Symptom Information: Sort according to HPO 

1
 (HPO:0001387) Joint stiffness Very frequent [Orphanet] 322 / 7739
2
 (HPO:0010783) Erythema Very frequent [Orphanet] 138 / 7739
3
 (HPO:0200042) Skin ulcer Frequent [Orphanet] 138 / 7739
4
 (HPO:0001596) Alopecia Occasional [Orphanet] 162 / 7739
5
 (HPO:0002289) Alopecia universalis rare [HPO:skoehler] 20 / 7739
6
 (HPO:0004370) Abnormality of temperature regulation Very frequent [Orphanet] 58 / 7739
7
 (HPO:0000164) Abnormality of the teeth Frequent [Orphanet] 291 / 7739
8
 (HPO:0001072) Thickened skin Very frequent [Orphanet] 87 / 7739
9
 (HPO:0100526) Neoplasm of the lung Occasional [Orphanet] 26 / 7739
10
 (HPO:0001250) Seizures Occasional [Orphanet] 1245 / 7739
11
 (HPO:0001006) Hypotrichosis Very frequent [Orphanet] 219 / 7739
12
 (HPO:0000407) Sensorineural hearing impairment Frequent [Orphanet] 524 / 7739
13
 (HPO:0002861) Melanoma Occasional [Orphanet] 18 / 7739
14
 (HPO:0000962) Hyperkeratosis Very frequent [Orphanet] 216 / 7739
15
 (HPO:0002797) Osteolysis Occasional [Orphanet] 68 / 7739
16
 (HPO:0001231) Abnormality of the fingernails Very frequent [Orphanet] 116 / 7739
17
 (HPO:0000670) Carious teeth Frequent [Orphanet] 145 / 7739
18
 (HPO:0000975) Hyperhidrosis rare [HPO:skoehler] 64 / 7739
19
 (HPO:0000989) Pruritus 111 / 7739
20
 (HPO:0001036) Parakeratosis 12 / 7739
21
 (HPO:0001371) Flexion contracture 220 / 7739
22
 (HPO:0002164) Nail dysplasia 82 / 7739
23
 (HPO:0007759) Opacification of the corneal stroma rare [HPO:skoehler] 77 / 7739
24
 (HPO:0007957) Corneal opacity rare [HPO:skoehler] 84 / 7739
25
 (HPO:0008069) Neoplasm of the skin Occasional [Orphanet] 84 / 7739
26
 (HPO:0008070) Sparse hair rare [HPO:skoehler] 94 / 7739
27
 (HPO:0008392) Subungual hyperkeratosis 6 / 7739
28
 (HPO:0008404) Nail dystrophy 89 / 7739
29
 (HPO:0009804) Reduced number of teeth Frequent [Orphanet] 137 / 7739
30
 (OMIM) Keratotic plaque around ear meatus 1 / 7739
31
 (OMIM) Keratotic plaque around nostrils 1 / 7739
32
 (OMIM) Perioral keratotic plaque 1 / 7739
33
 (OMIM) Leukokeratosis of tongue and/or buccal mucosa (in some patients) 1 / 7739
34
 (OMIM) Keratotic plaque (in some patients) 2 / 7739
35
 (OMIM) Perianal keratotic plaque 1 / 7739
36
 (OMIM) Keratotic plaque in perigenital region 1 / 7739
37
 (HPO:0100490) Camptodactyly of finger 212 / 7739
38
 (OMIM) Constricting digital bands 1 / 7739
39
 (OMIM) Autoamputation of fingers (in some patients) 1 / 7739
40
 (OMIM) Autoamputation of toes (in some patients) 1 / 7739
41
 (OMIM) Keratoderma, mutilating, of palms and soles 1 / 7739
42
 (OMIM) Keratotic plaque, periorificial 1 / 7739
43
 (OMIM) Pruritus of skin lesions, severe 1 / 7739
44
 (OMIM) Anhidrosis over skin lesions (rare) 1 / 7739
45
 (OMIM) Marked hyperkeratosis 2 / 7739
46
 (OMIM) Psoriasiform hyperplasia 1 / 7739
47
 (OMIM) Orthohyperkeratosis 4 / 7739
48
 (OMIM) Hypogranulosis 1 / 7739
49
 (OMIM) Transverse ridging 2 / 7739
50
 (OMIM) Pili torti defects (in some patients) 1 / 7739
51
 (OMIM) Trichorrhexis nodosa-type defects (in some patients) 1 / 7739
52
 (OMIM) Squamous cell carcinoma in area of palmoplantar keratoderma (rare) 1 / 7739
53
 (HPO:0100774) Hyperostosis Frequent [Orphanet] 17 / 7739
54
 (HPO:0000163) Abnormality of the oral cavity Occasional [Orphanet] 37 / 7739
55
 (HPO:0000006) Autosomal dominant inheritance 2518 / 7739
56
 (HPO:0000982) Palmoplantar keratoderma 40 / 7739