Symptom Information: Sort according to HPO 

1
 (HPO:0000726) Dementia Very frequent [IBIS] 21045164 IBIS 131 / 7739
2
 (HPO:0002077) Migraine with aura Frequent [IBIS] 21045164 IBIS 14 / 7739
3
 (HPO:0000716) Depression Occasional [IBIS] Very frequent [Orphanet] 20% (n=45) 7564728 IBIS 99 / 7739
4
 (HPO:0001575) Mood changes Occasional [IBIS] 20% (n=45) 7564728 IBIS 7 / 7739
5
 (HPO:0007359) Focal seizures Occasional [IBIS] 21045164 IBIS 27 / 7739
6
 (HPO:0002197) Generalized seizures Occasional [IBIS] 21045164 IBIS 30 / 7739
7
 (HPO:0003477) Peripheral axonal neuropathy Occasional [Orphanet] occasional [HPO] 15827866 IBIS 62 / 7739
8
 (HPO:0007178) Motor polyneuropathy Occasional [Orphanet] occasional [HPO] 19488673 IBIS 31 / 7739
9
 (HPO:0001933) Subcutaneous hemorrhage Occasional [Orphanet] 15727650 IBIS 50 / 7739
10
 (HPO:0000737) Irritability Very frequent [Orphanet] 15819734 IBIS 93 / 7739
11
 (HPO:0000739) Anxiety Very frequent [Orphanet] 23355563 IBIS 67 / 7739
12
 (HPO:0000741) Apathy Very frequent [Orphanet] 20301673 IBIS 42 / 7739
13
 (HPO:0000505) Visual impairment Frequent [Orphanet] 16193254 IBIS 297 / 7739
14
 (HPO:0001257) Spasticity Frequent [Orphanet] 11458185 IBIS 251 / 7739
15
 (HPO:0002619) Varicose veins Occasional [Orphanet] 16864835 IBIS 11 / 7739
16
 (HPO:0005293) Venous insufficiency Occasional [Orphanet] 16864835 IBIS 27 / 7739
17
 (HPO:0002076) Migraine Very frequent [Orphanet] 21409506 IBIS 41 / 7739
18
 (HPO:0002315) Headache Very frequent [Orphanet] 19207299 IBIS 175 / 7739
19
 (HPO:0000708) Behavioral abnormality Very frequent [Orphanet] 20301673 IBIS 212 / 7739
20
 (HPO:0002621) Atherosclerosis Occasional [Orphanet] 21178349 IBIS 33 / 7739
21
 (HPO:0001268) Mental deterioration Very frequent [Orphanet] hallmark [HPO] 16421111 IBIS 88 / 7739
22
 (HPO:0002361) Psychomotor deterioration Very frequent [Orphanet] hallmark [HPO] 23355563 IBIS 26 / 7739
23
 (HPO:0002353) EEG abnormality Frequent [Orphanet] 25870789 IBIS 188 / 7739
24
 (HPO:0001297) Stroke Frequent [Orphanet] 17726918 IBIS 44 / 7739
25
 (HPO:0002140) Ischemic stroke Frequent [Orphanet] 20301673 IBIS 70 / 7739
26
 (HPO:0002326) Transient ischemic attack Frequent [Orphanet] 9818928 IBIS 13 / 7739
27
 (HPO:0002120) Cerebral cortical atrophy Frequent [Orphanet] 16643314 IBIS 187 / 7739
28
 (HPO:0100308) Cerebral cortical hemiatrophy Frequent [Orphanet] 22000857 IBIS 7 / 7739
29
 (HPO:0002354) Memory impairment Frequent [Orphanet] 20301673 IBIS 63 / 7739
30
 (HPO:0006824) Cranial nerve paralysis Frequent [Orphanet] 17726918 IBIS 81 / 7739
31
 (HPO:0010628) Facial palsy Frequent [Orphanet] typical [HPO] 25834748 IBIS 146 / 7739
32
 (HPO:0000365) Hearing impairment Occasional [Orphanet] 15829071 IBIS 539 / 7739
33
 (HPO:0011947) Respiratory tract infection Occasional [Orphanet] occasional [HPO] 15364702 IBIS 28 / 7739
