Symptom Information: Sort according to HPO 

1
 (HPO:0010839) Increased urinary copper concentration Very frequent [IBIS] 100% (n=12) 27103860 IBIS 1 / 7739
2
 (HPO:0001410) Decreased liver function Very frequent [IBIS] 92% (n=12) 27103860 IBIS 59 / 7739
3
 (HPO:0003073) Hypoalbuminemia Frequent [IBIS] 84% (n=12) 27103860 IBIS 40 / 7739
4
 (HPO:0010837) Decreased serum ceruloplasmin Frequent [IBIS] 84% (n=12) 27103860 IBIS 2 / 7739
5
 (HPO:0000939) Osteoporosis Frequent [IBIS] 66% (n=32) 857745 IBIS 129 / 7739
6
 (HPO:0006462) Generalized bone demineralization Frequent [IBIS] 66% (n=32) 857745 IBIS 11 / 7739
7
 (HPO:0001337) Tremor Frequent [IBIS] 58% (n=12) 27103860 IBIS 200 / 7739
8
 (HPO:0002315) Headache Frequent [IBIS] 58% (n=12) 27103860 IBIS 175 / 7739
9
 (HPO:0000790) Hematuria Frequent [IBIS] 56% (n=25) 18661763 IBIS 106 / 7739
10
 (HPO:0200032) Kayser-Fleischer ring Frequent [IBIS] 50% (n=12) 27103860 IBIS 2 / 7739
11
 (HPO:0002013) Vomiting Frequent [IBIS] 50% (n=12) 27103860 IBIS 191 / 7739
12
 (HPO:0000093) Proteinuria Frequent [IBIS] 48% (n=25) 18661763 IBIS 169 / 7739
13
 (HPO:0000952) Jaundice Frequent [IBIS] 42% (n=12) 27103860 IBIS 105 / 7739
14
 (HPO:0001903) Anemia Frequent [IBIS] 33% (n=12) 27103860 IBIS 289 / 7739
15
 (HPO:0000980) Pallor Frequent [IBIS] 33% (n=12) 27103860 IBIS 52 / 7739
16
 (HPO:0003781) Excessive salivation Frequent [IBIS] 26209285 IBIS 15 / 7739
17
 (HPO:0001382) Joint hypermobility Occasional [IBIS] 28% (n=32) 857745 IBIS 231 / 7739
18
 (HPO:0000083) Renal insufficiency Occasional [IBIS] 28% (n=25) 18661763 IBIS 232 / 7739
19
 (MedDRA:10038182) Red blood cells urine positive Occasional [IBIS] 28% (n=25) 18661763 IBIS 1 / 7739
20
 (HPO:0001332) Dystonia Occasional [IBIS] 25% (n=12) 27103860 IBIS 197 / 7739
21
 (HPO:0002758) Osteoarthritis Occasional [IBIS] 25% (n=32) 857745 IBIS 78 / 7739
22
 (MedDRA:10004501) Beta 2 microglobulin urine increased Occasional [IBIS] 24% (n=25) 18661763 IBIS 1 / 7739
23
 (HPO:0000969) Edema Occasional [IBIS] 20% (n=25) 18661763 IBIS 117 / 7739
24
 (MedDRA:10004511) Beta-N-acetyl-D-glucosaminidase increased Occasional [IBIS] 20% (n=25) 18661763 IBIS 1 / 7739
25
 (HPO:0001251) Ataxia Occasional [IBIS] 17% (n=12) 27103860 IBIS 413 / 7739
26
 (HPO:0002321) Vertigo Occasional [IBIS] 17% (n=12) 27103860 IBIS 58 / 7739
27
 (HPO:0004787) Fulminant hepatitis Occasional [IBIS] 17% (n=12) 27103860 IBIS 3 / 7739
28
 (HPO:0003076) Glycosuria Occasional [IBIS] 16% (n=25) 18661763 IBIS 32 / 7739
29
