Symptom Information: Sort according to HPO 

1
 (HPO:0000572) Visual loss Occasional [Orphanet] 272 / 7739
2
 (HPO:0000365) Hearing impairment Occasional [Orphanet] 539 / 7739
3
 (HPO:0004370) Abnormality of temperature regulation Occasional [Orphanet] 58 / 7739
4
 (HPO:0002615) Hypotension Frequent [Orphanet] 52 / 7739
5
 (HPO:0001337) Tremor Frequent [Orphanet] 200 / 7739
6
 (HPO:0001288) Gait disturbance Frequent [Orphanet] 318 / 7739
7
 (HPO:0001257) Spasticity 251 / 7739
8
 (HPO:0001276) Hypertonia Frequent [Orphanet] 317 / 7739
9
 (HPO:0007370) Aplasia/Hypoplasia of the corpus callosum Occasional [Orphanet] 180 / 7739
10
 (HPO:0002015) Dysphagia Occasional [Orphanet] 301 / 7739
11
 (HPO:0000802) Impotence 20 / 7739
12
 (HPO:0008652) Autonomic erectile dysfunction 3 / 7739
13
 (HPO:0100639) Erectile abnormalities Frequent [Orphanet] 15 / 7739
14
 (HPO:0001251) Ataxia 413 / 7739
15
 (HPO:0002066) Gait ataxia Very frequent [Orphanet] 327 / 7739
16
 (HPO:0002019) Constipation Frequent [Orphanet] 194 / 7739
17
 (HPO:0002120) Cerebral cortical atrophy Occasional [Orphanet] 187 / 7739
18
 (HPO:0000639) Nystagmus Frequent [Orphanet] 555 / 7739
19
 (HPO:0000079) Abnormality of the urinary system 88 / 7739
20
 (HPO:0000751) Personality changes 33 / 7739
21
 (HPO:0001347) Hyperreflexia 363 / 7739
22
 (HPO:0002167) Neurological speech impairment Occasional [Orphanet] 308 / 7739
23
 (HPO:0002171) Gliosis 48 / 7739
24
 (HPO:0002344) Progressive neurologic deterioration 27 / 7739
25
 (HPO:0002415) Leukodystrophy 30 / 7739
26
 (HPO:0003487) Babinski sign 179 / 7739
27
 (HPO:0004926) Orthostatic hypotension due to autonomic dysfunction 2 / 7739
28
 (HPO:0005341) Autonomic bladder dysfunction 1 / 7739
29
 (HPO:0006994) Diffuse leukoencephalopathy 1 / 7739
30
 (HPO:0007024) Pseudobulbar paralysis 7 / 7739
31
 (HPO:0007262) Symmetric peripheral demyelination 1 / 7739
32
 (HPO:0007371) Corpus callosum atrophy 14 / 7739
33
 (HPO:0007480) Decreased sweating due to autonomic dysfunction 1 / 7739
34
 (HPO:0100543) Cognitive impairment 230 / 7739
35
 (OMIM) Abnormal bowel regulation due to autonomic dysfunction 1 / 7739
36
 (OMIM) Abnormal bladder regulation due to autonomic dysfunction 1 / 7739
37
 (HPO:0001317) Abnormality of the cerebellum 36 / 7739
38
 (OMIM) Loss of fine motor skills 1 / 7739
39
 (HPO:0007256) Abnormal pyramidal signs 116 / 7739
40
 (HPO:0002459) Dysautonomia 34 / 7739
41
 (OMIM) Leukodystrophy, demyelinating 1 / 7739
42
 (OMIM) Demyelination, symmetric 1 / 7739
43
 (OMIM) Brain imaging shows decreased white matter density 1 / 7739
44
 (OMIM) Cavitating white matter degeneration 1 / 7739
45
 (OMIM) Hypotrophic brainstem 1 / 7739
46
 (OMIM) White matter lesions in the brainstem may occur 1 / 7739
47
 (OMIM) Neuropathologic findings include leukoencephalopathy, predominantly in the upper corticospinal tract and cerebellar peduncles (initially) 1 / 7739
48
 (OMIM) Leukoencephalopathy in the frontal and parietal lobes (later) 1 / 7739
49
 (OMIM) Atrophic spinal cord 2 / 7739
50
 (OMIM) Oligodendrocytes with foamy cytoplasm 1 / 7739
51
 (OMIM) Decreased numbers of astrocytes 1 / 7739
52
 (OMIM) Astrocytes show reactive changes 1 / 7739
53
 (OMIM) Lack of inflammatory infiltrate 1 / 7739
54
 (OMIM) Preservation of U fibers 2 / 7739
55
 (OMIM) Sparing of optic tracts 1 / 7739
56
 (HPO:0000716) Depression 99 / 7739
57
 (OMIM) Patient cells have increased levels of LMNB1 mRNA and protein 1 / 7739
58
 (HPO:0100022) Abnormality of movement Frequent [Orphanet] 129 / 7739
59
 (HPO:0012758) Neurodevelopmental delay Occasional [Orphanet] 949 / 7739
60
 (HPO:0001428) Somatic mutation Very frequent [Orphanet] 100 / 7739
61
 (HPO:0002839) Urinary bladder sphincter dysfunction Frequent [Orphanet] 34 / 7739
62
 (HPO:0011442) Abnormality of central motor function Very frequent [Orphanet] 76 / 7739
63
 (HPO:0000006) Autosomal dominant inheritance 2518 / 7739
64
 (HPO:0003581) Adult onset 117 / 7739
65
 (HPO:0003676) Progressive disorder 148 / 7739