin-Vamos syndrome (Orphanet:3419)
WARBURG MICRO SYNDROME 3 (OMIM:614222)
Weaver-Williams syndrome (Orphanet:3448)
Wolf-Hirschhorn syndrome (Orphanet:280)