34
 (HPO:0002071) Abnormality of extrapyramidal motor function Occasional [Orphanet] 18258841 IBIS 76 / 7739
35
 (MedDRA:10063750) Life expectancy shortened Occasional [Orphanet] 15364702 IBIS 4 / 7739
36
 (HPO:0000822) Hypertension Occasional [Orphanet] 25109394 IBIS 224 / 7739
37
 (HPO:0001288) Gait disturbance Frequent [Orphanet] 20301673 IBIS 318 / 7739
38
 (HPO:0001269) Hemiparesis Very frequent [Orphanet] hallmark [HPO] 20301673 IBIS 51 / 7739
39
 (HPO:0002301) Hemiplegia Very frequent [Orphanet] hallmark [HPO] 15798438 IBIS 42 / 7739
40
 (HPO:0004374) Hemiplegia/hemiparesis Very frequent [Orphanet] 20301673 IBIS 158 / 7739
41
 (HPO:0001259) Coma Very frequent [Orphanet] 12531961 IBIS 65 / 7739
42
 (HPO:0001289) Confusion Very frequent [Orphanet] 20123231 IBIS 36 / 7739
43
 (HPO:0002329) Drowsiness Very frequent [Orphanet] 12531961 IBIS 19 / 7739
44
 (HPO:0002133) Status epilepticus Occasional [Orphanet] 20301673 IBIS 59 / 7739
45
 (HPO:0007763) Retinal telangiectasia Very frequent [Orphanet] 23635925 IBIS 6 / 7739
46
 (HPO:0001945) Fever Very frequent [Orphanet] 12531961 IBIS 218 / 7739
47
 (HPO:0002300) Mutism Very frequent [Orphanet] 20464302 IBIS 28 / 7739
48
 (HPO:0002357) Dysphasia Very frequent [Orphanet] 16796821 IBIS 33 / 7739
49
 (HPO:0002381) Aphasia Very frequent [Orphanet] 19369672 IBIS 27 / 7739
50
 (HPO:0001342) Cerebral hemorrhage Occasional [Orphanet] occasional [HPO] 24344756 IBIS 24 / 7739
51
 (HPO:0002170) Intracranial hemorrhage Occasional [Orphanet] 17135568 IBIS 40 / 7739
52
 (HPO:0001943) Hypoglycemia Occasional [Orphanet] 12791811 IBIS 131 / 7739
53
 (HPO:0100576) Amaurosis fugax Very frequent [Orphanet] 14687018 IBIS 13 / 7739
54
 (HPO:0000020) Urinary incontinence 20301673 IBIS 75 / 7739
55
 (HPO:0000512) Abnormal electroretinogram 15313839 IBIS 61 / 7739
56
 (HPO:0000572) Visual loss 23635925 IBIS 272 / 7739
57
 (HPO:0000618) Blindness 23635925 IBIS 124 / 7739
58
 (HPO:0000649) Abnormality of visual evoked potentials 15096408 IBIS 34 / 7739
59
 (HPO:0000951) Abnormality of the skin 10463351 IBIS 147 / 7739
60
 (HPO:0002167) Neurological speech impairment Very frequent [Orphanet] 16717212 IBIS 308 / 7739
61
 (HPO:0002352) Leukoencephalopathy 20301673 IBIS 32 / 7739
62
 (HPO:0002637) Cerebral ischemia Frequent [Orphanet] 21345538 IBIS 17 / 7739
63
 (HPO:0004370) Abnormality of temperature regulation Very frequent [Orphanet] 12531961 IBIS 58 / 7739
64
 (HPO:0004372) Reduced consciousness/confusion Very frequent [Orphanet] 11810186 IBIS 73 / 7739
65
 (HPO:0007024) Pseudobulbar paralysis 25834748 IBIS 7 / 7739
66
 (HPO:0007123) Subcortical dementia 23308019 IBIS 1 / 7739
67
 (HPO:0007236) Recurrent subcortical infarcts 20301673 IBIS 2 / 7739
68
 (HPO:0007634) Nonarteritic anterior ischemic optic neuropathy 15096408 IBIS 2 / 7739
