1
|
(HPO:0001250)
|
Seizures |
|
|
|
|
1245 / 7739
|
2
|
(HPO:0001259)
|
Coma |
|
|
|
|
65 / 7739
|
3
|
(HPO:0001276)
|
Hypertonia |
|
|
|
|
317 / 7739
|
4
|
(HPO:0001298)
|
Encephalopathy |
|
|
|
|
72 / 7739
|
5
|
(HPO:0002090)
|
Pneumonia |
|
|
|
|
59 / 7739
|
6
|
(HPO:0002171)
|
Gliosis |
|
|
|
|
48 / 7739
|
7
|
(HPO:0002181)
|
Cerebral edema |
|
|
|
|
19 / 7739
|
8
|
(HPO:0002445)
|
Tetraplegia |
rare [HPO:skoehler]
|
|
|
|
26 / 7739
|
9
|
(HPO:0002510)
|
Spastic tetraplegia |
|
|
|
|
54 / 7739
|
10
|
(HPO:0002922)
|
Increased CSF protein |
|
|
|
|
27 / 7739
|
11
|
(OMIM)
|
Altered breathing patterns during acute episodes |
|
|
|
|
1 / 7739
|
12
|
(OMIM)
|
Encephalopathy, acute, sudden-onset after febrile illness |
|
|
|
|
1 / 7739
|
13
|
(OMIM)
|
Extensor posturing |
|
|
|
|
1 / 7739
|
14
|
(OMIM)
|
Gaze deviation |
|
|
|
|
1 / 7739
|
15
|
(OMIM)
|
Altered breathing patterns |
|
|
|
|
1 / 7739
|
16
|
(OMIM)
|
Variable outcome after acute illness |
|
|
|
|
1 / 7739
|
17
|
(OMIM)
|
Spastic quadriplegia, residual mild-to-severe (in some patients) |
|
|
|
|
1 / 7739
|
18
|
(OMIM)
|
Mental retardation, residual mild-to-severe (in some patients) |
|
|
|
|
1 / 7739
|
19
|
(OMIM)
|
T2-weighted MRI shows hyperintensities in the thalamus, basal ganglia, and brainstem during acute illness (may later resolve) |
|
|
|
|
1 / 7739
|
20
|
(OMIM)
|
External capsule and claustrum may be involved |
|
|
|
|
1 / 7739
|
21
|
(OMIM)
|
Cellular necrosis |
|
|
|
|
1 / 7739
|
22
|
(HPO:0001892)
|
Abnormal bleeding |
|
|
|
|
85 / 7739
|
23
|
(OMIM)
|
Usually precipitated by viral infection (influenza A, influenza B, parainfluenza II, and Mycoplasma pneumoniae) |
|
|
|
|
1 / 7739
|
24
|
(OMIM)
|
Often an infecting organism cannot be identified |
|
|
|
|
1 / 7739
|
25
|
(OMIM)
|
Increased CSF protein during acute illness |
|
|
|
|
1 / 7739
|
26
|
(HPO:0000006)
|
Autosomal dominant inheritance |
|
|
|
|
2518 / 7739
|
27
|
(HPO:0003593)
|
Infantile onset |
|
|
|
|
249 / 7739
|
28
|
(HPO:0003829)
|
Incomplete penetrance |
|
|
|
|
85 / 7739
|