 (HPO:0011016) Abnormality of urine glucose concentration Occasional [IBIS] 16% (n=25) 18661763 IBIS 1 / 7739
30
 (MedDRA:10036030) Polyarthritis Occasional [IBIS] 16% (n=32) 857745 IBIS 3 / 7739
31
 (HPO:0000105) Enlarged kidneys Occasional [IBIS] 12% (n=25) 18661763 IBIS 30 / 7739
32
 (HPO:0003401) Paresthesia Occasional [IBIS] 8% (n=12) 27103860 IBIS 42 / 7739
33
 (HPO:0001279) Syncope Occasional [IBIS] 8% (n=12) 27103860 IBIS 94 / 7739
34
 (HPO:0001324) Muscle weakness Occasional [IBIS] 8% (n=12) 27103860 IBIS 859 / 7739
35
 (HPO:0001928) Abnormality of coagulation Occasional [IBIS] 8% (n=12) 27103860 IBIS 44 / 7739
36
 (HPO:0012751) Abnormal basal ganglia MRI signal intensity Occasional [IBIS] 8% (n=12) 27103860 IBIS 4 / 7739
37
 (HPO:0000707) Abnormality of the nervous system Occasional [IBIS] 27103860 IBIS 61 / 7739
38
 (HPO:0001878) Hemolytic anemia Rare [IBIS] 4% (n=25) 18661763 IBIS 83 / 7739
39
 (HPO:0003138) Increased blood urea nitrogen Rare [IBIS] 4% (n=25) 18661763 IBIS 14 / 7739
40
 (HPO:0003259) Elevated serum creatinine Rare [IBIS] 4% (n=25) 18661763 IBIS 31 / 7739
41
 (HPO:0012574) Mesangial proliferation Rare [IBIS] 4% (n=25) 18661763 IBIS 1 / 7739
42
 (HPO:0000124) Renal tubular dysfunction 25120295 IBIS 46 / 7739
43
 (HPO:0011038) Abnormality of renal resorption 25120295 IBIS 6 / 7739
44
 (HPO:0000726) Dementia 25906525 IBIS 131 / 7739
45
 (HPO:0000751) Personality changes 26692151 IBIS 33 / 7739
46
 (HPO:0000787) Nephrolithiasis 25120295 IBIS 78 / 7739
47
 (HPO:0000829) Hypoparathyroidism 26692151 IBIS 22 / 7739
48
 (HPO:0000934) Chondrocalcinosis 3361541 IBIS 13 / 7739
49
 (HPO:0001259) Coma 7322363 IBIS 65 / 7739
50
 (HPO:0001260) Dysarthria 27103860 IBIS 329 / 7739
51
 (HPO:0001271) Polyneuropathy 16216950 IBIS 56 / 7739
52
 (HPO:0001394) Cirrhosis 26692151 IBIS 102 / 7739
53
 (HPO:0001399) Hepatic failure 25380954 IBIS 80 / 7739
54
 (HPO:0002015) Dysphagia 27103860 IBIS 301 / 7739
55
 (HPO:0002040) Esophageal varix 4190630 IBIS 23 / 7739
56
 (HPO:0002150) Hypercalciuria 23087754 IBIS 45 / 7739
57
 (HPO:0002240) Hepatomegaly 26288636 IBIS 467 / 7739
58
 (HPO:0002275) Poor motor coordination 24798599 IBIS 6 / 7739
59
 (HPO:0002307) Drooling 26209285 IBIS 43 / 7739
60
 (HPO:0002749) Osteomalacia 3975658 IBIS 24 / 7739
61
 (HPO:0001369) Arthritis 22286624 IBIS 44 / 7739
62
 (HPO:0003109) Hyperphosphaturia 857745 IBIS 18 / 7739
63
 (HPO:0003355) Aminoaciduria 26692151 IBIS 65 / 7739
64
 (HPO:0007327) Mixed demyelinating and axonal polyneuropathy 16216950 IBIS 1 / 7739
65