69
 (HPO:0008046) Abnormality of the retinal vasculature Very frequent [Orphanet] 15313839 IBIS 41 / 7739
70
 (OMIM) Vasculopathy of the small arteries penetrating the white matter 8418535 IBIS 1 / 7739
71
 (OMIM) Affected arteries have electron-dense granular material close to vascular smooth muscle cell membranes 7732783 IBIS 1 / 7739
72
 (OMIM) Biopsy shows granular osmiophilic material of variable electron density adjacent to basal membrane of vascular smooth muscle cell 17620550 IBIS 1 / 7739
73
 (OMIM) Patients 20-30 years old have hyperintense lesions on T2-weighted MRI in the frontal and anterior temporal lobes 14593195 IBIS 1 / 7739
74
 (OMIM) Patients 30-40 years old have hyperintense lesions in periventricular areas, the external capsule, basal ganglia, thalamus, and brainstem 14593195 IBIS 1 / 7739
75
 (OMIM) Patients older than 50 years have hyperintensities, lacunar infarcts, and microbleeds 17620550 IBIS 1 / 7739
76
 (HPO:0100543) Cognitive impairment 20301673 IBIS 230 / 7739
77
 (HPO:0007204) Diffuse white matter abnormalities 20301673 IBIS 2 / 7739
78
 (HPO:0003657) Granular osmiophilic deposits (GROD) in cells 20301673 IBIS 3 / 7739
79
 (HPO:0001270) Motor delay 20301673 IBIS 322 / 7739
80
 (HPO:0001138) Optic neuropathy 16193254 IBIS 12 / 7739
81
 (HPO:0007108) Demyelinating peripheral neuropathy 15827866 IBIS 8 / 7739
82
 (HPO:0001300) Parkinsonism 19542611 IBIS 75 / 7739
83
 (HPO:0001260) Dysarthria 16864835 IBIS 329 / 7739
84
 (HPO:0002015) Dysphagia 16864835 IBIS 301 / 7739
85
 (HPO:0001310) Dysmetria 22218279 IBIS 76 / 7739
86
 (MedDRA:10008398) Change in sustained attention 10371078 IBIS 1 / 7739
87
 (HPO:0002445) Tetraplegia 8418535 IBIS 26 / 7739
88
 (HPO:0007162) Diffuse demyelination of the cerebral white matter 8418535 IBIS 3 / 7739
89
 (MedDRA:10072809) Arterial wall hypertrophy 8418535 IBIS 1 / 7739
90
 (OMIM) MRI shows T2-weighted signals in the basal ganglia 7564728 IBIS 4 / 7739
91
 (MedDRA:10019476) Hemiplegic migraine 8418535 IBIS 2 / 7739
92
 (MedDRA:10072731) White matter lesion 8418535 IBIS 7 / 7739
93
 (HPO:0006799) Basal ganglia cysts 9541301 IBIS 6 / 7739
94
 (HPO:0007305) CNS demyelination 9541301 IBIS 21 / 7739
95
 (OMIM) Hyaline thickening of cerebral arteries 9541301 IBIS 7 / 7739
96
 (HPO:0002067) Bradykinesia 9541301 IBIS 62 / 7739
97
 (HPO:0002078) Truncal ataxia 9541301 IBIS 41 / 7739
98
 (HPO:0001347) Hyperreflexia 9541301 IBIS 363 / 7739
99
 (HPO:0000587) Abnormality of the optic nerve 15313839 IBIS 5 / 7739
100
 (OMIM) Narrowing of retinal vessels 15313839 IBIS 3 / 7739
101
 (MedDRA:10051078) Lacunar infarction 14593195 IBIS 1 / 7739
102
 (HPO:0012444) Brain atrophy 16717211 IBIS 24 / 7739
103
 (HPO:0000709) Psychosis 10371078 IBIS 61 / 7739
104
 (MedDRA:10027939) Mood alterations with manic symptoms 21045164 IBIS 1 / 7739