Symptom Information: Sort according to HPO 

1
 (HPO:0000256) Macrocephaly Frequent [HPO:probinson] 298 / 7739
2
 (HPO:0000618) Blindness Occasional [HPO:probinson] 124 / 7739
3
 (HPO:0000648) Optic atrophy 238 / 7739
4
 (HPO:0000712) Emotional lability 44 / 7739
5
 (HPO:0000746) Delusions 21 / 7739
6
 (HPO:0000751) Personality changes 33 / 7739
7
 (HPO:0000869) Secondary amenorrhea 42 / 7739
8
 (HPO:0001250) Seizures 1245 / 7739
9
 (HPO:0001252) Muscular hypotonia 990 / 7739
10
 (HPO:0001324) Muscle weakness 859 / 7739
11
 (HPO:0001254) Lethargy 104 / 7739
12
 (HPO:0001257) Spasticity 251 / 7739
13
 (HPO:0001260) Dysarthria 329 / 7739
14
 (HPO:0002317) Unsteady gait 45 / 7739
15
 (HPO:0002352) Leukoencephalopathy 32 / 7739
16
 (HPO:0002354) Memory impairment 63 / 7739
17
 (HPO:0002376) Developmental regression 74 / 7739
18
 (HPO:0004485) Cessation of head growth 1 / 7739
19
 (HPO:0006808) Cerebral hypomyelination 16 / 7739
20
 (HPO:0007305) CNS demyelination 21 / 7739
21
 (HPO:0008193) Primary gonadal insufficiency 7 / 7739
22
 (HPO:0008209) Premature ovarian failure 28 / 7739
23
 (HPO:0008233) Decreased serum progesterone 7 / 7739
24
 (OMIM) Cessation of head growth in affected infants 6 / 7739
25
 (OMIM) Macrocephaly may develop in those who survive past age 2 years 6 / 7739
26
 (OMIM) Blindness may occur in affected infants 6 / 7739
27
 (OMIM) Ovarian failure, in a subset of affected patients (ovarioleukodystrophy) 6 / 7739
28
 (OMIM) Deterioration of motor development 6 / 7739
29
 (OMIM) Loss of coordination 6 / 7739
30
 (OMIM) Chronic-progressive course with episodes of rapid deterioration following fever or head trauma 6 / 7739
31
 (OMIM) Rapid, instantaneous neurologic decline may occur after fright 6 / 7739
32
 (OMIM) Developmental regression in affected children 6 / 7739
33
 (HPO:0001288) Gait disturbance 318 / 7739
34
 (HPO:0008947) Infantile muscular hypotonia 482 / 7739
35
 (HPO:0010547) Muscle flaccidity 466 / 7739
36
 (OMIM) Mild mental decline 6 / 7739
37
 (HPO:0100543) Cognitive impairment 230 / 7739
38
 (OMIM) Leukoencephalopathy, severe 6 / 7739
39
 (OMIM) Cavitating leukoencephalopathy 7 / 7739
40
 (OMIM) Cystic degeneration of cerebral white matter with preserved cortex 6 / 7739
41
 (OMIM) Over time, white matter vanishes and is replaced by CSF 6 / 7739
42
 (OMIM) MRI shows symmetric, diffuse lesions with CSF-like signal intensity 6 / 7739
43
 (OMIM) Biopsy shows white matter hypomyelination, demyelination, gliosis 6 / 7739
44
 (OMIM) Biopsy shows foamy lipid-laden macrophages 6 / 7739
45
 (OMIM) White matter rarefaction and cystic degeneration 6 / 7739
46
 (OMIM) Decreased amount of myelin-specific proteins 6 / 7739
47
 (OMIM) Decreased amount of myelin-specific lipids 6 / 7739
48
 (OMIM) Magnetic resonance spectroscopy (MRS) shows decreased N-acetylaspartic acid in unaffected white matter 6 / 7739
49
 (OMIM) MRS shows decreased choline in affected white matter 6 / 7739
50
 (OMIM) MRS shows decreased creatine in white matter 6 / 7739
51
 (HPO:0000741) Apathy 42 / 7739
52
 (OMIM) Psychiatric manifestations more common with adult-onset of disease 6 / 7739
53
 (OMIM) Subset of patients with ovarioleukodystrophy have primary amenorrhea 6 / 7739
54
 (OMIM) Increased serum gonadotropins 6 / 7739
55
 (OMIM) Decreased serum estrogen 6 / 7739
56
 (HPO:0000007) Autosomal recessive inheritance 2538 / 7739
57
 (HPO:0003621) Juvenile onset Frequent [HPO:probinson] 105 / 7739