 (HPO:0010838) High nonceruloplasmin-bound serum copper 27103860 IBIS 1 / 7739
66
 (MedDRA:10010075) Coma hepatic 7322363 IBIS 1 / 7739
67
 (OMIM) High liver copper 27103860 IBIS 1 / 7739
68
 (OMIM) Low serum ceruloplasmin 27103860 IBIS 1 / 7739
69
 (OMIM) High urinary copper 27103860 IBIS 1 / 7739
70
 (HPO:0100022) Abnormality of movement 27103860 IBIS 129 / 7739
71
 (HPO:0000298) Mask-like facies 27103860 IBIS 44 / 7739
72
 (HPO:0001288) Gait disturbance 27103860 IBIS 318 / 7739
73
 (HPO:0002200) Pseudobulbar signs 27103860 IBIS 15 / 7739
74
 (HPO:0012676) Copper accumulation in brain 27103860 IBIS 1 / 7739
75
 (HPO:0010836) Abnormality of copper homeostasis 27103860 IBIS 2 / 7739
76
 (HPO:0002459) Dysautonomia 27103860 IBIS 34 / 7739
77
 (HPO:0002067) Bradykinesia 27103860 IBIS 62 / 7739
78
 (HPO:0003201) Rhabdomyolysis 27103860 IBIS 27 / 7739
79
 (OMIM) Hypokalemic muscle weakness 27103860 IBIS 2 / 7739
80
 (HPO:0004448) Fulminant hepatic failure 26692151 IBIS 4 / 7739
81
 (HPO:0001392) Abnormality of the liver 26692151 IBIS 28 / 7739
82
 (HPO:0000121) Nephrocalcinosis 23087754 IBIS 57 / 7739
83
 (HPO:0001959) Polydipsia 23087754 IBIS 43 / 7739
84
 (HPO:0004334) Dermal atrophy 25617204 IBIS 34 / 7739
85
 (OMIM) Labile mood 26692151 IBIS 2 / 7739
86
 (HPO:0001575) Mood changes 26692151 IBIS 7 / 7739
87
 (HPO:0000716) Depression 26692151 IBIS 99 / 7739
88
 (HPO:0011999) Paranoia 26692151 IBIS 6 / 7739
89
 (HPO:0100753) Schizophrenia 26692151 IBIS 20 / 7739
90
 (HPO:0001638) Cardiomyopathy 26692151 IBIS 192 / 7739
91
 (HPO:0011675) Arrhythmia 26692151 IBIS 226 / 7739
92
 (HPO:0002748) Rickets 3975658 IBIS 41 / 7739
93
 (HPO:0012452) Restless legs 26940540 IBIS 2 / 7739
94
 (HPO:0009830) Peripheral neuropathy 16216950 IBIS 206 / 7739
95
 (OMIM) Sensorimotor polyneuropathy 16216950 IBIS 2 / 7739
96
 (HPO:0002071) Abnormality of extrapyramidal motor function 25906525 IBIS 76 / 7739
97
 (HPO:0005264) Abnormality of the gallbladder 22286624 IBIS 14 / 7739
98
 (HPO:0001971) Hypersplenism 25910248 IBIS 8 / 7739
99
 (HPO:0001744) Splenomegaly 25910248 IBIS 337 / 7739
100
 (HPO:0001876) Pancytopenia 25910248 IBIS 89 / 7739
101
 (HPO:0001367) Abnormal joint morphology 23576656 IBIS 53 / 7739
102
 (HPO:0010886) Osteochondritis Dissecans 857745 IBIS 9 / 7739
103
 (HPO:0003418) Back pain 857745 IBIS 17 / 7739
104
 (HPO:0001387) Joint stiffness 857745 IBIS 322 / 7739
105
 (HPO:0002653) Bone pain 857745 IBIS 75 / 7739
106
 (HPO:0008341) Distal renal tubular acidosis 25120295 IBIS 6 / 7739